Functional assessment of SLC4A11, an integral membrane protein mutated in corneal dystrophies Article Swipe
Sampath K. Loganathan
,
Hans-Peter Schneider
,
Patricio E. Morgan
,
Joachim W. Deitmer
,
Joseph R. Casey
·
YOU?
·
· 2016
· Open Access
·
· DOI: https://doi.org/10.1152/ajpcell.00078.2016
YOU?
·
· 2016
· Open Access
·
· DOI: https://doi.org/10.1152/ajpcell.00078.2016
SLC4A11, a member of the SLC4 family of bicarbonate transporters, is a widely expressed integral membrane protein, abundant in kidney and cornea. Mutations of SLC4A11 cause some cases of the blinding corneal dystrophies, congenital hereditary endothelial dystrophy, and Fuchs endothelial corneal dystrophy. These diseases are marked by fluid accumulation in the corneal stroma, secondary to defective fluid reabsorption by the corneal endothelium. The role of SLC4A11 in these corneal dystrophies is not firmly established, as SLC4A11 function remains unclear. To clarify the normal function(s) of SLC4A11, we characterized the protein following expression in the simple, low-background expression system Xenopus laevis oocytes. Since plant and fungal SLC4A11 orthologs transport borate, we measured cell swelling associated with accumulation of solute borate. The plant water/borate transporter NIP5;1 manifested borate transport, whereas human SLC4A11 did not. SLC4A11 supported osmotically driven water accumulation that was electroneutral and Na + independent. Studies in oocytes and HEK293 cells could not detect Na + -coupled HCO 3 − transport or Cl − /HCO 3 − exchange by SLC4A11. SLC4A11 mediated electroneutral NH 3 transport in oocytes. Voltage-dependent OH − or H + movement was not measurable in SLC4A11-expressing oocytes, but SLC4A11-expressing HEK293 cells manifested low-level cytosolic acidification at baseline. In mammalian cells, but not oocytes, OH − /H + conductance may arise when SLC4A11 activates another protein or itself is activated by another protein. These data argue against a role of human SLC4A11 in bicarbonate or borate transport. This work provides additional support for water and ammonia transport by SLC4A11. When expressed in oocytes, SLC4A11 transported NH 3 , not NH 3 /H + .
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- Type
- article
- Language
- en
- Landing Page
- https://doi.org/10.1152/ajpcell.00078.2016
- https://www.physiology.org/doi/pdf/10.1152/ajpcell.00078.2016
- OA Status
- bronze
- Cited By
- 47
- References
- 52
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W2513220870
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Raw OpenAlex JSON
- OpenAlex ID
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https://openalex.org/W2513220870Canonical identifier for this work in OpenAlex
- DOI
-
https://doi.org/10.1152/ajpcell.00078.2016Digital Object Identifier
- Title
-
Functional assessment of SLC4A11, an integral membrane protein mutated in corneal dystrophiesWork title
- Type
-
articleOpenAlex work type
- Language
-
enPrimary language
- Publication year
-
2016Year of publication
- Publication date
-
2016-08-25Full publication date if available
- Authors
-
Sampath K. Loganathan, Hans-Peter Schneider, Patricio E. Morgan, Joachim W. Deitmer, Joseph R. CaseyList of authors in order
- Landing page
-
https://doi.org/10.1152/ajpcell.00078.2016Publisher landing page
- PDF URL
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https://www.physiology.org/doi/pdf/10.1152/ajpcell.00078.2016Direct link to full text PDF
- Open access
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YesWhether a free full text is available
- OA status
-
bronzeOpen access status per OpenAlex
- OA URL
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https://www.physiology.org/doi/pdf/10.1152/ajpcell.00078.2016Direct OA link when available
- Concepts
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Chemistry, Xenopus, Cell biology, Corneal endothelium, HEK 293 cells, Cytosol, Transport protein, Biochemistry, Biology, Gene, Endothelium, Genetics, EnzymeTop concepts (fields/topics) attached by OpenAlex
- Cited by
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47Total citation count in OpenAlex
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2025: 3, 2024: 6, 2023: 3, 2022: 7, 2021: 4Per-year citation counts (last 5 years)
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52Number of works referenced by this work
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10Other works algorithmically related by OpenAlex
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