Frequency of targetable genetic alterations in resectable lung adenocarcinoma: Results from the LORD project Article Swipe
Yohan Bossé
,
Dominique K. Boudreau
,
Victoria Saavedra Armero
,
Zhonglin Li
,
Élody Tremblay
,
Nathalie Gaudreault
,
Andréanne Gagné
,
Patrice Desmeules
,
Philippe Joubert
·
YOU?
·
· 2025
· Open Access
·
· DOI: https://doi.org/10.1016/j.lungcan.2025.108530
YOU?
·
· 2025
· Open Access
·
· DOI: https://doi.org/10.1016/j.lungcan.2025.108530
There is still limited data on the prevalence of actionable molecular alterations in patients with early-stage resectable lung adenocarcinoma and prior studies reported important differences across geographic locations, demographic and pathologic characteristics. The tumors of 1,603 French Canadian patients with pathologically confirmed lung adenocarcinoma were interrogated using a 50-gene next-generation sequencing panel. The goal was to assess the prevalence of genetic alterations in eleven guideline-based oncogenic genes in resectable lung adenocarcinoma. Age, sex, pathological stage, smoking history and predominant histologic patterns were associated with molecular subtypes defined by oncogenic drivers. Age at surgery for the 1,603 patients was 65 ± 8 and includes 61 % of females, 6 % of patients without a smoking history and 70 % of stage I. The overall prevalence of targetable alterations for approved and investigational therapies was 65.9 % and 56.7 % of patients had tumors harboring at least one variant of strong clinical significance (tier I of the AMP/ASCO/CAP categorization). The most frequently mutated genes were KRAS (45.3 %), EGFR (11.5 %) and BRAF (3.9 %). MET exon 14 skipping alterations were identified in 47 patients (2.9 %) and oncogenic fusions in ALK, ROS1, RET and MET were found in 1.7 % of cases. As expected, EGFR activating mutations were associated with patients who never smoked, females, earlier disease stages, with more lepidic/acinar and less solid predominant patterns. Quasi similar but inverted relationships with clinico-pathological features were observed in one third of patients (n = 534) free of molecular alterations characterized by more males, patients who smoked, with later stage diagnosis and with more solid and less lepidic/acinar adenocarcinomas. This study highlights the epidemiology of guideline-based targetable alterations in French-Canadian patients with resectable lung adenocarcinoma. The large proportion of patients eligible for targeted therapies will have important impact on oncological practices in the current era of neoadjuvant and perioperative treatments.
Related Topics
Concepts
Medicine
Adenocarcinoma
Oncology
Lung
Internal medicine
Adenocarcinoma of the lung
General surgery
Cancer
Metadata
- Type
- article
- Language
- en
- Landing Page
- https://doi.org/10.1016/j.lungcan.2025.108530
- OA Status
- hybrid
- Cited By
- 1
- References
- 15
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W4409210105
All OpenAlex metadata
Raw OpenAlex JSON
- OpenAlex ID
-
https://openalex.org/W4409210105Canonical identifier for this work in OpenAlex
- DOI
-
https://doi.org/10.1016/j.lungcan.2025.108530Digital Object Identifier
- Title
-
Frequency of targetable genetic alterations in resectable lung adenocarcinoma: Results from the LORD projectWork title
- Type
-
articleOpenAlex work type
- Language
-
enPrimary language
- Publication year
-
2025Year of publication
- Publication date
-
2025-04-07Full publication date if available
- Authors
-
Yohan Bossé, Dominique K. Boudreau, Victoria Saavedra Armero, Zhonglin Li, Élody Tremblay, Nathalie Gaudreault, Andréanne Gagné, Patrice Desmeules, Philippe JoubertList of authors in order
- Landing page
-
https://doi.org/10.1016/j.lungcan.2025.108530Publisher landing page
- Open access
-
YesWhether a free full text is available
- OA status
-
hybridOpen access status per OpenAlex
- OA URL
-
https://doi.org/10.1016/j.lungcan.2025.108530Direct OA link when available
- Concepts
-
Medicine, Adenocarcinoma, Oncology, Lung, Internal medicine, Adenocarcinoma of the lung, General surgery, CancerTop concepts (fields/topics) attached by OpenAlex
- Cited by
-
1Total citation count in OpenAlex
- Citations by year (recent)
-
2025: 1Per-year citation counts (last 5 years)
- References (count)
-
15Number of works referenced by this work
- Related works (count)
-
10Other works algorithmically related by OpenAlex
Full payload
| id | https://openalex.org/W4409210105 |
|---|---|
| doi | https://doi.org/10.1016/j.lungcan.2025.108530 |
| ids.doi | https://doi.org/10.1016/j.lungcan.2025.108530 |
| ids.pmid | https://pubmed.ncbi.nlm.nih.gov/40209611 |
| ids.openalex | https://openalex.org/W4409210105 |
| fwci | 2.68294463 |
| mesh[0].qualifier_ui | |
| mesh[0].descriptor_ui | D006801 |
| mesh[0].is_major_topic | False |
| mesh[0].qualifier_name | |
| mesh[0].descriptor_name | Humans |
| mesh[1].qualifier_ui | |
| mesh[1].descriptor_ui | D005260 |
| mesh[1].is_major_topic | False |
| mesh[1].qualifier_name | |
| mesh[1].descriptor_name | Female |
| mesh[2].qualifier_ui | |
| mesh[2].descriptor_ui | D008297 |
| mesh[2].is_major_topic | False |
| mesh[2].qualifier_name | |
| mesh[2].descriptor_name | Male |
| mesh[3].qualifier_ui | |
| mesh[3].descriptor_ui | D000368 |
| mesh[3].is_major_topic | False |
| mesh[3].qualifier_name | |
| mesh[3].descriptor_name | Aged |
| mesh[4].qualifier_ui | Q000235 |
| mesh[4].descriptor_ui | D008175 |
| mesh[4].is_major_topic | True |
| mesh[4].qualifier_name | genetics |
| mesh[4].descriptor_name | Lung Neoplasms |
