Folic acid, either solely or combined with L‐citrulline, improves NO signaling and ameliorates chronic hypoxia‐induced pulmonary hypertension in newborn pigs Article Swipe
Matthew S. Douglass
,
Anna Dikalova
,
Mark R. Kaplowitz
,
Yongmei Zhang
,
Gary Cunningham
,
Marshall Summar
,
Candice D. Fike
·
YOU?
·
· 2021
· Open Access
·
· DOI: https://doi.org/10.14814/phy2.15096
YOU?
·
· 2021
· Open Access
·
· DOI: https://doi.org/10.14814/phy2.15096
Concomitant with developing pulmonary hypertension (PH), newborn piglets exposed to chronic hypoxia develop pulmonary vascular NO signaling impairments. PH is reduced and NO signaling is improved in chronically hypoxic piglets treated with the NO-arginine precursor, L-citrulline. Folic acid positively impacts NO signaling. We evaluated whether the effect on NO signaling and PH is greater using co-treatment with folic acid and L-citrulline than either alone. From day 3 to day 10 of hypoxia, piglets were treated solely with folic acid, solely with L-citrulline, or co-treated with both. Catheters were placed to measure in vivo hemodynamics. NO production was measured in vitro in dissected pulmonary arteries. Compared to normoxic piglets, pulmonary vascular resistance (PVR) was elevated and NO production was reduced in untreated hypoxic piglets. Regardless of treatment strategy, PVR was less in all three treated groups of hypoxic piglets when compared to the untreated hypoxic group. In addition, for all three groups of treated hypoxic piglets, NO production was higher than the untreated group. Improvements in PVR and NO production did not differ between piglets co-treated with folic acid and L-citrulline and those treated solely with either. Thus, the impact on NO production and PVR was not augmented by combining folic acid and L-citrulline treatments. Nonetheless, treatment with folic acid, either singly or when combined with L-citrulline, increases NO production and inhibits PH in chronically hypoxic newborn piglets. Folic acid merits consideration as a therapy for PH in human infants with chronic heart and lung conditions that are associated with chronic hypoxia.
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Metadata
- Type
- article
- Language
- en
- Landing Page
- https://doi.org/10.14814/phy2.15096
- OA Status
- gold
- Cited By
- 5
- References
- 54
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W3213536462
All OpenAlex metadata
Raw OpenAlex JSON
- OpenAlex ID
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https://openalex.org/W3213536462Canonical identifier for this work in OpenAlex
- DOI
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https://doi.org/10.14814/phy2.15096Digital Object Identifier
- Title
-
Folic acid, either solely or combined with L‐citrulline, improves NO signaling and ameliorates chronic hypoxia‐induced pulmonary hypertension in newborn pigsWork title
- Type
-
articleOpenAlex work type
- Language
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enPrimary language
- Publication year
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2021Year of publication
- Publication date
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2021-11-01Full publication date if available
- Authors
-
Matthew S. Douglass, Anna Dikalova, Mark R. Kaplowitz, Yongmei Zhang, Gary Cunningham, Marshall Summar, Candice D. FikeList of authors in order
- Landing page
-
https://doi.org/10.14814/phy2.15096Publisher landing page
- Open access
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YesWhether a free full text is available
- OA status
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goldOpen access status per OpenAlex
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https://doi.org/10.14814/phy2.15096Direct OA link when available
- Concepts
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Hypoxia (environmental), Pulmonary hypertension, Citrulline, Medicine, In vivo, Arginine, Internal medicine, Folic acid, Nitric oxide, Endocrinology, Pharmacology, Biochemistry, Chemistry, Biology, Amino acid, Oxygen, Biotechnology, Organic chemistryTop concepts (fields/topics) attached by OpenAlex
