Fetal Gene Regulatory Gene Deletions are Associated with Poor Cognition in Schizophrenia and Community-Based Samples Article Swipe
Jennifer K. Forsyth
,
Jinhan Zhu
,
Ariana S. Chavannes
,
Zachary Trevorrow
,
Mahnoor Hyat
,
Sam A. Sievertsen
,
Sophie Ferreira-Ianone
,
Matthew P. Conomos
,
Keith H. Nuechterlein
,
Robert F. Asarnow
,
Michael F. Green
,
Katherine H. Karlsgodt
,
Diana O. Perkins
,
Tyrone D. Cannon
,
Jean Addington
,
K.S. Cadenhead
,
Barbara A. Cornblatt
,
Matcheri S. Keshavan
,
Daniel H. Mathalon
,
William S. Stone
,
Ming T. Tsuang
,
Elaine F. Walker
,
Scott W. Woods
,
Katherine L. Narr
,
Sarah McEwen
,
Charles Schleifer
,
Cindy M. Yee
,
Caroline Diehl
,
Anika Guha
,
Gregory A. Miller
,
Aaron Alexander‐Bloch
,
Jakob Seidlitz
,
Richard A.I. Bethlehem
,
Roel A. Ophoff
,
Carrie E. Bearden
·
YOU?
·
· 2024
· Open Access
·
· DOI: https://doi.org/10.1101/2024.08.02.24311302
YOU?
·
· 2024
· Open Access
·
· DOI: https://doi.org/10.1101/2024.08.02.24311302
Objective Schizophrenia is a neurodevelopmental disorder involving clinical and genetic heterogeneity. Multiple recurrent copy number variants (CNVs) increase risk for schizophrenia spectrum disorders (SSD). However, how known risk CNVs and broader genome-wide CNVs influence clinical variability is unclear. Furthermore, whether biological annotation of CNV scores can improve power for patient stratification is unknown. Methods This study examined associations between severe phenotypes in 617 SSD individuals, namely, child-onset psychosis or borderline intellectual functioning (IQ), and: 1) known risk CNVs; 2) genome-wide deletion burden scores; and 3) novel scores capturing deletion burden in 18 previously validated and mutually exclusive gene-sets, representing distinct aspects of neurodevelopment. Associations with borderline IQ were assessed for replicability in 233 SSD-relatives and 581 controls, and 9,930 youth from the Adolescent Brain Cognitive Development (ABCD) Study. Results Known SSD- (odds ratios (OR)=7.07, 95%CI[1.60,31.32]) and neurodevelopmental disorder (NDD)-risk CNVs (OR=4.56, 95%CI[1.48,14.10]) were associated with borderline IQ in SSD. Furthermore, beyond effects of known NDD-risk CNVs, deletion of genes involved in regulating gene expression during fetal brain development was associated with borderline IQ across SSD cases and non-cases (OR=2.57, 95%CI[1.44,4.60]), and in the ABCD cohort (OR=1.33, 95%CI[1.00,1.76]). Exploratory structural MRI-based analyses showed associations between fetal gene regulatory gene deletions and altered gray matter volume ( b =0.09, 95%CI[0.004,0.17]) and cortical thickness ( b =0.14, 95%CI[0.05,0.24]) across SSD cases and non-cases. Conclusions Results confirm contributions of known risk CNVs to severe phenotypes in SSD, implicate disrupted fetal brain development in poor cognition, and demonstrate the utility of a neurodevelopmental framework for identifying mechanisms underlying severe SSD-relevant phenotypes.
Related Topics
Concepts
Metadata
- Type
- preprint
- Language
- en
- Landing Page
- https://doi.org/10.1101/2024.08.02.24311302
- OA Status
- green
- References
- 74
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W4402147613
All OpenAlex metadata
Raw OpenAlex JSON
- OpenAlex ID
-
https://openalex.org/W4402147613Canonical identifier for this work in OpenAlex
- DOI
-
https://doi.org/10.1101/2024.08.02.24311302Digital Object Identifier
- Title
-
Fetal Gene Regulatory Gene Deletions are Associated with Poor Cognition in Schizophrenia and Community-Based SamplesWork title
- Type
-
preprintOpenAlex work type
- Language
-
enPrimary language
- Publication year
-
2024Year of publication
- Publication date
-
2024-08-06Full publication date if available
- Authors
-
Jennifer K. Forsyth, Jinhan Zhu, Ariana S. Chavannes, Zachary Trevorrow, Mahnoor Hyat, Sam A. Sievertsen, Sophie Ferreira-Ianone, Matthew P. Conomos, Keith H. Nuechterlein, Robert F. Asarnow, Michael F. Green, Katherine H. Karlsgodt, Diana O. Perkins, Tyrone D. Cannon, Jean Addington, K.S. Cadenhead, Barbara A. Cornblatt, Matcheri S. Keshavan, Daniel H. Mathalon, William S. Stone, Ming T. Tsuang, Elaine F. Walker, Scott W. Woods, Katherine L. Narr, Sarah McEwen, Charles Schleifer, Cindy M. Yee, Caroline Diehl, Anika Guha, Gregory A. Miller, Aaron Alexander‐Bloch, Jakob Seidlitz, Richard A.I. Bethlehem, Roel A. Ophoff, Carrie E. BeardenList of authors in order
- Landing page
-
https://doi.org/10.1101/2024.08.02.24311302Publisher landing page
- Open access
-
YesWhether a free full text is available
- OA status
-
greenOpen access status per OpenAlex
- OA URL
-
https://www.ncbi.nlm.nih.gov/pmc/articles/11361264Direct OA link when available
- Concepts
-
Copy-number variation, Neurodevelopmental disorder, Schizophrenia (object-oriented programming), Psychosis, Intellectual disability, Population, Genetics, Biology, Gene, Psychology, Medicine, Psychiatry, Genome, Environmental healthTop concepts (fields/topics) attached by OpenAlex
- Cited by
-
0Total citation count in OpenAlex
- References (count)
-
74Number of works referenced by this work
- Related works (count)
-
10Other works algorithmically related by OpenAlex
Full payload
| id | https://openalex.org/W4402147613 |
|---|---|
| doi | https://doi.org/10.1101/2024.08.02.24311302 |
| ids.doi | https://doi.org/10.1101/2024.08.02.24311302 |
| ids.pmid | https://pubmed.ncbi.nlm.nih.gov/39211869 |
| ids.openalex | https://openalex.org/W4402147613 |
| fwci | |
| type | preprint |
| title | Fetal Gene Regulatory Gene Deletions are Associated with Poor Cognition in Schizophrenia and Community-Based Samples |
| biblio.issue | |
| biblio.volume | |
| biblio.last_page | |
| biblio.first_page | |
| topics[0].id | https://openalex.org/T11213 |
| topics[0].field.id | https://openalex.org/fields/13 |
| topics[0].field.display_name | Biochemistry, Genetics and Molecular Biology |
| topics[0].score | 0.9997000098228455 |
| topics[0].domain.id | https://openalex.org/domains/1 |
| topics[0].domain.display_name | Life Sciences |
| topics[0].subfield.id | https://openalex.org/subfields/1311 |
| topics[0].subfield.display_name | Genetics |
| topics[0].display_name | Genomic variations and chromosomal abnormalities |
| topics[1].id | https://openalex.org/T11677 |
| topics[1].field.id | https://openalex.org/fields/13 |
| topics[1].field.display_name | Biochemistry, Genetics and Molecular Biology |
| topics[1].score | 0.996399998664856 |
| topics[1].domain.id | https://openalex.org/domains/1 |
| topics[1].domain.display_name | Life Sciences |
| topics[1].subfield.id | https://openalex.org/subfields/1312 |
| topics[1].subfield.display_name | Molecular Biology |
| topics[1].display_name | Congenital heart defects research |
| topics[2].id | https://openalex.org/T10978 |
| topics[2].field.id | https://openalex.org/fields/27 |
| topics[2].field.display_name | Medicine |
| topics[2].score | 0.9958999752998352 |
| topics[2].domain.id | https://openalex.org/domains/4 |
| topics[2].domain.display_name | Health Sciences |
| topics[2].subfield.id | https://openalex.org/subfields/2735 |
| topics[2].subfield.display_name | Pediatrics, Perinatology and Child Health |
| topics[2].display_name | Prenatal Screening and Diagnostics |
| is_xpac | False |
| apc_list | |
| apc_paid | |
| concepts[0].id | https://openalex.org/C120821319 |
| concepts[0].level | 4 |
| concepts[0].score | 0.8192033767700195 |
| concepts[0].wikidata | https://www.wikidata.org/wiki/Q1501491 |
| concepts[0].display_name | Copy-number variation |
| concepts[1].id | https://openalex.org/C2779388368 |
| concepts[1].level | 3 |
| concepts[1].score | 0.5986307263374329 |
| concepts[1].wikidata | https://www.wikidata.org/wiki/Q3450985 |
| concepts[1].display_name | Neurodevelopmental disorder |
| concepts[2].id | https://openalex.org/C2776412080 |
| concepts[2].level | 2 |
| concepts[2].score | 0.5802038311958313 |
| concepts[2].wikidata | https://www.wikidata.org/wiki/Q7431605 |
| concepts[2].display_name | Schizophrenia (object-oriented programming) |
| concepts[3].id | https://openalex.org/C2779727114 |
| concepts[3].level | 2 |
| concepts[3].score | 0.5089659690856934 |
| concepts[3].wikidata | https://www.wikidata.org/wiki/Q170082 |
| concepts[3].display_name | Psychosis |
| concepts[4].id | https://openalex.org/C551499885 |
| concepts[4].level | 2 |
| concepts[4].score | 0.4521517753601074 |
