Functional Definition of Progenitors Versus Mature Endothelial Cells Reveals Key SoxF-Dependent Differentiation Process Article Swipe
Jatin Patel
,
Elke Seppanen
,
Mathieu P. Rodero
,
Ho Yi Wong
,
Prudence Donovan
,
Zoltán Neufeld
,
Nicholas M. Fisk
,
Mathias François
,
Kiarash Khosrotehrani
·
YOU?
·
· 2016
· Open Access
·
· DOI: https://doi.org/10.1161/circulationaha.116.024754
YOU?
·
· 2016
· Open Access
·
· DOI: https://doi.org/10.1161/circulationaha.116.024754
Background: During adult life, blood vessel formation is thought to occur via angiogenic processes involving branching from existing vessels. An alternate proposal suggests that neovessels form from endothelial progenitors able to assemble the intimal layers. We here aimed to define vessel-resident endothelial progenitors in vivo in a variety of tissues in physiological and pathological situations such as normal aorta, lungs, and wound healing, tumors, and placenta, as well. Methods: Based on protein expression levels of common endothelial markers using flow cytometry, 3 subpopulations of endothelial cells could be identified among VE-Cadherin+ and CD45– cells. Results: Lineage tracing by using Cdh5cre ERt2 /Rosa-YFP reporter strategy demonstrated that the CD31–/loVEGFR2lo/intracellular endothelial population was indeed an endovascular progenitor (EVP) of an intermediate CD31intVEGFR2lo/intracellular transit amplifying (TA) and a definitive differentiated (D) CD31hiVEGFR2hi/extracellular population. EVP cells arose from vascular-resident beds that could not be transferred by bone marrow transplantation. Furthermore, EVP displayed progenitor-like status with a high proportion of cells in a quiescent cell cycle phase as assessed in wounds, tumors, and aorta. Only EVP cells and not TA and D cells had self-renewal capacity as demonstrated by colony-forming capacity in limiting dilution and by transplantation in Matrigel plugs in recipient mice. RNA sequencing revealed prominent gene expression differences between EVP and D cells. In particular, EVP cells highly expressed genes related to progenitor function including Sox9 , Il33 , Egfr , and Pdfgrα. Conversely, D cells highly expressed genes related to differentiated endothelium including Ets1&2 , Gata2 , Cd31 , Vwf , and Notch . The RNA sequencing also pointed to an essential role of the Sox18 transcription factor. The role of SOX18 in the differentiation process was validated by using lineage-tracing experiments based on S ox18Cre ERt2 /Rosa-YFP mice. Besides, in the absence of functional SOX18/SOXF, EVP progenitors were still present, but TA and D populations were significantly reduced. Conclusions: Our findings support an entirely novel endothelial hierarchy, from EVP to TA to D, as defined by self-renewal, differentiation, and molecular profiling of an endothelial progenitor. This paradigm shift in our understanding of vascular-resident endothelial progenitors in tissue regeneration opens new avenues for better understanding of cardiovascular biology.
Related Topics
Concepts
Metadata
- Type
- article
- Language
- en
- Landing Page
- https://doi.org/10.1161/circulationaha.116.024754
- https://www.ahajournals.org/doi/pdf/10.1161/CIRCULATIONAHA.116.024754
- OA Status
- bronze
- Cited By
- 123
- References
- 56
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W2557862562
All OpenAlex metadata
Raw OpenAlex JSON
- OpenAlex ID
-
https://openalex.org/W2557862562Canonical identifier for this work in OpenAlex
- DOI
-
https://doi.org/10.1161/circulationaha.116.024754Digital Object Identifier
- Title
-
Functional Definition of Progenitors Versus Mature Endothelial Cells Reveals Key SoxF-Dependent Differentiation ProcessWork title
- Type
-
articleOpenAlex work type
- Language
-
enPrimary language
- Publication year
-
2016Year of publication
- Publication date
-
2016-11-30Full publication date if available
- Authors
-
Jatin Patel, Elke Seppanen, Mathieu P. Rodero, Ho Yi Wong, Prudence Donovan, Zoltán Neufeld, Nicholas M. Fisk, Mathias François, Kiarash KhosrotehraniList of authors in order
- Landing page
-
https://doi.org/10.1161/circulationaha.116.024754Publisher landing page
- PDF URL
-
https://www.ahajournals.org/doi/pdf/10.1161/CIRCULATIONAHA.116.024754Direct link to full text PDF
- Open access
-
YesWhether a free full text is available
- OA status
-
bronzeOpen access status per OpenAlex
- OA URL
-
https://www.ahajournals.org/doi/pdf/10.1161/CIRCULATIONAHA.116.024754Direct OA link when available
- Concepts
-
Progenitor cell, Cell biology, Endothelial stem cell, CD31, Population, Angiogenesis, Biology, Matrigel, Stem cell, Transplantation, Endothelium, Immunology, Medicine, Cancer research, Internal medicine, Genetics, In vitro, Environmental healthTop concepts (fields/topics) attached by OpenAlex
- Cited by
-
123Total citation count in OpenAlex
- Citations by year (recent)
-
2025: 7, 2024: 9, 2023: 22, 2022: 15, 2021: 21Per-year citation counts (last 5 years)
- References (count)
-
56Number of works referenced by this work
- Related works (count)
-
10Other works algorithmically related by OpenAlex
Full payload
| id | https://openalex.org/W2557862562 |
|---|---|
| doi | https://doi.org/10.1161/circulationaha.116.024754 |
| ids.doi | https://doi.org/10.1161/circulationaha.116.024754 |
| ids.mag | 2557862562 |
| ids.pmid | https://pubmed.ncbi.nlm.nih.gov/27899395 |
| ids.openalex | https://openalex.org/W2557862562 |
| fwci | 5.02645879 |
| mesh[0].qualifier_ui | |
| mesh[0].descriptor_ui | D000818 |
| mesh[0].is_major_topic | False |
| mesh[0].qualifier_name | |
| mesh[0].descriptor_name | Animals |
| mesh[1].qualifier_ui | Q000378 |
| mesh[1].descriptor_ui | D015703 |
| mesh[1].is_major_topic | False |
| mesh[1].qualifier_name | metabolism |
| mesh[1].descriptor_name | Antigens, CD |
| mesh[2].qualifier_ui | Q000378 |
| mesh[2].descriptor_ui | D001011 |
| mesh[2].is_major_topic | False |
| mesh[2].qualifier_name | metabolism |
| mesh[2].descriptor_name | Aorta |
| mesh[3].qualifier_ui | Q000473 |
| mesh[3].descriptor_ui | D001011 |
| mesh[3].is_major_topic | False |
| mesh[3].qualifier_name | pathology |
| mesh[3].descriptor_name | Aorta |
| mesh[4].qualifier_ui | |
| mesh[4].descriptor_ui | D016026 |
| mesh[4].is_major_topic | False |
| mesh[4].qualifier_name | |
| mesh[4].descriptor_name | Bone Marrow Transplantation |
| mesh[5].qualifier_ui | Q000378 |
| mesh[5].descriptor_ui | D015820 |
| mesh[5].is_major_topic | False |
| mesh[5].qualifier_name | metabolism |
| mesh[5].descriptor_name | Cadherins |
| mesh[6].qualifier_ui | |
| mesh[6].descriptor_ui | D002454 |
| mesh[6].is_major_topic | False |
| mesh[6].qualifier_name | |
| mesh[6].descriptor_name | Cell Differentiation |
| mesh[7].qualifier_ui | Q000166 |
| mesh[7].descriptor_ui | D042783 |
| mesh[7].is_major_topic | False |
| mesh[7].qualifier_name | cytology |
| mesh[7].descriptor_name | Endothelial Cells |
| mesh[8].qualifier_ui | Q000378 |
| mesh[8].descriptor_ui | D042783 |
| mesh[8].is_major_topic | False |
| mesh[8].qualifier_name | metabolism |
| mesh[8].descriptor_name | Endothelial Cells |
| mesh[9].qualifier_ui | Q000166 |
| mesh[9].descriptor_ui | D004730 |
| mesh[9].is_major_topic | False |
| mesh[9].qualifier_name | cytology |
| mesh[9].descriptor_name | Endothelium, Vascular |
| mesh[10].qualifier_ui | |
| mesh[10].descriptor_ui | D005260 |
| mesh[10].is_major_topic | False |
| mesh[10].qualifier_name | |
| mesh[10].descriptor_name | Female |
| mesh[11].qualifier_ui | Q000378 |
| mesh[11].descriptor_ui | D017493 |
| mesh[11].is_major_topic | False |
| mesh[11].qualifier_name | metabolism |
| mesh[11].descriptor_name | Leukocyte Common Antigens |
| mesh[12].qualifier_ui | |
| mesh[12].descriptor_ui | D051379 |
| mesh[12].is_major_topic | False |
| mesh[12].qualifier_name | |
| mesh[12].descriptor_name | Mice |
| mesh[13].qualifier_ui | |
| mesh[13].descriptor_ui | D008810 |
| mesh[13].is_major_topic | False |
| mesh[13].qualifier_name | |
| mesh[13].descriptor_name | Mice, Inbred C57BL |
| mesh[14].qualifier_ui | |
| mesh[14].descriptor_ui | D018919 |
| mesh[14].is_major_topic | False |
| mesh[14].qualifier_name | |
| mesh[14].descriptor_name | Neovascularization, Physiologic |
| mesh[15].qualifier_ui | Q000378 |
| mesh[15].descriptor_ui | D010920 |
| mesh[15].is_major_topic | False |
| mesh[15].qualifier_name | metabolism |
| mesh[15].descriptor_name | Placenta |
| mesh[16].qualifier_ui | Q000473 |
| mesh[16].descriptor_ui | D010920 |
| mesh[16].is_major_topic | False |
| mesh[16].qualifier_name | pathology |
| mesh[16].descriptor_name | Placenta |
| mesh[17].qualifier_ui | Q000378 |
| mesh[17].descriptor_ui | D019408 |
| mesh[17].is_major_topic | False |
| mesh[17].qualifier_name | metabolism |
| mesh[17].descriptor_name | Platelet Endothelial Cell Adhesion Molecule-1 |
| mesh[18].qualifier_ui | |
| mesh[18].descriptor_ui | D011247 |
| mesh[18].is_major_topic | False |
| mesh[18].qualifier_name | |
| mesh[18].descriptor_name | Pregnancy |
| mesh[19].qualifier_ui | Q000378 |
| mesh[19].descriptor_ui | D055760 |
| mesh[19].is_major_topic | False |
| mesh[19].qualifier_name | metabolism |
| mesh[19].descriptor_name | SOXF Transcription Factors |
| mesh[20].qualifier_ui | Q000166 |
| mesh[20].descriptor_ui | D013234 |
| mesh[20].is_major_topic | False |
| mesh[20].qualifier_name | cytology |
| mesh[20].descriptor_name | Stem Cells |
| mesh[21].qualifier_ui | Q000378 |
| mesh[21].descriptor_ui | D013234 |
| mesh[21].is_major_topic | False |
| mesh[21].qualifier_name | metabolism |
