Fitness effects of plasmids shape the structure of bacteria–plasmid interaction networks Article Swipe
Arthur Newbury
,
Bethany R. Dawson
,
Uli Klümper
,
Elze Hesse
,
Meaghan Castledine
,
Colin Fontaine
,
Angus Buckling
,
Dirk Sanders
·
YOU?
·
· 2022
· Open Access
·
· DOI: https://doi.org/10.1073/pnas.2118361119
YOU?
·
· 2022
· Open Access
·
· DOI: https://doi.org/10.1073/pnas.2118361119
Antimicrobial resistance (AMR) genes are often carried on broad host range plasmids, and the spread of AMR within microbial communities will therefore depend on the structure of bacteria–plasmid networks. Empirical and theoretical studies of ecological interaction networks suggest that network structure differs between communities that are predominantly mutualistic versus antagonistic, with the former showing more generalized interactions (i.e., species interact with many others to a similar extent). This suggests that mutualistic bacteria–plasmid networks—where antibiotics are present and plasmids carry AMR genes—will be more generalized than antagonistic interactions, where plasmids do not confer benefits to their hosts. We first develop a simple theory to explain this link: fitness benefits of harboring a mutualistic symbiont promote the spread of the symbiont to other species. We find support for this theory using an experimental bacteria–symbiont (plasmid) community, where the same plasmid can be mutualistic or antagonistic depending on the presence of antibiotics. This short-term and parsimonious mechanism complements a longer-term mechanism (coevolution and stability) explaining the link between mutualistic and antagonistic interactions and network structure.
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Metadata
- Type
- article
- Language
- en
- Landing Page
- https://doi.org/10.1073/pnas.2118361119
- OA Status
- hybrid
- Cited By
- 25
- References
- 43
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W4281483243
All OpenAlex metadata
Raw OpenAlex JSON
- OpenAlex ID
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https://openalex.org/W4281483243Canonical identifier for this work in OpenAlex
- DOI
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https://doi.org/10.1073/pnas.2118361119Digital Object Identifier
- Title
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Fitness effects of plasmids shape the structure of bacteria–plasmid interaction networksWork title
- Type
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articleOpenAlex work type
- Language
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enPrimary language
- Publication year
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2022Year of publication
- Publication date
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2022-05-25Full publication date if available
- Authors
-
Arthur Newbury, Bethany R. Dawson, Uli Klümper, Elze Hesse, Meaghan Castledine, Colin Fontaine, Angus Buckling, Dirk SandersList of authors in order
- Landing page
-
https://doi.org/10.1073/pnas.2118361119Publisher landing page
- Open access
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YesWhether a free full text is available
- OA status
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hybridOpen access status per OpenAlex
- OA URL
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https://doi.org/10.1073/pnas.2118361119Direct OA link when available
- Concepts
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Plasmid, Biology, Coevolution, Bacteria, Network structure, Genetics, Gene, Mechanism (biology), Evolutionary biology, Computational biology, Computer science, Distributed computing, Philosophy, EpistemologyTop concepts (fields/topics) attached by OpenAlex
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25Total citation count in OpenAlex
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2025: 4, 2024: 10, 2023: 7, 2022: 3, 2020: 1Per-year citation counts (last 5 years)
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43Number of works referenced by this work
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10Other works algorithmically related by OpenAlex
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