| concepts[4].wikidata | https://www.wikidata.org/wiki/Q183560 |
| concepts[4].display_name | Intellectual disability |
| concepts[5].id | https://openalex.org/C2908647359 |
| concepts[5].level | 2 |
| concepts[5].score | 0.44700857996940613 |
| concepts[5].wikidata | https://www.wikidata.org/wiki/Q2625603 |
| concepts[5].display_name | Population |
| concepts[6].id | https://openalex.org/C54355233 |
| concepts[6].level | 1 |
| concepts[6].score | 0.4149949252605438 |
| concepts[6].wikidata | https://www.wikidata.org/wiki/Q7162 |
| concepts[6].display_name | Genetics |
| concepts[7].id | https://openalex.org/C86803240 |
| concepts[7].level | 0 |
| concepts[7].score | 0.40262651443481445 |
| concepts[7].wikidata | https://www.wikidata.org/wiki/Q420 |
| concepts[7].display_name | Biology |
| concepts[8].id | https://openalex.org/C104317684 |
| concepts[8].level | 2 |
| concepts[8].score | 0.34107500314712524 |
| concepts[8].wikidata | https://www.wikidata.org/wiki/Q7187 |
| concepts[8].display_name | Gene |
| concepts[9].id | https://openalex.org/C15744967 |
| concepts[9].level | 0 |
| concepts[9].score | 0.28191328048706055 |
| concepts[9].wikidata | https://www.wikidata.org/wiki/Q9418 |
| concepts[9].display_name | Psychology |
| concepts[10].id | https://openalex.org/C71924100 |
| concepts[10].level | 0 |
| concepts[10].score | 0.26118186116218567 |
| concepts[10].wikidata | https://www.wikidata.org/wiki/Q11190 |
| concepts[10].display_name | Medicine |
| concepts[11].id | https://openalex.org/C118552586 |
| concepts[11].level | 1 |
| concepts[11].score | 0.22618836164474487 |
| concepts[11].wikidata | https://www.wikidata.org/wiki/Q7867 |
| concepts[11].display_name | Psychiatry |
| concepts[12].id | https://openalex.org/C141231307 |
| concepts[12].level | 3 |
| concepts[12].score | 0.12403380870819092 |
| concepts[12].wikidata | https://www.wikidata.org/wiki/Q7020 |
| concepts[12].display_name | Genome |
| concepts[13].id | https://openalex.org/C99454951 |
| concepts[13].level | 1 |
| concepts[13].score | 0.0 |
| concepts[13].wikidata | https://www.wikidata.org/wiki/Q932068 |
| concepts[13].display_name | Environmental health |
| keywords[0].id | https://openalex.org/keywords/copy-number-variation |
| keywords[0].score | 0.8192033767700195 |
| keywords[0].display_name | Copy-number variation |
| keywords[1].id | https://openalex.org/keywords/neurodevelopmental-disorder |
| keywords[1].score | 0.5986307263374329 |
| keywords[1].display_name | Neurodevelopmental disorder |
| keywords[2].id | https://openalex.org/keywords/schizophrenia |
| keywords[2].score | 0.5802038311958313 |
| keywords[2].display_name | Schizophrenia (object-oriented programming) |
| keywords[3].id | https://openalex.org/keywords/psychosis |
| keywords[3].score | 0.5089659690856934 |
| keywords[3].display_name | Psychosis |
| keywords[4].id | https://openalex.org/keywords/intellectual-disability |
| keywords[4].score | 0.4521517753601074 |
| keywords[4].display_name | Intellectual disability |
| keywords[5].id | https://openalex.org/keywords/population |
| keywords[5].score | 0.44700857996940613 |
| keywords[5].display_name | Population |
| keywords[6].id | https://openalex.org/keywords/genetics |
| keywords[6].score | 0.4149949252605438 |
| keywords[6].display_name | Genetics |
| keywords[7].id | https://openalex.org/keywords/biology |
| keywords[7].score | 0.40262651443481445 |
| keywords[7].display_name | Biology |
| keywords[8].id | https://openalex.org/keywords/gene |
| keywords[8].score | 0.34107500314712524 |
| keywords[8].display_name | Gene |
| keywords[9].id | https://openalex.org/keywords/psychology |
| keywords[9].score | 0.28191328048706055 |
| keywords[9].display_name | Psychology |
| keywords[10].id | https://openalex.org/keywords/medicine |
| keywords[10].score | 0.26118186116218567 |
| keywords[10].display_name | Medicine |
| keywords[11].id | https://openalex.org/keywords/psychiatry |
| keywords[11].score | 0.22618836164474487 |
| keywords[11].display_name | Psychiatry |
| keywords[12].id | https://openalex.org/keywords/genome |
| keywords[12].score | 0.12403380870819092 |
| keywords[12].display_name | Genome |
| language | en |
| locations[0].id | doi:10.1101/2024.08.02.24311302 |
| locations[0].is_oa | False |
| locations[0].source.id | https://openalex.org/S4306402567 |
| locations[0].source.issn | |
| locations[0].source.type | repository |
| locations[0].source.is_oa | False |
| locations[0].source.issn_l | |
| locations[0].source.is_core | False |
| locations[0].source.is_in_doaj | False |
| locations[0].source.display_name | bioRxiv (Cold Spring Harbor Laboratory) |
| locations[0].source.host_organization | https://openalex.org/I2750212522 |
| locations[0].source.host_organization_name | Cold Spring Harbor Laboratory |
| locations[0].source.host_organization_lineage | https://openalex.org/I2750212522 |
| locations[0].license | |
| locations[0].pdf_url | |
| locations[0].version | acceptedVersion |
| locations[0].raw_type | posted-content |
| locations[0].license_id | |
| locations[0].is_accepted | True |
| locations[0].is_published | False |
| locations[0].raw_source_name | |
| locations[0].landing_page_url | https://doi.org/10.1101/2024.08.02.24311302 |
| locations[1].id | pmid:39211869 |
| locations[1].is_oa | False |
| locations[1].source.id | https://openalex.org/S4306525036 |
| locations[1].source.issn | |
| locations[1].source.type | repository |
| locations[1].source.is_oa | False |
| locations[1].source.issn_l | |
| locations[1].source.is_core | False |
| locations[1].source.is_in_doaj | False |
| locations[1].source.display_name | PubMed |
| locations[1].source.host_organization | https://openalex.org/I1299303238 |
| locations[1].source.host_organization_name | National Institutes of Health |
| locations[1].source.host_organization_lineage | https://openalex.org/I1299303238 |
| locations[1].license | |
| locations[1].pdf_url | |
| locations[1].version | publishedVersion |
| locations[1].raw_type | |
| locations[1].license_id | |
| locations[1].is_accepted | True |
| locations[1].is_published | True |
| locations[1].raw_source_name | medRxiv : the preprint server for health sciences |
| locations[1].landing_page_url | https://pubmed.ncbi.nlm.nih.gov/39211869 |
| locations[2].id | pmh:oai:pubmedcentral.nih.gov:11361264 |
| locations[2].is_oa | True |
| locations[2].source.id | https://openalex.org/S2764455111 |
| locations[2].source.issn | |
| locations[2].source.type | repository |
| locations[2].source.is_oa | False |
| locations[2].source.issn_l | |
| locations[2].source.is_core | False |
| locations[2].source.is_in_doaj | False |
| locations[2].source.display_name | PubMed Central |
| locations[2].source.host_organization | https://openalex.org/I1299303238 |
| locations[2].source.host_organization_name | National Institutes of Health |
| locations[2].source.host_organization_lineage | https://openalex.org/I1299303238 |
| locations[2].license | |
| locations[2].pdf_url | |
| locations[2].version | submittedVersion |
| locations[2].raw_type | Text |
| locations[2].license_id | |
| locations[2].is_accepted | False |
| locations[2].is_published | False |
| locations[2].raw_source_name | medRxiv |
| locations[2].landing_page_url | https://www.ncbi.nlm.nih.gov/pmc/articles/11361264 |
| indexed_in | crossref, pubmed |
| authorships[0].author.id | https://openalex.org/A5002308446 |
| authorships[0].author.orcid | https://orcid.org/0000-0002-8786-0024 |
| authorships[0].author.display_name | Jennifer K. Forsyth |
| authorships[0].countries | US |
| authorships[0].affiliations[0].institution_ids | https://openalex.org/I201448701 |
| authorships[0].affiliations[0].raw_affiliation_string | University of Washington |
| authorships[0].institutions[0].id | https://openalex.org/I201448701 |
| authorships[0].institutions[0].ror | https://ror.org/00cvxb145 |
| authorships[0].institutions[0].type | education |
| authorships[0].institutions[0].lineage | https://openalex.org/I201448701 |
| authorships[0].institutions[0].country_code | US |
| authorships[0].institutions[0].display_name | University of Washington |
| authorships[0].author_position | first |
| authorships[0].raw_author_name | Jennifer K. Forsyth |
| authorships[0].is_corresponding | True |
| authorships[0].raw_affiliation_strings | University of Washington |
