Female Athletes and Resistance Training: Acute Hormonal Response and the Influence of the Menstrual Cycle on Training Performance Article Swipe

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Sabrina Vollrath , Norman Bitterlich , Dennis Lüdin , Anya Rothenbühler , Anthony C. Hackney , Silvio Lorenzetti , Anna Drewek , Basil Achermann , Therina du Toit , Petra Stute ·

YOU? · · 2025 · Open Access · · DOI: https://doi.org/10.20944/preprints202509.0555.v1

Aim: This prospective observational study aimed to evaluate acute adrenal-derived hormonal responses and training performance in elite female athletes during resistance training. Methods: Methods: In 19 elite female athletes, acute hormonal responses to resistance training were examined over four weeks, measured before and 60 minutes after exercise. Liquid chromatography–mass spectrometry provided a comprehensive steroid profile, including classical and adrenal-specific 11-oxygenated androgens. Performance metrics were tracked using velocity-based training method. Results: Results: Sixty minutes after resistance training, significant acute changes in steroid hormone concentrations were observed. Levels of 11β-hydroxyandrostenedione (11OHA4) (-0.707 nmol/l; p=0.012, -20%), androsterone (-0.201 nmol/l; p=0.049, -14.8%), and dehydroepiandrosterone (DHEA) (-3.813 nmol/l; p=0.006, -17.1%) decreased significantly. The total sums of glucocorticoids, mineralocorticoids, and of bioactive androgens decreased. No significant differences in absolute or relative velocity loss and estimated one-repetition maximum were observed, suggesting comparable strength and fatigue across menstrual cycle phases. Conclusion: The observed post-exercise decline in glucocorticoids, mineralocorticoids, androgens such as DHEA, indicate a coordinated acute suppression of adrenal steroidogenesis in response to resistance training in female elite athletes. No differences in strength parameters were observed across menstrual cycle phases.

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Type: article
Language: en
Landing Page: https://doi.org/10.20944/preprints202509.0555.v1
PDF: https://www.preprints.org/frontend/manuscript/5d42977be83269b82319a041475f26f4/download_pub
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DOI: https://doi.org/10.20944/preprints202509.0555.v1

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Title: Female Athletes and Resistance Training: Acute Hormonal Response and the Influence of the Menstrual Cycle on Training Performance

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Language: en

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Publication year: 2025

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Publication date: 2025-09-05

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Authors: Sabrina Vollrath, Norman Bitterlich, Dennis Lüdin, Anya Rothenbühler, Anthony C. Hackney, Silvio Lorenzetti, Anna Drewek, Basil Achermann, Therina du Toit, Petra Stute

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Landing page: https://doi.org/10.20944/preprints202509.0555.v1

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