FHR2 binds to HUVE necrotic cell and renal glomerular basal membrane, inhibiting TCC deposition and exhibiting cofactor activity Article Swipe
Emma Diletta Stea
,
Loreto Gesualdo
,
Teresa Rampino
,
Marilena Gregorini
,
Maria Antonietta Grignano
,
Thorsten Wiech
,
Giuseppe Castellano
,
Christine Skerka
,
Franz Zipfel
·
YOU?
·
· 2025
· Open Access
·
· DOI: https://doi.org/10.1016/j.imbio.2025.152980
YOU?
·
· 2025
· Open Access
·
· DOI: https://doi.org/10.1016/j.imbio.2025.152980
Related Topics
Concepts
Metadata
- Type
- article
- Language
- en
- Landing Page
- https://doi.org/10.1016/j.imbio.2025.152980
- OA Status
- gold
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W4413237247
All OpenAlex metadata
Raw OpenAlex JSON
- OpenAlex ID
-
https://openalex.org/W4413237247Canonical identifier for this work in OpenAlex
- DOI
-
https://doi.org/10.1016/j.imbio.2025.152980Digital Object Identifier
- Title
-
FHR2 binds to HUVE necrotic cell and renal glomerular basal membrane, inhibiting TCC deposition and exhibiting cofactor activityWork title
- Type
-
articleOpenAlex work type
- Language
-
enPrimary language
- Publication year
-
2025Year of publication
- Publication date
-
2025-07-01Full publication date if available
- Authors
-
Emma Diletta Stea, Loreto Gesualdo, Teresa Rampino, Marilena Gregorini, Maria Antonietta Grignano, Thorsten Wiech, Giuseppe Castellano, Christine Skerka, Franz ZipfelList of authors in order
- Landing page
-
https://doi.org/10.1016/j.imbio.2025.152980Publisher landing page
- Open access
-
YesWhether a free full text is available
- OA status
-
goldOpen access status per OpenAlex
- OA URL
-
https://doi.org/10.1016/j.imbio.2025.152980Direct OA link when available
- Concepts
-
Cofactor, Chemistry, Basal (medicine), Cell biology, Cell, Membrane, Biochemistry, Internal medicine, Biology, Endocrinology, Medicine, Enzyme, InsulinTop concepts (fields/topics) attached by OpenAlex
- Cited by
-
0Total citation count in OpenAlex
- Related works (count)
-
10Other works algorithmically related by OpenAlex
Full payload
| id | https://openalex.org/W4413237247 |
|---|---|
| doi | https://doi.org/10.1016/j.imbio.2025.152980 |
| ids.doi | https://doi.org/10.1016/j.imbio.2025.152980 |
| ids.openalex | https://openalex.org/W4413237247 |
| fwci | 0.0 |
| type | article |
| title | FHR2 binds to HUVE necrotic cell and renal glomerular basal membrane, inhibiting TCC deposition and exhibiting cofactor activity |
| biblio.issue | 4 |
| biblio.volume | 230 |
| biblio.last_page | 152980 |
| biblio.first_page | 152980 |
| topics[0].id | https://openalex.org/T10724 |
| topics[0].field.id | https://openalex.org/fields/13 |
| topics[0].field.display_name | Biochemistry, Genetics and Molecular Biology |
| topics[0].score | 0.762499988079071 |
| topics[0].domain.id | https://openalex.org/domains/1 |
| topics[0].domain.display_name | Life Sciences |
| topics[0].subfield.id | https://openalex.org/subfields/1312 |
| topics[0].subfield.display_name | Molecular Biology |
| topics[0].display_name | Ion Transport and Channel Regulation |
| topics[1].id | https://openalex.org/T14415 |
| topics[1].field.id | https://openalex.org/fields/27 |
| topics[1].field.display_name | Medicine |
| topics[1].score | 0.7559999823570251 |
| topics[1].domain.id | https://openalex.org/domains/4 |
| topics[1].domain.display_name | Health Sciences |
| topics[1].subfield.id | https://openalex.org/subfields/2734 |
| topics[1].subfield.display_name | Pathology and Forensic Medicine |
| topics[1].display_name | Biomedical Research and Pathophysiology |
| is_xpac | False |
| apc_list.value | 2930 |
| apc_list.currency | USD |
| apc_list.value_usd | 2930 |
| apc_paid.value | 2930 |
| apc_paid.currency | USD |
| apc_paid.value_usd | 2930 |
| concepts[0].id | https://openalex.org/C197957613 |
| concepts[0].level | 3 |
| concepts[0].score | 0.6011838912963867 |
| concepts[0].wikidata | https://www.wikidata.org/wiki/Q407280 |
| concepts[0].display_name | Cofactor |
| concepts[1].id | https://openalex.org/C185592680 |
| concepts[1].level | 0 |
| concepts[1].score | 0.5139438509941101 |
| concepts[1].wikidata | https://www.wikidata.org/wiki/Q2329 |