| authorships[1].author.id | https://openalex.org/A5104666664 |
| authorships[1].author.orcid | |
| authorships[1].author.display_name | Jinhan Zhu |
| authorships[1].countries | US |
| authorships[1].affiliations[0].institution_ids | https://openalex.org/I201448701 |
| authorships[1].affiliations[0].raw_affiliation_string | University of Washington |
| authorships[1].institutions[0].id | https://openalex.org/I201448701 |
| authorships[1].institutions[0].ror | https://ror.org/00cvxb145 |
| authorships[1].institutions[0].type | education |
| authorships[1].institutions[0].lineage | https://openalex.org/I201448701 |
| authorships[1].institutions[0].country_code | US |
| authorships[1].institutions[0].display_name | University of Washington |
| authorships[1].author_position | middle |
| authorships[1].raw_author_name | Jinhan Zhu |
| authorships[1].is_corresponding | False |
| authorships[1].raw_affiliation_strings | University of Washington |
| authorships[2].author.id | https://openalex.org/A5095939737 |
| authorships[2].author.orcid | |
| authorships[2].author.display_name | Ariana S. Chavannes |
| authorships[2].countries | US |
| authorships[2].affiliations[0].institution_ids | https://openalex.org/I201448701 |
| authorships[2].affiliations[0].raw_affiliation_string | University of Washington |
| authorships[2].institutions[0].id | https://openalex.org/I201448701 |
| authorships[2].institutions[0].ror | https://ror.org/00cvxb145 |
| authorships[2].institutions[0].type | education |
| authorships[2].institutions[0].lineage | https://openalex.org/I201448701 |
| authorships[2].institutions[0].country_code | US |
| authorships[2].institutions[0].display_name | University of Washington |
| authorships[2].author_position | middle |
| authorships[2].raw_author_name | Ariana S. Chavannes |
| authorships[2].is_corresponding | False |
| authorships[2].raw_affiliation_strings | University of Washington |
| authorships[3].author.id | https://openalex.org/A5052855122 |
| authorships[3].author.orcid | |
| authorships[3].author.display_name | Zachary Trevorrow |
| authorships[3].countries | US |
| authorships[3].affiliations[0].institution_ids | https://openalex.org/I201448701 |
| authorships[3].affiliations[0].raw_affiliation_string | University of Washington |
| authorships[3].institutions[0].id | https://openalex.org/I201448701 |
| authorships[3].institutions[0].ror | https://ror.org/00cvxb145 |
| authorships[3].institutions[0].type | education |
| authorships[3].institutions[0].lineage | https://openalex.org/I201448701 |
| authorships[3].institutions[0].country_code | US |
| authorships[3].institutions[0].display_name | University of Washington |
| authorships[3].author_position | middle |
| authorships[3].raw_author_name | Zachary H. Trevorrow |
| authorships[3].is_corresponding | False |
| authorships[3].raw_affiliation_strings | University of Washington |
| authorships[4].author.id | https://openalex.org/A5016299723 |
| authorships[4].author.orcid | https://orcid.org/0000-0001-8039-4860 |
| authorships[4].author.display_name | Mahnoor Hyat |
| authorships[4].countries | US |
| authorships[4].affiliations[0].institution_ids | https://openalex.org/I201448701 |
| authorships[4].affiliations[0].raw_affiliation_string | University of Washington |
| authorships[4].institutions[0].id | https://openalex.org/I201448701 |
| authorships[4].institutions[0].ror | https://ror.org/00cvxb145 |
| authorships[4].institutions[0].type | education |
| authorships[4].institutions[0].lineage | https://openalex.org/I201448701 |
| authorships[4].institutions[0].country_code | US |
| authorships[4].institutions[0].display_name | University of Washington |
| authorships[4].author_position | middle |
| authorships[4].raw_author_name | Mahnoor Hyat |
| authorships[4].is_corresponding | False |
| authorships[4].raw_affiliation_strings | University of Washington |
| authorships[5].author.id | https://openalex.org/A5106949487 |
| authorships[5].author.orcid | https://orcid.org/0009-0002-2657-4902 |
| authorships[5].author.display_name | Sam A. Sievertsen |
| authorships[5].countries | US |
| authorships[5].affiliations[0].institution_ids | https://openalex.org/I201448701 |
| authorships[5].affiliations[0].raw_affiliation_string | University of Washington |
| authorships[5].institutions[0].id | https://openalex.org/I201448701 |
| authorships[5].institutions[0].ror | https://ror.org/00cvxb145 |
| authorships[5].institutions[0].type | education |
| authorships[5].institutions[0].lineage | https://openalex.org/I201448701 |
| authorships[5].institutions[0].country_code | US |
| authorships[5].institutions[0].display_name | University of Washington |
| authorships[5].author_position | middle |
| authorships[5].raw_author_name | Sam A. Sievertsen |
| authorships[5].is_corresponding | False |
| authorships[5].raw_affiliation_strings | University of Washington |
| authorships[6].author.id | https://openalex.org/A5106949488 |
| authorships[6].author.orcid | |
| authorships[6].author.display_name | Sophie Ferreira-Ianone |
| authorships[6].countries | US |
| authorships[6].affiliations[0].institution_ids | https://openalex.org/I201448701 |
| authorships[6].affiliations[0].raw_affiliation_string | University of Washington |
| authorships[6].institutions[0].id | https://openalex.org/I201448701 |
| authorships[6].institutions[0].ror | https://ror.org/00cvxb145 |
| authorships[6].institutions[0].type | education |
| authorships[6].institutions[0].lineage | https://openalex.org/I201448701 |
| authorships[6].institutions[0].country_code | US |
| authorships[6].institutions[0].display_name | University of Washington |
| authorships[6].author_position | middle |
| authorships[6].raw_author_name | Sophie Ferreira-Ianone |
| authorships[6].is_corresponding | False |
| authorships[6].raw_affiliation_strings | University of Washington |
| authorships[7].author.id | https://openalex.org/A5036980922 |
| authorships[7].author.orcid | https://orcid.org/0000-0001-9744-0851 |
| authorships[7].author.display_name | Matthew P. Conomos |
| authorships[7].countries | US |
| authorships[7].affiliations[0].institution_ids | https://openalex.org/I201448701 |
| authorships[7].affiliations[0].raw_affiliation_string | University of Washington |
| authorships[7].institutions[0].id | https://openalex.org/I201448701 |
| authorships[7].institutions[0].ror | https://ror.org/00cvxb145 |
| authorships[7].institutions[0].type | education |
| authorships[7].institutions[0].lineage | https://openalex.org/I201448701 |
| authorships[7].institutions[0].country_code | US |
| authorships[7].institutions[0].display_name | University of Washington |
| authorships[7].author_position | middle |
| authorships[7].raw_author_name | Matthew P. Conomos |
| authorships[7].is_corresponding | False |
| authorships[7].raw_affiliation_strings | University of Washington |
| authorships[8].author.id | https://openalex.org/A5067023244 |
| authorships[8].author.orcid | https://orcid.org/0000-0002-8179-8952 |
| authorships[8].author.display_name | Keith H. Nuechterlein |
| authorships[8].countries | US |
| authorships[8].affiliations[0].institution_ids | https://openalex.org/I161318765 |
| authorships[8].affiliations[0].raw_affiliation_string | University of California, Los Angeles |
| authorships[8].institutions[0].id | https://openalex.org/I161318765 |
| authorships[8].institutions[0].ror | https://ror.org/046rm7j60 |
| authorships[8].institutions[0].type | education |
| authorships[8].institutions[0].lineage | https://openalex.org/I161318765 |
| authorships[8].institutions[0].country_code | US |
| authorships[8].institutions[0].display_name | University of California, Los Angeles |
| authorships[8].author_position | middle |
| authorships[8].raw_author_name | Keith H. Nuechterlein |
| authorships[8].is_corresponding | False |
| authorships[8].raw_affiliation_strings | University of California, Los Angeles |
| authorships[9].author.id | https://openalex.org/A5051857780 |
| authorships[9].author.orcid | https://orcid.org/0000-0002-4994-9642 |
| authorships[9].author.display_name | Robert F. Asarnow |
| authorships[9].countries | US |
| authorships[9].affiliations[0].institution_ids | https://openalex.org/I161318765 |
| authorships[9].affiliations[0].raw_affiliation_string | University of California, Los Angeles |
