Fibrosis and bone marrow: understanding causation and pathobiology Article Swipe
Kanjaksha Ghosh
,
Durjoy K. Shome
,
Bipin Kulkarni
,
Malay Ghosh
,
Kinjalka Ghosh
·
YOU?
·
· 2023
· Open Access
·
· DOI: https://doi.org/10.1186/s12967-023-04393-z
YOU?
·
· 2023
· Open Access
·
· DOI: https://doi.org/10.1186/s12967-023-04393-z
Bone marrow fibrosis represents an important structural change in the marrow that interferes with some of its normal functions. The aetiopathogenesis of fibrosis is not well established except in its primary form. The present review consolidates current understanding of marrow fibrosis. We searched PubMed without time restriction using key words: bone marrow and fibrosis as the main stem against the terms: growth factors, cytokines and chemokines, morphology, megakaryocytes and platelets, myeloproliferative disorders, myelodysplastic syndrome, collagen biosynthesis, mesenchymal stem cells, vitamins and minerals and hormones, and mechanism of tissue fibrosis. Tissue marrow fibrosis-related papers were short listed and analysed for the review. It emerged that bone marrow fibrosis is the outcome of complex interactions between growth factors, cytokines, chemokines and hormones together with their facilitators and inhibitors. Fibrogenesis is initiated by mobilisation of special immunophenotypic subsets of mesenchymal stem cells in the marrow that transform into fibroblasts. Fibrogenic stimuli may arise from neoplastic haemopoietic or non-hematopoietic cells, as well as immune cells involved in infections and inflammatory conditions. Autoimmunity is involved in a small subset of patients with marrow fibrosis. Megakaryocytes and platelets are either directly involved or are important intermediaries in stimulating mesenchymal stem cells. MMPs, TIMPs, TGF-β, PDGRF, and basic FGF and CRCXL4 chemokines are involved in these processes. Genetic and epigenetic changes underlie many of these conditions.
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Metadata
- Type
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- Language
- en
- Landing Page
- https://doi.org/10.1186/s12967-023-04393-z
- https://translational-medicine.biomedcentral.com/counter/pdf/10.1186/s12967-023-04393-z
- OA Status
- gold
- Cited By
- 27
- References
- 81
- Related Works
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- OpenAlex ID
- https://openalex.org/W4387451586
All OpenAlex metadata
Raw OpenAlex JSON
- OpenAlex ID
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https://openalex.org/W4387451586Canonical identifier for this work in OpenAlex
- DOI
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https://doi.org/10.1186/s12967-023-04393-zDigital Object Identifier
- Title
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Fibrosis and bone marrow: understanding causation and pathobiologyWork title
- Type
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reviewOpenAlex work type
- Language
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enPrimary language
- Publication year
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2023Year of publication
- Publication date
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2023-10-09Full publication date if available
- Authors
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Kanjaksha Ghosh, Durjoy K. Shome, Bipin Kulkarni, Malay Ghosh, Kinjalka GhoshList of authors in order
- Landing page
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https://doi.org/10.1186/s12967-023-04393-zPublisher landing page
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https://translational-medicine.biomedcentral.com/counter/pdf/10.1186/s12967-023-04393-zDirect link to full text PDF
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YesWhether a free full text is available
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goldOpen access status per OpenAlex
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https://translational-medicine.biomedcentral.com/counter/pdf/10.1186/s12967-023-04393-zDirect OA link when available
- Concepts
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Bone marrow, Fibrosis, Haematopoiesis, Mesenchymal stem cell, Stem cell, Immunology, Medicine, Chemokine, Myeloproliferative Disorders, Cancer research, Biology, Immune system, Pathology, Cell biologyTop concepts (fields/topics) attached by OpenAlex
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27Total citation count in OpenAlex
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2025: 14, 2024: 13Per-year citation counts (last 5 years)
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81Number of works referenced by this work
- Related works (count)
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10Other works algorithmically related by OpenAlex
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