| concepts[1].display_name | Chemistry |
| concepts[2].id | https://openalex.org/C2778024521 |
| concepts[2].level | 3 |
| concepts[2].score | 0.5002801418304443 |
| concepts[2].wikidata | https://www.wikidata.org/wiki/Q55639806 |
| concepts[2].display_name | Basal (medicine) |
| concepts[3].id | https://openalex.org/C95444343 |
| concepts[3].level | 1 |
| concepts[3].score | 0.4876621961593628 |
| concepts[3].wikidata | https://www.wikidata.org/wiki/Q7141 |
| concepts[3].display_name | Cell biology |
| concepts[4].id | https://openalex.org/C1491633281 |
| concepts[4].level | 2 |
| concepts[4].score | 0.43936675786972046 |
| concepts[4].wikidata | https://www.wikidata.org/wiki/Q7868 |
| concepts[4].display_name | Cell |
| concepts[5].id | https://openalex.org/C41625074 |
| concepts[5].level | 2 |
| concepts[5].score | 0.42069047689437866 |
| concepts[5].wikidata | https://www.wikidata.org/wiki/Q176088 |
| concepts[5].display_name | Membrane |
| concepts[6].id | https://openalex.org/C55493867 |
| concepts[6].level | 1 |
| concepts[6].score | 0.35026511549949646 |
| concepts[6].wikidata | https://www.wikidata.org/wiki/Q7094 |
| concepts[6].display_name | Biochemistry |
| concepts[7].id | https://openalex.org/C126322002 |
| concepts[7].level | 1 |
| concepts[7].score | 0.3423171043395996 |
| concepts[7].wikidata | https://www.wikidata.org/wiki/Q11180 |
| concepts[7].display_name | Internal medicine |
| concepts[8].id | https://openalex.org/C86803240 |
| concepts[8].level | 0 |
| concepts[8].score | 0.2938327193260193 |
| concepts[8].wikidata | https://www.wikidata.org/wiki/Q420 |
| concepts[8].display_name | Biology |
| concepts[9].id | https://openalex.org/C134018914 |
| concepts[9].level | 1 |
| concepts[9].score | 0.29174917936325073 |
| concepts[9].wikidata | https://www.wikidata.org/wiki/Q162606 |
| concepts[9].display_name | Endocrinology |
| concepts[10].id | https://openalex.org/C71924100 |
| concepts[10].level | 0 |
| concepts[10].score | 0.23655983805656433 |
| concepts[10].wikidata | https://www.wikidata.org/wiki/Q11190 |
| concepts[10].display_name | Medicine |
| concepts[11].id | https://openalex.org/C181199279 |
| concepts[11].level | 2 |
| concepts[11].score | 0.12922805547714233 |
| concepts[11].wikidata | https://www.wikidata.org/wiki/Q8047 |
| concepts[11].display_name | Enzyme |
| concepts[12].id | https://openalex.org/C2779306644 |
| concepts[12].level | 2 |
| concepts[12].score | 0.0 |
| concepts[12].wikidata | https://www.wikidata.org/wiki/Q2002370 |
| concepts[12].display_name | Insulin |
| keywords[0].id | https://openalex.org/keywords/cofactor |
| keywords[0].score | 0.6011838912963867 |
| keywords[0].display_name | Cofactor |
| keywords[1].id | https://openalex.org/keywords/chemistry |
| keywords[1].score | 0.5139438509941101 |
| keywords[1].display_name | Chemistry |
| keywords[2].id | https://openalex.org/keywords/basal |
| keywords[2].score | 0.5002801418304443 |
| keywords[2].display_name | Basal (medicine) |
| keywords[3].id | https://openalex.org/keywords/cell-biology |
| keywords[3].score | 0.4876621961593628 |
| keywords[3].display_name | Cell biology |
| keywords[4].id | https://openalex.org/keywords/cell |
| keywords[4].score | 0.43936675786972046 |
| keywords[4].display_name | Cell |
| keywords[5].id | https://openalex.org/keywords/membrane |
| keywords[5].score | 0.42069047689437866 |
| keywords[5].display_name | Membrane |
| keywords[6].id | https://openalex.org/keywords/biochemistry |
| keywords[6].score | 0.35026511549949646 |
| keywords[6].display_name | Biochemistry |
| keywords[7].id | https://openalex.org/keywords/internal-medicine |
| keywords[7].score | 0.3423171043395996 |
| keywords[7].display_name | Internal medicine |
| keywords[8].id | https://openalex.org/keywords/biology |
| keywords[8].score | 0.2938327193260193 |
| keywords[8].display_name | Biology |
| keywords[9].id | https://openalex.org/keywords/endocrinology |
| keywords[9].score | 0.29174917936325073 |
| keywords[9].display_name | Endocrinology |
| keywords[10].id | https://openalex.org/keywords/medicine |
| keywords[10].score | 0.23655983805656433 |
| keywords[10].display_name | Medicine |
