Figure S9 from Direct Inhibition of RAS Reveals the Features of Oncogenic Signaling Driven by RAS G12 and Q61 Mutations Article Swipe

PDF

Michelangelo Marasco , Dinesh Kumar , Santiago Garcia Borrego , Tessa Seale , Giulia Maddalena , Riccardo Mezzadra , Kylie Belanger , Soren Cole , Brayan Perez , Wei Luan , Radha Mukherjee , Ilinca Aricescu , Vladimir Markov , Yuxin Zhu , Sabrina Arena , Alberto Bardelli , Elisa de Stanchina , Scott W. Lowe , Richard A. Burkhart , Jacquelyn W. Zimmerman , Rona Yaeger , Scott Kopetz , Neal Rosen , Sandra Misale ·

YOU? · · 2025 · Open Access · · DOI: https://doi.org/10.1158/2159-8290.29467400

Figure S9 shows the dose-response curves of RMC-7977 alone or in combination with Cetuximab 25μg/mL in a panel of human cancer cell lines harboring RAS G12X or RAS Q61X mutations.

Related Topics

Biology

Concepts

Genetics Cancer research Biology

Metadata

Type: preprint
Language: en
Landing Page: https://doi.org/10.1158/2159-8290.29467400
PDF: https://aacr.figshare.com/articles/journal_contribution/Figure_S9_from_Direct_Inhibition_of_RAS_Reveals_the_Features_of_Oncogenic_Signaling_Driven_by_RAS_G12_and_Q61_Mutations/29467400/1/files/55948220.pdf
OA Status: gold
Related Works: 10
OpenAlex ID: https://openalex.org/W4411971360

All OpenAlex metadata

Raw OpenAlex JSON

OpenAlex ID: https://openalex.org/W4411971360

Canonical identifier for this work in OpenAlex
DOI: https://doi.org/10.1158/2159-8290.29467400

Digital Object Identifier
Title: Figure S9 from Direct Inhibition of RAS Reveals the Features of Oncogenic Signaling Driven by RAS G12 and Q61 Mutations

Work title
Type: preprint

OpenAlex work type
Language: en

Primary language
Publication year: 2025

Year of publication
Publication date: 2025-07-03

Full publication date if available
Authors: Michelangelo Marasco, Dinesh Kumar, Santiago Garcia Borrego, Tessa Seale, Giulia Maddalena, Riccardo Mezzadra, Kylie Belanger, Soren Cole, Brayan Perez, Wei Luan, Radha Mukherjee, Ilinca Aricescu, Vladimir Markov, Yuxin Zhu, Sabrina Arena, Alberto Bardelli, Elisa de Stanchina, Scott W. Lowe, Richard A. Burkhart, Jacquelyn W. Zimmerman, Rona Yaeger, Scott Kopetz, Neal Rosen, Sandra Misale

List of authors in order
Landing page: https://doi.org/10.1158/2159-8290.29467400

Publisher landing page
PDF URL: https://aacr.figshare.com/articles/journal_contribution/Figure_S9_from_Direct_Inhibition_of_RAS_Reveals_the_Features_of_Oncogenic_Signaling_Driven_by_RAS_G12_and_Q61_Mutations/29467400/1/files/55948220.pdf

Direct link to full text PDF
Open access: Yes

Whether a free full text is available
OA status: gold

Open access status per OpenAlex
OA URL: https://aacr.figshare.com/articles/journal_contribution/Figure_S9_from_Direct_Inhibition_of_RAS_Reveals_the_Features_of_Oncogenic_Signaling_Driven_by_RAS_G12_and_Q61_Mutations/29467400/1/files/55948220.pdf