- Cited by
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5Total citation count in OpenAlex
- Citations by year (recent)
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2024: 3, 2023: 1, 2021: 1Per-year citation counts (last 5 years)
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54Number of works referenced by this work
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10Other works algorithmically related by OpenAlex
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| abstract_inverted_index.greater | 53 |
| abstract_inverted_index.hypoxia | 11 |
| abstract_inverted_index.hypoxic | 28, 121, 136, 143, 153, 224 |
| abstract_inverted_index.impacts | 39 |
| abstract_inverted_index.infants | 238 |
| abstract_inverted_index.measure | 90 |
| abstract_inverted_index.newborn | 6, 225 |
| abstract_inverted_index.piglets | 7, 29, 72, 137, 173 |
| abstract_inverted_index.reduced | 20, 118 |
| abstract_inverted_index.therapy | 233 |
| abstract_inverted_index.treated | 30, 74, 133, 152, 182 |
| abstract_inverted_index.whether | 44 |
| abstract_inverted_index.Compared | 104 |
| abstract_inverted_index.combined | 213 |
| abstract_inverted_index.compared | 139 |
| abstract_inverted_index.elevated | 113 |
| abstract_inverted_index.hypoxia, | 71 |
| abstract_inverted_index.hypoxia. | 250 |
| abstract_inverted_index.improved | 25 |
| abstract_inverted_index.inhibits | 220 |
| abstract_inverted_index.measured | 97 |
| abstract_inverted_index.normoxic | 106 |
| abstract_inverted_index.piglets, | 107, 154 |
| abstract_inverted_index.piglets. | 122, 226 |
| abstract_inverted_index.vascular | 14, 109 |
| abstract_inverted_index.Catheters | 86 |
| abstract_inverted_index.addition, | 146 |
| abstract_inverted_index.arteries. | 103 |
| abstract_inverted_index.augmented | 196 |
| abstract_inverted_index.combining | 198 |
| abstract_inverted_index.dissected | 101 |
| abstract_inverted_index.evaluated | 43 |
| abstract_inverted_index.increases | 216 |
| abstract_inverted_index.pulmonary | 3, 13, 102, 108 |
| abstract_inverted_index.signaling | 16, 23, 49 |
| abstract_inverted_index.strategy, | 126 |
| abstract_inverted_index.treatment | 125, 205 |
| abstract_inverted_index.untreated | 120, 142, 161 |
| abstract_inverted_index.Regardless | 123 |
| abstract_inverted_index.associated | 247 |
| abstract_inverted_index.co-treated | 83, 174 |
| abstract_inverted_index.conditions | 244 |
| abstract_inverted_index.developing | 2 |
| abstract_inverted_index.positively | 38 |
| abstract_inverted_index.precursor, | 34 |
| abstract_inverted_index.production | 95, 116, 156, 168, 191, 218 |
| abstract_inverted_index.resistance | 110 |
| abstract_inverted_index.signaling. | 41 |
| abstract_inverted_index.Concomitant | 0 |
| abstract_inverted_index.NO-arginine | 33 |
| abstract_inverted_index.chronically | 27, 223 |
| abstract_inverted_index.treatments. | 203 |
| abstract_inverted_index.Improvements | 163 |
| abstract_inverted_index.L-citrulline | 60, 179, 202 |
| abstract_inverted_index.Nonetheless, | 204 |
| abstract_inverted_index.co-treatment | 55 |
| abstract_inverted_index.hypertension | 4 |
| abstract_inverted_index.impairments. | 17 |
| abstract_inverted_index.L-citrulline, | 81, 215 |
| abstract_inverted_index.L-citrulline. | 35 |
| abstract_inverted_index.consideration | 230 |
| abstract_inverted_index.hemodynamics. | 93 |
| cited_by_percentile_year.max | 97 |
| cited_by_percentile_year.min | 89 |
| corresponding_author_ids | https://openalex.org/A5064776181 |
| countries_distinct_count | 1 |
| institutions_distinct_count | 7 |
| corresponding_institution_ids | https://openalex.org/I223532165 |
| sustainable_development_goals[0].id | https://metadata.un.org/sdg/3 |
| sustainable_development_goals[0].score | 0.6600000262260437 |
| sustainable_development_goals[0].display_name | Good health and well-being |
| citation_normalized_percentile.value | 0.7360612 |
| citation_normalized_percentile.is_in_top_1_percent | False |
| citation_normalized_percentile.is_in_top_10_percent | False |