Figure S5 from Scaffolding Protein Connector Enhancer of Kinase Suppressor of Ras 1 (CNKSR1) Regulates MAPK Inhibition Responsiveness in Pancreas Cancer via Crosstalk with AKT Signaling Article Swipe

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Dandan Li , Anne M. Miermont , Rushikesh Sable , Humair S. Quadri , Lesley A. Mathews Griner , Scott E. Martin , Taivan Odzorig , Soumita De , Marc Ferrer , Astin S. Powers , Stephen M. Hewitt , Udo Rudloff ·

YOU? · · 2023 · Open Access · · DOI: https://doi.org/10.1158/1541-7786.22552180.v1

Selumetinib fails to recruit CNKSR1 and p-AKT to the plasma membrane in CNKSR1 low cell lines; Proximal ligation of CNKSR1 and p-AKT in CNKSR1 low cell lines treated with vehicle vs selumetinib;CNKSR1 p-AKT PLA signal after treatment with selumetinib is dependent on the presence of both primary antibodies; Silencing of CNKSR1 in the CNKSR1high cell lines abrogates PLA signal; and Immunofluorescence staining of PIP3 and CNKSR1 in YAPC treated with vehicle and selumetinib.

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Selumetinib Protein kinase B Cancer research MAPK/ERK pathway Cell biology Chemistry Signal transduction MEK inhibitor Molecular biology Biology

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Type: preprint
Language: en
Landing Page: https://doi.org/10.1158/1541-7786.22552180.v1
PDF: https://aacr.figshare.com/articles/journal_contribution/Figure_S5_from_Scaffolding_Protein_Connector_Enhancer_of_Kinase_Suppressor_of_Ras_1_CNKSR1_Regulates_MAPK_Inhibition_Responsiveness_in_Pancreas_Cancer_via_Crosstalk_with_AKT_Signaling/22552180/1/files/40019596.pdf
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DOI: https://doi.org/10.1158/1541-7786.22552180.v1

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Title: Figure S5 from Scaffolding Protein Connector Enhancer of Kinase Suppressor of Ras 1 (CNKSR1) Regulates MAPK Inhibition Responsiveness in Pancreas Cancer via Crosstalk with AKT Signaling

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Language: en

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Publication year: 2023

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Authors: Dandan Li, Anne M. Miermont, Rushikesh Sable, Humair S. Quadri, Lesley A. Mathews Griner, Scott E. Martin, Taivan Odzorig, Soumita De, Marc Ferrer, Astin S. Powers, Stephen M. Hewitt, Udo Rudloff

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Concepts: Selumetinib, Protein kinase B, Cancer research, MAPK/ERK pathway, Cell biology, Chemistry, Signal transduction, MEK inhibitor, Molecular biology, Biology

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