Functional and Phenotypic Characterization of Siglec-6 on Human Mast Cells Article Swipe
Piper A. Robida
,
Clayton H. Rische
,
Netali Ben-Baruch Morgenstern
,
Rethavathi Janarthanam
,
Yun Cao
,
Rebecca A. Krier-Burris
,
Wouter Korver
,
Alan Xu
,
Thuy T. Luu
,
Julia Schanin
,
John Leung
,
Marc E. Rothenberg
,
Joshua B. Wechsler
,
Bradford A. Youngblood
,
Bruce S. Bochner
,
Jeremy A. O’Sullivan
·
YOU?
·
· 2022
· Open Access
·
· DOI: https://doi.org/10.3390/cells11071138
YOU?
·
· 2022
· Open Access
·
· DOI: https://doi.org/10.3390/cells11071138
Mast cells are tissue-resident cells that contribute to allergic diseases, among others, due to excessive or inappropriate cellular activation and degranulation. Therapeutic approaches to modulate mast cell activation are urgently needed. Siglec-6 is an immunoreceptor tyrosine-based inhibitory motif (ITIM)-bearing receptor selectively expressed by mast cells, making it a promising target for therapeutic intervention. However, the effects of its engagement on mast cells are poorly defined. Siglec-6 expression and endocytosis on primary human mast cells and mast cell lines were assessed by flow cytometry. SIGLEC6 mRNA expression was examined by single-cell RNAseq in esophageal tissue biopsy samples. The ability of Siglec-6 engagement or co-engagement to prevent primary mast cell activation was determined based on assessments of mediator and cytokine secretion and degranulation markers. Siglec-6 was highly expressed by all mast cells examined, and the SIGLEC6 transcript was restricted to mast cells in esophageal biopsy samples. Siglec-6 endocytosis occurred with delayed kinetics relative to the related receptor Siglec-8. Co-crosslinking of Siglec-6 with FcεRIα enhanced the inhibition of mast cell activation and diminished downstream ERK1/2 and p38 phosphorylation. The selective, stable expression and potent inhibitory capacity of Siglec-6 on human mast cells are favorable for its use as a therapeutic target in mast cell-driven diseases.
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Metadata
- Type
- article
- Language
- en
- Landing Page
- https://doi.org/10.3390/cells11071138
- https://www.mdpi.com/2073-4409/11/7/1138/pdf?version=1648539978
- OA Status
- gold
- Cited By
- 28
- References
- 61
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W4220791167
All OpenAlex metadata
Raw OpenAlex JSON
- OpenAlex ID
-
https://openalex.org/W4220791167Canonical identifier for this work in OpenAlex
- DOI
-
https://doi.org/10.3390/cells11071138Digital Object Identifier
- Title
-
Functional and Phenotypic Characterization of Siglec-6 on Human Mast CellsWork title
- Type
-
articleOpenAlex work type
- Language
-
enPrimary language
- Publication year
-
2022Year of publication
- Publication date
-
2022-03-28Full publication date if available
- Authors
-
Piper A. Robida, Clayton H. Rische, Netali Ben-Baruch Morgenstern, Rethavathi Janarthanam, Yun Cao, Rebecca A. Krier-Burris, Wouter Korver, Alan Xu, Thuy T. Luu, Julia Schanin, John Leung, Marc E. Rothenberg, Joshua B. Wechsler, Bradford A. Youngblood, Bruce S. Bochner, Jeremy A. O’SullivanList of authors in order
- Landing page
-
https://doi.org/10.3390/cells11071138Publisher landing page
- PDF URL
-
https://www.mdpi.com/2073-4409/11/7/1138/pdf?version=1648539978Direct link to full text PDF
- Open access
-
YesWhether a free full text is available
- OA status
-
goldOpen access status per OpenAlex
- OA URL
-
https://www.mdpi.com/2073-4409/11/7/1138/pdf?version=1648539978Direct OA link when available
- Concepts
-
Degranulation, Mast cell, Cell biology, Biology, SIGLEC, Interleukin 33, Endocytosis, Immunology, Receptor, Immune system, Cytokine, Biochemistry, InterleukinTop concepts (fields/topics) attached by OpenAlex
- Cited by
-
28Total citation count in OpenAlex
- Citations by year (recent)
-
2025: 5, 2024: 8, 2023: 11, 2022: 4Per-year citation counts (last 5 years)
- References (count)
-
61Number of works referenced by this work
- Related works (count)
-
10Other works algorithmically related by OpenAlex
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