Fine-tuning spatial-temporal dynamics and surface receptor expression support plasma cell-intrinsic longevity Article Swipe
Zhixin Jing
,
Phillip M. Galbo
,
Luis Ovando
,
Megan Demouth
,
Skylar Welte
,
Rosa Park
,
Kartik Chandran
,
Yinghao Wu
,
Thomas MacCarthy
,
Deyou Zheng
,
David Fooksman
·
YOU?
·
· 2024
· Open Access
·
· DOI: https://doi.org/10.7554/elife.89712.3
YOU?
·
· 2024
· Open Access
·
· DOI: https://doi.org/10.7554/elife.89712.3
Durable serological memory following vaccination is critically dependent on the production and survival of long-lived plasma cells (LLPCs). Yet, the factors that control LLPC specification and survival remain poorly resolved. Using intravital two-photon imaging, we find that in contrast to most plasma cells (PCs) in the bone marrow (BM), LLPCs are uniquely sessile and organized into clusters that are dependent on APRIL, an important survival factor. Using deep, bulk RNA sequencing, and surface protein flow-based phenotyping, we find that LLPCs express a unique transcriptome and phenotype compared to bulk PCs, fine-tuning expression of key cell surface molecules, CD93, CD81, CXCR4, CD326, CD44, and CD48, important for adhesion and homing. Conditional deletion of Cxcr4 in PCs following immunization leads to rapid mobilization from the BM, reduced survival of antigen-specific PCs, and ultimately accelerated decay of antibody titer. In naïve mice, the endogenous LLPCs BCR repertoire exhibits reduced diversity, reduced somatic mutations, and increased public clones and IgM isotypes, particularly in young mice, suggesting LLPC specification is non-random. As mice age, the BM PC compartment becomes enriched in LLPCs, which may outcompete and limit entry of new PCs into the LLPC niche and pool.
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- Type
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- Language
- en
- Landing Page
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- OA Status
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- Cited By
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All OpenAlex metadata
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https://doi.org/10.7554/elife.89712.3Digital Object Identifier
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Fine-tuning spatial-temporal dynamics and surface receptor expression support plasma cell-intrinsic longevityWork title
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articleOpenAlex work type
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enPrimary language
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2024Year of publication
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2024-06-18Full publication date if available
- Authors
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Zhixin Jing, Phillip M. Galbo, Luis Ovando, Megan Demouth, Skylar Welte, Rosa Park, Kartik Chandran, Yinghao Wu, Thomas MacCarthy, Deyou Zheng, David FooksmanList of authors in order
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https://doi.org/10.7554/elife.89712.3Publisher landing page
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YesWhether a free full text is available
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goldOpen access status per OpenAlex
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https://doi.org/10.7554/elife.89712.3Direct OA link when available
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Biology, Cell biology, Homing (biology), EcologyTop concepts (fields/topics) attached by OpenAlex
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4Total citation count in OpenAlex
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2025: 3, 2024: 1Per-year citation counts (last 5 years)
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