and Histologically Transformed Small-Cell Lung Cancer Is Sensitive to Lurbinectedin Treatment Through the Modulation of EMT and NOTCH Signaling Pathways Article Swipe

View

Subhamoy Chakraborty , Charles Coleman , Parvathy Manoj , Deniz Demircioğlu , Nisargbhai Shah , Elisa de Stanchina , Charles M. Rudin , Dan Hasson , Triparna Sen ·

YOU? · · 2025 · Open Access · · DOI: https://doi.org/10.1158/1078-0432.30708498

Figure S1. Lurbinectedin decreases cell viability in a time and dose-dependent manner.

Related Topics

Concepts

Lung cancer Cancer research Notch signaling pathway Signal transduction Medicine Cell Lung Cancer Modulation (music) Biology Metastasis Cell biology Cell signaling NF-κB Pathology Chemistry Cell survival

Metadata

Type: article
Landing Page: https://doi.org/10.1158/1078-0432.30708498
OA Status: gold
OpenAlex ID: https://openalex.org/W7106611970

All OpenAlex metadata

Raw OpenAlex JSON

OpenAlex ID: https://openalex.org/W7106611970

Canonical identifier for this work in OpenAlex
DOI: https://doi.org/10.1158/1078-0432.30708498

Digital Object Identifier
Title: Figure S1 from <i>De Novo</i> and Histologically Transformed Small-Cell Lung Cancer Is Sensitive to Lurbinectedin Treatment Through the Modulation of EMT and NOTCH Signaling Pathways

Work title
Type: article

OpenAlex work type
Publication year: 2025

Year of publication
Publication date: 2025-11-25

Full publication date if available
Authors: Subhamoy Chakraborty, Charles Coleman, Parvathy Manoj, Deniz Demircioğlu, Nisargbhai Shah, Elisa de Stanchina, Charles M. Rudin, Dan Hasson, Triparna Sen

List of authors in order
Landing page: https://doi.org/10.1158/1078-0432.30708498

Publisher landing page
Open access: Yes

Whether a free full text is available
OA status: gold

Open access status per OpenAlex
OA URL: https://doi.org/10.1158/1078-0432.30708498

Direct OA link when available
Concepts: Lung cancer, Cancer research, Notch signaling pathway, Signal transduction, Medicine, Cell, Lung, Cancer, Modulation (music), Biology, Metastasis, Cell biology, Cell signaling, NF-κB, Pathology, Chemistry, Cell survival

