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Functional analysis of<i>UGT201D3</i>associated with abamectin resistance in<i>Tetranychus cinnabarinus</i>(Boisduval)
August 2018 • Mengyao Wang, Xin‐Yang Liu, Li Shi, Jia‐Lu Liu, Guangmao Shen, Ping Zhang, Wen‐Cai Lu, Lin He
Abstract Uridine diphosphate (UDP)‐glycosyltransferases (UGTs) are widely distributed within living organisms and share roles in biotransformation of various lipophilic endo‐ and xenobiotics with activated UDP sugars. In this study, it was found that the activity of UGTs in abamectin‐resistant (AbR) strain was significantly higher (2.35‐fold) than that in susceptible strain (SS) of Tetranychus cinnabarinus . Further analysis showed that 5‐nitrouracil, the inhibitor of UGTs, could enhance the lethal effect of abame…
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