From clinical variables to multiomics analysis: a margin morphology-based gross classification system for hepatocellular carcinoma stratification Article Swipe

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Zhongqi Fan , Meishan Jin , Lei Zhang , Nanya Wang , Mingyue Li , Chuanlei Wang , Wei Feng , Ping Zhang , Xiaohong Du , Xiaodong Sun , Wei Qiu , Meng Wang , Hongbin Wang , Xiaoju Shi , Junfeng Ye , Chao Jiang , Jianpeng Zhou , Wengang Chai , Jun Qi , Ting Li , Ruoyan Zhang , Xingkai Liu , Bo Huang , Kaiyuan Chai , Yannan Cao , Wentao Mu , Yu Huang , Tian Yang , Huimao Zhang , Limei Qu , Yahui Liu , Guangyi Wang , Guoyue Lv ·

YOU? · · 2023 · Open Access · · DOI: https://doi.org/10.1136/gutjnl-2023-330461

Objective Selecting interventions for patients with solitary hepatocellular carcinoma (HCC) remains a challenge. Despite gross classification being proposed as a potential prognostic predictor, its widespread use has been restricted due to inadequate studies with sufficient patient numbers and the lack of established mechanisms. We sought to investigate the prognostic impacts on patients with HCC of different gross subtypes and assess their corresponding molecular landscapes. Design A prospective cohort of 400 patients who underwent hepatic resection for solitary HCC was reviewed and analysed and gross classification was assessed. Multiomics analyses were performed on tumours and non-tumour tissues from 49 patients to investigate the mechanisms underlying gross classification. Inverse probability of treatment weight (IPTW) was used to control for confounding factors. Results Overall 3-year survival rates varied significantly among the four gross subtypes (type I: 91%, type II: 80%, type III: 74.6%, type IV: 38.8%). Type IV was found to be independently associated with poor prognosis in both the entire cohort and the IPTW cohort. The four gross subtypes exhibited three distinct transcriptional modules. Particularly, type IV tumours exhibited increased angiogenesis and immune score as well as decreased metabolic pathways, together with highest frequency of TP53 mutations. Patients with type IV HCC may benefit from adjuvant intra-arterial therapy other than the other three subtypes. Accordingly, a modified trichotomous margin morphological gross classification was established. Conclusion Different gross types of HCC showed significantly different prognosis and molecular characteristics. Gross classification may aid in development of precise individualised diagnosis and treatment strategies for HCC.

Related Topics

Hepatocellular Carcinoma

Concepts

Hepatocellular carcinoma Cohort Medicine Internal medicine Gross examination Oncology Confounding Pathology

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Type: article
Language: en
Landing Page: https://doi.org/10.1136/gutjnl-2023-330461
PDF: https://gut.bmj.com/content/gutjnl/early/2023/08/07/gutjnl-2023-330461.full.pdf
OA Status: hybrid
Cited By: 14
References: 49
Related Works: 10
OpenAlex ID: https://openalex.org/W4385625493

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DOI: https://doi.org/10.1136/gutjnl-2023-330461

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Title: From clinical variables to multiomics analysis: a margin morphology-based gross classification system for hepatocellular carcinoma stratification

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Type: article

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Language: en

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Publication year: 2023

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Publication date: 2023-08-07

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Authors: Zhongqi Fan, Meishan Jin, Lei Zhang, Nanya Wang, Mingyue Li, Chuanlei Wang, Wei Feng, Ping Zhang, Xiaohong Du, Xiaodong Sun, Wei Qiu, Meng Wang, Hongbin Wang, Xiaoju Shi, Junfeng Ye, Chao Jiang, Jianpeng Zhou, Wengang Chai, Jun Qi, Ting Li, Ruoyan Zhang, Xingkai Liu, Bo Huang, Kaiyuan Chai, Yannan Cao, Wentao Mu, Yu Huang, Tian Yang, Huimao Zhang, Limei Qu, Yahui Liu, Guangyi Wang, Guoyue Lv

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Landing page: https://doi.org/10.1136/gutjnl-2023-330461

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PDF URL: https://gut.bmj.com/content/gutjnl/early/2023/08/07/gutjnl-2023-330461.full.pdf

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OA URL: https://gut.bmj.com/content/gutjnl/early/2023/08/07/gutjnl-2023-330461.full.pdf

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Concepts: Hepatocellular carcinoma, Cohort, Medicine, Internal medicine, Gross examination, Oncology, Confounding, Pathology

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Cited by: 14

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Citations by year (recent): 2025: 7, 2024: 7

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publication_year	2023
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