| mesh[21].descriptor_name | Stem Cells |
| mesh[22].qualifier_ui | Q000378 |
| mesh[22].descriptor_ui | D040301 |
| mesh[22].is_major_topic | False |
| mesh[22].qualifier_name | metabolism |
| mesh[22].descriptor_name | Vascular Endothelial Growth Factor Receptor-2 |
| mesh[23].qualifier_ui | Q000473 |
| mesh[23].descriptor_ui | D014947 |
| mesh[23].is_major_topic | False |
| mesh[23].qualifier_name | pathology |
| mesh[23].descriptor_name | Wounds and Injuries |
| mesh[24].qualifier_ui | Q000628 |
| mesh[24].descriptor_ui | D014947 |
| mesh[24].is_major_topic | False |
| mesh[24].qualifier_name | therapy |
| mesh[24].descriptor_name | Wounds and Injuries |
| mesh[25].qualifier_ui | |
| mesh[25].descriptor_ui | D000818 |
| mesh[25].is_major_topic | False |
| mesh[25].qualifier_name | |
| mesh[25].descriptor_name | Animals |
| mesh[26].qualifier_ui | Q000378 |
| mesh[26].descriptor_ui | D015703 |
| mesh[26].is_major_topic | False |
| mesh[26].qualifier_name | metabolism |
| mesh[26].descriptor_name | Antigens, CD |
| mesh[27].qualifier_ui | Q000378 |
| mesh[27].descriptor_ui | D001011 |
| mesh[27].is_major_topic | False |
| mesh[27].qualifier_name | metabolism |
| mesh[27].descriptor_name | Aorta |
| mesh[28].qualifier_ui | Q000473 |
| mesh[28].descriptor_ui | D001011 |
| mesh[28].is_major_topic | False |
| mesh[28].qualifier_name | pathology |
| mesh[28].descriptor_name | Aorta |
| mesh[29].qualifier_ui | |
| mesh[29].descriptor_ui | D016026 |
| mesh[29].is_major_topic | False |
| mesh[29].qualifier_name | |
| mesh[29].descriptor_name | Bone Marrow Transplantation |
| mesh[30].qualifier_ui | Q000378 |
| mesh[30].descriptor_ui | D015820 |
| mesh[30].is_major_topic | False |
| mesh[30].qualifier_name | metabolism |
| mesh[30].descriptor_name | Cadherins |
| mesh[31].qualifier_ui | |
| mesh[31].descriptor_ui | D002454 |
| mesh[31].is_major_topic | False |
| mesh[31].qualifier_name | |
| mesh[31].descriptor_name | Cell Differentiation |
| mesh[32].qualifier_ui | Q000166 |
| mesh[32].descriptor_ui | D042783 |
| mesh[32].is_major_topic | False |
| mesh[32].qualifier_name | cytology |
| mesh[32].descriptor_name | Endothelial Cells |
| mesh[33].qualifier_ui | Q000378 |
| mesh[33].descriptor_ui | D042783 |
| mesh[33].is_major_topic | False |
| mesh[33].qualifier_name | metabolism |
| mesh[33].descriptor_name | Endothelial Cells |
| mesh[34].qualifier_ui | Q000166 |
| mesh[34].descriptor_ui | D004730 |
| mesh[34].is_major_topic | False |
| mesh[34].qualifier_name | cytology |
| mesh[34].descriptor_name | Endothelium, Vascular |
| mesh[35].qualifier_ui | |
| mesh[35].descriptor_ui | D005260 |
| mesh[35].is_major_topic | False |
| mesh[35].qualifier_name | |
| mesh[35].descriptor_name | Female |
| mesh[36].qualifier_ui | Q000378 |
| mesh[36].descriptor_ui | D017493 |
| mesh[36].is_major_topic | False |
| mesh[36].qualifier_name | metabolism |
| mesh[36].descriptor_name | Leukocyte Common Antigens |
| mesh[37].qualifier_ui | |
| mesh[37].descriptor_ui | D051379 |
| mesh[37].is_major_topic | False |
| mesh[37].qualifier_name | |
| mesh[37].descriptor_name | Mice |
| mesh[38].qualifier_ui | |
| mesh[38].descriptor_ui | D008810 |
| mesh[38].is_major_topic | False |
| mesh[38].qualifier_name | |
| mesh[38].descriptor_name | Mice, Inbred C57BL |
| mesh[39].qualifier_ui | |
| mesh[39].descriptor_ui | D018919 |
| mesh[39].is_major_topic | False |
| mesh[39].qualifier_name | |
| mesh[39].descriptor_name | Neovascularization, Physiologic |
| mesh[40].qualifier_ui | Q000378 |
| mesh[40].descriptor_ui | D010920 |
| mesh[40].is_major_topic | False |
| mesh[40].qualifier_name | metabolism |
| mesh[40].descriptor_name | Placenta |
| mesh[41].qualifier_ui | Q000473 |
| mesh[41].descriptor_ui | D010920 |
| mesh[41].is_major_topic | False |
| mesh[41].qualifier_name | pathology |
| mesh[41].descriptor_name | Placenta |
| mesh[42].qualifier_ui | Q000378 |
| mesh[42].descriptor_ui | D019408 |
| mesh[42].is_major_topic | False |
| mesh[42].qualifier_name | metabolism |
| mesh[42].descriptor_name | Platelet Endothelial Cell Adhesion Molecule-1 |
| mesh[43].qualifier_ui | |
| mesh[43].descriptor_ui | D011247 |
| mesh[43].is_major_topic | False |
| mesh[43].qualifier_name | |
| mesh[43].descriptor_name | Pregnancy |
| mesh[44].qualifier_ui | Q000378 |
| mesh[44].descriptor_ui | D055760 |
| mesh[44].is_major_topic | False |
| mesh[44].qualifier_name | metabolism |
| mesh[44].descriptor_name | SOXF Transcription Factors |
| mesh[45].qualifier_ui | Q000166 |
| mesh[45].descriptor_ui | D013234 |
| mesh[45].is_major_topic | False |
| mesh[45].qualifier_name | cytology |
| mesh[45].descriptor_name | Stem Cells |
| mesh[46].qualifier_ui | Q000378 |
| mesh[46].descriptor_ui | D013234 |
| mesh[46].is_major_topic | False |
| mesh[46].qualifier_name | metabolism |
| mesh[46].descriptor_name | Stem Cells |
| mesh[47].qualifier_ui | Q000378 |
| mesh[47].descriptor_ui | D040301 |
| mesh[47].is_major_topic | False |
| mesh[47].qualifier_name | metabolism |
| mesh[47].descriptor_name | Vascular Endothelial Growth Factor Receptor-2 |
| mesh[48].qualifier_ui | Q000473 |
| mesh[48].descriptor_ui | D014947 |
| mesh[48].is_major_topic | False |
| mesh[48].qualifier_name | pathology |
| mesh[48].descriptor_name | Wounds and Injuries |
| mesh[49].qualifier_ui | Q000628 |
| mesh[49].descriptor_ui | D014947 |
| mesh[49].is_major_topic | False |
| mesh[49].qualifier_name | therapy |
| mesh[49].descriptor_name | Wounds and Injuries |
| type | article |
| title | Functional Definition of Progenitors Versus Mature Endothelial Cells Reveals Key SoxF-Dependent Differentiation Process |
| biblio.issue | 8 |
| biblio.volume | 135 |
| biblio.last_page | 805 |
| biblio.first_page | 786 |
| topics[0].id | https://openalex.org/T10422 |
| topics[0].field.id | https://openalex.org/fields/13 |
| topics[0].field.display_name | Biochemistry, Genetics and Molecular Biology |
| topics[0].score | 0.9994000196456909 |
| topics[0].domain.id | https://openalex.org/domains/1 |
| topics[0].domain.display_name | Life Sciences |
| topics[0].subfield.id | https://openalex.org/subfields/1312 |
| topics[0].subfield.display_name | Molecular Biology |
| topics[0].display_name | Angiogenesis and VEGF in Cancer |
| topics[1].id | https://openalex.org/T11685 |
| topics[1].field.id | https://openalex.org/fields/13 |
| topics[1].field.display_name | Biochemistry, Genetics and Molecular Biology |
| topics[1].score | 0.9610999822616577 |
| topics[1].domain.id | https://openalex.org/domains/1 |
| topics[1].domain.display_name | Life Sciences |
| topics[1].subfield.id | https://openalex.org/subfields/1307 |
| topics[1].subfield.display_name | Cell Biology |
| topics[1].display_name | Zebrafish Biomedical Research Applications |
| topics[2].id | https://openalex.org/T11677 |
| topics[2].field.id | https://openalex.org/fields/13 |
| topics[2].field.display_name | Biochemistry, Genetics and Molecular Biology |
| topics[2].score | 0.9521999955177307 |
| topics[2].domain.id | https://openalex.org/domains/1 |
| topics[2].domain.display_name | Life Sciences |
| topics[2].subfield.id | https://openalex.org/subfields/1312 |
| topics[2].subfield.display_name | Molecular Biology |
| topics[2].display_name | Congenital heart defects research |
| is_xpac | False |
| apc_list | |
| apc_paid | |
| concepts[0].id | https://openalex.org/C201750760 |
| concepts[0].level | 3 |
| concepts[0].score | 0.7395785450935364 |
| concepts[0].wikidata | https://www.wikidata.org/wiki/Q1896218 |
| concepts[0].display_name | Progenitor cell |
| concepts[1].id | https://openalex.org/C95444343 |
| concepts[1].level | 1 |
| concepts[1].score | 0.6394469738006592 |
| concepts[1].wikidata | https://www.wikidata.org/wiki/Q7141 |
| concepts[1].display_name | Cell biology |
| concepts[2].id | https://openalex.org/C123012128 |
| concepts[2].level | 3 |
| concepts[2].score | 0.6181647181510925 |
| concepts[2].wikidata | https://www.wikidata.org/wiki/Q5376430 |
| concepts[2].display_name | Endothelial stem cell |
| concepts[3].id | https://openalex.org/C2778939058 |
| concepts[3].level | 3 |
| concepts[3].score | 0.5802775025367737 |
| concepts[3].wikidata | https://www.wikidata.org/wiki/Q4046167 |
| concepts[3].display_name | CD31 |
| concepts[4].id | https://openalex.org/C2908647359 |
| concepts[4].level | 2 |
| concepts[4].score | 0.523775041103363 |
| concepts[4].wikidata | https://www.wikidata.org/wiki/Q2625603 |
| concepts[4].display_name | Population |
| concepts[5].id | https://openalex.org/C2780394083 |
| concepts[5].level | 2 |
| concepts[5].score | 0.515182614326477 |
| concepts[5].wikidata | https://www.wikidata.org/wiki/Q539568 |
| concepts[5].display_name | Angiogenesis |
| concepts[6].id | https://openalex.org/C86803240 |
| concepts[6].level | 0 |
| concepts[6].score | 0.48515018820762634 |
| concepts[6].wikidata | https://www.wikidata.org/wiki/Q420 |
| concepts[6].display_name | Biology |
| concepts[7].id | https://openalex.org/C2778608917 |
| concepts[7].level | 3 |
| concepts[7].score | 0.4667176604270935 |
| concepts[7].wikidata | https://www.wikidata.org/wiki/Q6787805 |
| concepts[7].display_name | Matrigel |
| concepts[8].id | https://openalex.org/C28328180 |
| concepts[8].level | 2 |
| concepts[8].score | 0.46126630902290344 |
| concepts[8].wikidata | https://www.wikidata.org/wiki/Q48196 |
| concepts[8].display_name | Stem cell |
| concepts[9].id | https://openalex.org/C2911091166 |
| concepts[9].level | 2 |
| concepts[9].score | 0.45333462953567505 |
| concepts[9].wikidata | https://www.wikidata.org/wiki/Q106419912 |
