Fully Automated and Scalable Pipeline for Macaque Brain Registration Article Swipe
Junjie Zhuo
,
Z. Zhang
,
Chi Xiao
,
M. Z. Wang
,
Shmushkovich Bi
,
Liang Shi
,
Qingming Luo
,
Hui Gong
,
Zhiming Shen
,
Xiaoquan Yang
,
Pengcheng Li
·
YOU?
·
· 2025
· Open Access
·
· DOI: https://doi.org/10.1101/2025.07.10.663842
YOU?
·
· 2025
· Open Access
·
· DOI: https://doi.org/10.1101/2025.07.10.663842
With the rapid development of various whole-brain ex vivo imaging technologies, there is a growing need to develop cross-modal 3D image registration methods to integrate multimodal imaging datasets. While comprehensive cross-modality registration tools such as D-LMBmap and mBrainAligner have been successfully implemented for mouse brains, macaque whole-brain registration presents unique challenges. These include more pronounced non-uniform deformations in larger ex vivo specimens, greater modality-specific contrast differences relative to standard space, and increased inter-individual variability. To address these challenges, we developed Macaca-Star, which incorporates deep learning models and self-individual MRI to tackle cross-modal and ex vivo sample deformation challenges in macaque whole-brain registration. Macaca-Star provides fully automated alignment of fMOST and 2D fluorescent slice images to the NMT MRI standard space, allowing for comprehensive integration of anterograde axonal projections and retrograde-traced neuronal soma profiles.
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Metadata
- Type
- preprint
- Language
- en
- Landing Page
- https://doi.org/10.1101/2025.07.10.663842
- https://www.biorxiv.org/content/biorxiv/early/2025/07/16/2025.07.10.663842.full.pdf
- OA Status
- green
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W4412486858
All OpenAlex metadata
Raw OpenAlex JSON
- OpenAlex ID
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https://openalex.org/W4412486858Canonical identifier for this work in OpenAlex
- DOI
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https://doi.org/10.1101/2025.07.10.663842Digital Object Identifier
- Title
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Fully Automated and Scalable Pipeline for Macaque Brain RegistrationWork title
- Type
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preprintOpenAlex work type
- Language
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enPrimary language
- Publication year
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2025Year of publication
- Publication date
-
2025-07-16Full publication date if available
- Authors
-
Junjie Zhuo, Z. Zhang, Chi Xiao, M. Z. Wang, Shmushkovich Bi, Liang Shi, Qingming Luo, Hui Gong, Zhiming Shen, Xiaoquan Yang, Pengcheng LiList of authors in order
- Landing page
-
https://doi.org/10.1101/2025.07.10.663842Publisher landing page
- PDF URL
-
https://www.biorxiv.org/content/biorxiv/early/2025/07/16/2025.07.10.663842.full.pdfDirect link to full text PDF
- Open access
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YesWhether a free full text is available
- OA status
-
greenOpen access status per OpenAlex
- OA URL
-
https://www.biorxiv.org/content/biorxiv/early/2025/07/16/2025.07.10.663842.full.pdfDirect OA link when available
- Concepts
-
Macaque, Pipeline (software), Computer science, Scalability, Artificial intelligence, Computer vision, Neuroscience, Programming language, Psychology, DatabaseTop concepts (fields/topics) attached by OpenAlex
- Cited by
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0Total citation count in OpenAlex
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10Other works algorithmically related by OpenAlex
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