| authorships[9].institutions[0].id | https://openalex.org/I161318765 |
| authorships[9].institutions[0].ror | https://ror.org/046rm7j60 |
| authorships[9].institutions[0].type | education |
| authorships[9].institutions[0].lineage | https://openalex.org/I161318765 |
| authorships[9].institutions[0].country_code | US |
| authorships[9].institutions[0].display_name | University of California, Los Angeles |
| authorships[9].author_position | middle |
| authorships[9].raw_author_name | Robert F. Asarnow |
| authorships[9].is_corresponding | False |
| authorships[9].raw_affiliation_strings | University of California, Los Angeles |
| authorships[10].author.id | https://openalex.org/A5003154905 |
| authorships[10].author.orcid | https://orcid.org/0000-0001-5620-8562 |
| authorships[10].author.display_name | Michael F. Green |
| authorships[10].countries | US |
| authorships[10].affiliations[0].institution_ids | https://openalex.org/I161318765 |
| authorships[10].affiliations[0].raw_affiliation_string | University of California, Los Angeles |
| authorships[10].institutions[0].id | https://openalex.org/I161318765 |
| authorships[10].institutions[0].ror | https://ror.org/046rm7j60 |
| authorships[10].institutions[0].type | education |
| authorships[10].institutions[0].lineage | https://openalex.org/I161318765 |
| authorships[10].institutions[0].country_code | US |
| authorships[10].institutions[0].display_name | University of California, Los Angeles |
| authorships[10].author_position | middle |
| authorships[10].raw_author_name | Michael F. Green |
| authorships[10].is_corresponding | False |
| authorships[10].raw_affiliation_strings | University of California, Los Angeles |
| authorships[11].author.id | https://openalex.org/A5009032760 |
| authorships[11].author.orcid | https://orcid.org/0000-0003-3332-4231 |
| authorships[11].author.display_name | Katherine H. Karlsgodt |
| authorships[11].countries | US |
| authorships[11].affiliations[0].institution_ids | https://openalex.org/I161318765 |
| authorships[11].affiliations[0].raw_affiliation_string | University of California, Los Angeles |
| authorships[11].institutions[0].id | https://openalex.org/I161318765 |
| authorships[11].institutions[0].ror | https://ror.org/046rm7j60 |
| authorships[11].institutions[0].type | education |
| authorships[11].institutions[0].lineage | https://openalex.org/I161318765 |
| authorships[11].institutions[0].country_code | US |
| authorships[11].institutions[0].display_name | University of California, Los Angeles |
| authorships[11].author_position | middle |
| authorships[11].raw_author_name | Katherine H. Karlsgodt |
| authorships[11].is_corresponding | False |
| authorships[11].raw_affiliation_strings | University of California, Los Angeles |
| authorships[12].author.id | https://openalex.org/A5005838731 |
| authorships[12].author.orcid | https://orcid.org/0000-0001-9396-2206 |
| authorships[12].author.display_name | Diana O. Perkins |
| authorships[12].countries | US |
| authorships[12].affiliations[0].institution_ids | https://openalex.org/I114027177 |
| authorships[12].affiliations[0].raw_affiliation_string | University of North Carolina, Chapel Hill |
| authorships[12].institutions[0].id | https://openalex.org/I114027177 |
| authorships[12].institutions[0].ror | https://ror.org/0130frc33 |
| authorships[12].institutions[0].type | education |
| authorships[12].institutions[0].lineage | https://openalex.org/I114027177 |
| authorships[12].institutions[0].country_code | US |
| authorships[12].institutions[0].display_name | University of North Carolina at Chapel Hill |
| authorships[12].author_position | middle |
| authorships[12].raw_author_name | Diana O. Perkins |
| authorships[12].is_corresponding | False |
| authorships[12].raw_affiliation_strings | University of North Carolina, Chapel Hill |
| authorships[13].author.id | https://openalex.org/A5090423513 |
| authorships[13].author.orcid | https://orcid.org/0000-0002-5632-3154 |
| authorships[13].author.display_name | Tyrone D. Cannon |
| authorships[13].countries | US |
| authorships[13].affiliations[0].institution_ids | https://openalex.org/I32971472 |
| authorships[13].affiliations[0].raw_affiliation_string | Yale University |
| authorships[13].institutions[0].id | https://openalex.org/I32971472 |
| authorships[13].institutions[0].ror | https://ror.org/03v76x132 |
| authorships[13].institutions[0].type | education |
| authorships[13].institutions[0].lineage | https://openalex.org/I32971472 |
| authorships[13].institutions[0].country_code | US |
| authorships[13].institutions[0].display_name | Yale University |
| authorships[13].author_position | middle |
| authorships[13].raw_author_name | Tyrone D. Cannon |
| authorships[13].is_corresponding | False |
| authorships[13].raw_affiliation_strings | Yale University |
| authorships[14].author.id | https://openalex.org/A5049765674 |
| authorships[14].author.orcid | https://orcid.org/0000-0002-8298-0756 |
| authorships[14].author.display_name | Jean Addington |
| authorships[14].countries | CA |
| authorships[14].affiliations[0].institution_ids | https://openalex.org/I168635309 |
| authorships[14].affiliations[0].raw_affiliation_string | University of Calgary |
| authorships[14].institutions[0].id | https://openalex.org/I168635309 |
| authorships[14].institutions[0].ror | https://ror.org/03yjb2x39 |
| authorships[14].institutions[0].type | education |
| authorships[14].institutions[0].lineage | https://openalex.org/I168635309 |
| authorships[14].institutions[0].country_code | CA |
| authorships[14].institutions[0].display_name | University of Calgary |
| authorships[14].author_position | middle |
| authorships[14].raw_author_name | Jean M. Addington |
| authorships[14].is_corresponding | False |
| authorships[14].raw_affiliation_strings | University of Calgary |
| authorships[15].author.id | https://openalex.org/A5039501975 |
| authorships[15].author.orcid | |
| authorships[15].author.display_name | K.S. Cadenhead |
| authorships[15].countries | US |
| authorships[15].affiliations[0].institution_ids | https://openalex.org/I36258959 |
| authorships[15].affiliations[0].raw_affiliation_string | University of California, San Diego |
| authorships[15].institutions[0].id | https://openalex.org/I36258959 |
| authorships[15].institutions[0].ror | https://ror.org/0168r3w48 |
| authorships[15].institutions[0].type | education |
| authorships[15].institutions[0].lineage | https://openalex.org/I36258959 |
| authorships[15].institutions[0].country_code | US |
| authorships[15].institutions[0].display_name | University of California, San Diego |
| authorships[15].author_position | middle |
| authorships[15].raw_author_name | Kristen S. Cadenhead |
| authorships[15].is_corresponding | False |
| authorships[15].raw_affiliation_strings | University of California, San Diego |
| authorships[16].author.id | https://openalex.org/A5003224847 |
| authorships[16].author.orcid | https://orcid.org/0000-0002-3194-6304 |
| authorships[16].author.display_name | Barbara A. Cornblatt |
| authorships[16].countries | US |
| authorships[16].affiliations[0].institution_ids | https://openalex.org/I4210106353 |
| authorships[16].affiliations[0].raw_affiliation_string | Donald and Barbara Zucker School of Medicine at Hofstra/Northwell |
| authorships[16].institutions[0].id | https://openalex.org/I4210106353 |
| authorships[16].institutions[0].ror | https://ror.org/01ff5td15 |
| authorships[16].institutions[0].type | education |
| authorships[16].institutions[0].lineage | https://openalex.org/I1302444339, https://openalex.org/I139290212, https://openalex.org/I4210106353 |
| authorships[16].institutions[0].country_code | US |
| authorships[16].institutions[0].display_name | Donald & Barbara Zucker School of Medicine at Hofstra/Northwell |
| authorships[16].author_position | middle |
| authorships[16].raw_author_name | Barbara A. Cornblatt |
| authorships[16].is_corresponding | False |
| authorships[16].raw_affiliation_strings | Donald and Barbara Zucker School of Medicine at Hofstra/Northwell |
| authorships[17].author.id | https://openalex.org/A5000706062 |
| authorships[17].author.orcid | https://orcid.org/0000-0002-5945-888X |
| authorships[17].author.display_name | Matcheri S. Keshavan |
| authorships[17].countries | IL |
| authorships[17].affiliations[0].institution_ids | https://openalex.org/I2799899409 |