Top concepts (fields/topics) attached by OpenAlex
Cited by: 0

Total citation count in OpenAlex

Full payload

id	https://openalex.org/W7106611970
doi	https://doi.org/10.1158/1078-0432.30708498
ids.doi	https://doi.org/10.1158/1078-0432.30708498
ids.openalex	https://openalex.org/W7106611970
fwci	0.0
type	article
title	Figure S1 from <i>De Novo</i> and Histologically Transformed Small-Cell Lung Cancer Is Sensitive to Lurbinectedin Treatment Through the Modulation of EMT and NOTCH Signaling Pathways
biblio.issue
biblio.volume
biblio.last_page
biblio.first_page
is_xpac	False
apc_list
apc_paid
concepts[0].id	https://openalex.org/C2776256026
concepts[0].level	2
concepts[0].score	0.5754486322402954
concepts[0].wikidata	https://www.wikidata.org/wiki/Q47912
concepts[0].display_name	Lung cancer
concepts[1].id	https://openalex.org/C502942594
concepts[1].level	1
concepts[1].score	0.5207653641700745
concepts[1].wikidata	https://www.wikidata.org/wiki/Q3421914
concepts[1].display_name	Cancer research
concepts[2].id	https://openalex.org/C161879069
concepts[2].level	3
concepts[2].score	0.5175307989120483
concepts[2].wikidata	https://www.wikidata.org/wiki/Q904082
concepts[2].display_name	Notch signaling pathway
concepts[3].id	https://openalex.org/C62478195
concepts[3].level	2
concepts[3].score	0.48729589581489563
concepts[3].wikidata	https://www.wikidata.org/wiki/Q828130
concepts[3].display_name	Signal transduction
concepts[4].id	https://openalex.org/C71924100
concepts[4].level	0
concepts[4].score	0.474770724773407
concepts[4].wikidata	https://www.wikidata.org/wiki/Q11190
concepts[4].display_name	Medicine
concepts[5].id	https://openalex.org/C1491633281
concepts[5].level	2
concepts[5].score	0.32808294892311096
concepts[5].wikidata	https://www.wikidata.org/wiki/Q7868
concepts[5].display_name	Cell
concepts[6].id	https://openalex.org/C2777714996
concepts[6].level	2
concepts[6].score	0.3237307369709015
concepts[6].wikidata	https://www.wikidata.org/wiki/Q7886
concepts[6].display_name	Lung
concepts[7].id	https://openalex.org/C121608353
concepts[7].level	2
concepts[7].score	0.3142460882663727
concepts[7].wikidata	https://www.wikidata.org/wiki/Q12078
concepts[7].display_name	Cancer
concepts[8].id	https://openalex.org/C123079801
concepts[8].level	2
concepts[8].score	0.30953776836395264
concepts[8].wikidata	https://www.wikidata.org/wiki/Q750240
concepts[8].display_name	Modulation (music)
concepts[9].id	https://openalex.org/C86803240
concepts[9].level	0
concepts[9].score	0.30779293179512024
concepts[9].wikidata	https://www.wikidata.org/wiki/Q420
concepts[9].display_name	Biology
concepts[10].id	https://openalex.org/C2779013556
concepts[10].level	3
concepts[10].score	0.3065131604671478
concepts[10].wikidata	https://www.wikidata.org/wiki/Q181876
concepts[10].display_name	Metastasis
concepts[11].id	https://openalex.org/C95444343
concepts[11].level	1
concepts[11].score	0.30168700218200684
concepts[11].wikidata	https://www.wikidata.org/wiki/Q7141
concepts[11].display_name	Cell biology
concepts[12].id	https://openalex.org/C150555746
concepts[12].level	3
concepts[12].score	0.28105756640434265
concepts[12].wikidata	https://www.wikidata.org/wiki/Q210973
concepts[12].display_name	Cell signaling
concepts[13].id	https://openalex.org/C2777730290
concepts[13].level	3
concepts[13].score	0.2762840688228607
concepts[13].wikidata	https://www.wikidata.org/wiki/Q411114
concepts[13].display_name	NF-κB
concepts[14].id	https://openalex.org/C142724271
concepts[14].level	1
concepts[14].score	0.2645164430141449
concepts[14].wikidata	https://www.wikidata.org/wiki/Q7208
concepts[14].display_name	Pathology
concepts[15].id	https://openalex.org/C185592680
concepts[15].level	0
concepts[15].score	0.2619210481643677
concepts[15].wikidata	https://www.wikidata.org/wiki/Q2329
concepts[15].display_name	Chemistry
concepts[16].id	https://openalex.org/C3019137385
concepts[16].level	3
concepts[16].score	0.25594693422317505
concepts[16].wikidata	https://www.wikidata.org/wiki/Q189159
concepts[16].display_name	Cell survival
keywords[0].id	https://openalex.org/keywords/lung-cancer
keywords[0].score	0.5754486322402954
keywords[0].display_name	Lung cancer
keywords[1].id	https://openalex.org/keywords/notch-signaling-pathway
keywords[1].score	0.5175307989120483
keywords[1].display_name	Notch signaling pathway
keywords[2].id	https://openalex.org/keywords/signal-transduction
keywords[2].score	0.48729589581489563
keywords[2].display_name	Signal transduction
keywords[3].id	https://openalex.org/keywords/cell
keywords[3].score	0.32808294892311096
keywords[3].display_name	Cell
keywords[4].id	https://openalex.org/keywords/lung
keywords[4].score	0.3237307369709015
keywords[4].display_name	Lung
keywords[5].id	https://openalex.org/keywords/cancer
keywords[5].score	0.3142460882663727
keywords[5].display_name	Cancer
language
locations[0].id	doi:10.1158/1078-0432.30708498
locations[0].is_oa	True
locations[0].source
locations[0].license	cc-by
locations[0].pdf_url
locations[0].version	acceptedVersion
locations[0].raw_type	posted-content