| keywords[11].id | https://openalex.org/keywords/enzyme |
| keywords[11].score | 0.12922805547714233 |
| keywords[11].display_name | Enzyme |
| language | en |
| locations[0].id | doi:10.1016/j.imbio.2025.152980 |
| locations[0].is_oa | True |
| locations[0].source.id | https://openalex.org/S164377831 |
| locations[0].source.issn | 0171-2985, 1878-3279 |
| locations[0].source.type | journal |
| locations[0].source.is_oa | True |
| locations[0].source.issn_l | 0171-2985 |
| locations[0].source.is_core | True |
| locations[0].source.is_in_doaj | True |
| locations[0].source.display_name | Immunobiology |
| locations[0].source.host_organization | https://openalex.org/P4310320990 |
| locations[0].source.host_organization_name | Elsevier BV |
| locations[0].source.host_organization_lineage | https://openalex.org/P4310320990 |
| locations[0].license | |
| locations[0].pdf_url | |
| locations[0].version | publishedVersion |
| locations[0].raw_type | journal-article |
| locations[0].license_id | |
| locations[0].is_accepted | True |
| locations[0].is_published | True |
| locations[0].raw_source_name | Immunobiology |
| locations[0].landing_page_url | https://doi.org/10.1016/j.imbio.2025.152980 |
| indexed_in | crossref, doaj |
| authorships[0].author.id | https://openalex.org/A5079021408 |
| authorships[0].author.orcid | https://orcid.org/0000-0001-7248-2289 |
| authorships[0].author.display_name | Emma Diletta Stea |
| authorships[0].author_position | first |
| authorships[0].raw_author_name | Emma Diletta Stea |
| authorships[0].is_corresponding | False |
| authorships[1].author.id | https://openalex.org/A5108117434 |
| authorships[1].author.orcid | |
| authorships[1].author.display_name | Loreto Gesualdo |
| authorships[1].author_position | middle |
| authorships[1].raw_author_name | Loreto Gesualdo |
| authorships[1].is_corresponding | False |
| authorships[2].author.id | https://openalex.org/A5031804980 |
| authorships[2].author.orcid | https://orcid.org/0000-0002-5311-9174 |
| authorships[2].author.display_name | Teresa Rampino |
| authorships[2].author_position | middle |
| authorships[2].raw_author_name | Teresa Rampino |
| authorships[2].is_corresponding | False |
| authorships[3].author.id | https://openalex.org/A5040723869 |
| authorships[3].author.orcid | https://orcid.org/0000-0003-1440-6872 |
| authorships[3].author.display_name | Marilena Gregorini |
| authorships[3].author_position | middle |
| authorships[3].raw_author_name | Marilena Gregorini |
| authorships[3].is_corresponding | False |
| authorships[4].author.id | https://openalex.org/A5084344168 |
| authorships[4].author.orcid | https://orcid.org/0000-0003-1439-7662 |
| authorships[4].author.display_name | Maria Antonietta Grignano |
| authorships[4].author_position | middle |
| authorships[4].raw_author_name | Mariantonietta Grignano |
| authorships[4].is_corresponding | False |
| authorships[5].author.id | https://openalex.org/A5015868168 |
| authorships[5].author.orcid | https://orcid.org/0000-0003-4053-1474 |
| authorships[5].author.display_name | Thorsten Wiech |
| authorships[5].author_position | middle |
| authorships[5].raw_author_name | Thorsten Wiech |
| authorships[5].is_corresponding | False |
| authorships[6].author.id | https://openalex.org/A5063287766 |
| authorships[6].author.orcid | https://orcid.org/0000-0002-0153-3795 |
| authorships[6].author.display_name | Giuseppe Castellano |
| authorships[6].author_position | middle |
| authorships[6].raw_author_name | Giuseppe Castellano |
| authorships[6].is_corresponding | False |
| authorships[7].author.id | https://openalex.org/A5108224597 |
| authorships[7].author.orcid | |
| authorships[7].author.display_name | Christine Skerka |
| authorships[7].author_position | middle |
| authorships[7].raw_author_name | Christine Skerka |
| authorships[7].is_corresponding | False |
| authorships[8].author.id | https://openalex.org/A5080029269 |
| authorships[8].author.orcid | |
| authorships[8].author.display_name | Franz Zipfel |
| authorships[8].author_position | last |
| authorships[8].raw_author_name | Franz Peter Zipfel |
| authorships[8].is_corresponding | False |
