Figure S4 from ERBB4-Mediated Signaling Is a Mediator of Resistance to PI3K and BTK Inhibitors in B-cell Lymphoid Neoplasms Article Swipe

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Alberto J. Arribas , Sara Napoli , Luciano Cascione , Laura Barnabei , Giulio Sartori , Eleonora Cannas , Eugenio Gaudio , Chiara Tarantelli , Afua A. Mensah , Filippo Spriano , Antonella Zucchetto , Francesca Maria Rossi , Andrea Rinaldi , Manuel Castro de Moura , Sandra Jovic , Roberta Bordone Pittau , Anastasios Stathis , Georg Stüssi , Valter Gattei , Jennifer R. Brown , Manel Esteller , Emanuele Zucca , Davide Rossi , Francesco Bertoni ·

YOU? · · 2025 · Open Access · · DOI: https://doi.org/10.1158/1535-7163.28548001

(A) Heatmap of functionally annotated genes showing log2-scaled fold change and -log10 adjusted P-value (FDR) by RNA-seq comparing K1718 parental and resistant cells. (B) Gene set enrichment analyses (GSEA, Broad Institute) comparing parental and resistant per each line. Statistically significant differences with values of absolute NES higher than1, P <0.05 and FDR <0.25.

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Mtor

Biology

Cell Biology

Receptor Tyrosine Kinase

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Bruton's tyrosine kinase Mediator ERBB4 Cancer research PI3K/AKT/mTOR pathway Biology Cell biology Signal transduction Tyrosine kinase Receptor tyrosine kinase

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Language: en
Landing Page: https://doi.org/10.1158/1535-7163.28548001
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Title: Figure S4 from ERBB4-Mediated Signaling Is a Mediator of Resistance to PI3K and BTK Inhibitors in B-cell Lymphoid Neoplasms

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Publication year: 2025

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Authors: Alberto J. Arribas, Sara Napoli, Luciano Cascione, Laura Barnabei, Giulio Sartori, Eleonora Cannas, Eugenio Gaudio, Chiara Tarantelli, Afua A. Mensah, Filippo Spriano, Antonella Zucchetto, Francesca Maria Rossi, Andrea Rinaldi, Manuel Castro de Moura, Sandra Jovic, Roberta Bordone Pittau, Anastasios Stathis, Georg Stüssi, Valter Gattei, Jennifer R. Brown, Manel Esteller, Emanuele Zucca, Davide Rossi, Francesco Bertoni

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Concepts: Bruton's tyrosine kinase, Mediator, ERBB4, Cancer research, PI3K/AKT/mTOR pathway, Biology, Cell biology, Signal transduction, Tyrosine kinase, Receptor tyrosine kinase

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