Direct OA link when available
Concepts: Genetics, Cancer research, Biology

Top concepts (fields/topics) attached by OpenAlex
Cited by: 0

Total citation count in OpenAlex
Related works (count): 10

Other works algorithmically related by OpenAlex

Full payload

id	https://openalex.org/W4411971360
doi	https://doi.org/10.1158/2159-8290.29467400
ids.doi	https://doi.org/10.1158/2159-8290.29467400
ids.openalex	https://openalex.org/W4411971360
fwci	0.0
type	preprint
title	Figure S9 from Direct Inhibition of RAS Reveals the Features of Oncogenic Signaling Driven by RAS G12 and Q61 Mutations
biblio.issue
biblio.volume
biblio.last_page
biblio.first_page
topics[0].id	https://openalex.org/T10169
topics[0].field.id	https://openalex.org/fields/13
topics[0].field.display_name	Biochemistry, Genetics and Molecular Biology
topics[0].score	0.8938999772071838
topics[0].domain.id	https://openalex.org/domains/1
topics[0].domain.display_name	Life Sciences
topics[0].subfield.id	https://openalex.org/subfields/1312
topics[0].subfield.display_name	Molecular Biology
topics[0].display_name	Protein Kinase Regulation and GTPase Signaling
topics[1].id	https://openalex.org/T13526
topics[1].field.id	https://openalex.org/fields/13
topics[1].field.display_name	Biochemistry, Genetics and Molecular Biology
topics[1].score	0.8148999810218811
topics[1].domain.id	https://openalex.org/domains/1
topics[1].domain.display_name	Life Sciences
topics[1].subfield.id	https://openalex.org/subfields/1312
topics[1].subfield.display_name	Molecular Biology
topics[1].display_name	14-3-3 protein interactions
topics[2].id	https://openalex.org/T11041
topics[2].field.id	https://openalex.org/fields/13
topics[2].field.display_name	Biochemistry, Genetics and Molecular Biology
topics[2].score	0.7717000246047974
topics[2].domain.id	https://openalex.org/domains/1
topics[2].domain.display_name	Life Sciences
topics[2].subfield.id	https://openalex.org/subfields/1312
topics[2].subfield.display_name	Molecular Biology
topics[2].display_name	Ubiquitin and proteasome pathways
is_xpac	False
apc_list
apc_paid
concepts[0].id	https://openalex.org/C54355233
concepts[0].level	1
concepts[0].score	0.4652844965457916
concepts[0].wikidata	https://www.wikidata.org/wiki/Q7162
concepts[0].display_name	Genetics
concepts[1].id	https://openalex.org/C502942594
concepts[1].level	1
concepts[1].score	0.42060378193855286
concepts[1].wikidata	https://www.wikidata.org/wiki/Q3421914
concepts[1].display_name	Cancer research
concepts[2].id	https://openalex.org/C86803240
concepts[2].level	0
concepts[2].score	0.3484262228012085
concepts[2].wikidata	https://www.wikidata.org/wiki/Q420
concepts[2].display_name	Biology
keywords[0].id	https://openalex.org/keywords/genetics
keywords[0].score	0.4652844965457916
keywords[0].display_name	Genetics
keywords[1].id	https://openalex.org/keywords/cancer-research
keywords[1].score	0.42060378193855286
keywords[1].display_name	Cancer research
keywords[2].id	https://openalex.org/keywords/biology
keywords[2].score	0.3484262228012085
keywords[2].display_name	Biology
language	en
locations[0].id	doi:10.1158/2159-8290.29467400
locations[0].is_oa	True
locations[0].source
locations[0].license	cc-by
locations[0].pdf_url	https://aacr.figshare.com/articles/journal_contribution/Figure_S9_from_Direct_Inhibition_of_RAS_Reveals_the_Features_of_Oncogenic_Signaling_Driven_by_RAS_G12_and_Q61_Mutations/29467400/1/files/55948220.pdf
locations[0].version	acceptedVersion
locations[0].raw_type	posted-content
locations[0].license_id	https://openalex.org/licenses/cc-by
locations[0].is_accepted	True
locations[0].is_published	False
locations[0].raw_source_name
locations[0].landing_page_url	https://doi.org/10.1158/2159-8290.29467400
indexed_in	crossref
