Frontispiece: The Physico‐Chemical Basis of DNA Radiosensitization: Implications for Cancer Radiation Therapy Article Swipe
Related Concepts
DNA
DNA damage
Reactivity (psychology)
Electron
Chemistry
Biophysics
Cancer
Nanotechnology
Radiochemistry
Materials science
Biochemistry
Physics
Biology
Medicine
Genetics
Pathology
Quantum mechanics
Alternative medicine
Robin Schürmann
,
Stefanie N. Vogel
,
Kenny Ebel
,
Ilko Bald
·
YOU?
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· 2018
· Open Access
·
· DOI: https://doi.org/10.1002/chem.201884161
· OA: W2884639331
YOU?
·
· 2018
· Open Access
·
· DOI: https://doi.org/10.1002/chem.201884161
· OA: W2884639331
The concept of physico-chemical radiosensitization is based on the enhanced reactivity of DNA towards secondary low-energy electrons, or the increase of local concentration of such electrons. This can for example be achieved by incorporation of halogenated nucleosides into DNA, or by administration of metal nanoparticles. In their Concept article on page 10271 ff., I. Bald et al. discuss the fundamental mechanisms of low-energy electron-induced DNA damage and present the recent experimental advancements in the quantification of DNA strand breaks in chemically modified DNA.
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