| authorships[17].affiliations[0].raw_affiliation_string | Harvard Medical School at Beth Israel Deaconess Medical Center |
| authorships[17].institutions[0].id | https://openalex.org/I2799899409 |
| authorships[17].institutions[0].ror | https://ror.org/01cqmqj90 |
| authorships[17].institutions[0].type | healthcare |
| authorships[17].institutions[0].lineage | https://openalex.org/I2799899409 |
| authorships[17].institutions[0].country_code | IL |
| authorships[17].institutions[0].display_name | Hadassah Medical Center |
| authorships[17].author_position | middle |
| authorships[17].raw_author_name | Matcheri S. Keshavan |
| authorships[17].is_corresponding | False |
| authorships[17].raw_affiliation_strings | Harvard Medical School at Beth Israel Deaconess Medical Center |
| authorships[18].author.id | https://openalex.org/A5018920191 |
| authorships[18].author.orcid | https://orcid.org/0000-0001-6090-4974 |
| authorships[18].author.display_name | Daniel H. Mathalon |
| authorships[18].countries | US |
| authorships[18].affiliations[0].institution_ids | https://openalex.org/I180670191 |
| authorships[18].affiliations[0].raw_affiliation_string | University of California, San Francisco |
| authorships[18].institutions[0].id | https://openalex.org/I180670191 |
| authorships[18].institutions[0].ror | https://ror.org/043mz5j54 |
| authorships[18].institutions[0].type | education |
| authorships[18].institutions[0].lineage | https://openalex.org/I180670191 |
| authorships[18].institutions[0].country_code | US |
| authorships[18].institutions[0].display_name | University of California, San Francisco |
| authorships[18].author_position | middle |
| authorships[18].raw_author_name | Daniel H. Mathalon |
| authorships[18].is_corresponding | False |
| authorships[18].raw_affiliation_strings | University of California, San Francisco |
| authorships[19].author.id | https://openalex.org/A5056528052 |
| authorships[19].author.orcid | https://orcid.org/0000-0003-2932-7288 |
| authorships[19].author.display_name | William S. Stone |
| authorships[19].countries | IL |
| authorships[19].affiliations[0].institution_ids | https://openalex.org/I2799899409 |
| authorships[19].affiliations[0].raw_affiliation_string | Harvard Medical School at Beth Israel Deaconess Medical Center |
| authorships[19].institutions[0].id | https://openalex.org/I2799899409 |
| authorships[19].institutions[0].ror | https://ror.org/01cqmqj90 |
| authorships[19].institutions[0].type | healthcare |
| authorships[19].institutions[0].lineage | https://openalex.org/I2799899409 |
| authorships[19].institutions[0].country_code | IL |
| authorships[19].institutions[0].display_name | Hadassah Medical Center |
| authorships[19].author_position | middle |
| authorships[19].raw_author_name | William S. Stone |
| authorships[19].is_corresponding | False |
| authorships[19].raw_affiliation_strings | Harvard Medical School at Beth Israel Deaconess Medical Center |
| authorships[20].author.id | https://openalex.org/A5044176155 |
| authorships[20].author.orcid | https://orcid.org/0000-0002-0076-5340 |
| authorships[20].author.display_name | Ming T. Tsuang |
| authorships[20].countries | US |
| authorships[20].affiliations[0].institution_ids | https://openalex.org/I36258959 |
| authorships[20].affiliations[0].raw_affiliation_string | University of California, San Diego |
| authorships[20].institutions[0].id | https://openalex.org/I36258959 |
| authorships[20].institutions[0].ror | https://ror.org/0168r3w48 |
| authorships[20].institutions[0].type | education |
| authorships[20].institutions[0].lineage | https://openalex.org/I36258959 |
| authorships[20].institutions[0].country_code | US |
| authorships[20].institutions[0].display_name | University of California, San Diego |
| authorships[20].author_position | middle |
| authorships[20].raw_author_name | Ming T. Tsuang |
| authorships[20].is_corresponding | False |
| authorships[20].raw_affiliation_strings | University of California, San Diego |
| authorships[21].author.id | https://openalex.org/A5037164680 |
| authorships[21].author.orcid | https://orcid.org/0000-0002-9798-8101 |
| authorships[21].author.display_name | Elaine F. Walker |
| authorships[21].countries | US |
| authorships[21].affiliations[0].institution_ids | https://openalex.org/I150468666 |
| authorships[21].affiliations[0].raw_affiliation_string | Emory University |
| authorships[21].institutions[0].id | https://openalex.org/I150468666 |
| authorships[21].institutions[0].ror | https://ror.org/03czfpz43 |
| authorships[21].institutions[0].type | education |
| authorships[21].institutions[0].lineage | https://openalex.org/I150468666 |
| authorships[21].institutions[0].country_code | US |
| authorships[21].institutions[0].display_name | Emory University |
| authorships[21].author_position | middle |
| authorships[21].raw_author_name | Elaine F. Walker |
| authorships[21].is_corresponding | False |
| authorships[21].raw_affiliation_strings | Emory University |
| authorships[22].author.id | https://openalex.org/A5073531380 |
| authorships[22].author.orcid | https://orcid.org/0000-0002-3103-5228 |
| authorships[22].author.display_name | Scott W. Woods |
| authorships[22].countries | US |
| authorships[22].affiliations[0].institution_ids | https://openalex.org/I32971472 |
| authorships[22].affiliations[0].raw_affiliation_string | Yale University |
| authorships[22].institutions[0].id | https://openalex.org/I32971472 |
| authorships[22].institutions[0].ror | https://ror.org/03v76x132 |
| authorships[22].institutions[0].type | education |
| authorships[22].institutions[0].lineage | https://openalex.org/I32971472 |
| authorships[22].institutions[0].country_code | US |
| authorships[22].institutions[0].display_name | Yale University |
| authorships[22].author_position | middle |
| authorships[22].raw_author_name | Scott W. Woods |
| authorships[22].is_corresponding | False |
| authorships[22].raw_affiliation_strings | Yale University |
| authorships[23].author.id | https://openalex.org/A5083948964 |
| authorships[23].author.orcid | https://orcid.org/0000-0002-9396-7936 |
| authorships[23].author.display_name | Katherine L. Narr |
| authorships[23].countries | US |
| authorships[23].affiliations[0].institution_ids | https://openalex.org/I161318765 |
| authorships[23].affiliations[0].raw_affiliation_string | University of California, Los Angeles |
| authorships[23].institutions[0].id | https://openalex.org/I161318765 |
| authorships[23].institutions[0].ror | https://ror.org/046rm7j60 |
| authorships[23].institutions[0].type | education |
| authorships[23].institutions[0].lineage | https://openalex.org/I161318765 |
| authorships[23].institutions[0].country_code | US |
| authorships[23].institutions[0].display_name | University of California, Los Angeles |
| authorships[23].author_position | middle |
| authorships[23].raw_author_name | Katherine L. Narr |
| authorships[23].is_corresponding | False |
| authorships[23].raw_affiliation_strings | University of California, Los Angeles |
| authorships[24].author.id | https://openalex.org/A5086422468 |
| authorships[24].author.orcid | https://orcid.org/0000-0001-6425-6126 |
| authorships[24].author.display_name | Sarah McEwen |
| authorships[24].countries | US |
| authorships[24].affiliations[0].institution_ids | https://openalex.org/I161318765 |
| authorships[24].affiliations[0].raw_affiliation_string | University of California, Los Angeles |
| authorships[24].institutions[0].id | https://openalex.org/I161318765 |
| authorships[24].institutions[0].ror | https://ror.org/046rm7j60 |
| authorships[24].institutions[0].type | education |
| authorships[24].institutions[0].lineage | https://openalex.org/I161318765 |
| authorships[24].institutions[0].country_code | US |
| authorships[24].institutions[0].display_name | University of California, Los Angeles |
| authorships[24].author_position | middle |
| authorships[24].raw_author_name | Sarah C. McEwen |
| authorships[24].is_corresponding | False |
| authorships[24].raw_affiliation_strings | University of California, Los Angeles |
| authorships[25].author.id | https://openalex.org/A5016070090 |
| authorships[25].author.orcid | https://orcid.org/0000-0001-8411-0968 |
| authorships[25].author.display_name | Charles Schleifer |
| authorships[25].countries | US |
| authorships[25].affiliations[0].institution_ids | https://openalex.org/I161318765 |