authorships[0].author.id	https://openalex.org/A5041526574
authorships[0].author.orcid	https://orcid.org/0000-0001-7082-9824
authorships[0].author.display_name	Michelangelo Marasco
authorships[0].author_position	first
authorships[0].raw_author_name	Michelangelo Marasco
authorships[0].is_corresponding	False
authorships[1].author.id	https://openalex.org/A5100406061
authorships[1].author.orcid	https://orcid.org/0000-0002-0935-9875
authorships[1].author.display_name	Dinesh Kumar
authorships[1].author_position	middle
authorships[1].raw_author_name	Dinesh Kumar
authorships[1].is_corresponding	False
authorships[2].author.id	https://openalex.org/A5101622751
authorships[2].author.orcid	https://orcid.org/0000-0001-8998-6002
authorships[2].author.display_name	Santiago Garcia Borrego
authorships[2].author_position	middle
authorships[2].raw_author_name	Santiago Garcia Borrego
authorships[2].is_corresponding	False
authorships[3].author.id	https://openalex.org/A5040283575
authorships[3].author.orcid	https://orcid.org/0000-0002-9535-9694
authorships[3].author.display_name	Tessa Seale
authorships[3].author_position	middle
authorships[3].raw_author_name	Tessa Seale
authorships[3].is_corresponding	False
authorships[4].author.id	https://openalex.org/A5083651413
authorships[4].author.orcid	https://orcid.org/0000-0002-1714-1171
authorships[4].author.display_name	Giulia Maddalena
authorships[4].author_position	middle
authorships[4].raw_author_name	Giulia Maddalena
authorships[4].is_corresponding	False
authorships[5].author.id	https://openalex.org/A5058453474
authorships[5].author.orcid	https://orcid.org/0000-0002-7737-8461
authorships[5].author.display_name	Riccardo Mezzadra
authorships[5].author_position	middle
authorships[5].raw_author_name	Riccardo Mezzadra
authorships[5].is_corresponding	False
authorships[6].author.id	https://openalex.org/A5064421057
authorships[6].author.orcid	https://orcid.org/0000-0003-1613-8533
authorships[6].author.display_name	Kylie Belanger
authorships[6].author_position	middle
authorships[6].raw_author_name	Kylie Belanger
authorships[6].is_corresponding	False
authorships[7].author.id	https://openalex.org/A5017445984
authorships[7].author.orcid
authorships[7].author.display_name	Soren Cole
authorships[7].author_position	middle
authorships[7].raw_author_name	Soren Cole
authorships[7].is_corresponding	False
authorships[8].author.id	https://openalex.org/A5111327809
authorships[8].author.orcid
authorships[8].author.display_name	Brayan Perez
authorships[8].author_position	middle
authorships[8].raw_author_name	Brayan Perez
authorships[8].is_corresponding	False
authorships[9].author.id	https://openalex.org/A5048285089
authorships[9].author.orcid	https://orcid.org/0000-0002-9988-0612
authorships[9].author.display_name	Wei Luan
authorships[9].author_position	middle
authorships[9].raw_author_name	Wei Luan
authorships[9].is_corresponding	False
authorships[10].author.id	https://openalex.org/A5006197947
authorships[10].author.orcid
authorships[10].author.display_name	Radha Mukherjee
authorships[10].author_position	middle
authorships[10].raw_author_name	Radha Mukherjee
authorships[10].is_corresponding	False
authorships[11].author.id	https://openalex.org/A5057482480
authorships[11].author.orcid
authorships[11].author.display_name	Ilinca Aricescu
authorships[11].author_position	middle
authorships[11].raw_author_name	Ilinca Aricescu
authorships[11].is_corresponding	False
authorships[12].author.id	https://openalex.org/A5103146087
authorships[12].author.orcid	https://orcid.org/0000-0002-8190-3177
authorships[12].author.display_name	Vladimir Markov
authorships[12].author_position	middle
authorships[12].raw_author_name	Vladimir Markov
authorships[12].is_corresponding	False