| mesh[5].qualifier_ui | Q000473 |
| mesh[5].descriptor_ui | D008175 |
| mesh[5].is_major_topic | True |
| mesh[5].qualifier_name | pathology |
| mesh[5].descriptor_name | Lung Neoplasms |
| mesh[6].qualifier_ui | Q000601 |
| mesh[6].descriptor_ui | D008175 |
| mesh[6].is_major_topic | True |
| mesh[6].qualifier_name | surgery |
| mesh[6].descriptor_name | Lung Neoplasms |
| mesh[7].qualifier_ui | Q000453 |
| mesh[7].descriptor_ui | D008175 |
| mesh[7].is_major_topic | True |
| mesh[7].qualifier_name | epidemiology |
| mesh[7].descriptor_name | Lung Neoplasms |
| mesh[8].qualifier_ui | Q000235 |
| mesh[8].descriptor_ui | D000077192 |
| mesh[8].is_major_topic | True |
| mesh[8].qualifier_name | genetics |
| mesh[8].descriptor_name | Adenocarcinoma of Lung |
| mesh[9].qualifier_ui | Q000473 |
| mesh[9].descriptor_ui | D000077192 |
| mesh[9].is_major_topic | True |
| mesh[9].qualifier_name | pathology |
| mesh[9].descriptor_name | Adenocarcinoma of Lung |
| mesh[10].qualifier_ui | Q000601 |
| mesh[10].descriptor_ui | D000077192 |
| mesh[10].is_major_topic | True |
| mesh[10].qualifier_name | surgery |
| mesh[10].descriptor_name | Adenocarcinoma of Lung |
| mesh[11].qualifier_ui | Q000453 |
| mesh[11].descriptor_ui | D000077192 |
| mesh[11].is_major_topic | True |
| mesh[11].qualifier_name | epidemiology |
| mesh[11].descriptor_name | Adenocarcinoma of Lung |
| mesh[12].qualifier_ui | |
| mesh[12].descriptor_ui | D008875 |
| mesh[12].is_major_topic | False |
| mesh[12].qualifier_name | |
| mesh[12].descriptor_name | Middle Aged |
| mesh[13].qualifier_ui | |
| mesh[13].descriptor_ui | D009154 |
| mesh[13].is_major_topic | True |
| mesh[13].qualifier_name | |
| mesh[13].descriptor_name | Mutation |
| mesh[14].qualifier_ui | |
| mesh[14].descriptor_ui | D059014 |
| mesh[14].is_major_topic | False |
| mesh[14].qualifier_name | |
| mesh[14].descriptor_name | High-Throughput Nucleotide Sequencing |
| mesh[15].qualifier_ui | |
| mesh[15].descriptor_ui | D009367 |
| mesh[15].is_major_topic | False |
| mesh[15].qualifier_name | |
| mesh[15].descriptor_name | Neoplasm Staging |
| mesh[16].qualifier_ui | Q000235 |
| mesh[16].descriptor_ui | D066246 |
| mesh[16].is_major_topic | False |
| mesh[16].qualifier_name | genetics |
| mesh[16].descriptor_name | ErbB Receptors |
| mesh[17].qualifier_ui | |
| mesh[17].descriptor_ui | D000369 |
| mesh[17].is_major_topic | False |
| mesh[17].qualifier_name | |
| mesh[17].descriptor_name | Aged, 80 and over |
| mesh[18].qualifier_ui | Q000235 |
| mesh[18].descriptor_ui | D014408 |
| mesh[18].is_major_topic | False |
| mesh[18].qualifier_name | genetics |
| mesh[18].descriptor_name | Biomarkers, Tumor |
| mesh[19].qualifier_ui | Q000453 |
| mesh[19].descriptor_ui | D002170 |
| mesh[19].is_major_topic | False |
| mesh[19].qualifier_name | epidemiology |
| mesh[19].descriptor_name | Canada |
| type | article |
| title | Frequency of targetable genetic alterations in resectable lung adenocarcinoma: Results from the LORD project |
| biblio.issue | |
| biblio.volume | 203 |
| biblio.last_page | 108530 |
| biblio.first_page | 108530 |
| grants[0].funder | https://openalex.org/F4320313653 |
| grants[0].award_id | |
| grants[0].funder_display_name | Fondation Institut Universitaire de Cardiologie et de Pneumologie de Québec |
| topics[0].id | https://openalex.org/T11482 |
| topics[0].field.id | https://openalex.org/fields/13 |
| topics[0].field.display_name | Biochemistry, Genetics and Molecular Biology |
| topics[0].score | 0.9991000294685364 |
| topics[0].domain.id | https://openalex.org/domains/1 |
| topics[0].domain.display_name | Life Sciences |
| topics[0].subfield.id | https://openalex.org/subfields/1312 |
| topics[0].subfield.display_name | Molecular Biology |
| topics[0].display_name | RNA modifications and cancer |
| topics[1].id | https://openalex.org/T10417 |
| topics[1].field.id | https://openalex.org/fields/27 |
| topics[1].field.display_name | Medicine |
| topics[1].score | 0.9980000257492065 |
| topics[1].domain.id | https://openalex.org/domains/4 |
| topics[1].domain.display_name | Health Sciences |
| topics[1].subfield.id | https://openalex.org/subfields/2740 |
| topics[1].subfield.display_name | Pulmonary and Respiratory Medicine |
| topics[1].display_name | Lung Cancer Treatments and Mutations |
| topics[2].id | https://openalex.org/T11287 |
| topics[2].field.id | https://openalex.org/fields/13 |
| topics[2].field.display_name | Biochemistry, Genetics and Molecular Biology |
| topics[2].score | 0.9979000091552734 |
| topics[2].domain.id | https://openalex.org/domains/1 |
| topics[2].domain.display_name | Life Sciences |
| topics[2].subfield.id | https://openalex.org/subfields/1306 |
| topics[2].subfield.display_name | Cancer Research |
| topics[2].display_name | Cancer Genomics and Diagnostics |
| funders[0].id | https://openalex.org/F4320313653 |
| funders[0].ror | |
| funders[0].display_name | Fondation Institut Universitaire de Cardiologie et de Pneumologie de Québec |
| is_xpac | False |
| apc_list.value | 3110 |
| apc_list.currency | USD |
| apc_list.value_usd | 3110 |
| apc_paid.value | 3110 |
| apc_paid.currency | USD |
| apc_paid.value_usd | 3110 |
| concepts[0].id | https://openalex.org/C71924100 |
| concepts[0].level | 0 |
| concepts[0].score | 0.9205734729766846 |
| concepts[0].wikidata | https://www.wikidata.org/wiki/Q11190 |
| concepts[0].display_name | Medicine |
| concepts[1].id | https://openalex.org/C2781182431 |
| concepts[1].level | 3 |
| concepts[1].score | 0.6210483908653259 |
