Figure 3 from Evaluation of Ferroptosis as a Biomarker to Predict Treatment Outcomes of Cancer Immunotherapy Article Swipe

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Zhijun Zhou , Yang Cai , Hao Yuan , Qun Chen , Sophia W. Zhao , Jingxuan Yang , Mingyang Liu , Alex X. Arreola , Yu Ren , Chao Xu , Lacey R. McNally , Michael S. Bronze , Courtney W. Houchen , Kuirong Jiang , Wei R. Chen , Yuqing Zhang , Min Li ·

YOU? · · 2025 · Open Access · · DOI: https://doi.org/10.1158/2767-9764.29836675

Ferroptosis-high tumors showed attenuated immunosenescence and enhanced immune response. A and B, Gene set enrichment analysis to examine ferroptosis enrichment and activation of the immune response in ferroptosis-high and ferroptosis-low tumors in the IMvigor210 cohort. C and D, Comparison of the IFN-γ signature score and expanded immune score of ferroptosis-low and ferroptosis-high tumors in the IMvigor210 cohort. E, Heatmap shows the correlation between ferroptosis and the expression of IFN-γ immune response signature genes in tumors of the IMvigor210 cohort. F, Heatmap shows the correlation between ferroptosis and the expression of immunosenescence suppressor genes in tumors of the IMvigor210 cohort. *, P < 0.05; ***, P < 0.001. NES, normalized enrichment scale.

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Immune system Biomarker Cohort Cancer Cancer research Immunotherapy Immunology Medicine Biology Internal medicine Genetics

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Type: preprint
Language: en
Landing Page: https://doi.org/10.1158/2767-9764.29836675
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DOI: https://doi.org/10.1158/2767-9764.29836675

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Title: Figure 3 from Evaluation of Ferroptosis as a Biomarker to Predict Treatment Outcomes of Cancer Immunotherapy

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Publication year: 2025

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Publication date: 2025-08-06

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Authors: Zhijun Zhou, Yang Cai, Hao Yuan, Qun Chen, Sophia W. Zhao, Jingxuan Yang, Mingyang Liu, Alex X. Arreola, Yu Ren, Chao Xu, Lacey R. McNally, Michael S. Bronze, Courtney W. Houchen, Kuirong Jiang, Wei R. Chen, Yuqing Zhang, Min Li

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Concepts: Immune system, Biomarker, Cohort, Cancer, Cancer research, Immunotherapy, Immunology, Medicine, Biology, Internal medicine, Genetics

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