locations[0].license_id	https://openalex.org/licenses/cc-by
locations[0].is_accepted	True
locations[0].is_published	False
locations[0].raw_source_name
locations[0].landing_page_url	https://doi.org/10.1158/1078-0432.30708498
indexed_in	crossref
authorships[0].author.id	https://openalex.org/A2743638942
authorships[0].author.orcid	https://orcid.org/0000-0003-0626-9011
authorships[0].author.display_name	Subhamoy Chakraborty
authorships[0].author_position	first
authorships[0].raw_author_name	Subhamoy Chakraborty
authorships[0].is_corresponding	True
authorships[1].author.id	https://openalex.org/A2006623634
authorships[1].author.orcid	https://orcid.org/0009-0002-9884-8159
authorships[1].author.display_name	Charles Coleman
authorships[1].author_position	middle
authorships[1].raw_author_name	Charles Coleman
authorships[1].is_corresponding	False
authorships[2].author.id	https://openalex.org/A2621787425
authorships[2].author.orcid	https://orcid.org/0000-0002-1121-0121
authorships[2].author.display_name	Parvathy Manoj
authorships[2].author_position	middle
authorships[2].raw_author_name	Parvathy Manoj
authorships[2].is_corresponding	False
authorships[3].author.id	https://openalex.org/A2493809221
authorships[3].author.orcid	https://orcid.org/0000-0001-5471-6918
authorships[3].author.display_name	Deniz Demircioğlu
authorships[3].author_position	middle
authorships[3].raw_author_name	Deniz Demircioglu
authorships[3].is_corresponding	False
authorships[4].author.id	https://openalex.org/A4361638862
authorships[4].author.orcid
authorships[4].author.display_name	Nisargbhai Shah
authorships[4].author_position	middle
authorships[4].raw_author_name	Nisargbhai Shah
authorships[4].is_corresponding	False
authorships[5].author.id	https://openalex.org/A1537015278
authorships[5].author.orcid	https://orcid.org/0000-0002-3873-315X
authorships[5].author.display_name	Elisa de Stanchina
authorships[5].author_position	middle
authorships[5].raw_author_name	Elisa de Stanchina
authorships[5].is_corresponding	False
authorships[6].author.id	https://openalex.org/A2251758842
authorships[6].author.orcid	https://orcid.org/0000-0001-5204-3465
authorships[6].author.display_name	Charles M. Rudin
authorships[6].author_position	middle
authorships[6].raw_author_name	Charles M. Rudin
authorships[6].is_corresponding	False
authorships[7].author.id	https://openalex.org/A2112882632
authorships[7].author.orcid	https://orcid.org/0000-0001-7943-1636
authorships[7].author.display_name	Dan Hasson
authorships[7].author_position	middle
authorships[7].raw_author_name	Dan Hasson
authorships[7].is_corresponding	False
authorships[8].author.id	https://openalex.org/A2529028151
authorships[8].author.orcid	https://orcid.org/0000-0003-4673-7481
authorships[8].author.display_name	Triparna Sen
authorships[8].author_position	last
authorships[8].raw_author_name	Triparna Sen
authorships[8].is_corresponding	False
has_content.pdf	False
has_content.grobid_xml	False
is_paratext	False
open_access.is_oa	True
open_access.oa_url	https://doi.org/10.1158/1078-0432.30708498
open_access.oa_status	gold
open_access.any_repository_has_fulltext	False
created_date	2025-11-25T00:00:00
display_name	Figure S1 from <i>De Novo</i> and Histologically Transformed Small-Cell Lung Cancer Is Sensitive to Lurbinectedin Treatment Through the Modulation of EMT and NOTCH Signaling Pathways
has_fulltext	False
is_retracted	False
updated_date	2025-11-27T01:12:40.094763
primary_topic
cited_by_count	0
locations_count	1
best_oa_location.id	doi:10.1158/1078-0432.30708498
best_oa_location.is_oa	True
best_oa_location.source
best_oa_location.license	cc-by
best_oa_location.pdf_url
best_oa_location.version	acceptedVersion
best_oa_location.raw_type	posted-content
best_oa_location.license_id	https://openalex.org/licenses/cc-by
best_oa_location.is_accepted	True
best_oa_location.is_published	False
best_oa_location.raw_source_name
best_oa_location.landing_page_url	https://doi.org/10.1158/1078-0432.30708498
primary_location.id	doi:10.1158/1078-0432.30708498
primary_location.is_oa	True
primary_location.source
primary_location.license	cc-by
primary_location.pdf_url
primary_location.version	acceptedVersion
primary_location.raw_type	posted-content
primary_location.license_id	https://openalex.org/licenses/cc-by
primary_location.is_accepted	True
primary_location.is_published	False
primary_location.raw_source_name
primary_location.landing_page_url	https://doi.org/10.1158/1078-0432.30708498
publication_date	2025-11-25
publication_year	2025
referenced_works_count	0
abstract_inverted_index.a	7
abstract_inverted_index.in	6
abstract_inverted_index.S1.	1
abstract_inverted_index.and	9
abstract_inverted_index.cell	4
abstract_inverted_index.time	8
abstract_inverted_index.decreases	3
abstract_inverted_index.viability	5
abstract_inverted_index.Lurbinectedin	2
abstract_inverted_index.dose-dependent	10
abstract_inverted_index.<p>Figure	0
abstract_inverted_index.manner.</p>	11
cited_by_percentile_year
countries_distinct_count	0
institutions_distinct_count	9
citation_normalized_percentile