| concepts[1].wikidata | https://www.wikidata.org/wiki/Q356033 |
| concepts[1].display_name | Adenocarcinoma |
| concepts[2].id | https://openalex.org/C143998085 |
| concepts[2].level | 1 |
| concepts[2].score | 0.5768208503723145 |
| concepts[2].wikidata | https://www.wikidata.org/wiki/Q162555 |
| concepts[2].display_name | Oncology |
| concepts[3].id | https://openalex.org/C2777714996 |
| concepts[3].level | 2 |
| concepts[3].score | 0.5333661437034607 |
| concepts[3].wikidata | https://www.wikidata.org/wiki/Q7886 |
| concepts[3].display_name | Lung |
| concepts[4].id | https://openalex.org/C126322002 |
| concepts[4].level | 1 |
| concepts[4].score | 0.503877580165863 |
| concepts[4].wikidata | https://www.wikidata.org/wiki/Q11180 |
| concepts[4].display_name | Internal medicine |
| concepts[5].id | https://openalex.org/C2779563347 |
| concepts[5].level | 4 |
| concepts[5].score | 0.4174268841743469 |
| concepts[5].wikidata | https://www.wikidata.org/wiki/Q843799 |
| concepts[5].display_name | Adenocarcinoma of the lung |
| concepts[6].id | https://openalex.org/C61434518 |
| concepts[6].level | 1 |
| concepts[6].score | 0.4041716456413269 |
| concepts[6].wikidata | https://www.wikidata.org/wiki/Q932510 |
| concepts[6].display_name | General surgery |
| concepts[7].id | https://openalex.org/C121608353 |
| concepts[7].level | 2 |
| concepts[7].score | 0.08761224150657654 |
| concepts[7].wikidata | https://www.wikidata.org/wiki/Q12078 |
| concepts[7].display_name | Cancer |
| keywords[0].id | https://openalex.org/keywords/medicine |
| keywords[0].score | 0.9205734729766846 |
| keywords[0].display_name | Medicine |
| keywords[1].id | https://openalex.org/keywords/adenocarcinoma |
| keywords[1].score | 0.6210483908653259 |
| keywords[1].display_name | Adenocarcinoma |
| keywords[2].id | https://openalex.org/keywords/oncology |
| keywords[2].score | 0.5768208503723145 |
| keywords[2].display_name | Oncology |
| keywords[3].id | https://openalex.org/keywords/lung |
| keywords[3].score | 0.5333661437034607 |
| keywords[3].display_name | Lung |
| keywords[4].id | https://openalex.org/keywords/internal-medicine |
| keywords[4].score | 0.503877580165863 |
| keywords[4].display_name | Internal medicine |
| keywords[5].id | https://openalex.org/keywords/adenocarcinoma-of-the-lung |
| keywords[5].score | 0.4174268841743469 |
| keywords[5].display_name | Adenocarcinoma of the lung |
| keywords[6].id | https://openalex.org/keywords/general-surgery |
| keywords[6].score | 0.4041716456413269 |
| keywords[6].display_name | General surgery |
| keywords[7].id | https://openalex.org/keywords/cancer |
| keywords[7].score | 0.08761224150657654 |
| keywords[7].display_name | Cancer |
| language | en |
| locations[0].id | doi:10.1016/j.lungcan.2025.108530 |
| locations[0].is_oa | True |
| locations[0].source.id | https://openalex.org/S100767427 |
| locations[0].source.issn | 0169-5002, 1872-8332 |
| locations[0].source.type | journal |
| locations[0].source.is_oa | False |
| locations[0].source.issn_l | 0169-5002 |
| locations[0].source.is_core | True |
| locations[0].source.is_in_doaj | False |
| locations[0].source.display_name | Lung Cancer |
| locations[0].source.host_organization | https://openalex.org/P4310320990 |
| locations[0].source.host_organization_name | Elsevier BV |
| locations[0].source.host_organization_lineage | https://openalex.org/P4310320990 |
| locations[0].license | cc-by |
| locations[0].pdf_url | |
| locations[0].version | publishedVersion |
| locations[0].raw_type | journal-article |
| locations[0].license_id | https://openalex.org/licenses/cc-by |
| locations[0].is_accepted | True |
| locations[0].is_published | True |
| locations[0].raw_source_name | Lung Cancer |
| locations[0].landing_page_url | https://doi.org/10.1016/j.lungcan.2025.108530 |
| locations[1].id | pmid:40209611 |
| locations[1].is_oa | False |
| locations[1].source.id | https://openalex.org/S4306525036 |
| locations[1].source.issn | |
| locations[1].source.type | repository |
| locations[1].source.is_oa | False |
| locations[1].source.issn_l | |
| locations[1].source.is_core | False |
| locations[1].source.is_in_doaj | False |
| locations[1].source.display_name | PubMed |
| locations[1].source.host_organization | https://openalex.org/I1299303238 |
| locations[1].source.host_organization_name | National Institutes of Health |
| locations[1].source.host_organization_lineage | https://openalex.org/I1299303238 |
| locations[1].license | |
| locations[1].pdf_url | |
| locations[1].version | publishedVersion |
| locations[1].raw_type | |
| locations[1].license_id | |
| locations[1].is_accepted | True |
| locations[1].is_published | True |
| locations[1].raw_source_name | Lung cancer (Amsterdam, Netherlands) |
| locations[1].landing_page_url | https://pubmed.ncbi.nlm.nih.gov/40209611 |
| indexed_in | crossref, pubmed |
| authorships[0].author.id | https://openalex.org/A5077109568 |
| authorships[0].author.orcid | https://orcid.org/0000-0002-3067-3711 |
| authorships[0].author.display_name | Yohan Bossé |
| authorships[0].countries | CA |
| authorships[0].affiliations[0].institution_ids | https://openalex.org/I4210135357, https://openalex.org/I43406934 |
| authorships[0].affiliations[0].raw_affiliation_string | Institut universitaire de cardiologie et de pneumologie de Québec - Université Laval, Quebec City, Canada; Department of Molecular Medicine, Université Laval, Quebec City, Canada. Electronic address: [email protected]. |