| concepts[9].display_name | Transplantation |
| concepts[10].id | https://openalex.org/C2776992346 |
| concepts[10].level | 2 |
| concepts[10].score | 0.4118030071258545 |
| concepts[10].wikidata | https://www.wikidata.org/wiki/Q111140 |
| concepts[10].display_name | Endothelium |
| concepts[11].id | https://openalex.org/C203014093 |
| concepts[11].level | 1 |
| concepts[11].score | 0.3877967596054077 |
| concepts[11].wikidata | https://www.wikidata.org/wiki/Q101929 |
| concepts[11].display_name | Immunology |
| concepts[12].id | https://openalex.org/C71924100 |
| concepts[12].level | 0 |
| concepts[12].score | 0.34149181842803955 |
| concepts[12].wikidata | https://www.wikidata.org/wiki/Q11190 |
| concepts[12].display_name | Medicine |
| concepts[13].id | https://openalex.org/C502942594 |
| concepts[13].level | 1 |
| concepts[13].score | 0.3306516408920288 |
| concepts[13].wikidata | https://www.wikidata.org/wiki/Q3421914 |
| concepts[13].display_name | Cancer research |
| concepts[14].id | https://openalex.org/C126322002 |
| concepts[14].level | 1 |
| concepts[14].score | 0.14616790413856506 |
| concepts[14].wikidata | https://www.wikidata.org/wiki/Q11180 |
| concepts[14].display_name | Internal medicine |
| concepts[15].id | https://openalex.org/C54355233 |
| concepts[15].level | 1 |
| concepts[15].score | 0.1258699595928192 |
| concepts[15].wikidata | https://www.wikidata.org/wiki/Q7162 |
| concepts[15].display_name | Genetics |
| concepts[16].id | https://openalex.org/C202751555 |
| concepts[16].level | 2 |
| concepts[16].score | 0.065569669008255 |
| concepts[16].wikidata | https://www.wikidata.org/wiki/Q221681 |
| concepts[16].display_name | In vitro |
| concepts[17].id | https://openalex.org/C99454951 |
| concepts[17].level | 1 |
| concepts[17].score | 0.0 |
| concepts[17].wikidata | https://www.wikidata.org/wiki/Q932068 |
| concepts[17].display_name | Environmental health |
| keywords[0].id | https://openalex.org/keywords/progenitor-cell |
| keywords[0].score | 0.7395785450935364 |
| keywords[0].display_name | Progenitor cell |
| keywords[1].id | https://openalex.org/keywords/cell-biology |
| keywords[1].score | 0.6394469738006592 |
| keywords[1].display_name | Cell biology |
| keywords[2].id | https://openalex.org/keywords/endothelial-stem-cell |
| keywords[2].score | 0.6181647181510925 |
| keywords[2].display_name | Endothelial stem cell |
| keywords[3].id | https://openalex.org/keywords/cd31 |
| keywords[3].score | 0.5802775025367737 |
| keywords[3].display_name | CD31 |
| keywords[4].id | https://openalex.org/keywords/population |
| keywords[4].score | 0.523775041103363 |
| keywords[4].display_name | Population |
| keywords[5].id | https://openalex.org/keywords/angiogenesis |
| keywords[5].score | 0.515182614326477 |
| keywords[5].display_name | Angiogenesis |
| keywords[6].id | https://openalex.org/keywords/biology |
| keywords[6].score | 0.48515018820762634 |
| keywords[6].display_name | Biology |
| keywords[7].id | https://openalex.org/keywords/matrigel |
| keywords[7].score | 0.4667176604270935 |
| keywords[7].display_name | Matrigel |
| keywords[8].id | https://openalex.org/keywords/stem-cell |
| keywords[8].score | 0.46126630902290344 |
| keywords[8].display_name | Stem cell |
| keywords[9].id | https://openalex.org/keywords/transplantation |
| keywords[9].score | 0.45333462953567505 |
| keywords[9].display_name | Transplantation |
| keywords[10].id | https://openalex.org/keywords/endothelium |
| keywords[10].score | 0.4118030071258545 |
| keywords[10].display_name | Endothelium |
| keywords[11].id | https://openalex.org/keywords/immunology |
| keywords[11].score | 0.3877967596054077 |
| keywords[11].display_name | Immunology |
| keywords[12].id | https://openalex.org/keywords/medicine |
| keywords[12].score | 0.34149181842803955 |
| keywords[12].display_name | Medicine |
| keywords[13].id | https://openalex.org/keywords/cancer-research |
| keywords[13].score | 0.3306516408920288 |
| keywords[13].display_name | Cancer research |
| keywords[14].id | https://openalex.org/keywords/internal-medicine |
| keywords[14].score | 0.14616790413856506 |
| keywords[14].display_name | Internal medicine |
| keywords[15].id | https://openalex.org/keywords/genetics |
| keywords[15].score | 0.1258699595928192 |
| keywords[15].display_name | Genetics |
| keywords[16].id | https://openalex.org/keywords/in-vitro |
| keywords[16].score | 0.065569669008255 |
| keywords[16].display_name | In vitro |
| language | en |
| locations[0].id | doi:10.1161/circulationaha.116.024754 |
| locations[0].is_oa | True |
| locations[0].source.id | https://openalex.org/S116251202 |
| locations[0].source.issn | 0009-7322, 1524-4539 |
| locations[0].source.type | journal |
| locations[0].source.is_oa | False |
| locations[0].source.issn_l | 0009-7322 |
| locations[0].source.is_core | True |
| locations[0].source.is_in_doaj | False |
| locations[0].source.display_name | Circulation |
| locations[0].source.host_organization | https://openalex.org/P4310315671 |
| locations[0].source.host_organization_name | Lippincott Williams & Wilkins |
| locations[0].source.host_organization_lineage | https://openalex.org/P4310315671, https://openalex.org/P4310318547 |
| locations[0].source.host_organization_lineage_names | Lippincott Williams & Wilkins, Wolters Kluwer |
| locations[0].license | |
| locations[0].pdf_url | https://www.ahajournals.org/doi/pdf/10.1161/CIRCULATIONAHA.116.024754 |
| locations[0].version | publishedVersion |
| locations[0].raw_type | journal-article |
| locations[0].license_id | |
| locations[0].is_accepted | True |
| locations[0].is_published | True |
| locations[0].raw_source_name | Circulation |
| locations[0].landing_page_url | https://doi.org/10.1161/circulationaha.116.024754 |
| locations[1].id | pmid:27899395 |
| locations[1].is_oa | False |
| locations[1].source.id | https://openalex.org/S4306525036 |
| locations[1].source.issn | |
| locations[1].source.type | repository |
| locations[1].source.is_oa | False |
| locations[1].source.issn_l | |
| locations[1].source.is_core | False |
| locations[1].source.is_in_doaj | False |
| locations[1].source.display_name | PubMed |
| locations[1].source.host_organization | https://openalex.org/I1299303238 |
| locations[1].source.host_organization_name | National Institutes of Health |
| locations[1].source.host_organization_lineage | https://openalex.org/I1299303238 |
| locations[1].license | |
| locations[1].pdf_url | |
| locations[1].version | publishedVersion |
| locations[1].raw_type | |
| locations[1].license_id | |
| locations[1].is_accepted | True |
| locations[1].is_published | True |
| locations[1].raw_source_name | Circulation |
| locations[1].landing_page_url | https://pubmed.ncbi.nlm.nih.gov/27899395 |
| locations[2].id | pmh:oai:HAL:hal-02996529v1 |
| locations[2].is_oa | False |
| locations[2].source.id | https://openalex.org/S4306402512 |
| locations[2].source.issn | |
| locations[2].source.type | repository |
| locations[2].source.is_oa | False |
| locations[2].source.issn_l | |
| locations[2].source.is_core | False |
| locations[2].source.is_in_doaj | False |
| locations[2].source.display_name | HAL (Le Centre pour la Communication Scientifique Directe) |
| locations[2].source.host_organization | https://openalex.org/I1294671590 |
| locations[2].source.host_organization_name | Centre National de la Recherche Scientifique |
| locations[2].source.host_organization_lineage | https://openalex.org/I1294671590 |
| locations[2].license | |
| locations[2].pdf_url | |
| locations[2].version | submittedVersion |
| locations[2].raw_type | Journal articles |
| locations[2].license_id | |
| locations[2].is_accepted | False |
| locations[2].is_published | False |
| locations[2].raw_source_name | Circulation, 2017, 135 (8), pp.786-805. ⟨10.1161/CIRCULATIONAHA.116.024754⟩ |
| locations[2].landing_page_url | https://hal.science/hal-02996529 |
| indexed_in | crossref, pubmed |
| authorships[0].author.id | https://openalex.org/A5044696095 |
| authorships[0].author.orcid | https://orcid.org/0000-0002-3511-0029 |
| authorships[0].author.display_name | Jatin Patel |
| authorships[0].countries | AU |
| authorships[0].affiliations[0].institution_ids | https://openalex.org/I165143802 |
| authorships[0].affiliations[0].raw_affiliation_string | The University of Queensland, School of Mathematics and Physics, Brisbane, QLD, Australia (Z.N.) |
| authorships[0].affiliations[1].institution_ids | https://openalex.org/I1308309334, https://openalex.org/I165143802 |
| authorships[0].affiliations[1].raw_affiliation_string | The University of Queensland, UQ Diamantina Institute, Translational Research Institute, Woolloongabba, QLD, Australia (P.D., K.K.) |
| authorships[0].affiliations[2].institution_ids | https://openalex.org/I165143802 |
| authorships[0].affiliations[2].raw_affiliation_string | The University of Queensland, Institute of Molecular Biosciences, Brisbane, QLD, Australia (M.F.). |
| authorships[0].affiliations[3].institution_ids | https://openalex.org/I1308309334, https://openalex.org/I165143802 |
| authorships[0].affiliations[3].raw_affiliation_string | From The University of Queensland, UQ Centre for Clinical Research, Experimental Dermatology Group, Brisbane, QLD, Australia (J.P., E.J.S., M.P.R., H.Y.W., N.M.F., K.K.); The University of Queensland, UQ Diamantina Institute, Translational Research Institute, Woolloongabba, QLD, Australia (P.D., K.K.); The University of Queensland, School of Mathematics and Physics, Brisbane, QLD, Australia (Z.N.); and The University of Queensland, Institute of Molecular Biosciences, Brisbane, QLD, Australia (M.F.). |