| authorships[25].affiliations[0].raw_affiliation_string | University of California, Los Angeles |
| authorships[25].institutions[0].id | https://openalex.org/I161318765 |
| authorships[25].institutions[0].ror | https://ror.org/046rm7j60 |
| authorships[25].institutions[0].type | education |
| authorships[25].institutions[0].lineage | https://openalex.org/I161318765 |
| authorships[25].institutions[0].country_code | US |
| authorships[25].institutions[0].display_name | University of California, Los Angeles |
| authorships[25].author_position | middle |
| authorships[25].raw_author_name | Charles H. Schleifer |
| authorships[25].is_corresponding | False |
| authorships[25].raw_affiliation_strings | University of California, Los Angeles |
| authorships[26].author.id | https://openalex.org/A5034746344 |
| authorships[26].author.orcid | https://orcid.org/0000-0003-1341-1661 |
| authorships[26].author.display_name | Cindy M. Yee |
| authorships[26].countries | US |
| authorships[26].affiliations[0].institution_ids | https://openalex.org/I161318765 |
| authorships[26].affiliations[0].raw_affiliation_string | University of California, Los Angeles |
| authorships[26].institutions[0].id | https://openalex.org/I161318765 |
| authorships[26].institutions[0].ror | https://ror.org/046rm7j60 |
| authorships[26].institutions[0].type | education |
| authorships[26].institutions[0].lineage | https://openalex.org/I161318765 |
| authorships[26].institutions[0].country_code | US |
| authorships[26].institutions[0].display_name | University of California, Los Angeles |
| authorships[26].author_position | middle |
| authorships[26].raw_author_name | Cindy M. Yee |
| authorships[26].is_corresponding | False |
| authorships[26].raw_affiliation_strings | University of California, Los Angeles |
| authorships[27].author.id | https://openalex.org/A5014536845 |
| authorships[27].author.orcid | https://orcid.org/0000-0001-7792-7400 |
| authorships[27].author.display_name | Caroline Diehl |
| authorships[27].countries | US |
| authorships[27].affiliations[0].institution_ids | https://openalex.org/I161318765 |
| authorships[27].affiliations[0].raw_affiliation_string | University of California, Los Angeles |
| authorships[27].institutions[0].id | https://openalex.org/I161318765 |
| authorships[27].institutions[0].ror | https://ror.org/046rm7j60 |
| authorships[27].institutions[0].type | education |
| authorships[27].institutions[0].lineage | https://openalex.org/I161318765 |
| authorships[27].institutions[0].country_code | US |
| authorships[27].institutions[0].display_name | University of California, Los Angeles |
| authorships[27].author_position | middle |
| authorships[27].raw_author_name | Caroline K. Diehl |
| authorships[27].is_corresponding | False |
| authorships[27].raw_affiliation_strings | University of California, Los Angeles |
| authorships[28].author.id | https://openalex.org/A5066880544 |
| authorships[28].author.orcid | https://orcid.org/0000-0002-4576-5037 |
| authorships[28].author.display_name | Anika Guha |
| authorships[28].countries | US |
| authorships[28].affiliations[0].institution_ids | https://openalex.org/I161318765 |
| authorships[28].affiliations[0].raw_affiliation_string | University of California, Los Angeles |
| authorships[28].institutions[0].id | https://openalex.org/I161318765 |
| authorships[28].institutions[0].ror | https://ror.org/046rm7j60 |
| authorships[28].institutions[0].type | education |
| authorships[28].institutions[0].lineage | https://openalex.org/I161318765 |
| authorships[28].institutions[0].country_code | US |
| authorships[28].institutions[0].display_name | University of California, Los Angeles |
| authorships[28].author_position | middle |
| authorships[28].raw_author_name | Anika Guha |
| authorships[28].is_corresponding | False |
| authorships[28].raw_affiliation_strings | University of California, Los Angeles |
| authorships[29].author.id | https://openalex.org/A5071710409 |
| authorships[29].author.orcid | https://orcid.org/0000-0002-2702-610X |
| authorships[29].author.display_name | Gregory A. Miller |
| authorships[29].countries | US |
| authorships[29].affiliations[0].institution_ids | https://openalex.org/I161318765 |
| authorships[29].affiliations[0].raw_affiliation_string | University of California, Los Angeles |
| authorships[29].institutions[0].id | https://openalex.org/I161318765 |
| authorships[29].institutions[0].ror | https://ror.org/046rm7j60 |
| authorships[29].institutions[0].type | education |
| authorships[29].institutions[0].lineage | https://openalex.org/I161318765 |
| authorships[29].institutions[0].country_code | US |
| authorships[29].institutions[0].display_name | University of California, Los Angeles |
| authorships[29].author_position | middle |
| authorships[29].raw_author_name | Gregory A. Miller |
| authorships[29].is_corresponding | False |
| authorships[29].raw_affiliation_strings | University of California, Los Angeles |
| authorships[30].author.id | https://openalex.org/A5021517716 |
| authorships[30].author.orcid | https://orcid.org/0000-0001-6554-1893 |
| authorships[30].author.display_name | Aaron Alexander‐Bloch |
| authorships[30].countries | US |
| authorships[30].affiliations[0].institution_ids | https://openalex.org/I36788626 |
| authorships[30].affiliations[0].raw_affiliation_string | University of Pennsylvania |
| authorships[30].institutions[0].id | https://openalex.org/I36788626 |
| authorships[30].institutions[0].ror | https://ror.org/01spssf70 |
| authorships[30].institutions[0].type | education |
| authorships[30].institutions[0].lineage | https://openalex.org/I36788626 |
| authorships[30].institutions[0].country_code | US |
| authorships[30].institutions[0].display_name | California University of Pennsylvania |
| authorships[30].author_position | middle |
| authorships[30].raw_author_name | Aaron F. Alexander-Bloch |
| authorships[30].is_corresponding | False |
| authorships[30].raw_affiliation_strings | University of Pennsylvania |
| authorships[31].author.id | https://openalex.org/A5056578190 |
| authorships[31].author.orcid | https://orcid.org/0000-0002-8164-7476 |
| authorships[31].author.display_name | Jakob Seidlitz |
| authorships[31].countries | US |
| authorships[31].affiliations[0].institution_ids | https://openalex.org/I36788626 |
| authorships[31].affiliations[0].raw_affiliation_string | University of Pennsylvania |
| authorships[31].institutions[0].id | https://openalex.org/I36788626 |
| authorships[31].institutions[0].ror | https://ror.org/01spssf70 |
| authorships[31].institutions[0].type | education |
| authorships[31].institutions[0].lineage | https://openalex.org/I36788626 |
| authorships[31].institutions[0].country_code | US |
| authorships[31].institutions[0].display_name | California University of Pennsylvania |
| authorships[31].author_position | middle |
| authorships[31].raw_author_name | Jakob Seidlitz |
| authorships[31].is_corresponding | False |
| authorships[31].raw_affiliation_strings | University of Pennsylvania |
| authorships[32].author.id | https://openalex.org/A5014830769 |
| authorships[32].author.orcid | https://orcid.org/0000-0002-0714-0685 |
| authorships[32].author.display_name | Richard A.I. Bethlehem |
| authorships[32].countries | GB |
| authorships[32].affiliations[0].institution_ids | https://openalex.org/I241749 |
| authorships[32].affiliations[0].raw_affiliation_string | University of Cambridge |
| authorships[32].institutions[0].id | https://openalex.org/I241749 |
| authorships[32].institutions[0].ror | https://ror.org/013meh722 |
| authorships[32].institutions[0].type | education |
| authorships[32].institutions[0].lineage | https://openalex.org/I241749 |
| authorships[32].institutions[0].country_code | GB |
| authorships[32].institutions[0].display_name | University of Cambridge |
| authorships[32].author_position | middle |
| authorships[32].raw_author_name | Richard A. I. Bethlehem |
| authorships[32].is_corresponding | False |
| authorships[32].raw_affiliation_strings | University of Cambridge |
| authorships[33].author.id | https://openalex.org/A5022855713 |
| authorships[33].author.orcid | https://orcid.org/0000-0002-8287-6457 |
| authorships[33].author.display_name | Roel A. Ophoff |
| authorships[33].countries | US |
| authorships[33].affiliations[0].institution_ids | https://openalex.org/I161318765 |