| authorships[0].institutions[0].id | https://openalex.org/I4210135357 |
| authorships[0].institutions[0].ror | https://ror.org/03gf7z214 |
| authorships[0].institutions[0].type | education |
| authorships[0].institutions[0].lineage | https://openalex.org/I4210135357 |
| authorships[0].institutions[0].country_code | CA |
| authorships[0].institutions[0].display_name | Institut Universitaire de Cardiologie et de Pneumologie de Québec |
| authorships[0].institutions[1].id | https://openalex.org/I43406934 |
| authorships[0].institutions[1].ror | https://ror.org/04sjchr03 |
| authorships[0].institutions[1].type | education |
| authorships[0].institutions[1].lineage | https://openalex.org/I43406934 |
| authorships[0].institutions[1].country_code | CA |
| authorships[0].institutions[1].display_name | Université Laval |
| authorships[0].author_position | first |
| authorships[0].raw_author_name | Yohan Bossé |
| authorships[0].is_corresponding | False |
| authorships[0].raw_affiliation_strings | Institut universitaire de cardiologie et de pneumologie de Québec - Université Laval, Quebec City, Canada; Department of Molecular Medicine, Université Laval, Quebec City, Canada. Electronic address: [email protected]. |
| authorships[1].author.id | https://openalex.org/A5027278761 |
| authorships[1].author.orcid | https://orcid.org/0000-0002-2406-2447 |
| authorships[1].author.display_name | Dominique K. Boudreau |
| authorships[1].countries | CA |
| authorships[1].affiliations[0].institution_ids | https://openalex.org/I4210135357, https://openalex.org/I43406934 |
| authorships[1].affiliations[0].raw_affiliation_string | Institut universitaire de cardiologie et de pneumologie de Québec - Université Laval, Quebec City, Canada. |
| authorships[1].institutions[0].id | https://openalex.org/I4210135357 |
| authorships[1].institutions[0].ror | https://ror.org/03gf7z214 |
| authorships[1].institutions[0].type | education |
| authorships[1].institutions[0].lineage | https://openalex.org/I4210135357 |
| authorships[1].institutions[0].country_code | CA |
| authorships[1].institutions[0].display_name | Institut Universitaire de Cardiologie et de Pneumologie de Québec |
| authorships[1].institutions[1].id | https://openalex.org/I43406934 |
| authorships[1].institutions[1].ror | https://ror.org/04sjchr03 |
| authorships[1].institutions[1].type | education |
| authorships[1].institutions[1].lineage | https://openalex.org/I43406934 |
| authorships[1].institutions[1].country_code | CA |
| authorships[1].institutions[1].display_name | Université Laval |
| authorships[1].author_position | middle |
| authorships[1].raw_author_name | Dominique K Boudreau |
| authorships[1].is_corresponding | False |
| authorships[1].raw_affiliation_strings | Institut universitaire de cardiologie et de pneumologie de Québec - Université Laval, Quebec City, Canada. |
| authorships[2].author.id | https://openalex.org/A5045378276 |
| authorships[2].author.orcid | https://orcid.org/0000-0002-8704-4086 |
| authorships[2].author.display_name | Victoria Saavedra Armero |
| authorships[2].countries | CA |
| authorships[2].affiliations[0].institution_ids | https://openalex.org/I4210135357, https://openalex.org/I43406934 |
| authorships[2].affiliations[0].raw_affiliation_string | Institut universitaire de cardiologie et de pneumologie de Québec - Université Laval, Quebec City, Canada. |
| authorships[2].institutions[0].id | https://openalex.org/I4210135357 |
| authorships[2].institutions[0].ror | https://ror.org/03gf7z214 |
| authorships[2].institutions[0].type | education |
| authorships[2].institutions[0].lineage | https://openalex.org/I4210135357 |
| authorships[2].institutions[0].country_code | CA |
| authorships[2].institutions[0].display_name | Institut Universitaire de Cardiologie et de Pneumologie de Québec |
| authorships[2].institutions[1].id | https://openalex.org/I43406934 |
| authorships[2].institutions[1].ror | https://ror.org/04sjchr03 |
| authorships[2].institutions[1].type | education |
| authorships[2].institutions[1].lineage | https://openalex.org/I43406934 |
| authorships[2].institutions[1].country_code | CA |
| authorships[2].institutions[1].display_name | Université Laval |
| authorships[2].author_position | middle |
| authorships[2].raw_author_name | Victoria Saavedra Armero |
| authorships[2].is_corresponding | False |
| authorships[2].raw_affiliation_strings | Institut universitaire de cardiologie et de pneumologie de Québec - Université Laval, Quebec City, Canada. |
| authorships[3].author.id | https://openalex.org/A5052600804 |
| authorships[3].author.orcid | https://orcid.org/0000-0003-3659-2389 |
| authorships[3].author.display_name | Zhonglin Li |
| authorships[3].countries | CA |
| authorships[3].affiliations[0].institution_ids | https://openalex.org/I4210135357, https://openalex.org/I43406934 |
| authorships[3].affiliations[0].raw_affiliation_string | Institut universitaire de cardiologie et de pneumologie de Québec - Université Laval, Quebec City, Canada. |
| authorships[3].institutions[0].id | https://openalex.org/I4210135357 |
| authorships[3].institutions[0].ror | https://ror.org/03gf7z214 |
| authorships[3].institutions[0].type | education |
| authorships[3].institutions[0].lineage | https://openalex.org/I4210135357 |
| authorships[3].institutions[0].country_code | CA |
| authorships[3].institutions[0].display_name | Institut Universitaire de Cardiologie et de Pneumologie de Québec |
| authorships[3].institutions[1].id | https://openalex.org/I43406934 |
| authorships[3].institutions[1].ror | https://ror.org/04sjchr03 |
