Fecal Nervonic Acid as a Biomarker for Diagnosing and Monitoring Inflammatory Bowel Disease Article Swipe
C Kunst
,
Tanja Elger
,
Johanna Loibl
,
Muriel Huss
,
Arne Kandulski
,
Sabrina Krautbauer
,
Martina Müller
,
Gerhard Liebisch
,
Hauke Christian Tews
,
Christa Buechler
·
YOU?
·
· 2024
· Open Access
·
· DOI: https://doi.org/10.3390/biomedicines12122764
YOU?
·
· 2024
· Open Access
·
· DOI: https://doi.org/10.3390/biomedicines12122764
Background/Objectives: Inflammatory bowel disease (IBD) is a chronic immune-mediated pathology associated with the dysregulation of lipid metabolism. The administration of nervonic acid, a very long-chain fatty acid, has been shown to improve colonic inflammation in a mouse model of colitis. Our study aimed to quantify fecal levels of nervonic acid, as well as the very long-chain fatty acids, lignoceric acid, and pentacosanoic acid, to identify associations with IBD activity. Methods: Stool samples were collected from 62 patients with IBD and 17 healthy controls. Nervonic acid, lignoceric acid, and pentacosanoic acid were quantified by gas chromatography coupled with mass spectrometry (GC-MS). Lipid levels, normalized to the dry weight of fecal homogenates, were used for calculations. Results: Patients with IBD exhibited elevated fecal nervonic acid levels compared to healthy controls, with no significant differences observed between ulcerative colitis and Crohn’s disease. A fecal nervonic acid concentration of 0.49 µmol/g distinguished IBD patients from controls, achieving a sensitivity of 71% and a specificity of 82%. Fecal nervonic acid levels showed a positive correlation with both C-reactive protein and fecal calprotectin and increased proportionally with rising fecal calprotectin levels. IBD patients treated with corticosteroids or interleukin-12/23 antibodies had higher levels of fecal nervonic acid than those in other therapies, with no difference in serum C-reactive protein and calprotectin levels between these groups. Conclusions: In summary, this analysis indicates that fecal nervonic acid may emerge as a novel specific biomarker for IBD diagnosis and disease monitoring.
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Metadata
- Type
- article
- Language
- en
- Landing Page
- https://doi.org/10.3390/biomedicines12122764
- OA Status
- gold
- Cited By
- 3
- References
- 55
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W4405002658
All OpenAlex metadata
Raw OpenAlex JSON
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https://openalex.org/W4405002658Canonical identifier for this work in OpenAlex
- DOI
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https://doi.org/10.3390/biomedicines12122764Digital Object Identifier
- Title
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Fecal Nervonic Acid as a Biomarker for Diagnosing and Monitoring Inflammatory Bowel DiseaseWork title
- Type
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articleOpenAlex work type
- Language
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enPrimary language
- Publication year
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2024Year of publication
- Publication date
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2024-12-04Full publication date if available
- Authors
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C Kunst, Tanja Elger, Johanna Loibl, Muriel Huss, Arne Kandulski, Sabrina Krautbauer, Martina Müller, Gerhard Liebisch, Hauke Christian Tews, Christa BuechlerList of authors in order
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https://doi.org/10.3390/biomedicines12122764Publisher landing page
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YesWhether a free full text is available
- OA status
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goldOpen access status per OpenAlex
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https://doi.org/10.3390/biomedicines12122764Direct OA link when available
- Concepts
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Calprotectin, Inflammatory bowel disease, Feces, Ulcerative colitis, Gastroenterology, Internal medicine, Biomarker, Colitis, Medicine, Immunology, Disease, Chemistry, Biology, Biochemistry, MicrobiologyTop concepts (fields/topics) attached by OpenAlex
- Cited by
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3Total citation count in OpenAlex
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2025: 3Per-year citation counts (last 5 years)
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55Number of works referenced by this work
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10Other works algorithmically related by OpenAlex
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