| authorships[0].institutions[0].id | https://openalex.org/I165143802 |
| authorships[0].institutions[0].ror | https://ror.org/00rqy9422 |
| authorships[0].institutions[0].type | education |
| authorships[0].institutions[0].lineage | https://openalex.org/I165143802 |
| authorships[0].institutions[0].country_code | AU |
| authorships[0].institutions[0].display_name | The University of Queensland |
| authorships[0].institutions[1].id | https://openalex.org/I1308309334 |
| authorships[0].institutions[1].ror | https://ror.org/00v807439 |
| authorships[0].institutions[1].type | facility |
| authorships[0].institutions[1].lineage | https://openalex.org/I1308309334 |
| authorships[0].institutions[1].country_code | AU |
| authorships[0].institutions[1].display_name | Translational Research Institute |
| authorships[0].author_position | first |
| authorships[0].raw_author_name | Jatin Patel |
| authorships[0].is_corresponding | False |
| authorships[0].raw_affiliation_strings | From The University of Queensland, UQ Centre for Clinical Research, Experimental Dermatology Group, Brisbane, QLD, Australia (J.P., E.J.S., M.P.R., H.Y.W., N.M.F., K.K.); The University of Queensland, UQ Diamantina Institute, Translational Research Institute, Woolloongabba, QLD, Australia (P.D., K.K.); The University of Queensland, School of Mathematics and Physics, Brisbane, QLD, Australia (Z.N.); and The University of Queensland, Institute of Molecular Biosciences, Brisbane, QLD, Australia (M.F.)., The University of Queensland, Institute of Molecular Biosciences, Brisbane, QLD, Australia (M.F.)., The University of Queensland, School of Mathematics and Physics, Brisbane, QLD, Australia (Z.N.), The University of Queensland, UQ Diamantina Institute, Translational Research Institute, Woolloongabba, QLD, Australia (P.D., K.K.) |
| authorships[1].author.id | https://openalex.org/A5061621490 |
| authorships[1].author.orcid | https://orcid.org/0000-0003-1673-4167 |
| authorships[1].author.display_name | Elke Seppanen |
| authorships[1].countries | AU |
| authorships[1].affiliations[0].institution_ids | https://openalex.org/I165143802 |
| authorships[1].affiliations[0].raw_affiliation_string | The University of Queensland, Institute of Molecular Biosciences, Brisbane, QLD, Australia (M.F.). |
| authorships[1].affiliations[1].institution_ids | https://openalex.org/I1308309334, https://openalex.org/I165143802 |
| authorships[1].affiliations[1].raw_affiliation_string | The University of Queensland, UQ Diamantina Institute, Translational Research Institute, Woolloongabba, QLD, Australia (P.D., K.K.) |
| authorships[1].affiliations[2].institution_ids | https://openalex.org/I165143802 |
| authorships[1].affiliations[2].raw_affiliation_string | The University of Queensland, School of Mathematics and Physics, Brisbane, QLD, Australia (Z.N.) |
| authorships[1].affiliations[3].institution_ids | https://openalex.org/I1308309334, https://openalex.org/I165143802 |
| authorships[1].affiliations[3].raw_affiliation_string | From The University of Queensland, UQ Centre for Clinical Research, Experimental Dermatology Group, Brisbane, QLD, Australia (J.P., E.J.S., M.P.R., H.Y.W., N.M.F., K.K.); The University of Queensland, UQ Diamantina Institute, Translational Research Institute, Woolloongabba, QLD, Australia (P.D., K.K.); The University of Queensland, School of Mathematics and Physics, Brisbane, QLD, Australia (Z.N.); and The University of Queensland, Institute of Molecular Biosciences, Brisbane, QLD, Australia (M.F.). |
| authorships[1].institutions[0].id | https://openalex.org/I165143802 |
| authorships[1].institutions[0].ror | https://ror.org/00rqy9422 |
| authorships[1].institutions[0].type | education |
| authorships[1].institutions[0].lineage | https://openalex.org/I165143802 |
| authorships[1].institutions[0].country_code | AU |
| authorships[1].institutions[0].display_name | The University of Queensland |
| authorships[1].institutions[1].id | https://openalex.org/I1308309334 |
| authorships[1].institutions[1].ror | https://ror.org/00v807439 |
| authorships[1].institutions[1].type | facility |
| authorships[1].institutions[1].lineage | https://openalex.org/I1308309334 |
| authorships[1].institutions[1].country_code | AU |
| authorships[1].institutions[1].display_name | Translational Research Institute |
| authorships[1].author_position | middle |
| authorships[1].raw_author_name | Elke J. Seppanen |
| authorships[1].is_corresponding | False |
| authorships[1].raw_affiliation_strings | From The University of Queensland, UQ Centre for Clinical Research, Experimental Dermatology Group, Brisbane, QLD, Australia (J.P., E.J.S., M.P.R., H.Y.W., N.M.F., K.K.); The University of Queensland, UQ Diamantina Institute, Translational Research Institute, Woolloongabba, QLD, Australia (P.D., K.K.); The University of Queensland, School of Mathematics and Physics, Brisbane, QLD, Australia (Z.N.); and The University of Queensland, Institute of Molecular Biosciences, Brisbane, QLD, Australia (M.F.)., The University of Queensland, Institute of Molecular Biosciences, Brisbane, QLD, Australia (M.F.)., The University of Queensland, School of Mathematics and Physics, Brisbane, QLD, Australia (Z.N.), The University of Queensland, UQ Diamantina Institute, Translational Research Institute, Woolloongabba, QLD, Australia (P.D., K.K.) |
| authorships[2].author.id | https://openalex.org/A5063570436 |
| authorships[2].author.orcid | https://orcid.org/0000-0002-1300-0187 |
| authorships[2].author.display_name | Mathieu P. Rodero |
| authorships[2].countries | AU |
| authorships[2].affiliations[0].institution_ids | https://openalex.org/I1308309334, https://openalex.org/I165143802 |
| authorships[2].affiliations[0].raw_affiliation_string | From The University of Queensland, UQ Centre for Clinical Research, Experimental Dermatology Group, Brisbane, QLD, Australia (J.P., E.J.S., M.P.R., H.Y.W., N.M.F., K.K.); The University of Queensland, UQ Diamantina Institute, Translational Research Institute, Woolloongabba, QLD, Australia (P.D., K.K.); The University of Queensland, School of Mathematics and Physics, Brisbane, QLD, Australia (Z.N.); and The University of Queensland, Institute of Molecular Biosciences, Brisbane, QLD, Australia (M.F.). |
| authorships[2].affiliations[1].institution_ids | https://openalex.org/I165143802 |
| authorships[2].affiliations[1].raw_affiliation_string | The University of Queensland, Institute of Molecular Biosciences, Brisbane, QLD, Australia (M.F.). |
| authorships[2].affiliations[2].institution_ids | https://openalex.org/I165143802 |
| authorships[2].affiliations[2].raw_affiliation_string | The University of Queensland, School of Mathematics and Physics, Brisbane, QLD, Australia (Z.N.) |
| authorships[2].affiliations[3].institution_ids | https://openalex.org/I1308309334, https://openalex.org/I165143802 |
| authorships[2].affiliations[3].raw_affiliation_string | The University of Queensland, UQ Diamantina Institute, Translational Research Institute, Woolloongabba, QLD, Australia (P.D., K.K.) |
| authorships[2].institutions[0].id | https://openalex.org/I165143802 |
| authorships[2].institutions[0].ror | https://ror.org/00rqy9422 |
| authorships[2].institutions[0].type | education |
| authorships[2].institutions[0].lineage | https://openalex.org/I165143802 |
| authorships[2].institutions[0].country_code | AU |
| authorships[2].institutions[0].display_name | The University of Queensland |
| authorships[2].institutions[1].id | https://openalex.org/I1308309334 |
| authorships[2].institutions[1].ror | https://ror.org/00v807439 |
| authorships[2].institutions[1].type | facility |
| authorships[2].institutions[1].lineage | https://openalex.org/I1308309334 |
| authorships[2].institutions[1].country_code | AU |
| authorships[2].institutions[1].display_name | Translational Research Institute |
| authorships[2].author_position | middle |
| authorships[2].raw_author_name | Mathieu P. Rodero |
| authorships[2].is_corresponding | False |
| authorships[2].raw_affiliation_strings | From The University of Queensland, UQ Centre for Clinical Research, Experimental Dermatology Group, Brisbane, QLD, Australia (J.P., E.J.S., M.P.R., H.Y.W., N.M.F., K.K.); The University of Queensland, UQ Diamantina Institute, Translational Research Institute, Woolloongabba, QLD, Australia (P.D., K.K.); The University of Queensland, School of Mathematics and Physics, Brisbane, QLD, Australia (Z.N.); and The University of Queensland, Institute of Molecular Biosciences, Brisbane, QLD, Australia (M.F.)., The University of Queensland, Institute of Molecular Biosciences, Brisbane, QLD, Australia (M.F.)., The University of Queensland, School of Mathematics and Physics, Brisbane, QLD, Australia (Z.N.), The University of Queensland, UQ Diamantina Institute, Translational Research Institute, Woolloongabba, QLD, Australia (P.D., K.K.) |
| authorships[3].author.id | https://openalex.org/A5038590583 |
| authorships[3].author.orcid | https://orcid.org/0000-0002-1245-4056 |
| authorships[3].author.display_name | Ho Yi Wong |
| authorships[3].countries | AU |
| authorships[3].affiliations[0].institution_ids | https://openalex.org/I1308309334, https://openalex.org/I165143802 |
| authorships[3].affiliations[0].raw_affiliation_string | The University of Queensland, UQ Diamantina Institute, Translational Research Institute, Woolloongabba, QLD, Australia (P.D., K.K.) |
