Figure 5 from Integrated Multimodal Analyses of DNA Damage Response and Immune Markers as Predictors of Response in Metastatic Triple-Negative Breast Cancer in the TNT Trial (NCT00532727) Article Swipe

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Holly Tovey , Orsolya Sipos , Joel S. Parker , Katherine A. Hoadley , Jelmar Quist , Sarah Kernaghan , Lucy Kilburn , Roberto Salgado , Sherene Loi , Richard D. Kennedy , Ioannis Roxanis , Patrycja Gazińska , Sarah E. Pinder , Judith M. Bliss , Charles M. Perou , Syed Haider , Anita Grigoriadis , Andrew Tutt , Maggie C.U. Cheang ·

YOU? · · 2023 · Open Access · · DOI: https://doi.org/10.1158/1078-0432.24145967.v1

Results of a novel clustering. A, Response rates by novel clusters and treatment groups. P values are presented from Fisher exact tests. Clusters 4 and 6 are not shown due to small numbers. B, Heatmap showing biological features of each novel cluster. PGA, percentage of genome altered; SI, Shannon diversity index; NtAI, number of telomeric allelic imbalances; AiCna, allelic imbalanced CNA; AbCna, allelic balanced CNA; CnLOH, copy number neutral loss of heterozygosity.

Related Topics

Loss Of Heterozygosity

Biology

Breast Cancer

Immune System

Triple-Negative Breast Cancer

Cancer

Molecular Biology

Concepts

Loss of heterozygosity Allele Genetics Biology Breast cancer Immune system Triple-negative breast cancer Cancer research Cancer Molecular biology Gene

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Type: preprint
Language: en
Landing Page: https://doi.org/10.1158/1078-0432.24145967.v1
OA Status: gold
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OpenAlex ID: https://openalex.org/W4386778139

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DOI: https://doi.org/10.1158/1078-0432.24145967.v1

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Title: Figure 5 from Integrated Multimodal Analyses of DNA Damage Response and Immune Markers as Predictors of Response in Metastatic Triple-Negative Breast Cancer in the TNT Trial (NCT00532727)

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Type: preprint

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Language: en

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Publication year: 2023

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Publication date: 2023-09-15

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Authors: Holly Tovey, Orsolya Sipos, Joel S. Parker, Katherine A. Hoadley, Jelmar Quist, Sarah Kernaghan, Lucy Kilburn, Roberto Salgado, Sherene Loi, Richard D. Kennedy, Ioannis Roxanis, Patrycja Gazińska, Sarah E. Pinder, Judith M. Bliss, Charles M. Perou, Syed Haider, Anita Grigoriadis, Andrew Tutt, Maggie C.U. Cheang

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Landing page: https://doi.org/10.1158/1078-0432.24145967.v1

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Concepts: Loss of heterozygosity, Allele, Genetics, Biology, Breast cancer, Immune system, Triple-negative breast cancer, Cancer research, Cancer, Molecular biology, Gene

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