authorships[13].author.id	https://openalex.org/A5002662075
authorships[13].author.orcid	https://orcid.org/0000-0002-0886-4116
authorships[13].author.display_name	Yuxin Zhu
authorships[13].author_position	middle
authorships[13].raw_author_name	Yuxin Zhu
authorships[13].is_corresponding	False
authorships[14].author.id	https://openalex.org/A5035320829
authorships[14].author.orcid	https://orcid.org/0000-0002-1318-2494
authorships[14].author.display_name	Sabrina Arena
authorships[14].author_position	middle
authorships[14].raw_author_name	Sabrina Arena
authorships[14].is_corresponding	False
authorships[15].author.id	https://openalex.org/A5064011158
authorships[15].author.orcid	https://orcid.org/0000-0003-1647-5070
authorships[15].author.display_name	Alberto Bardelli
authorships[15].author_position	middle
authorships[15].raw_author_name	Alberto Bardelli
authorships[15].is_corresponding	False
authorships[16].author.id	https://openalex.org/A5004111432
authorships[16].author.orcid	https://orcid.org/0000-0002-3873-315X
authorships[16].author.display_name	Elisa de Stanchina
authorships[16].author_position	middle
authorships[16].raw_author_name	Elisa de Stanchina
authorships[16].is_corresponding	False
authorships[17].author.id	https://openalex.org/A5025451142
authorships[17].author.orcid	https://orcid.org/0000-0002-5284-9650
authorships[17].author.display_name	Scott W. Lowe
authorships[17].author_position	middle
authorships[17].raw_author_name	Scott W. Lowe
authorships[17].is_corresponding	False
authorships[18].author.id	https://openalex.org/A5039843730
authorships[18].author.orcid	https://orcid.org/0000-0003-1087-0870
authorships[18].author.display_name	Richard A. Burkhart
authorships[18].author_position	middle
authorships[18].raw_author_name	Richard A. Burkhart
authorships[18].is_corresponding	False
authorships[19].author.id	https://openalex.org/A5016005335
authorships[19].author.orcid	https://orcid.org/0000-0002-7775-2943
authorships[19].author.display_name	Jacquelyn W. Zimmerman
authorships[19].author_position	middle
authorships[19].raw_author_name	Jacquelyn W. Zimmerman
authorships[19].is_corresponding	False
authorships[20].author.id	https://openalex.org/A5038339239
authorships[20].author.orcid	https://orcid.org/0000-0002-7233-5454
authorships[20].author.display_name	Rona Yaeger
authorships[20].author_position	middle
authorships[20].raw_author_name	Rona Yaeger
authorships[20].is_corresponding	False
authorships[21].author.id	https://openalex.org/A5006348751
authorships[21].author.orcid	https://orcid.org/0000-0001-9647-3416
authorships[21].author.display_name	Scott Kopetz
authorships[21].author_position	middle
authorships[21].raw_author_name	Scott E. Kopetz
authorships[21].is_corresponding	False
authorships[22].author.id	https://openalex.org/A5060228803
authorships[22].author.orcid	https://orcid.org/0000-0002-8307-654X
authorships[22].author.display_name	Neal Rosen
authorships[22].author_position	middle
authorships[22].raw_author_name	Neal Rosen
authorships[22].is_corresponding	False
authorships[23].author.id	https://openalex.org/A5011823761
authorships[23].author.orcid	https://orcid.org/0000-0002-6031-0137
authorships[23].author.display_name	Sandra Misale
authorships[23].author_position	last
authorships[23].raw_author_name	Sandra Misale
authorships[23].is_corresponding	False
has_content.pdf	True
has_content.grobid_xml	True
is_paratext	False
open_access.is_oa	True
open_access.oa_url	https://aacr.figshare.com/articles/journal_contribution/Figure_S9_from_Direct_Inhibition_of_RAS_Reveals_the_Features_of_Oncogenic_Signaling_Driven_by_RAS_G12_and_Q61_Mutations/29467400/1/files/55948220.pdf
open_access.oa_status	gold
open_access.any_repository_has_fulltext	False
