Figure S8 from Type I Interferon Signaling via the EGR2 Transcriptional Regulator Potentiates CAR T cell-intrinsic Dysfunction Article Swipe

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Regulator Interferon IRF1 Cell biology Negative regulator Cancer research Signal transduction Biology Transcription factor Genetics Gene

In-Young Jung , Robert L. Bartoszek , Andrew J. Rech , Sierra M. Collins , Soon‐Keat Ooi , Erik F. Williams , Caitlin R. Hopkins , Vivek Narayan , Naomi B. Haas , Noelle V. Frey , Elizabeth O. Hexner , Donald L. Siegel , Gabriela Plesa , David L. Porter , Adrian Cantu , J.K. Everett , Sònia Guedan , Shelley L. Berger , Frederic D. Bushman , Friederike Herbst , Joseph A. Fraietta ·

YOU? · · 2024 · Open Access · · DOI: https://doi.org/10.1158/2159-8290.27025274 · OA: W4402806301

<p>Comparison of Type I IFN gene expression in different CAR-T engineering approaches. (A-F) show volcano plots and a heatmap of gene expression in engineered CAR T-cells, with type I IFN genes highlighted in blue. These data represent different CAR-T engineering approaches, including: BRG1/BRM-associated factors (BAF) complex, Gata3, INO80 complex knockout (PMID35750052), BATF overexpression (PMID34282330), 4-1BB- versus CD28-based GD2 CAR activity (PMID 25939063) and 1xx CD19 CAR T-cells (GSE121226). These plots allow for a comparison of the levels of type I IFN gene expression in each of these different CAR-T engineering methods.</p>