| has_content.pdf | False |
| has_content.grobid_xml | False |
| is_paratext | False |
| open_access.is_oa | True |
| open_access.oa_url | https://doi.org/10.1016/j.imbio.2025.152980 |
| open_access.oa_status | gold |
| open_access.any_repository_has_fulltext | False |
| created_date | 2025-10-10T00:00:00 |
| display_name | FHR2 binds to HUVE necrotic cell and renal glomerular basal membrane, inhibiting TCC deposition and exhibiting cofactor activity |
| has_fulltext | False |
| is_retracted | False |
| updated_date | 2025-11-06T03:46:38.306776 |
| primary_topic.id | https://openalex.org/T10724 |
| primary_topic.field.id | https://openalex.org/fields/13 |
| primary_topic.field.display_name | Biochemistry, Genetics and Molecular Biology |
| primary_topic.score | 0.762499988079071 |
| primary_topic.domain.id | https://openalex.org/domains/1 |
| primary_topic.domain.display_name | Life Sciences |
| primary_topic.subfield.id | https://openalex.org/subfields/1312 |
| primary_topic.subfield.display_name | Molecular Biology |
| primary_topic.display_name | Ion Transport and Channel Regulation |
| related_works | https://openalex.org/W1523595220, https://openalex.org/W2150391754, https://openalex.org/W2064710306, https://openalex.org/W1997484252, https://openalex.org/W1979156653, https://openalex.org/W2197530792, https://openalex.org/W2249456921, https://openalex.org/W2383949092, https://openalex.org/W2184834470, https://openalex.org/W2098689981 |
| cited_by_count | 0 |
| locations_count | 1 |
| best_oa_location.id | doi:10.1016/j.imbio.2025.152980 |
| best_oa_location.is_oa | True |
| best_oa_location.source.id | https://openalex.org/S164377831 |
| best_oa_location.source.issn | 0171-2985, 1878-3279 |
| best_oa_location.source.type | journal |
| best_oa_location.source.is_oa | True |
| best_oa_location.source.issn_l | 0171-2985 |
| best_oa_location.source.is_core | True |
| best_oa_location.source.is_in_doaj | True |
| best_oa_location.source.display_name | Immunobiology |
| best_oa_location.source.host_organization | https://openalex.org/P4310320990 |
| best_oa_location.source.host_organization_name | Elsevier BV |
| best_oa_location.source.host_organization_lineage | https://openalex.org/P4310320990 |
| best_oa_location.license | |
| best_oa_location.pdf_url | |
| best_oa_location.version | publishedVersion |
| best_oa_location.raw_type | journal-article |
| best_oa_location.license_id | |
| best_oa_location.is_accepted | True |
| best_oa_location.is_published | True |
| best_oa_location.raw_source_name | Immunobiology |
| best_oa_location.landing_page_url | https://doi.org/10.1016/j.imbio.2025.152980 |
| primary_location.id | doi:10.1016/j.imbio.2025.152980 |
| primary_location.is_oa | True |
| primary_location.source.id | https://openalex.org/S164377831 |
| primary_location.source.issn | 0171-2985, 1878-3279 |
| primary_location.source.type | journal |
| primary_location.source.is_oa | True |
| primary_location.source.issn_l | 0171-2985 |
| primary_location.source.is_core | True |
| primary_location.source.is_in_doaj | True |
| primary_location.source.display_name | Immunobiology |
| primary_location.source.host_organization | https://openalex.org/P4310320990 |
| primary_location.source.host_organization_name | Elsevier BV |
| primary_location.source.host_organization_lineage | https://openalex.org/P4310320990 |
| primary_location.license | |
| primary_location.pdf_url | |
| primary_location.version | publishedVersion |
| primary_location.raw_type | journal-article |
| primary_location.license_id | |
| primary_location.is_accepted | True |
| primary_location.is_published | True |
| primary_location.raw_source_name | Immunobiology |
| primary_location.landing_page_url | https://doi.org/10.1016/j.imbio.2025.152980 |
| publication_date | 2025-07-01 |
| publication_year | 2025 |
| referenced_works_count | 0 |
| abstract_inverted_index | |
| cited_by_percentile_year | |
| countries_distinct_count | 0 |
| institutions_distinct_count | 9 |
| citation_normalized_percentile.value | 0.34557056 |
| citation_normalized_percentile.is_in_top_1_percent | False |
| citation_normalized_percentile.is_in_top_10_percent | False |