Five New Pregnane Glycosides from Gymnema sylvestre and Their α-Glucosidase and α-Amylase Inhibitory Activities Article Swipe

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Phan Văn Kiệm , Dương Thị Hải Yến , Nguyễn Văn Hưng , Nguyễn Xuân Nhiệm , Bùi Hữu Tài , Đỗ Thị Trang , Phạm Hải Yến , Tran Minh Ngoc , Châu Văn Minh , SeonJu Park , Jae Lee , Sun Yeou Kim , Seung Hyun Kim ·

YOU? · · 2020 · Open Access · · DOI: https://doi.org/10.3390/molecules25112525

Gymnema sylvestre, a medicinal plant, has been used in Indian ayurvedic traditional medicine for the treatment of diabetes. Phytochemical investigation of Gymnema sylvestre led to the isolation of five new pregnane glycosides, gymsylosides A–E (1–5) and four known oleanane saponins, 3β-O-β-D-glucopyranosyl (1→6)-β-D-glucopyranosyl oleanolic acid 28-O-β-D-glucopyranosyl ester (6), gymnemoside-W1 (7), 3β-O-β-D-xylopyranosyl-(1→6)-β-D- glucopyranosyl-(1→6)-β-D-glucopyranosyl oleanolic acid 28-O-β-D-glucopyranosyl ester (8), and alternoside XIX (9). Their structures were identified based on spectroscopic evidence and comparison with those reported in the literature. All compounds were evaluated for their α-glucosidase and α-amylase inhibitory activities. Compounds 2–4 showed significant α-amylase inhibitory activity, with IC50 values ranging from 113.0 to 176.2 µM.

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Gymnema sylvestre Oleanolic acid Glycoside Phytochemical Stigmasterol Pregnane Traditional medicine Chemistry Stereochemistry Biochemistry Medicine Chromatography Alternative medicine Pathology

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Type: article
Language: en
Landing Page: https://doi.org/10.3390/molecules25112525
PDF: https://www.mdpi.com/1420-3049/25/11/2525/pdf?version=1591096521
OA Status: gold
Cited By: 23
References: 19
Related Works: 10
OpenAlex ID: https://openalex.org/W3030660766

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DOI: https://doi.org/10.3390/molecules25112525

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Title: Five New Pregnane Glycosides from Gymnema sylvestre and Their α-Glucosidase and α-Amylase Inhibitory Activities

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Language: en

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Publication year: 2020

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Publication date: 2020-05-28

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Authors: Phan Văn Kiệm, Dương Thị Hải Yến, Nguyễn Văn Hưng, Nguyễn Xuân Nhiệm, Bùi Hữu Tài, Đỗ Thị Trang, Phạm Hải Yến, Tran Minh Ngoc, Châu Văn Minh, SeonJu Park, Jae Lee, Sun Yeou Kim, Seung Hyun Kim

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Landing page: https://doi.org/10.3390/molecules25112525

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Concepts: Gymnema sylvestre, Oleanolic acid, Glycoside, Phytochemical, Stigmasterol, Pregnane, Traditional medicine, Chemistry, Stereochemistry, Biochemistry, Medicine, Chromatography, Alternative medicine, Pathology

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Cited by: 23

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