| authorships[3].affiliations[1].institution_ids | https://openalex.org/I1308309334, https://openalex.org/I165143802 |
| authorships[3].affiliations[1].raw_affiliation_string | From The University of Queensland, UQ Centre for Clinical Research, Experimental Dermatology Group, Brisbane, QLD, Australia (J.P., E.J.S., M.P.R., H.Y.W., N.M.F., K.K.); The University of Queensland, UQ Diamantina Institute, Translational Research Institute, Woolloongabba, QLD, Australia (P.D., K.K.); The University of Queensland, School of Mathematics and Physics, Brisbane, QLD, Australia (Z.N.); and The University of Queensland, Institute of Molecular Biosciences, Brisbane, QLD, Australia (M.F.). |
| authorships[3].affiliations[2].institution_ids | https://openalex.org/I165143802 |
| authorships[3].affiliations[2].raw_affiliation_string | The University of Queensland, Institute of Molecular Biosciences, Brisbane, QLD, Australia (M.F.). |
| authorships[3].affiliations[3].institution_ids | https://openalex.org/I165143802 |
| authorships[3].affiliations[3].raw_affiliation_string | The University of Queensland, School of Mathematics and Physics, Brisbane, QLD, Australia (Z.N.) |
| authorships[3].institutions[0].id | https://openalex.org/I165143802 |
| authorships[3].institutions[0].ror | https://ror.org/00rqy9422 |
| authorships[3].institutions[0].type | education |
| authorships[3].institutions[0].lineage | https://openalex.org/I165143802 |
| authorships[3].institutions[0].country_code | AU |
| authorships[3].institutions[0].display_name | The University of Queensland |
| authorships[3].institutions[1].id | https://openalex.org/I1308309334 |
| authorships[3].institutions[1].ror | https://ror.org/00v807439 |
| authorships[3].institutions[1].type | facility |
| authorships[3].institutions[1].lineage | https://openalex.org/I1308309334 |
| authorships[3].institutions[1].country_code | AU |
| authorships[3].institutions[1].display_name | Translational Research Institute |
| authorships[3].author_position | middle |
| authorships[3].raw_author_name | Ho Yi Wong |
| authorships[3].is_corresponding | False |
| authorships[3].raw_affiliation_strings | From The University of Queensland, UQ Centre for Clinical Research, Experimental Dermatology Group, Brisbane, QLD, Australia (J.P., E.J.S., M.P.R., H.Y.W., N.M.F., K.K.); The University of Queensland, UQ Diamantina Institute, Translational Research Institute, Woolloongabba, QLD, Australia (P.D., K.K.); The University of Queensland, School of Mathematics and Physics, Brisbane, QLD, Australia (Z.N.); and The University of Queensland, Institute of Molecular Biosciences, Brisbane, QLD, Australia (M.F.)., The University of Queensland, Institute of Molecular Biosciences, Brisbane, QLD, Australia (M.F.)., The University of Queensland, School of Mathematics and Physics, Brisbane, QLD, Australia (Z.N.), The University of Queensland, UQ Diamantina Institute, Translational Research Institute, Woolloongabba, QLD, Australia (P.D., K.K.) |
| authorships[4].author.id | https://openalex.org/A5110012447 |
| authorships[4].author.orcid | |
| authorships[4].author.display_name | Prudence Donovan |
| authorships[4].countries | AU |
| authorships[4].affiliations[0].institution_ids | https://openalex.org/I165143802 |
| authorships[4].affiliations[0].raw_affiliation_string | The University of Queensland, School of Mathematics and Physics, Brisbane, QLD, Australia (Z.N.) |
| authorships[4].affiliations[1].institution_ids | https://openalex.org/I165143802 |
| authorships[4].affiliations[1].raw_affiliation_string | The University of Queensland, Institute of Molecular Biosciences, Brisbane, QLD, Australia (M.F.). |
| authorships[4].affiliations[2].institution_ids | https://openalex.org/I1308309334, https://openalex.org/I165143802 |
| authorships[4].affiliations[2].raw_affiliation_string | The University of Queensland, UQ Diamantina Institute, Translational Research Institute, Woolloongabba, QLD, Australia (P.D., K.K.) |
| authorships[4].affiliations[3].institution_ids | https://openalex.org/I1308309334, https://openalex.org/I165143802 |
| authorships[4].affiliations[3].raw_affiliation_string | From The University of Queensland, UQ Centre for Clinical Research, Experimental Dermatology Group, Brisbane, QLD, Australia (J.P., E.J.S., M.P.R., H.Y.W., N.M.F., K.K.); The University of Queensland, UQ Diamantina Institute, Translational Research Institute, Woolloongabba, QLD, Australia (P.D., K.K.); The University of Queensland, School of Mathematics and Physics, Brisbane, QLD, Australia (Z.N.); and The University of Queensland, Institute of Molecular Biosciences, Brisbane, QLD, Australia (M.F.). |
| authorships[4].institutions[0].id | https://openalex.org/I165143802 |
| authorships[4].institutions[0].ror | https://ror.org/00rqy9422 |
| authorships[4].institutions[0].type | education |
| authorships[4].institutions[0].lineage | https://openalex.org/I165143802 |
| authorships[4].institutions[0].country_code | AU |
| authorships[4].institutions[0].display_name | The University of Queensland |
| authorships[4].institutions[1].id | https://openalex.org/I1308309334 |
| authorships[4].institutions[1].ror | https://ror.org/00v807439 |
| authorships[4].institutions[1].type | facility |
| authorships[4].institutions[1].lineage | https://openalex.org/I1308309334 |
| authorships[4].institutions[1].country_code | AU |
| authorships[4].institutions[1].display_name | Translational Research Institute |
| authorships[4].author_position | middle |
| authorships[4].raw_author_name | Prudence Donovan |
| authorships[4].is_corresponding | False |
| authorships[4].raw_affiliation_strings | From The University of Queensland, UQ Centre for Clinical Research, Experimental Dermatology Group, Brisbane, QLD, Australia (J.P., E.J.S., M.P.R., H.Y.W., N.M.F., K.K.); The University of Queensland, UQ Diamantina Institute, Translational Research Institute, Woolloongabba, QLD, Australia (P.D., K.K.); The University of Queensland, School of Mathematics and Physics, Brisbane, QLD, Australia (Z.N.); and The University of Queensland, Institute of Molecular Biosciences, Brisbane, QLD, Australia (M.F.)., The University of Queensland, Institute of Molecular Biosciences, Brisbane, QLD, Australia (M.F.)., The University of Queensland, School of Mathematics and Physics, Brisbane, QLD, Australia (Z.N.), The University of Queensland, UQ Diamantina Institute, Translational Research Institute, Woolloongabba, QLD, Australia (P.D., K.K.) |
| authorships[5].author.id | https://openalex.org/A5055338740 |
| authorships[5].author.orcid | https://orcid.org/0000-0003-3236-9278 |
| authorships[5].author.display_name | Zoltán Neufeld |
| authorships[5].countries | AU |
| authorships[5].affiliations[0].institution_ids | https://openalex.org/I165143802 |
| authorships[5].affiliations[0].raw_affiliation_string | The University of Queensland, Institute of Molecular Biosciences, Brisbane, QLD, Australia (M.F.). |
| authorships[5].affiliations[1].institution_ids | https://openalex.org/I165143802 |
| authorships[5].affiliations[1].raw_affiliation_string | The University of Queensland, School of Mathematics and Physics, Brisbane, QLD, Australia (Z.N.) |
| authorships[5].affiliations[2].institution_ids | https://openalex.org/I1308309334, https://openalex.org/I165143802 |
| authorships[5].affiliations[2].raw_affiliation_string | From The University of Queensland, UQ Centre for Clinical Research, Experimental Dermatology Group, Brisbane, QLD, Australia (J.P., E.J.S., M.P.R., H.Y.W., N.M.F., K.K.); The University of Queensland, UQ Diamantina Institute, Translational Research Institute, Woolloongabba, QLD, Australia (P.D., K.K.); The University of Queensland, School of Mathematics and Physics, Brisbane, QLD, Australia (Z.N.); and The University of Queensland, Institute of Molecular Biosciences, Brisbane, QLD, Australia (M.F.). |
| authorships[5].affiliations[3].institution_ids | https://openalex.org/I1308309334, https://openalex.org/I165143802 |
| authorships[5].affiliations[3].raw_affiliation_string | The University of Queensland, UQ Diamantina Institute, Translational Research Institute, Woolloongabba, QLD, Australia (P.D., K.K.) |
| authorships[5].institutions[0].id | https://openalex.org/I165143802 |
| authorships[5].institutions[0].ror | https://ror.org/00rqy9422 |
| authorships[5].institutions[0].type | education |
| authorships[5].institutions[0].lineage | https://openalex.org/I165143802 |
| authorships[5].institutions[0].country_code | AU |
| authorships[5].institutions[0].display_name | The University of Queensland |
| authorships[5].institutions[1].id | https://openalex.org/I1308309334 |
| authorships[5].institutions[1].ror | https://ror.org/00v807439 |
| authorships[5].institutions[1].type | facility |
| authorships[5].institutions[1].lineage | https://openalex.org/I1308309334 |
| authorships[5].institutions[1].country_code | AU |
| authorships[5].institutions[1].display_name | Translational Research Institute |
| authorships[5].author_position | middle |
| authorships[5].raw_author_name | Zoltan Neufeld |
| authorships[5].is_corresponding | False |