| authorships[33].affiliations[0].raw_affiliation_string | University of California, Los Angeles |
| authorships[33].institutions[0].id | https://openalex.org/I161318765 |
| authorships[33].institutions[0].ror | https://ror.org/046rm7j60 |
| authorships[33].institutions[0].type | education |
| authorships[33].institutions[0].lineage | https://openalex.org/I161318765 |
| authorships[33].institutions[0].country_code | US |
| authorships[33].institutions[0].display_name | University of California, Los Angeles |
| authorships[33].author_position | middle |
| authorships[33].raw_author_name | Roel A. Ophoff |
| authorships[33].is_corresponding | False |
| authorships[33].raw_affiliation_strings | University of California, Los Angeles |
| authorships[34].author.id | https://openalex.org/A5012270886 |
| authorships[34].author.orcid | https://orcid.org/0000-0002-8516-923X |
| authorships[34].author.display_name | Carrie E. Bearden |
| authorships[34].countries | US |
| authorships[34].affiliations[0].institution_ids | https://openalex.org/I161318765 |
| authorships[34].affiliations[0].raw_affiliation_string | University of California, Los Angeles |
| authorships[34].institutions[0].id | https://openalex.org/I161318765 |
| authorships[34].institutions[0].ror | https://ror.org/046rm7j60 |
| authorships[34].institutions[0].type | education |
| authorships[34].institutions[0].lineage | https://openalex.org/I161318765 |
| authorships[34].institutions[0].country_code | US |
| authorships[34].institutions[0].display_name | University of California, Los Angeles |
| authorships[34].author_position | last |
| authorships[34].raw_author_name | Carrie E. Bearden |
| authorships[34].is_corresponding | False |
| authorships[34].raw_affiliation_strings | University of California, Los Angeles |
| has_content.pdf | False |
| has_content.grobid_xml | False |
| is_paratext | False |
| open_access.is_oa | True |
| open_access.oa_url | https://www.ncbi.nlm.nih.gov/pmc/articles/11361264 |
| open_access.oa_status | green |
| open_access.any_repository_has_fulltext | False |
| created_date | 2025-10-10T00:00:00 |
| display_name | Fetal Gene Regulatory Gene Deletions are Associated with Poor Cognition in Schizophrenia and Community-Based Samples |
| has_fulltext | False |
| is_retracted | False |
| updated_date | 2025-11-06T03:46:38.306776 |
| primary_topic.id | https://openalex.org/T11213 |
| primary_topic.field.id | https://openalex.org/fields/13 |
| primary_topic.field.display_name | Biochemistry, Genetics and Molecular Biology |
| primary_topic.score | 0.9997000098228455 |
| primary_topic.domain.id | https://openalex.org/domains/1 |
| primary_topic.domain.display_name | Life Sciences |
| primary_topic.subfield.id | https://openalex.org/subfields/1311 |
| primary_topic.subfield.display_name | Genetics |
| primary_topic.display_name | Genomic variations and chromosomal abnormalities |
| related_works | https://openalex.org/W2513883126, https://openalex.org/W3118014344, https://openalex.org/W2525895979, https://openalex.org/W4206244413, https://openalex.org/W2488063178, https://openalex.org/W4304620041, https://openalex.org/W2804752758, https://openalex.org/W4224437069, https://openalex.org/W3133960269, https://openalex.org/W2981333376 |
| cited_by_count | 0 |
| locations_count | 3 |
| best_oa_location.id | pmh:oai:pubmedcentral.nih.gov:11361264 |
| best_oa_location.is_oa | True |
| best_oa_location.source.id | https://openalex.org/S2764455111 |
| best_oa_location.source.issn | |
| best_oa_location.source.type | repository |
| best_oa_location.source.is_oa | False |
| best_oa_location.source.issn_l | |
| best_oa_location.source.is_core | False |
| best_oa_location.source.is_in_doaj | False |
| best_oa_location.source.display_name | PubMed Central |
| best_oa_location.source.host_organization | https://openalex.org/I1299303238 |
| best_oa_location.source.host_organization_name | National Institutes of Health |
| best_oa_location.source.host_organization_lineage | https://openalex.org/I1299303238 |
| best_oa_location.license | |
| best_oa_location.pdf_url | |
| best_oa_location.version | submittedVersion |
| best_oa_location.raw_type | Text |
| best_oa_location.license_id | |
| best_oa_location.is_accepted | False |
| best_oa_location.is_published | False |
| best_oa_location.raw_source_name | medRxiv |
| best_oa_location.landing_page_url | https://www.ncbi.nlm.nih.gov/pmc/articles/11361264 |
| primary_location.id | doi:10.1101/2024.08.02.24311302 |
| primary_location.is_oa | False |
| primary_location.source.id | https://openalex.org/S4306402567 |
| primary_location.source.issn | |
| primary_location.source.type | repository |
| primary_location.source.is_oa | False |
| primary_location.source.issn_l | |
| primary_location.source.is_core | False |
| primary_location.source.is_in_doaj | False |
| primary_location.source.display_name | bioRxiv (Cold Spring Harbor Laboratory) |
| primary_location.source.host_organization | https://openalex.org/I2750212522 |
| primary_location.source.host_organization_name | Cold Spring Harbor Laboratory |
| primary_location.source.host_organization_lineage | https://openalex.org/I2750212522 |
| primary_location.license | |
| primary_location.pdf_url | |
| primary_location.version | acceptedVersion |
| primary_location.raw_type | posted-content |
| primary_location.license_id | |
| primary_location.is_accepted | True |
| primary_location.is_published | False |
| primary_location.raw_source_name | |
| primary_location.landing_page_url | https://doi.org/10.1101/2024.08.02.24311302 |
| publication_date | 2024-08-06 |
| publication_year | 2024 |
| referenced_works | https://openalex.org/W2981149635, https://openalex.org/W4317811195, https://openalex.org/W1986137375, https://openalex.org/W2945575042, https://openalex.org/W2156436903, https://openalex.org/W3032034316, https://openalex.org/W2551102722, https://openalex.org/W2510482597, https://openalex.org/W1964512314, https://openalex.org/W1944444102, https://openalex.org/W4210717784, https://openalex.org/W2765389138, https://openalex.org/W2513914028, https://openalex.org/W2911317912, https://openalex.org/W3044950964, https://openalex.org/W3107098794, https://openalex.org/W2058010582, https://openalex.org/W2800399483, https://openalex.org/W4319080486, https://openalex.org/W4280523270, https://openalex.org/W3121115799, https://openalex.org/W2789286209, https://openalex.org/W2957854641, https://openalex.org/W2740510276, https://openalex.org/W1508717233, https://openalex.org/W2022689242, https://openalex.org/W2089278519, https://openalex.org/W2804287612, https://openalex.org/W2936793067, https://openalex.org/W4225246927, https://openalex.org/W2149681218, https://openalex.org/W2142452151, https://openalex.org/W2173732482, https://openalex.org/W2153773863, https://openalex.org/W2036841261, https://openalex.org/W2962685339, https://openalex.org/W2019794729, https://openalex.org/W2231185426, https://openalex.org/W2284353620, https://openalex.org/W2106650442, https://openalex.org/W3130061971, https://openalex.org/W4411219456, https://openalex.org/W4292983700, https://openalex.org/W1978517482, https://openalex.org/W2805508163, https://openalex.org/W2129282939, https://openalex.org/W2285997904, https://openalex.org/W3125809335, https://openalex.org/W2614741472, https://openalex.org/W2075152176, https://openalex.org/W3006026509, https://openalex.org/W4223530847, https://openalex.org/W2051409304, https://openalex.org/W1986425967, https://openalex.org/W3207963768, https://openalex.org/W2015104782, https://openalex.org/W2016667558, https://openalex.org/W2117164569, https://openalex.org/W2058292185, https://openalex.org/W2637381607, https://openalex.org/W4388139418, https://openalex.org/W2890305691, https://openalex.org/W2405930128, https://openalex.org/W2130678362, https://openalex.org/W2110105653, https://openalex.org/W2332877535, https://openalex.org/W2112289643, https://openalex.org/W3029661147, https://openalex.org/W2018329909, https://openalex.org/W4206727716, https://openalex.org/W2156266906, https://openalex.org/W2023092959, https://openalex.org/W2004877079, https://openalex.org/W2402942859 |
| referenced_works_count | 74 |
| abstract_inverted_index.( | 205, 212 |
| abstract_inverted_index.a | 4, 247 |
| abstract_inverted_index.b | 206, 213 |
| abstract_inverted_index.1) | 75 |