| authorships[3].institutions[1].type | education |
| authorships[3].institutions[1].lineage | https://openalex.org/I43406934 |
| authorships[3].institutions[1].country_code | CA |
| authorships[3].institutions[1].display_name | Université Laval |
| authorships[3].author_position | middle |
| authorships[3].raw_author_name | Zhonglin Li |
| authorships[3].is_corresponding | False |
| authorships[3].raw_affiliation_strings | Institut universitaire de cardiologie et de pneumologie de Québec - Université Laval, Quebec City, Canada. |
| authorships[4].author.id | https://openalex.org/A5051002594 |
| authorships[4].author.orcid | https://orcid.org/0009-0002-4170-2714 |
| authorships[4].author.display_name | Élody Tremblay |
| authorships[4].countries | CA |
| authorships[4].affiliations[0].institution_ids | https://openalex.org/I4210135357, https://openalex.org/I43406934 |
| authorships[4].affiliations[0].raw_affiliation_string | Institut universitaire de cardiologie et de pneumologie de Québec - Université Laval, Quebec City, Canada. |
| authorships[4].institutions[0].id | https://openalex.org/I4210135357 |
| authorships[4].institutions[0].ror | https://ror.org/03gf7z214 |
| authorships[4].institutions[0].type | education |
| authorships[4].institutions[0].lineage | https://openalex.org/I4210135357 |
| authorships[4].institutions[0].country_code | CA |
| authorships[4].institutions[0].display_name | Institut Universitaire de Cardiologie et de Pneumologie de Québec |
| authorships[4].institutions[1].id | https://openalex.org/I43406934 |
| authorships[4].institutions[1].ror | https://ror.org/04sjchr03 |
| authorships[4].institutions[1].type | education |
| authorships[4].institutions[1].lineage | https://openalex.org/I43406934 |
| authorships[4].institutions[1].country_code | CA |
| authorships[4].institutions[1].display_name | Université Laval |
| authorships[4].author_position | middle |
| authorships[4].raw_author_name | Élody Tremblay |
| authorships[4].is_corresponding | False |
| authorships[4].raw_affiliation_strings | Institut universitaire de cardiologie et de pneumologie de Québec - Université Laval, Quebec City, Canada. |
| authorships[5].author.id | https://openalex.org/A5081112788 |
| authorships[5].author.orcid | https://orcid.org/0000-0002-5351-596X |
| authorships[5].author.display_name | Nathalie Gaudreault |
| authorships[5].countries | CA |
| authorships[5].affiliations[0].institution_ids | https://openalex.org/I4210135357, https://openalex.org/I43406934 |
| authorships[5].affiliations[0].raw_affiliation_string | Institut universitaire de cardiologie et de pneumologie de Québec - Université Laval, Quebec City, Canada. |
| authorships[5].institutions[0].id | https://openalex.org/I4210135357 |
| authorships[5].institutions[0].ror | https://ror.org/03gf7z214 |
| authorships[5].institutions[0].type | education |
| authorships[5].institutions[0].lineage | https://openalex.org/I4210135357 |
| authorships[5].institutions[0].country_code | CA |
| authorships[5].institutions[0].display_name | Institut Universitaire de Cardiologie et de Pneumologie de Québec |
| authorships[5].institutions[1].id | https://openalex.org/I43406934 |
| authorships[5].institutions[1].ror | https://ror.org/04sjchr03 |
| authorships[5].institutions[1].type | education |
| authorships[5].institutions[1].lineage | https://openalex.org/I43406934 |
| authorships[5].institutions[1].country_code | CA |
| authorships[5].institutions[1].display_name | Université Laval |
| authorships[5].author_position | middle |
| authorships[5].raw_author_name | Nathalie Gaudreault |
| authorships[5].is_corresponding | False |
| authorships[5].raw_affiliation_strings | Institut universitaire de cardiologie et de pneumologie de Québec - Université Laval, Quebec City, Canada. |
| authorships[6].author.id | https://openalex.org/A5012522004 |
| authorships[6].author.orcid | https://orcid.org/0000-0002-3833-4159 |
| authorships[6].author.display_name | Andréanne Gagné |
| authorships[6].countries | CA |
| authorships[6].affiliations[0].institution_ids | https://openalex.org/I4210135357, https://openalex.org/I43406934 |
| authorships[6].affiliations[0].raw_affiliation_string | Institut universitaire de cardiologie et de pneumologie de Québec - Université Laval, Quebec City, Canada. |
| authorships[6].institutions[0].id | https://openalex.org/I4210135357 |
| authorships[6].institutions[0].ror | https://ror.org/03gf7z214 |
| authorships[6].institutions[0].type | education |
| authorships[6].institutions[0].lineage | https://openalex.org/I4210135357 |
| authorships[6].institutions[0].country_code | CA |
| authorships[6].institutions[0].display_name | Institut Universitaire de Cardiologie et de Pneumologie de Québec |
| authorships[6].institutions[1].id | https://openalex.org/I43406934 |
| authorships[6].institutions[1].ror | https://ror.org/04sjchr03 |
| authorships[6].institutions[1].type | education |
| authorships[6].institutions[1].lineage | https://openalex.org/I43406934 |
| authorships[6].institutions[1].country_code | CA |
| authorships[6].institutions[1].display_name | Université Laval |
| authorships[6].author_position | middle |
| authorships[6].raw_author_name | Andréanne Gagné |
| authorships[6].is_corresponding | False |
| authorships[6].raw_affiliation_strings | Institut universitaire de cardiologie et de pneumologie de Québec - Université Laval, Quebec City, Canada. |
| authorships[7].author.id | https://openalex.org/A5057285899 |
