Figure 3 from Modeling High-Risk Pediatric Cancers in Zebrafish to Inform Precision Therapy Article Swipe
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· 2025
· Open Access
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· DOI: https://doi.org/10.1158/2767-9764.29644699
· OA: W4412919423
<p>Mouse and larval zebrafish PDX drug efficacy for nonresponsive patients. <b>A to C,</b> Patient information, alongside mouse PDX waterfall plot of maximum tumor regression, and larval zebrafish tumor cell numbers for each therapy for neuroblastoma zccs373 (<b>A</b>), sarcoma zccs262 (<b>B</b>), and osteosarcoma zccs43 (<b>C</b>). For mouse PDX data, colored columns represent individual mice. For larval zebrafish data, error bars represent mean ± SEM, each colored dot represents an individual larva, and a threshold is based on SEM of 1 dpi. Statistical analysis was conducted using a one-way ANOVA with the Dunnett multiple comparisons test, comparing the mean of each treatment group with control (4 dpi), <i>P</i> values: *, < 0.05; **, < 0.01; ***, < 0.001; ****, < 0.0001). mut, mutant; dpi, days post-injection.</p>