| abstract_inverted_index.18 | 92 |
| abstract_inverted_index.2) | 79 |
| abstract_inverted_index.3) | 85 |
| abstract_inverted_index.IQ | 107, 147, 173 |
| abstract_inverted_index.in | 62, 91, 112, 148, 161, 182, 232, 239 |
| abstract_inverted_index.is | 3, 37, 52 |
| abstract_inverted_index.of | 43, 102, 153, 158, 225, 246 |
| abstract_inverted_index.or | 69 |
| abstract_inverted_index.to | 229 |
| abstract_inverted_index.233 | 113 |
| abstract_inverted_index.581 | 116 |
| abstract_inverted_index.617 | 63 |
| abstract_inverted_index.CNV | 44 |
| abstract_inverted_index.SSD | 64, 175, 217 |
| abstract_inverted_index.and | 9, 30, 84, 95, 115, 118, 136, 177, 181, 200, 209, 219, 242 |
| abstract_inverted_index.can | 46 |
| abstract_inverted_index.for | 20, 49, 110, 250 |
| abstract_inverted_index.how | 26 |
| abstract_inverted_index.the | 122, 183, 244 |
| abstract_inverted_index.was | 169 |
| abstract_inverted_index.ABCD | 184 |
| abstract_inverted_index.CNVs | 29, 33, 140, 228 |
| abstract_inverted_index.SSD, | 233 |
| abstract_inverted_index.SSD- | 131 |
| abstract_inverted_index.SSD. | 149 |
| abstract_inverted_index.This | 55 |
| abstract_inverted_index.and: | 74 |
| abstract_inverted_index.copy | 14 |
| abstract_inverted_index.from | 121 |
| abstract_inverted_index.gene | 163, 196, 198 |
| abstract_inverted_index.gray | 202 |
| abstract_inverted_index.poor | 240 |
| abstract_inverted_index.risk | 19, 28, 77, 227 |
| abstract_inverted_index.were | 108, 143 |
| abstract_inverted_index.with | 105, 145, 171 |
| abstract_inverted_index.(IQ), | 73 |
| abstract_inverted_index.(odds | 132 |
| abstract_inverted_index.9,930 | 119 |
| abstract_inverted_index.Brain | 124 |
| abstract_inverted_index.CNVs, | 156 |
| abstract_inverted_index.CNVs; | 78 |
| abstract_inverted_index.Known | 130 |
| abstract_inverted_index.brain | 167, 237 |
| abstract_inverted_index.cases | 176, 218 |
| abstract_inverted_index.fetal | 166, 195, 236 |
| abstract_inverted_index.genes | 159 |
| abstract_inverted_index.known | 27, 76, 154, 226 |
| abstract_inverted_index.novel | 86 |
| abstract_inverted_index.power | 48 |
| abstract_inverted_index.study | 56 |
| abstract_inverted_index.youth | 120 |
| abstract_inverted_index.(ABCD) | 127 |
| abstract_inverted_index.(CNVs) | 17 |
| abstract_inverted_index.(SSD). | 24 |
| abstract_inverted_index.=0.09, | 207 |
| abstract_inverted_index.=0.14, | 214 |
| abstract_inverted_index.Study. | 128 |
| abstract_inverted_index.across | 174, 216 |
| abstract_inverted_index.beyond | 151 |
| abstract_inverted_index.burden | 82, 90 |
| abstract_inverted_index.cohort | 185 |
| abstract_inverted_index.during | 165 |
| abstract_inverted_index.matter | 203 |
| abstract_inverted_index.number | 15 |
| abstract_inverted_index.ratios | 133 |
| abstract_inverted_index.scores | 45, 87 |
| abstract_inverted_index.severe | 60, 230, 254 |
| abstract_inverted_index.showed | 192 |
| abstract_inverted_index.volume | 204 |
| abstract_inverted_index.Methods | 54 |
| abstract_inverted_index.Results | 129, 222 |
| abstract_inverted_index.altered | 201 |
| abstract_inverted_index.aspects | 101 |
| abstract_inverted_index.between | 59, 194 |
| abstract_inverted_index.broader | 31 |
| abstract_inverted_index.confirm | 223 |
| abstract_inverted_index.effects | 152 |
| abstract_inverted_index.genetic | 10 |
| abstract_inverted_index.improve | 47 |
| abstract_inverted_index.namely, | 66 |
| abstract_inverted_index.patient | 50 |
| abstract_inverted_index.scores; | 83 |
| abstract_inverted_index.utility | 245 |
| abstract_inverted_index.whether | 40 |
| abstract_inverted_index.ABSTRACT | 0 |
| abstract_inverted_index.However, | 25 |
| abstract_inverted_index.Multiple | 12 |
| abstract_inverted_index.NDD-risk | 155 |
| abstract_inverted_index.analyses | 191 |
| abstract_inverted_index.assessed | 109 |
| abstract_inverted_index.clinical | 8, 35 |
| abstract_inverted_index.cortical | 210 |
| abstract_inverted_index.deletion | 81, 89, 157 |
| abstract_inverted_index.disorder | 6, 138 |
| abstract_inverted_index.distinct | 100 |
| abstract_inverted_index.examined | 57 |
| abstract_inverted_index.increase | 18 |
| abstract_inverted_index.involved | 160 |
| abstract_inverted_index.mutually | 96 |
| abstract_inverted_index.spectrum | 22 |
| abstract_inverted_index.unclear. | 38 |
| abstract_inverted_index.unknown. | 53 |
| abstract_inverted_index.variants | 16 |
| abstract_inverted_index.(OR=1.33, | 186 |
| abstract_inverted_index.(OR=2.57, | 179 |
| abstract_inverted_index.(OR=4.56, | 141 |
| abstract_inverted_index.Cognitive | 125 |
| abstract_inverted_index.MRI-based | 190 |
| abstract_inverted_index.Objective | 1 |
| abstract_inverted_index.capturing | 88 |
| abstract_inverted_index.controls, | 117 |
| abstract_inverted_index.deletions | 199 |
| abstract_inverted_index.disorders | 23 |
| abstract_inverted_index.disrupted | 235 |
| abstract_inverted_index.exclusive | 97 |
| abstract_inverted_index.framework | 249 |
| abstract_inverted_index.implicate | 234 |
| abstract_inverted_index.influence | 34 |
| abstract_inverted_index.involving | 7 |
| abstract_inverted_index.non-cases | 178 |
| abstract_inverted_index.psychosis | 68 |
| abstract_inverted_index.recurrent | 13 |
| abstract_inverted_index.thickness | 211 |
| abstract_inverted_index.validated | 94 |
| abstract_inverted_index.(NDD)-risk | 139 |
| abstract_inverted_index.(OR)=7.07, | 134 |
| abstract_inverted_index.Adolescent | 123 |
| abstract_inverted_index.annotation | 42 |
| abstract_inverted_index.associated | 144, 170 |
| abstract_inverted_index.biological | 41 |
| abstract_inverted_index.borderline | 70, 106, 146, 172 |
| abstract_inverted_index.cognition, | 241 |
| abstract_inverted_index.expression | 164 |
| abstract_inverted_index.gene-sets, | 98 |
| abstract_inverted_index.mechanisms | 252 |
| abstract_inverted_index.non-cases. | 220 |
| abstract_inverted_index.phenotypes | 61, 231 |
| abstract_inverted_index.previously | 93 |
| abstract_inverted_index.regulating | 162 |
| abstract_inverted_index.regulatory | 197 |
| abstract_inverted_index.structural | 189 |
| abstract_inverted_index.underlying | 253 |
| abstract_inverted_index.Conclusions | 221 |
| abstract_inverted_index.Development | 126 |
| abstract_inverted_index.Exploratory | 188 |
| abstract_inverted_index.child-onset | 67 |
| abstract_inverted_index.demonstrate | 243 |
| abstract_inverted_index.development | 168, 238 |
| abstract_inverted_index.functioning | 72 |
| abstract_inverted_index.genome-wide | 32, 80 |
| abstract_inverted_index.identifying | 251 |
| abstract_inverted_index.phenotypes. | 256 |
| abstract_inverted_index.variability | 36 |
| abstract_inverted_index.Associations | 104 |
| abstract_inverted_index.Furthermore, | 39, 150 |
| abstract_inverted_index.SSD-relevant | 255 |
| abstract_inverted_index.associations | 58, 193 |
| abstract_inverted_index.individuals, | 65 |
| abstract_inverted_index.intellectual | 71 |
| abstract_inverted_index.representing | 99 |
| abstract_inverted_index.SSD-relatives | 114 |
| abstract_inverted_index.Schizophrenia | 2 |
| abstract_inverted_index.contributions | 224 |
| abstract_inverted_index.replicability | 111 |
| abstract_inverted_index.schizophrenia | 21 |
| abstract_inverted_index.heterogeneity. | 11 |
| abstract_inverted_index.stratification | 51 |
| abstract_inverted_index.95%CI[0.05,0.24]) | 215 |
| abstract_inverted_index.neurodevelopment. | 103 |
| abstract_inverted_index.95%CI[0.004,0.17]) | 208 |
| abstract_inverted_index.95%CI[1.00,1.76]). | 187 |
| abstract_inverted_index.95%CI[1.44,4.60]), | 180 |
| abstract_inverted_index.95%CI[1.48,14.10]) | 142 |
| abstract_inverted_index.95%CI[1.60,31.32]) | 135 |
| abstract_inverted_index.neurodevelopmental | 5, 137, 248 |
| cited_by_percentile_year | |
| corresponding_author_ids | https://openalex.org/A5002308446 |
| countries_distinct_count | 4 |
| institutions_distinct_count | 35 |
| corresponding_institution_ids | https://openalex.org/I201448701 |
| sustainable_development_goals[0].id | https://metadata.un.org/sdg/1 |
| sustainable_development_goals[0].score | 0.6800000071525574 |
| sustainable_development_goals[0].display_name | No poverty |
| citation_normalized_percentile.value | 0.19174693 |
| citation_normalized_percentile.is_in_top_1_percent | False |
| citation_normalized_percentile.is_in_top_10_percent | False |