Frontispiece: Characterization of Giant Modular PKSs Provides Insight into Genetic Mechanism for Structural Diversification of Aminopolyol Polyketides Article Swipe
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Polyketide
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Lihan Zhang
,
Takuya Hashimoto
,
Bin Qin
,
Junko Hashimoto
,
Ikuko Kozone
,
Teppei Kawahara
,
Masahiro Okada
,
Takayoshi Awakawa
,
Takuya Ito
,
Yoshinori Asakawa
,
Masashi Ueki
,
Shunji Takahashi
,
Hiroyuki Osada
,
Toshiyuki Wakimoto
,
Haruo Ikeda
,
Kazuo Shin‐ya
,
Ikuro Abe
·
YOU?
·
· 2017
· Open Access
·
· DOI: https://doi.org/10.1002/anie.201780761
· OA: W4237654153
YOU?
·
· 2017
· Open Access
·
· DOI: https://doi.org/10.1002/anie.201780761
· OA: W4237654153
Polyketide Biosynthesis: Aminopolyols are biosynthesized by polyketide synthases (PKSs). In their Communication on page 1740 I. Abe et al. show that heterologous expression of over 150 kbp PKS gene clusters afforded novel aminopolyols. Phylogenetic comparison of four aminopolyol PKS gene clusters showed the mechanism of PKS reprogramming in nature.
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