| authorships[5].raw_affiliation_strings | From The University of Queensland, UQ Centre for Clinical Research, Experimental Dermatology Group, Brisbane, QLD, Australia (J.P., E.J.S., M.P.R., H.Y.W., N.M.F., K.K.); The University of Queensland, UQ Diamantina Institute, Translational Research Institute, Woolloongabba, QLD, Australia (P.D., K.K.); The University of Queensland, School of Mathematics and Physics, Brisbane, QLD, Australia (Z.N.); and The University of Queensland, Institute of Molecular Biosciences, Brisbane, QLD, Australia (M.F.)., The University of Queensland, Institute of Molecular Biosciences, Brisbane, QLD, Australia (M.F.)., The University of Queensland, School of Mathematics and Physics, Brisbane, QLD, Australia (Z.N.), The University of Queensland, UQ Diamantina Institute, Translational Research Institute, Woolloongabba, QLD, Australia (P.D., K.K.) |
| authorships[6].author.id | https://openalex.org/A5003945445 |
| authorships[6].author.orcid | https://orcid.org/0000-0003-0031-7975 |
| authorships[6].author.display_name | Nicholas M. Fisk |
| authorships[6].countries | AU |
| authorships[6].affiliations[0].institution_ids | https://openalex.org/I1308309334, https://openalex.org/I165143802 |
| authorships[6].affiliations[0].raw_affiliation_string | From The University of Queensland, UQ Centre for Clinical Research, Experimental Dermatology Group, Brisbane, QLD, Australia (J.P., E.J.S., M.P.R., H.Y.W., N.M.F., K.K.); The University of Queensland, UQ Diamantina Institute, Translational Research Institute, Woolloongabba, QLD, Australia (P.D., K.K.); The University of Queensland, School of Mathematics and Physics, Brisbane, QLD, Australia (Z.N.); and The University of Queensland, Institute of Molecular Biosciences, Brisbane, QLD, Australia (M.F.). |
| authorships[6].affiliations[1].institution_ids | https://openalex.org/I165143802 |
| authorships[6].affiliations[1].raw_affiliation_string | The University of Queensland, Institute of Molecular Biosciences, Brisbane, QLD, Australia (M.F.). |
| authorships[6].affiliations[2].institution_ids | https://openalex.org/I1308309334, https://openalex.org/I165143802 |
| authorships[6].affiliations[2].raw_affiliation_string | The University of Queensland, UQ Diamantina Institute, Translational Research Institute, Woolloongabba, QLD, Australia (P.D., K.K.) |
| authorships[6].affiliations[3].institution_ids | https://openalex.org/I165143802 |
| authorships[6].affiliations[3].raw_affiliation_string | The University of Queensland, School of Mathematics and Physics, Brisbane, QLD, Australia (Z.N.) |
| authorships[6].institutions[0].id | https://openalex.org/I165143802 |
| authorships[6].institutions[0].ror | https://ror.org/00rqy9422 |
| authorships[6].institutions[0].type | education |
| authorships[6].institutions[0].lineage | https://openalex.org/I165143802 |
| authorships[6].institutions[0].country_code | AU |
| authorships[6].institutions[0].display_name | The University of Queensland |
| authorships[6].institutions[1].id | https://openalex.org/I1308309334 |
| authorships[6].institutions[1].ror | https://ror.org/00v807439 |
| authorships[6].institutions[1].type | facility |
| authorships[6].institutions[1].lineage | https://openalex.org/I1308309334 |
| authorships[6].institutions[1].country_code | AU |
| authorships[6].institutions[1].display_name | Translational Research Institute |
| authorships[6].author_position | middle |
| authorships[6].raw_author_name | Nicholas M. Fisk |
| authorships[6].is_corresponding | False |
| authorships[6].raw_affiliation_strings | From The University of Queensland, UQ Centre for Clinical Research, Experimental Dermatology Group, Brisbane, QLD, Australia (J.P., E.J.S., M.P.R., H.Y.W., N.M.F., K.K.); The University of Queensland, UQ Diamantina Institute, Translational Research Institute, Woolloongabba, QLD, Australia (P.D., K.K.); The University of Queensland, School of Mathematics and Physics, Brisbane, QLD, Australia (Z.N.); and The University of Queensland, Institute of Molecular Biosciences, Brisbane, QLD, Australia (M.F.)., The University of Queensland, Institute of Molecular Biosciences, Brisbane, QLD, Australia (M.F.)., The University of Queensland, School of Mathematics and Physics, Brisbane, QLD, Australia (Z.N.), The University of Queensland, UQ Diamantina Institute, Translational Research Institute, Woolloongabba, QLD, Australia (P.D., K.K.) |
| authorships[7].author.id | https://openalex.org/A5000281775 |
| authorships[7].author.orcid | https://orcid.org/0000-0002-9846-6882 |
| authorships[7].author.display_name | Mathias François |
| authorships[7].countries | AU |
| authorships[7].affiliations[0].institution_ids | https://openalex.org/I165143802 |
| authorships[7].affiliations[0].raw_affiliation_string | The University of Queensland, Institute of Molecular Biosciences, Brisbane, QLD, Australia (M.F.). |
| authorships[7].affiliations[1].institution_ids | https://openalex.org/I165143802 |
| authorships[7].affiliations[1].raw_affiliation_string | The University of Queensland, School of Mathematics and Physics, Brisbane, QLD, Australia (Z.N.) |
| authorships[7].affiliations[2].institution_ids | https://openalex.org/I1308309334, https://openalex.org/I165143802 |
| authorships[7].affiliations[2].raw_affiliation_string | The University of Queensland, UQ Diamantina Institute, Translational Research Institute, Woolloongabba, QLD, Australia (P.D., K.K.) |
| authorships[7].affiliations[3].institution_ids | https://openalex.org/I1308309334, https://openalex.org/I165143802 |
| authorships[7].affiliations[3].raw_affiliation_string | From The University of Queensland, UQ Centre for Clinical Research, Experimental Dermatology Group, Brisbane, QLD, Australia (J.P., E.J.S., M.P.R., H.Y.W., N.M.F., K.K.); The University of Queensland, UQ Diamantina Institute, Translational Research Institute, Woolloongabba, QLD, Australia (P.D., K.K.); The University of Queensland, School of Mathematics and Physics, Brisbane, QLD, Australia (Z.N.); and The University of Queensland, Institute of Molecular Biosciences, Brisbane, QLD, Australia (M.F.). |
| authorships[7].institutions[0].id | https://openalex.org/I165143802 |
| authorships[7].institutions[0].ror | https://ror.org/00rqy9422 |
| authorships[7].institutions[0].type | education |
| authorships[7].institutions[0].lineage | https://openalex.org/I165143802 |
| authorships[7].institutions[0].country_code | AU |
| authorships[7].institutions[0].display_name | The University of Queensland |
| authorships[7].institutions[1].id | https://openalex.org/I1308309334 |
| authorships[7].institutions[1].ror | https://ror.org/00v807439 |
| authorships[7].institutions[1].type | facility |
| authorships[7].institutions[1].lineage | https://openalex.org/I1308309334 |
| authorships[7].institutions[1].country_code | AU |
| authorships[7].institutions[1].display_name | Translational Research Institute |
| authorships[7].author_position | middle |
| authorships[7].raw_author_name | Mathias Francois |
| authorships[7].is_corresponding | False |
| authorships[7].raw_affiliation_strings | From The University of Queensland, UQ Centre for Clinical Research, Experimental Dermatology Group, Brisbane, QLD, Australia (J.P., E.J.S., M.P.R., H.Y.W., N.M.F., K.K.); The University of Queensland, UQ Diamantina Institute, Translational Research Institute, Woolloongabba, QLD, Australia (P.D., K.K.); The University of Queensland, School of Mathematics and Physics, Brisbane, QLD, Australia (Z.N.); and The University of Queensland, Institute of Molecular Biosciences, Brisbane, QLD, Australia (M.F.)., The University of Queensland, Institute of Molecular Biosciences, Brisbane, QLD, Australia (M.F.)., The University of Queensland, School of Mathematics and Physics, Brisbane, QLD, Australia (Z.N.), The University of Queensland, UQ Diamantina Institute, Translational Research Institute, Woolloongabba, QLD, Australia (P.D., K.K.) |
| authorships[8].author.id | https://openalex.org/A5035641630 |
| authorships[8].author.orcid | https://orcid.org/0000-0002-6406-4076 |
| authorships[8].author.display_name | Kiarash Khosrotehrani |
| authorships[8].countries | AU |
| authorships[8].affiliations[0].institution_ids | https://openalex.org/I165143802 |
| authorships[8].affiliations[0].raw_affiliation_string | The University of Queensland, School of Mathematics and Physics, Brisbane, QLD, Australia (Z.N.) |
| authorships[8].affiliations[1].institution_ids | https://openalex.org/I1308309334, https://openalex.org/I165143802 |
| authorships[8].affiliations[1].raw_affiliation_string | The University of Queensland, UQ Diamantina Institute, Translational Research Institute, Woolloongabba, QLD, Australia (P.D., K.K.) |
| authorships[8].affiliations[2].institution_ids | https://openalex.org/I165143802 |
| authorships[8].affiliations[2].raw_affiliation_string | The University of Queensland, Institute of Molecular Biosciences, Brisbane, QLD, Australia (M.F.). |
| authorships[8].affiliations[3].institution_ids | https://openalex.org/I1308309334, https://openalex.org/I165143802 |
| authorships[8].affiliations[3].raw_affiliation_string | From The University of Queensland, UQ Centre for Clinical Research, Experimental Dermatology Group, Brisbane, QLD, Australia (J.P., E.J.S., M.P.R., H.Y.W., N.M.F., K.K.); The University of Queensland, UQ Diamantina Institute, Translational Research Institute, Woolloongabba, QLD, Australia (P.D., K.K.); The University of Queensland, School of Mathematics and Physics, Brisbane, QLD, Australia (Z.N.); and The University of Queensland, Institute of Molecular Biosciences, Brisbane, QLD, Australia (M.F.). |
| authorships[8].institutions[0].id | https://openalex.org/I165143802 |
| authorships[8].institutions[0].ror | https://ror.org/00rqy9422 |
| authorships[8].institutions[0].type | education |