| authorships[7].author.orcid | https://orcid.org/0000-0002-1747-6705 |
| authorships[7].author.display_name | Patrice Desmeules |
| authorships[7].countries | CA |
| authorships[7].affiliations[0].institution_ids | https://openalex.org/I4210135357, https://openalex.org/I43406934 |
| authorships[7].affiliations[0].raw_affiliation_string | Institut universitaire de cardiologie et de pneumologie de Québec - Université Laval, Quebec City, Canada. |
| authorships[7].institutions[0].id | https://openalex.org/I4210135357 |
| authorships[7].institutions[0].ror | https://ror.org/03gf7z214 |
| authorships[7].institutions[0].type | education |
| authorships[7].institutions[0].lineage | https://openalex.org/I4210135357 |
| authorships[7].institutions[0].country_code | CA |
| authorships[7].institutions[0].display_name | Institut Universitaire de Cardiologie et de Pneumologie de Québec |
| authorships[7].institutions[1].id | https://openalex.org/I43406934 |
| authorships[7].institutions[1].ror | https://ror.org/04sjchr03 |
| authorships[7].institutions[1].type | education |
| authorships[7].institutions[1].lineage | https://openalex.org/I43406934 |
| authorships[7].institutions[1].country_code | CA |
| authorships[7].institutions[1].display_name | Université Laval |
| authorships[7].author_position | middle |
| authorships[7].raw_author_name | Patrice Desmeules |
| authorships[7].is_corresponding | False |
| authorships[7].raw_affiliation_strings | Institut universitaire de cardiologie et de pneumologie de Québec - Université Laval, Quebec City, Canada. |
| authorships[8].author.id | https://openalex.org/A5091615631 |
| authorships[8].author.orcid | https://orcid.org/0000-0001-7784-6387 |
| authorships[8].author.display_name | Philippe Joubert |
| authorships[8].countries | CA |
| authorships[8].affiliations[0].institution_ids | https://openalex.org/I4210135357, https://openalex.org/I43406934 |
| authorships[8].affiliations[0].raw_affiliation_string | Institut universitaire de cardiologie et de pneumologie de Québec - Université Laval, Quebec City, Canada; Department of Molecular Biology, Pathology and Medical Biochemistry, Université Laval, Quebec City, Canada. |
| authorships[8].institutions[0].id | https://openalex.org/I4210135357 |
| authorships[8].institutions[0].ror | https://ror.org/03gf7z214 |
| authorships[8].institutions[0].type | education |
| authorships[8].institutions[0].lineage | https://openalex.org/I4210135357 |
| authorships[8].institutions[0].country_code | CA |
| authorships[8].institutions[0].display_name | Institut Universitaire de Cardiologie et de Pneumologie de Québec |
| authorships[8].institutions[1].id | https://openalex.org/I43406934 |
| authorships[8].institutions[1].ror | https://ror.org/04sjchr03 |
| authorships[8].institutions[1].type | education |
| authorships[8].institutions[1].lineage | https://openalex.org/I43406934 |
| authorships[8].institutions[1].country_code | CA |
| authorships[8].institutions[1].display_name | Université Laval |
| authorships[8].author_position | last |
| authorships[8].raw_author_name | Philippe Joubert |
| authorships[8].is_corresponding | False |
| authorships[8].raw_affiliation_strings | Institut universitaire de cardiologie et de pneumologie de Québec - Université Laval, Quebec City, Canada; Department of Molecular Biology, Pathology and Medical Biochemistry, Université Laval, Quebec City, Canada. |
| has_content.pdf | False |
| has_content.grobid_xml | False |
| is_paratext | False |
| open_access.is_oa | True |
| open_access.oa_url | https://doi.org/10.1016/j.lungcan.2025.108530 |
| open_access.oa_status | hybrid |
| open_access.any_repository_has_fulltext | False |
| created_date | 2025-10-10T00:00:00 |
| display_name | Frequency of targetable genetic alterations in resectable lung adenocarcinoma: Results from the LORD project |
| has_fulltext | False |
| is_retracted | False |
| updated_date | 2025-11-06T03:46:38.306776 |
| primary_topic.id | https://openalex.org/T11482 |
| primary_topic.field.id | https://openalex.org/fields/13 |
| primary_topic.field.display_name | Biochemistry, Genetics and Molecular Biology |
| primary_topic.score | 0.9991000294685364 |
| primary_topic.domain.id | https://openalex.org/domains/1 |
| primary_topic.domain.display_name | Life Sciences |
| primary_topic.subfield.id | https://openalex.org/subfields/1312 |
| primary_topic.subfield.display_name | Molecular Biology |
| primary_topic.display_name | RNA modifications and cancer |
| related_works | https://openalex.org/W2066500467, https://openalex.org/W2388915439, https://openalex.org/W4389519690, https://openalex.org/W1978952945, https://openalex.org/W3014767152, https://openalex.org/W2469790125, https://openalex.org/W2337761277, https://openalex.org/W2090926117, https://openalex.org/W2964613982, https://openalex.org/W3176956155 |
| cited_by_count | 1 |
| counts_by_year[0].year | 2025 |
| counts_by_year[0].cited_by_count | 1 |
| locations_count | 2 |
| best_oa_location.id | doi:10.1016/j.lungcan.2025.108530 |
| best_oa_location.is_oa | True |
| best_oa_location.source.id | https://openalex.org/S100767427 |
| best_oa_location.source.issn | 0169-5002, 1872-8332 |
| best_oa_location.source.type | journal |
| best_oa_location.source.is_oa | False |
| best_oa_location.source.issn_l | 0169-5002 |
| best_oa_location.source.is_core | True |
| best_oa_location.source.is_in_doaj | False |
| best_oa_location.source.display_name | Lung Cancer |
| best_oa_location.source.host_organization | https://openalex.org/P4310320990 |
