Figure 2 from PELP1 Is a Novel Therapeutic Target in Hepatocellular Carcinoma Article Swipe

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Khaled Mohamed Nassar , Xue Yang , Adriana Baker , Rahul Gopalam , William C. Arnold , Timilehin T. Adeniran , Marian H. Hernandez Fernandez , Megharani Mahajan , Zhao Lai , Yidong Chen , Gangadhara R. Sareddy , Suryavathi Viswanadhapalli , Lu‐Zhe Sun , Ratna K. Vadlamudi , Uday P. Pratap ·

YOU? · · 2024 · Open Access · · DOI: https://doi.org/10.1158/2767-9764.27178704

PELP1-KD/SMIP34 treatment decreased cell viability, clonogenicity, and invasiveness of HCC cells. PELP1-KD in Huh7 and Hep3B cell lines were confirmed by Western blot (A). Cell viability and clonogenic assays were performed to assess the impact of PELP1 KD on the growth of Huh7 and Hep3B cells (B and C). The effect of PELP1-KD on the invasion of HCC cells was performed using Matrigel invasion chamber assays (D). The effect of SMIP34 on the cell viability of six HCC cells was measured using MTT assay (E). Effect of SMIP34 (5 μmol/L) on clonogenic cell survival was examined using colony formation assay (F). The effect of SMIP34 (10 μmol/L) treatment on HCC cells invasion was performed using Matrigel invasion chamber assay (G). The results show the mean ± SEM, n = 3. P values are calculated using the Student t test and one-way ANOVA, *, p < 0.05; **, p < 0.01; ***, p < 0.001; ****, p < 0.0001.

Related Topics

Hepatocellular Carcinoma

Oncology

Medicine

Internal Medicine

Concepts

Hepatocellular carcinoma Oncology Medicine Cancer research Internal medicine

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Type: preprint
Language: en
Landing Page: https://doi.org/10.1158/2767-9764.27178704
OA Status: gold
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OpenAlex ID: https://openalex.org/W4403197312

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DOI: https://doi.org/10.1158/2767-9764.27178704

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Title: Figure 2 from PELP1 Is a Novel Therapeutic Target in Hepatocellular Carcinoma

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Type: preprint

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Language: en

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Publication year: 2024

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Publication date: 2024-10-07

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Authors: Khaled Mohamed Nassar, Xue Yang, Adriana Baker, Rahul Gopalam, William C. Arnold, Timilehin T. Adeniran, Marian H. Hernandez Fernandez, Megharani Mahajan, Zhao Lai, Yidong Chen, Gangadhara R. Sareddy, Suryavathi Viswanadhapalli, Lu‐Zhe Sun, Ratna K. Vadlamudi, Uday P. Pratap

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Landing page: https://doi.org/10.1158/2767-9764.27178704

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Concepts: Hepatocellular carcinoma, Oncology, Medicine, Cancer research, Internal medicine

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Cited by: 0

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