Fmoc-Diphenylalanine Hydrogels: Optimization of Preparation Methods and Structural Insights Article Swipe
Carlo Diaferia
,
Elisabetta Rosa
,
Giancarlo Morelli
,
Antonella Accardo
·
YOU?
·
· 2022
· Open Access
·
· DOI: https://doi.org/10.3390/ph15091048
YOU?
·
· 2022
· Open Access
·
· DOI: https://doi.org/10.3390/ph15091048
Hydrogels (HGs) are tri-dimensional materials with a non-Newtonian flow behaviour formed by networks able to encapsulate high amounts of water or other biological fluids. They can be prepared using both synthetic or natural polymers and their mechanical and functional properties may change according to the preparation method, the solvent, the pH, and to others experimental parameters. Recently, many short and ultra-short peptides have been investigated as building blocks for the formulation of biocompatible hydrogels suitable for different biomedical applications. Due to its simplicity and capability to gel in physiological conditions, Fmoc-FF dipeptide is one of the most studied peptide hydrogelators. Although its identification dates to 15 ago, its behaviour is currently studied because of the observation that the final material obtained is deeply dependent on the preparation method. To collect information about their formulation, here are reported some different strategies adopted until now for the Fmoc-FF HG preparation, noting the changes in the structural arrangement and behaviour in terms of stiffness, matrix porosity, and stability induced by the different formulation strategy on the final material.
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Metadata
- Type
- review
- Language
- en
- Landing Page
- https://doi.org/10.3390/ph15091048
- https://www.mdpi.com/1424-8247/15/9/1048/pdf?version=1661408078
- OA Status
- gold
- Cited By
- 45
- References
- 77
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W4293206720
All OpenAlex metadata
Raw OpenAlex JSON
- OpenAlex ID
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https://openalex.org/W4293206720Canonical identifier for this work in OpenAlex
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https://doi.org/10.3390/ph15091048Digital Object Identifier
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Fmoc-Diphenylalanine Hydrogels: Optimization of Preparation Methods and Structural InsightsWork title
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reviewOpenAlex work type
- Language
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enPrimary language
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2022Year of publication
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2022-08-25Full publication date if available
- Authors
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Carlo Diaferia, Elisabetta Rosa, Giancarlo Morelli, Antonella AccardoList of authors in order
- Landing page
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https://doi.org/10.3390/ph15091048Publisher landing page
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https://www.mdpi.com/1424-8247/15/9/1048/pdf?version=1661408078Direct link to full text PDF
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goldOpen access status per OpenAlex
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https://www.mdpi.com/1424-8247/15/9/1048/pdf?version=1661408078Direct OA link when available
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Self-healing hydrogels, Natural polymers, Biocompatible material, Materials science, Polymer, Rheology, Nanotechnology, Chemical engineering, Biomedical engineering, Composite material, Polymer chemistry, Medicine, EngineeringTop concepts (fields/topics) attached by OpenAlex
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45Total citation count in OpenAlex
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2025: 20, 2024: 10, 2023: 13, 2022: 2Per-year citation counts (last 5 years)
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77Number of works referenced by this work
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10Other works algorithmically related by OpenAlex
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