| authorships[8].institutions[0].lineage | https://openalex.org/I165143802 |
| authorships[8].institutions[0].country_code | AU |
| authorships[8].institutions[0].display_name | The University of Queensland |
| authorships[8].institutions[1].id | https://openalex.org/I1308309334 |
| authorships[8].institutions[1].ror | https://ror.org/00v807439 |
| authorships[8].institutions[1].type | facility |
| authorships[8].institutions[1].lineage | https://openalex.org/I1308309334 |
| authorships[8].institutions[1].country_code | AU |
| authorships[8].institutions[1].display_name | Translational Research Institute |
| authorships[8].author_position | last |
| authorships[8].raw_author_name | Kiarash Khosrotehrani |
| authorships[8].is_corresponding | False |
| authorships[8].raw_affiliation_strings | From The University of Queensland, UQ Centre for Clinical Research, Experimental Dermatology Group, Brisbane, QLD, Australia (J.P., E.J.S., M.P.R., H.Y.W., N.M.F., K.K.); The University of Queensland, UQ Diamantina Institute, Translational Research Institute, Woolloongabba, QLD, Australia (P.D., K.K.); The University of Queensland, School of Mathematics and Physics, Brisbane, QLD, Australia (Z.N.); and The University of Queensland, Institute of Molecular Biosciences, Brisbane, QLD, Australia (M.F.)., The University of Queensland, Institute of Molecular Biosciences, Brisbane, QLD, Australia (M.F.)., The University of Queensland, School of Mathematics and Physics, Brisbane, QLD, Australia (Z.N.), The University of Queensland, UQ Diamantina Institute, Translational Research Institute, Woolloongabba, QLD, Australia (P.D., K.K.) |
| has_content.pdf | True |
| has_content.grobid_xml | True |
| is_paratext | False |
| open_access.is_oa | True |
| open_access.oa_url | https://www.ahajournals.org/doi/pdf/10.1161/CIRCULATIONAHA.116.024754 |
| open_access.oa_status | bronze |
| open_access.any_repository_has_fulltext | False |
| created_date | 2025-10-10T00:00:00 |
| display_name | Functional Definition of Progenitors Versus Mature Endothelial Cells Reveals Key SoxF-Dependent Differentiation Process |
| has_fulltext | False |
| is_retracted | False |
| updated_date | 2025-11-06T03:46:38.306776 |
| primary_topic.id | https://openalex.org/T10422 |
| primary_topic.field.id | https://openalex.org/fields/13 |
| primary_topic.field.display_name | Biochemistry, Genetics and Molecular Biology |
| primary_topic.score | 0.9994000196456909 |
| primary_topic.domain.id | https://openalex.org/domains/1 |
| primary_topic.domain.display_name | Life Sciences |
| primary_topic.subfield.id | https://openalex.org/subfields/1312 |
| primary_topic.subfield.display_name | Molecular Biology |
| primary_topic.display_name | Angiogenesis and VEGF in Cancer |
| related_works | https://openalex.org/W2368592645, https://openalex.org/W2355691790, https://openalex.org/W1994953171, https://openalex.org/W1976071046, https://openalex.org/W2379207253, https://openalex.org/W2063301313, https://openalex.org/W2917256950, https://openalex.org/W2382767916, https://openalex.org/W2098743872, https://openalex.org/W2048771968 |
| cited_by_count | 123 |
| counts_by_year[0].year | 2025 |
| counts_by_year[0].cited_by_count | 7 |
| counts_by_year[1].year | 2024 |
| counts_by_year[1].cited_by_count | 9 |
| counts_by_year[2].year | 2023 |
| counts_by_year[2].cited_by_count | 22 |
| counts_by_year[3].year | 2022 |
| counts_by_year[3].cited_by_count | 15 |
| counts_by_year[4].year | 2021 |
| counts_by_year[4].cited_by_count | 21 |
| counts_by_year[5].year | 2020 |
| counts_by_year[5].cited_by_count | 20 |
| counts_by_year[6].year | 2019 |
| counts_by_year[6].cited_by_count | 13 |
| counts_by_year[7].year | 2018 |
| counts_by_year[7].cited_by_count | 12 |
| counts_by_year[8].year | 2017 |
| counts_by_year[8].cited_by_count | 4 |
| locations_count | 3 |
| best_oa_location.id | doi:10.1161/circulationaha.116.024754 |
| best_oa_location.is_oa | True |
| best_oa_location.source.id | https://openalex.org/S116251202 |
| best_oa_location.source.issn | 0009-7322, 1524-4539 |
| best_oa_location.source.type | journal |
| best_oa_location.source.is_oa | False |
| best_oa_location.source.issn_l | 0009-7322 |
| best_oa_location.source.is_core | True |
| best_oa_location.source.is_in_doaj | False |
| best_oa_location.source.display_name | Circulation |
| best_oa_location.source.host_organization | https://openalex.org/P4310315671 |
| best_oa_location.source.host_organization_name | Lippincott Williams & Wilkins |
| best_oa_location.source.host_organization_lineage | https://openalex.org/P4310315671, https://openalex.org/P4310318547 |
| best_oa_location.source.host_organization_lineage_names | Lippincott Williams & Wilkins, Wolters Kluwer |
| best_oa_location.license | |
| best_oa_location.pdf_url | https://www.ahajournals.org/doi/pdf/10.1161/CIRCULATIONAHA.116.024754 |
| best_oa_location.version | publishedVersion |
| best_oa_location.raw_type | journal-article |
| best_oa_location.license_id | |
| best_oa_location.is_accepted | True |
| best_oa_location.is_published | True |
| best_oa_location.raw_source_name | Circulation |
| best_oa_location.landing_page_url | https://doi.org/10.1161/circulationaha.116.024754 |
| primary_location.id | doi:10.1161/circulationaha.116.024754 |
| primary_location.is_oa | True |
| primary_location.source.id | https://openalex.org/S116251202 |
| primary_location.source.issn | 0009-7322, 1524-4539 |
| primary_location.source.type | journal |
| primary_location.source.is_oa | False |
| primary_location.source.issn_l | 0009-7322 |
| primary_location.source.is_core | True |
| primary_location.source.is_in_doaj | False |
| primary_location.source.display_name | Circulation |
| primary_location.source.host_organization | https://openalex.org/P4310315671 |
| primary_location.source.host_organization_name | Lippincott Williams & Wilkins |
| primary_location.source.host_organization_lineage | https://openalex.org/P4310315671, https://openalex.org/P4310318547 |
| primary_location.source.host_organization_lineage_names | Lippincott Williams & Wilkins, Wolters Kluwer |
| primary_location.license | |
| primary_location.pdf_url | https://www.ahajournals.org/doi/pdf/10.1161/CIRCULATIONAHA.116.024754 |
| primary_location.version | publishedVersion |
| primary_location.raw_type | journal-article |
| primary_location.license_id | |
| primary_location.is_accepted | True |
| primary_location.is_published | True |
| primary_location.raw_source_name | Circulation |
| primary_location.landing_page_url | https://doi.org/10.1161/circulationaha.116.024754 |
| publication_date | 2016-11-30 |
| publication_year | 2016 |
| referenced_works | https://openalex.org/W2048320764, https://openalex.org/W2144026946, https://openalex.org/W2053704719, https://openalex.org/W2164902067, https://openalex.org/W2042116568, https://openalex.org/W2145524503, https://openalex.org/W2095132685, https://openalex.org/W2008062232, https://openalex.org/W2127432537, https://openalex.org/W2138756918, https://openalex.org/W1502896205, https://openalex.org/W2164598295, https://openalex.org/W2161892120, https://openalex.org/W2159741565, https://openalex.org/W2032817968, https://openalex.org/W2126138300, https://openalex.org/W1586032297, https://openalex.org/W2169456326, https://openalex.org/W2179438025, https://openalex.org/W1829927964, https://openalex.org/W2050700175, https://openalex.org/W2096856910, https://openalex.org/W2121058001, https://openalex.org/W2091014900, https://openalex.org/W2001609725, https://openalex.org/W2087827471, https://openalex.org/W2027764467, https://openalex.org/W2131515610, https://openalex.org/W2080154785, https://openalex.org/W1964018614, https://openalex.org/W1979251800, https://openalex.org/W2037403597, https://openalex.org/W2033234683, https://openalex.org/W2169401708, https://openalex.org/W1993582702, https://openalex.org/W2344214796, https://openalex.org/W2140211868, https://openalex.org/W2125933184, https://openalex.org/W2166807613, https://openalex.org/W1968034850, https://openalex.org/W2161092951, https://openalex.org/W2113754447, https://openalex.org/W2168537112, https://openalex.org/W1993854911, https://openalex.org/W2074467657, https://openalex.org/W2125039061, https://openalex.org/W2087912166, https://openalex.org/W1968861575, https://openalex.org/W2099136912, https://openalex.org/W1966018836, https://openalex.org/W2048447073, https://openalex.org/W2087363756, https://openalex.org/W2062648563, https://openalex.org/W1872124954, https://openalex.org/W2344737936, https://openalex.org/W1873493820 |
| referenced_works_count | 56 |
| abstract_inverted_index., | 223, 225, 227, 242, 244, 246, 248 |
| abstract_inverted_index.. | 251 |
| abstract_inverted_index.3 | 81 |
| abstract_inverted_index.D | 176, 208, 231, 302 |
| abstract_inverted_index.S | 282 |
| abstract_inverted_index.a | 46, 124, 151, 157 |
| abstract_inverted_index.An | 19 |
| abstract_inverted_index.D, | 321 |
| abstract_inverted_index.In | 210 |
| abstract_inverted_index.TA | 174, 300, 319 |
| abstract_inverted_index.We | 35 |
| abstract_inverted_index.an | 112, 117, 258, 311, 331 |
| abstract_inverted_index.as | 56, 66, 162, 181, 322 |
| abstract_inverted_index.be | 87, 139 |
| abstract_inverted_index.by | 97, 141, 183, 190, 276, 324 |
| abstract_inverted_index.in | 43, 45, 50, 156, 164, 186, 192, 195, 270, 288, 337, 344 |
| abstract_inverted_index.is | 7 |
| abstract_inverted_index.of | 48, 74, 83, 116, 154, 261, 268, 291, 330, 340, 353 |
| abstract_inverted_index.on | 70, 281 |