created_date	2025-10-10T00:00:00
display_name	Figure S9 from Direct Inhibition of RAS Reveals the Features of Oncogenic Signaling Driven by RAS G12 and Q61 Mutations
has_fulltext	True
is_retracted	False
updated_date	2025-11-06T03:46:38.306776
primary_topic.id	https://openalex.org/T10169
primary_topic.field.id	https://openalex.org/fields/13
primary_topic.field.display_name	Biochemistry, Genetics and Molecular Biology
primary_topic.score	0.8938999772071838
primary_topic.domain.id	https://openalex.org/domains/1
primary_topic.domain.display_name	Life Sciences
primary_topic.subfield.id	https://openalex.org/subfields/1312
primary_topic.subfield.display_name	Molecular Biology
primary_topic.display_name	Protein Kinase Regulation and GTPase Signaling
related_works	https://openalex.org/W4391375266, https://openalex.org/W2082860237, https://openalex.org/W2119695867, https://openalex.org/W2130076355, https://openalex.org/W1990804418, https://openalex.org/W1993764875, https://openalex.org/W2046158694, https://openalex.org/W2788277189, https://openalex.org/W2013243191, https://openalex.org/W1971568933
cited_by_count	0
locations_count	1
best_oa_location.id	doi:10.1158/2159-8290.29467400
best_oa_location.is_oa	True
best_oa_location.source
best_oa_location.license	cc-by
best_oa_location.pdf_url	https://aacr.figshare.com/articles/journal_contribution/Figure_S9_from_Direct_Inhibition_of_RAS_Reveals_the_Features_of_Oncogenic_Signaling_Driven_by_RAS_G12_and_Q61_Mutations/29467400/1/files/55948220.pdf
best_oa_location.version	acceptedVersion
best_oa_location.raw_type	posted-content
best_oa_location.license_id	https://openalex.org/licenses/cc-by
best_oa_location.is_accepted	True
best_oa_location.is_published	False
best_oa_location.raw_source_name
best_oa_location.landing_page_url	https://doi.org/10.1158/2159-8290.29467400
primary_location.id	doi:10.1158/2159-8290.29467400
primary_location.is_oa	True
primary_location.source
primary_location.license	cc-by
primary_location.pdf_url	https://aacr.figshare.com/articles/journal_contribution/Figure_S9_from_Direct_Inhibition_of_RAS_Reveals_the_Features_of_Oncogenic_Signaling_Driven_by_RAS_G12_and_Q61_Mutations/29467400/1/files/55948220.pdf
primary_location.version	acceptedVersion
primary_location.raw_type	posted-content
primary_location.license_id	https://openalex.org/licenses/cc-by
primary_location.is_accepted	True
primary_location.is_published	False
primary_location.raw_source_name
primary_location.landing_page_url	https://doi.org/10.1158/2159-8290.29467400
publication_date	2025-07-03
publication_year	2025
referenced_works_count	0
abstract_inverted_index.a	16
abstract_inverted_index.S9	1
abstract_inverted_index.in	10, 15
abstract_inverted_index.of	6, 18
abstract_inverted_index.or	9, 26
abstract_inverted_index.RAS	24, 27
abstract_inverted_index.the	3
abstract_inverted_index.G12X	25
abstract_inverted_index.Q61X	28
abstract_inverted_index.cell	21
abstract_inverted_index.with	12
abstract_inverted_index.alone	8
abstract_inverted_index.human	19
abstract_inverted_index.lines	22
abstract_inverted_index.panel	17
abstract_inverted_index.shows	2
abstract_inverted_index.cancer	20
abstract_inverted_index.curves	5
abstract_inverted_index.25μg/mL	14
abstract_inverted_index.RMC-7977	7
abstract_inverted_index.Cetuximab	13
abstract_inverted_index.harboring	23
abstract_inverted_index.combination	11
abstract_inverted_index.dose-response	4
abstract_inverted_index.<p>Figure	0
abstract_inverted_index.mutations.</p>	29
cited_by_percentile_year
countries_distinct_count	0
institutions_distinct_count	24
citation_normalized_percentile.value	0.2618753
citation_normalized_percentile.is_in_top_1_percent	False
citation_normalized_percentile.is_in_top_10_percent	False