Functional comparison of Clostridium butyricum and sodium butyrate supplementation on growth, intestinal health, and the anti-inflammatory response of broilers Article Swipe
Ling Liu
,
Huayun Ling
,
Wei Zhang
,
Ying Zhou
,
Youguo Li
,
Nan Peng
,
Shumiao Zhao
·
YOU?
·
· 2021
· Open Access
·
· DOI: https://doi.org/10.21203/rs.3.rs-955295/v1
YOU?
·
· 2021
· Open Access
·
· DOI: https://doi.org/10.21203/rs.3.rs-955295/v1
Background: Butyrate has been reported to promote proliferation of colonic epithelial cells and maintain intestinal barrier integrity in broilers. Although supplementation of Clostridium butyricum and sodium butyrate have been shown to confer benefits on broilers, their effects and mechanisms have not been compared.Results: In this study, C. butyricum and sodium butyrate were added into the basal diet of broilers and their effects on growth performance, intestinal health, and anti-inflammatory response were analyzed. It was found that both C. butyricum and sodium butyrate showed good probiotic effects on broilers. Their effects on growth rate and expression of inflammation related genes were even superior to that of antibiotic. Besides, the two dietary supplements improved intestinal structure integrity and secretion of inflammatory cytokines, although the antibiotic had negative effects. Comparison of the two supplements revealed that sodium butyrate more effectively improved the growth and intestinal structure of broilers than C. butyricum. On the contrary, C. butyricum was superior to sodium butyrate in promoting tight junction protein expression, SCFAs production, and anti-inflammatory response.Conclusions: In summary, this study demonstrates the positive effects of C. butyricum and sodium butyrate on broilers, and will serve as a reference for selection of appropriate butyrate supplementation for broilers in the breeding industry.
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Metadata
- Type
- preprint
- Language
- en
- Landing Page
- https://doi.org/10.21203/rs.3.rs-955295/v1
- https://www.researchsquare.com/article/rs-955295/latest.pdf
- OA Status
- green
- Cited By
- 1
- References
- 28
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W3212476380
All OpenAlex metadata
Raw OpenAlex JSON
- OpenAlex ID
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https://openalex.org/W3212476380Canonical identifier for this work in OpenAlex
- DOI
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https://doi.org/10.21203/rs.3.rs-955295/v1Digital Object Identifier
- Title
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Functional comparison of Clostridium butyricum and sodium butyrate supplementation on growth, intestinal health, and the anti-inflammatory response of broilersWork title
- Type
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preprintOpenAlex work type
- Language
-
enPrimary language
- Publication year
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2021Year of publication
- Publication date
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2021-10-12Full publication date if available
- Authors
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Ling Liu, Huayun Ling, Wei Zhang, Ying Zhou, Youguo Li, Nan Peng, Shumiao ZhaoList of authors in order
- Landing page
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https://doi.org/10.21203/rs.3.rs-955295/v1Publisher landing page
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https://www.researchsquare.com/article/rs-955295/latest.pdfDirect link to full text PDF
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YesWhether a free full text is available
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greenOpen access status per OpenAlex
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https://www.researchsquare.com/article/rs-955295/latest.pdfDirect OA link when available
- Concepts
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Clostridium butyricum, Butyrate, Sodium butyrate, Probiotic, Biology, Clostridium, Antibiotics, Food science, Microbiology, Biochemistry, Bacteria, Fermentation, Gene, GeneticsTop concepts (fields/topics) attached by OpenAlex
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1Total citation count in OpenAlex
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2025: 1Per-year citation counts (last 5 years)
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10Other works algorithmically related by OpenAlex
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