| best_oa_location.source.host_organization_name | Elsevier BV |
| best_oa_location.source.host_organization_lineage | https://openalex.org/P4310320990 |
| best_oa_location.license | cc-by |
| best_oa_location.pdf_url | |
| best_oa_location.version | publishedVersion |
| best_oa_location.raw_type | journal-article |
| best_oa_location.license_id | https://openalex.org/licenses/cc-by |
| best_oa_location.is_accepted | True |
| best_oa_location.is_published | True |
| best_oa_location.raw_source_name | Lung Cancer |
| best_oa_location.landing_page_url | https://doi.org/10.1016/j.lungcan.2025.108530 |
| primary_location.id | doi:10.1016/j.lungcan.2025.108530 |
| primary_location.is_oa | True |
| primary_location.source.id | https://openalex.org/S100767427 |
| primary_location.source.issn | 0169-5002, 1872-8332 |
| primary_location.source.type | journal |
| primary_location.source.is_oa | False |
| primary_location.source.issn_l | 0169-5002 |
| primary_location.source.is_core | True |
| primary_location.source.is_in_doaj | False |
| primary_location.source.display_name | Lung Cancer |
| primary_location.source.host_organization | https://openalex.org/P4310320990 |
| primary_location.source.host_organization_name | Elsevier BV |
| primary_location.source.host_organization_lineage | https://openalex.org/P4310320990 |
| primary_location.license | cc-by |
| primary_location.pdf_url | |
| primary_location.version | publishedVersion |
| primary_location.raw_type | journal-article |
| primary_location.license_id | https://openalex.org/licenses/cc-by |
| primary_location.is_accepted | True |
| primary_location.is_published | True |
| primary_location.raw_source_name | Lung Cancer |
| primary_location.landing_page_url | https://doi.org/10.1016/j.lungcan.2025.108530 |
| publication_date | 2025-04-07 |
| publication_year | 2025 |
| referenced_works | https://openalex.org/W2613362156, https://openalex.org/W4379280261, https://openalex.org/W4394675771, https://openalex.org/W4399761443, https://openalex.org/W4400355399, https://openalex.org/W4213232115, https://openalex.org/W2896872272, https://openalex.org/W4390621251, https://openalex.org/W4387728976, https://openalex.org/W2566723262, https://openalex.org/W4405925703, https://openalex.org/W4312056142, https://openalex.org/W4399660867, https://openalex.org/W6703566168, https://openalex.org/W2337836619 |
| referenced_works_count | 15 |
| abstract_inverted_index.% | 104, 108, 117, 134, 137, 198 |
| abstract_inverted_index.6 | 107 |
| abstract_inverted_index.8 | 100 |
| abstract_inverted_index.= | 241 |
| abstract_inverted_index.I | 152 |
| abstract_inverted_index.a | 47, 112 |
| abstract_inverted_index.%) | 168, 184 |
| abstract_inverted_index.(n | 240 |
| abstract_inverted_index.14 | 175 |
| abstract_inverted_index.47 | 181 |
| abstract_inverted_index.61 | 103 |
| abstract_inverted_index.65 | 98 |
| abstract_inverted_index.70 | 116 |
| abstract_inverted_index.As | 201 |
| abstract_inverted_index.I. | 120 |
| abstract_inverted_index.at | 91, 143 |
| abstract_inverted_index.by | 87, 248 |
| abstract_inverted_index.in | 12, 62, 67, 180, 188, 196, 235, 275, 298 |
| abstract_inverted_index.is | 1 |
| abstract_inverted_index.of | 8, 34, 59, 105, 109, 118, 124, 138, 147, 153, 199, 238, 244, 271, 285, 302 |
| abstract_inverted_index.on | 5, 295 |
| abstract_inverted_index.to | 55 |
| abstract_inverted_index.± | 99 |
| abstract_inverted_index.%), | 165 |
| abstract_inverted_index.%). | 172 |
| abstract_inverted_index.1.7 | 197 |
| abstract_inverted_index.Age | 90 |
| abstract_inverted_index.MET | 173, 193 |
| abstract_inverted_index.RET | 191 |
| abstract_inverted_index.The | 32, 52, 121, 157, 282 |
| abstract_inverted_index.and | 19, 29, 77, 101, 115, 129, 135, 169, 185, 192, 220, 258, 262, 304 |
| abstract_inverted_index.but | 227 |
| abstract_inverted_index.era | 301 |
| abstract_inverted_index.for | 93, 127, 288 |
| abstract_inverted_index.had | 140 |
| abstract_inverted_index.one | 145, 236 |
| abstract_inverted_index.the | 6, 57, 94, 154, 269, 299 |
| abstract_inverted_index.was | 54, 97, 132 |
| abstract_inverted_index.who | 210, 252 |
| abstract_inverted_index.(2.9 | 183 |
| abstract_inverted_index.(3.9 | 171 |
| abstract_inverted_index.534) | 242 |
| abstract_inverted_index.56.7 | 136 |
| abstract_inverted_index.65.9 | 133 |
| abstract_inverted_index.ALK, | 189 |
| abstract_inverted_index.Age, | 71 |
| abstract_inverted_index.BRAF | 170 |
| abstract_inverted_index.EGFR | 166, 203 |
| abstract_inverted_index.KRAS | 163 |
| abstract_inverted_index.This | 266 |
| abstract_inverted_index.data | 4 |
| abstract_inverted_index.exon | 174 |
| abstract_inverted_index.free | 243 |
| abstract_inverted_index.goal | 53 |
| abstract_inverted_index.have | 292 |
| abstract_inverted_index.less | 221, 263 |
| abstract_inverted_index.lung | 17, 42, 69, 280 |
| abstract_inverted_index.more | 218, 249, 260 |
| abstract_inverted_index.most | 158 |
| abstract_inverted_index.sex, | 72 |
| abstract_inverted_index.were | 44, 81, 162, 178, 194, 206, 233 |
| abstract_inverted_index.will | 291 |
| abstract_inverted_index.with | 14, 39, 83, 208, 217, 230, 254, 259, 278 |
| abstract_inverted_index.(11.5 | 167 |
| abstract_inverted_index.(45.3 | 164 |
| abstract_inverted_index.(tier | 151 |
| abstract_inverted_index.1,603 | 35, 95 |
| abstract_inverted_index.Quasi | 225 |
| abstract_inverted_index.ROS1, | 190 |
| abstract_inverted_index.There | 0 |
| abstract_inverted_index.found | 195 |
| abstract_inverted_index.genes | 66, 161 |