| abstract_inverted_index.to | 9, 30, 38, 218, 237, 257, 318, 320 |
| abstract_inverted_index.(D) | 127 |
| abstract_inverted_index.EVP | 130, 146, 170, 206, 212, 294, 317 |
| abstract_inverted_index.Our | 308 |
| abstract_inverted_index.RNA | 198, 253 |
| abstract_inverted_index.The | 252, 266 |
| abstract_inverted_index.Vwf | 247 |
| abstract_inverted_index.and | 52, 60, 64, 91, 123, 167, 172, 175, 189, 207, 228, 249, 301, 327 |
| abstract_inverted_index.but | 299 |
| abstract_inverted_index.for | 350 |
| abstract_inverted_index.had | 178 |
| abstract_inverted_index.new | 348 |
| abstract_inverted_index.not | 138, 173 |
| abstract_inverted_index.our | 338 |
| abstract_inverted_index.the | 32, 106, 262, 271, 289 |
| abstract_inverted_index.via | 11 |
| abstract_inverted_index.was | 110, 274 |
| abstract_inverted_index.(TA) | 122 |
| abstract_inverted_index.Cd31 | 245 |
| abstract_inverted_index.ERt2 | 100, 284 |
| abstract_inverted_index.Egfr | 226 |
| abstract_inverted_index.Il33 | 224 |
| abstract_inverted_index.Only | 169 |
| abstract_inverted_index.Sox9 | 222 |
| abstract_inverted_index.This | 334 |
| abstract_inverted_index.able | 29 |
| abstract_inverted_index.also | 255 |
| abstract_inverted_index.beds | 135 |
| abstract_inverted_index.bone | 142 |
| abstract_inverted_index.cell | 159 |
| abstract_inverted_index.flow | 79 |
| abstract_inverted_index.form | 25 |
| abstract_inverted_index.from | 16, 26, 133, 316 |
| abstract_inverted_index.gene | 202 |
| abstract_inverted_index.here | 36 |
| abstract_inverted_index.high | 152 |
| abstract_inverted_index.role | 260, 267 |
| abstract_inverted_index.such | 55 |
| abstract_inverted_index.that | 23, 105, 136 |
| abstract_inverted_index.vivo | 44 |
| abstract_inverted_index.were | 296, 304 |
| abstract_inverted_index.with | 150 |
| abstract_inverted_index.(EVP) | 115 |
| abstract_inverted_index.Based | 69 |
| abstract_inverted_index.Gata2 | 243 |
| abstract_inverted_index.Notch | 250 |
| abstract_inverted_index.SOX18 | 269 |
| abstract_inverted_index.Sox18 | 263 |
| abstract_inverted_index.adult | 2 |
| abstract_inverted_index.aimed | 37 |
| abstract_inverted_index.among | 89 |
| abstract_inverted_index.arose | 132 |
| abstract_inverted_index.based | 280 |
| abstract_inverted_index.blood | 4 |
| abstract_inverted_index.cells | 85, 131, 155, 171, 177, 213, 232 |
| abstract_inverted_index.could | 86, 137 |
| abstract_inverted_index.cycle | 160 |
| abstract_inverted_index.genes | 216, 235 |
| abstract_inverted_index.life, | 3 |
| abstract_inverted_index.mice. | 197, 286 |
| abstract_inverted_index.novel | 313 |
| abstract_inverted_index.occur | 10 |
| abstract_inverted_index.opens | 347 |
| abstract_inverted_index.phase | 161 |
| abstract_inverted_index.plugs | 194 |
| abstract_inverted_index.shift | 336 |
| abstract_inverted_index.still | 297 |
| abstract_inverted_index.using | 78, 98, 277 |
| abstract_inverted_index.well. | 67 |
| abstract_inverted_index.wound | 61 |
| abstract_inverted_index.During | 1 |
| abstract_inverted_index.aorta, | 58 |
| abstract_inverted_index.aorta. | 168 |
| abstract_inverted_index.better | 351 |
| abstract_inverted_index.cells. | 93, 209 |
| abstract_inverted_index.common | 75 |
| abstract_inverted_index.define | 39 |
| abstract_inverted_index.highly | 214, 233 |
| abstract_inverted_index.indeed | 111 |
| abstract_inverted_index.levels | 73 |
| abstract_inverted_index.lungs, | 59 |
| abstract_inverted_index.marrow | 143 |
| abstract_inverted_index.normal | 57 |
| abstract_inverted_index.status | 149 |
| abstract_inverted_index.tissue | 345 |
| abstract_inverted_index.vessel | 5 |
| abstract_inverted_index.CD45– | 92 |
| abstract_inverted_index.Cdh5cre | 99 |
| abstract_inverted_index.Lineage | 95 |
| abstract_inverted_index.absence | 290 |
| abstract_inverted_index.avenues | 349 |
| abstract_inverted_index.between | 205 |
| abstract_inverted_index.defined | 323 |
| abstract_inverted_index.factor. | 265 |
| abstract_inverted_index.intimal | 33 |
| abstract_inverted_index.layers. | 34 |
| abstract_inverted_index.markers | 77 |
| abstract_inverted_index.ox18Cre | 283 |
| abstract_inverted_index.pointed | 256 |
| abstract_inverted_index.process | 273 |
| abstract_inverted_index.protein | 71 |
| abstract_inverted_index.related | 217, 236 |
| abstract_inverted_index.support | 310 |
| abstract_inverted_index.thought | 8 |
| abstract_inverted_index.tissues | 49 |
| abstract_inverted_index.tracing | 96 |
| abstract_inverted_index.transit | 120 |
| abstract_inverted_index.tumors, | 63, 166 |
| abstract_inverted_index.variety | 47 |
| abstract_inverted_index.wounds, | 165 |
| abstract_inverted_index.Besides, | 287 |
| abstract_inverted_index.Matrigel | 193 |
| abstract_inverted_index.Methods: | 68 |
| abstract_inverted_index.Pdfgrα. | 229 |
| abstract_inverted_index.Results: | 94 |
| abstract_inverted_index.assemble | 31 |
| abstract_inverted_index.assessed | 163 |
| abstract_inverted_index.biology. | 355 |
| abstract_inverted_index.capacity | 180, 185 |
| abstract_inverted_index.dilution | 188 |
| abstract_inverted_index.entirely | 312 |
| abstract_inverted_index.existing | 17 |
| abstract_inverted_index.findings | 309 |
| abstract_inverted_index.function | 220 |
| abstract_inverted_index.healing, | 62 |
| abstract_inverted_index.limiting | 187 |
| abstract_inverted_index.paradigm | 335 |
| abstract_inverted_index.present, | 298 |
| abstract_inverted_index.proposal | 21 |
| abstract_inverted_index.reduced. | 306 |
| abstract_inverted_index.reporter | 102 |
| abstract_inverted_index.revealed | 200 |
| abstract_inverted_index.strategy | 103 |
| abstract_inverted_index.suggests | 22 |
| abstract_inverted_index.vessels. | 18 |
| abstract_inverted_index./Rosa-YFP | 101, 285 |
| abstract_inverted_index.alternate | 20 |
| abstract_inverted_index.branching | 15 |
| abstract_inverted_index.displayed | 147 |
| abstract_inverted_index.essential | 259 |
| abstract_inverted_index.expressed | 215, 234 |
| abstract_inverted_index.formation | 6 |
| abstract_inverted_index.including | 221, 240 |
| abstract_inverted_index.involving | 14 |
| abstract_inverted_index.molecular | 328 |
| abstract_inverted_index.placenta, | 65 |
| abstract_inverted_index.processes | 13 |
| abstract_inverted_index.profiling | 329 |
| abstract_inverted_index.prominent | 201 |
| abstract_inverted_index.quiescent | 158 |
| abstract_inverted_index.recipient | 196 |
| abstract_inverted_index.validated | 275 |
| abstract_inverted_index.Ets1&2 | 241 |
| abstract_inverted_index.amplifying | 121 |
| abstract_inverted_index.angiogenic | 12 |
| abstract_inverted_index.cytometry, | 80 |
| abstract_inverted_index.definitive | 125 |
| abstract_inverted_index.expression | 72, 203 |
| abstract_inverted_index.functional | 292 |
| abstract_inverted_index.hierarchy, | 315 |
| abstract_inverted_index.identified | 88 |
| abstract_inverted_index.neovessels | 24 |
| abstract_inverted_index.population | 109 |
| abstract_inverted_index.progenitor | 114, 219 |
| abstract_inverted_index.proportion | 153 |
| abstract_inverted_index.sequencing | 199, 254 |
| abstract_inverted_index.situations | 54 |
| abstract_inverted_index.Background: | 0 |
| abstract_inverted_index.Conversely, | 230 |
| abstract_inverted_index.SOX18/SOXF, | 293 |
| abstract_inverted_index.differences | 204 |
| abstract_inverted_index.endothelial | 27, 41, 76, 84, 108, 314, 332, 342 |
| abstract_inverted_index.endothelium | 239 |
| abstract_inverted_index.experiments | 279 |
| abstract_inverted_index.particular, | 211 |
| abstract_inverted_index.population. | 129 |
| abstract_inverted_index.populations | 303 |
| abstract_inverted_index.progenitor. | 333 |
| abstract_inverted_index.progenitors | 28, 42, 295, 343 |
| abstract_inverted_index.transferred | 140 |
| abstract_inverted_index.Conclusions: | 307 |
| abstract_inverted_index.Furthermore, | 145 |
| abstract_inverted_index.VE-Cadherin+ | 90 |
| abstract_inverted_index.demonstrated | 104, 182 |
| abstract_inverted_index.endovascular | 113 |
| abstract_inverted_index.intermediate | 118 |
| abstract_inverted_index.pathological | 53 |
| abstract_inverted_index.regeneration | 346 |
| abstract_inverted_index.self-renewal | 179 |
| abstract_inverted_index.physiological | 51 |
| abstract_inverted_index.self-renewal, | 325 |
| abstract_inverted_index.significantly | 305 |
| abstract_inverted_index.transcription | 264 |
| abstract_inverted_index.understanding | 339, 352 |
| abstract_inverted_index.cardiovascular | 354 |
| abstract_inverted_index.colony-forming | 184 |
| abstract_inverted_index.differentiated | 126, 238 |
| abstract_inverted_index.subpopulations | 82 |
| abstract_inverted_index.differentiation | 272 |
| abstract_inverted_index.lineage-tracing | 278 |
| abstract_inverted_index.progenitor-like | 148 |
| abstract_inverted_index.transplantation | 191 |
| abstract_inverted_index.vessel-resident | 40 |
| abstract_inverted_index.differentiation, | 326 |
| abstract_inverted_index.transplantation. | 144 |
| abstract_inverted_index.vascular-resident | 134, 341 |
| abstract_inverted_index.CD31hiVEGFR2hi/extracellular | 128 |
| abstract_inverted_index.CD31intVEGFR2lo/intracellular | 119 |
| abstract_inverted_index.CD31–/loVEGFR2lo/intracellular | 107 |
| cited_by_percentile_year.max | 100 |
| cited_by_percentile_year.min | 97 |
| countries_distinct_count | 1 |
| institutions_distinct_count | 9 |
| citation_normalized_percentile.value | 0.96068941 |
| citation_normalized_percentile.is_in_top_1_percent | False |
| citation_normalized_percentile.is_in_top_10_percent | True |