Fixation probability of a nonmutator in a large population of asexual\n mutators Article Swipe

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YOU? · · 2017 · Open Access · · DOI: https://doi.org/10.48550/arxiv.1705.00153

In an adapted population of mutators in which most mutations are deleterious,\na nonmutator that lowers the mutation rate is under indirect selection and can\nsweep to fixation. Using a multitype branching process, we calculate the\nfixation probability of a rare nonmutator in a large population of asexual\nmutators. We show that when beneficial mutations are absent, the fixation\nprobability is a nonmonotonic function of the mutation rate of the mutator: it\nfirst increases sublinearly and then decreases exponentially. We also find that\nbeneficial mutations can enhance the fixation probability of a nonmutator. Our\nanalysis is relevant to an understanding of recent experiments in which a\nreduction in the mutation rates has been observed.\n

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Fixation (population genetics) Mutation rate Population Mutation Branching process Biology Statistical physics Genetics Physics Gene Demography Sociology

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Type: preprint
Landing Page: http://arxiv.org/abs/1705.00153
PDF: https://arxiv.org/pdf/1705.00153
OA Status: green
Related Works: 10
OpenAlex ID: https://openalex.org/W4302876353

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DOI: https://doi.org/10.48550/arxiv.1705.00153

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Title: Fixation probability of a nonmutator in a large population of asexual\n mutators

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Type: preprint

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Publication year: 2017

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Publication date: 2017-04-29

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Authors: Kavita Jain, Ananthu James

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Landing page: https://arxiv.org/abs/1705.00153

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PDF URL: https://arxiv.org/pdf/1705.00153

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Concepts: Fixation (population genetics), Mutation rate, Population, Mutation, Branching process, Biology, Statistical physics, Genetics, Physics, Gene, Demography, Sociology

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