| abstract_inverted_index.large | 283 |
| abstract_inverted_index.later | 255 |
| abstract_inverted_index.least | 144 |
| abstract_inverted_index.never | 211 |
| abstract_inverted_index.prior | 20 |
| abstract_inverted_index.solid | 222, 261 |
| abstract_inverted_index.stage | 119, 256 |
| abstract_inverted_index.still | 2 |
| abstract_inverted_index.study | 267 |
| abstract_inverted_index.third | 237 |
| abstract_inverted_index.using | 46 |
| abstract_inverted_index.French | 36 |
| abstract_inverted_index.across | 25 |
| abstract_inverted_index.assess | 56 |
| abstract_inverted_index.cases. | 200 |
| abstract_inverted_index.eleven | 63 |
| abstract_inverted_index.impact | 294 |
| abstract_inverted_index.males, | 250 |
| abstract_inverted_index.panel. | 51 |
| abstract_inverted_index.stage, | 74 |
| abstract_inverted_index.strong | 148 |
| abstract_inverted_index.tumors | 33, 141 |
| abstract_inverted_index.50-gene | 48 |
| abstract_inverted_index.current | 300 |
| abstract_inverted_index.defined | 86 |
| abstract_inverted_index.disease | 215 |
| abstract_inverted_index.earlier | 214 |
| abstract_inverted_index.fusions | 187 |
| abstract_inverted_index.genetic | 60 |
| abstract_inverted_index.history | 76, 114 |
| abstract_inverted_index.limited | 3 |
| abstract_inverted_index.mutated | 160 |
| abstract_inverted_index.overall | 122 |
| abstract_inverted_index.similar | 226 |
| abstract_inverted_index.smoked, | 212, 253 |
| abstract_inverted_index.smoking | 75, 113 |
| abstract_inverted_index.stages, | 216 |
| abstract_inverted_index.studies | 21 |
| abstract_inverted_index.surgery | 92 |
| abstract_inverted_index.variant | 146 |
| abstract_inverted_index.without | 111 |
| abstract_inverted_index.Canadian | 37 |
| abstract_inverted_index.approved | 128 |
| abstract_inverted_index.clinical | 149 |
| abstract_inverted_index.drivers. | 89 |
| abstract_inverted_index.eligible | 287 |
| abstract_inverted_index.features | 232 |
| abstract_inverted_index.females, | 106, 213 |
| abstract_inverted_index.includes | 102 |
| abstract_inverted_index.inverted | 228 |
| abstract_inverted_index.observed | 234 |
| abstract_inverted_index.patients | 13, 38, 96, 110, 139, 182, 209, 239, 251, 277, 286 |
| abstract_inverted_index.patterns | 80 |
| abstract_inverted_index.reported | 22 |
| abstract_inverted_index.skipping | 176 |
| abstract_inverted_index.subtypes | 85 |
| abstract_inverted_index.targeted | 289 |
| abstract_inverted_index.confirmed | 41 |
| abstract_inverted_index.diagnosis | 257 |
| abstract_inverted_index.expected, | 202 |
| abstract_inverted_index.harboring | 142 |
| abstract_inverted_index.important | 23, 293 |
| abstract_inverted_index.molecular | 10, 84, 245 |
| abstract_inverted_index.mutations | 205 |
| abstract_inverted_index.oncogenic | 65, 88, 186 |
| abstract_inverted_index.patterns. | 224 |
| abstract_inverted_index.practices | 297 |
| abstract_inverted_index.therapies | 131, 290 |
| abstract_inverted_index.actionable | 9 |
| abstract_inverted_index.activating | 204 |
| abstract_inverted_index.associated | 82, 207 |
| abstract_inverted_index.frequently | 159 |
| abstract_inverted_index.geographic | 26 |
| abstract_inverted_index.highlights | 268 |
| abstract_inverted_index.histologic | 79 |
| abstract_inverted_index.identified | 179 |
| abstract_inverted_index.locations, | 27 |
| abstract_inverted_index.pathologic | 30 |
| abstract_inverted_index.prevalence | 7, 58, 123 |
| abstract_inverted_index.proportion | 284 |
| abstract_inverted_index.resectable | 16, 68, 279 |
| abstract_inverted_index.sequencing | 50 |
| abstract_inverted_index.targetable | 125, 273 |
| abstract_inverted_index.alterations | 11, 61, 126, 177, 246, 274 |
| abstract_inverted_index.demographic | 28 |
| abstract_inverted_index.differences | 24 |
| abstract_inverted_index.early-stage | 15 |
| abstract_inverted_index.neoadjuvant | 303 |
| abstract_inverted_index.oncological | 296 |
| abstract_inverted_index.predominant | 78, 223 |
| abstract_inverted_index.treatments. | 306 |
| abstract_inverted_index.AMP/ASCO/CAP | 155 |
| abstract_inverted_index.epidemiology | 270 |
| abstract_inverted_index.interrogated | 45 |
| abstract_inverted_index.pathological | 73 |
| abstract_inverted_index.significance | 150 |
| abstract_inverted_index.characterized | 247 |
| abstract_inverted_index.perioperative | 305 |
| abstract_inverted_index.relationships | 229 |
| abstract_inverted_index.adenocarcinoma | 18, 43 |
| abstract_inverted_index.lepidic/acinar | 219, 264 |
| abstract_inverted_index.pathologically | 40 |
| abstract_inverted_index.French-Canadian | 276 |
| abstract_inverted_index.adenocarcinoma. | 70, 281 |
| abstract_inverted_index.guideline-based | 64, 272 |
| abstract_inverted_index.investigational | 130 |
| abstract_inverted_index.next-generation | 49 |
| abstract_inverted_index.adenocarcinomas. | 265 |
| abstract_inverted_index.categorization). | 156 |
| abstract_inverted_index.characteristics. | 31 |
| abstract_inverted_index.clinico-pathological | 231 |
| cited_by_percentile_year.max | 95 |
| cited_by_percentile_year.min | 91 |
| countries_distinct_count | 1 |
| institutions_distinct_count | 9 |
| sustainable_development_goals[0].id | https://metadata.un.org/sdg/2 |
| sustainable_development_goals[0].score | 0.550000011920929 |
| sustainable_development_goals[0].display_name | Zero hunger |
| citation_normalized_percentile.value | 0.80683791 |
| citation_normalized_percentile.is_in_top_1_percent | False |
| citation_normalized_percentile.is_in_top_10_percent | True |