FLUOROUS SUPPORTED SYNTHESIS OF PYRAZOLONE DERIVATIVES FROM ALLYLIC ALCOHOLS USING A PALLADIUM-CATALYZED STRATEGY Article Swipe
Related Concepts
Allylic rearrangement
Isomerization
Palladium
Pyrazolone
Catalysis
Chemistry
Organic chemistry
Heck reaction
Combinatorial chemistry
Nicolas Gouault
,
Alexandre Cariou
,
Jean‐François Cupif
,
Patrícia de Aguiar Amaral
,
Michèle David
·
YOU?
·
· 2016
· Open Access
·
· DOI: https://doi.org/10.5935/0100-4042.20160098
· OA: W2529011526
YOU?
·
· 2016
· Open Access
·
· DOI: https://doi.org/10.5935/0100-4042.20160098
· OA: W2529011526
Ten substituted pyrazolone derivatives were easily synthesized from perfluorinated allylic alcohols, via a straightforward two steps reaction involving a Heck-coupling/isomerization reaction and subsequent condensation of hydrazines. This fluorous supported methodology, that combines a cyclo-release approach and F-SPE purification allows for the obtaining of the final products with a good purity.
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