FIGURE 5 from Chemokine Analysis in Patients with Metastatic Uveal Melanoma Suggests a Role for CCL21 Signaling in Combined Epigenetic Therapy and Checkpoint Immunotherapy Article Swipe
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· 2023
· Open Access
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· DOI: https://doi.org/10.1158/2767-9764.22930553.v1
· OA: W4377020454
<p>Kaplan–Meier analysis showing. PFS (<b>A</b>) and OS (<b>B</b>), respectively using pretreatment plasma CCL21 (pg/mL) measurements based on their median values. <b>C,</b> Correlation between CCL21 (pg/mL) and CD3<sup>+</sup>CCR7<sup>+</sup>CD45RA<sup>+</sup> (% counts) matched patient samples (<i>n</i> = 23). <b>D,</b> Flow cytometry–based comparison between short- and long-term survivors for CD3<sup>+</sup>CCR7<sup>+</sup>CD45RA<sup>+</sup> % (T naïve and T stem cell memory) analysis using pretreatment blood samples (<i>n</i> = 24). Statistical test was unpaired two-tailed <i>t</i> tests, assuming equal variance. <b>E,</b> Kaplan–Meier analysis showing OS using median CD3<sup>+</sup>CCR7<sup>+</sup>CD45RA<sup>+</sup> % values.</p>
