Figure 5 from Peripheral Blood IFN Responses to Toll-Like Receptor 1/2 Signaling Associate with Longer Survival in Men with Metastatic Prostate Cancer Treated with Sipuleucel-T Article Swipe

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Michael C. Brown , Vincent M. D’Anniballe , David Boczkowski , Harini Kandadi , Nadeem A. Sheikh , William Kornahrens , Elisabeth I. Heath , Archana Thakur , Wei Chen , Lawrence G. Lum , Frank C. Cackowski , Julie L. Boerner , Michael D. Gunn , Andrew J. Armstrong , Smita K. Nair ·

YOU? · · 2024 · Open Access · · DOI: https://doi.org/10.1158/2767-9764.27255849

TLR1/2 responses associate with post–sip-T survival independent of race and TLR1/2 SNP status. A–C, Survival stratified by race in the merged PRIME and KCI cohorts (A), PRIME cohort alone (B), or KCI cohort alone (C). D and E, Survival of White (D) or Black (E) patients from the merged (PRIME and KCI) cohorts stratified by respective cohort median (PRIME or KCI) IFN-β induction after TLR1/2 stimulation. F and G, Survival of the PRIME cohort (TLR1 SNP genotyping was not performed in the KCI cohort) stratified by TLR1 602 I/I or I/S vs. TLR1 602 S/S for all races (F) or for White patients (G). H and I, Survival of patients with TLR1 602 I/I or I/S SNP (H) or TLR 602 S/S (I) stratified by median IFN-β induction after TLR1/2 stimulation. HRs and 95% CI are from the Mantel–Haenszel test; P values are from the Mantel–Cox log-rank test. See Supplementary Fig. S7 for extended data.

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Prostate cancer Peripheral blood Medicine Receptor Toll Toll-like receptor Internal medicine Cancer Oncology Cancer research Immunology Innate immune system

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Type: preprint
Language: en
Landing Page: https://doi.org/10.1158/2767-9764.27255849
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Title: Figure 5 from Peripheral Blood IFN Responses to Toll-Like Receptor 1/2 Signaling Associate with Longer Survival in Men with Metastatic Prostate Cancer Treated with Sipuleucel-T

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Publication year: 2024

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Authors: Michael C. Brown, Vincent M. D’Anniballe, David Boczkowski, Harini Kandadi, Nadeem A. Sheikh, William Kornahrens, Elisabeth I. Heath, Archana Thakur, Wei Chen, Lawrence G. Lum, Frank C. Cackowski, Julie L. Boerner, Michael D. Gunn, Andrew J. Armstrong, Smita K. Nair

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Concepts: Prostate cancer, Peripheral blood, Medicine, Receptor, Toll, Toll-like receptor, Internal medicine, Cancer, Oncology, Cancer research, Immunology, Innate immune system

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