Functional Magnetic Resonance Imaging in the Final Stage of Creutzfeldt-Jakob Disease Article Swipe
Stefan Golaszewski
,
Betty Wutzl
,
Axel F. Unterrainer
,
Cristina Florea
,
Kerstin Schwenker
,
Vanessa Frey
,
Martin Kronbichler
,
Frank Rattay
,
Raffaele Nardone
,
Larissa Hauer
,
Johann Sellner
,
Eugen Trinka
·
YOU?
·
· 2020
· Open Access
·
· DOI: https://doi.org/10.3390/diagnostics10050309
YOU?
·
· 2020
· Open Access
·
· DOI: https://doi.org/10.3390/diagnostics10050309
Sporadic Creutzfeldt-Jakob disease (sCJD) is a rare fatal degenerative disease of the central nervous system. The clinical course is characterized by rapid progression of neurological and neuromuscular symptoms. The late stage with loss of consciousness is not well characterized. We report a 62-year-old male patient with sCJD with the clinical picture of a vegetative state/apallic syndrome, in whom we studied cortical responses using a vibration paradigm. The functional magnetic resonance imaging (fMRI) investigation demonstrated a clear response within the sensorimotor cortex, the cerebellum, the parietal cortex, the insular, and frontal inferior region. The finding of persistent cortical activity on fMRI in a patient with CJD in a state of unconsciousness has implications for the clinical management and for ethical considerations.
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- Type
- article
- Language
- en
- Landing Page
- https://doi.org/10.3390/diagnostics10050309
- https://www.mdpi.com/2075-4418/10/5/309/pdf?version=1589552005
- OA Status
- gold
- Cited By
- 1
- References
- 18
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W3024770536
All OpenAlex metadata
Raw OpenAlex JSON
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https://openalex.org/W3024770536Canonical identifier for this work in OpenAlex
- DOI
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https://doi.org/10.3390/diagnostics10050309Digital Object Identifier
- Title
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Functional Magnetic Resonance Imaging in the Final Stage of Creutzfeldt-Jakob DiseaseWork title
- Type
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articleOpenAlex work type
- Language
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enPrimary language
- Publication year
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2020Year of publication
- Publication date
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2020-05-15Full publication date if available
- Authors
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Stefan Golaszewski, Betty Wutzl, Axel F. Unterrainer, Cristina Florea, Kerstin Schwenker, Vanessa Frey, Martin Kronbichler, Frank Rattay, Raffaele Nardone, Larissa Hauer, Johann Sellner, Eugen TrinkaList of authors in order
- Landing page
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https://doi.org/10.3390/diagnostics10050309Publisher landing page
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https://www.mdpi.com/2075-4418/10/5/309/pdf?version=1589552005Direct link to full text PDF
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YesWhether a free full text is available
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goldOpen access status per OpenAlex
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https://www.mdpi.com/2075-4418/10/5/309/pdf?version=1589552005Direct OA link when available
- Concepts
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Unconsciousness, Functional magnetic resonance imaging, Magnetic resonance imaging, Neuroscience, Cerebellum, Medicine, Cortex (anatomy), Disease, Psychology, Pathology, Psychiatry, RadiologyTop concepts (fields/topics) attached by OpenAlex
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1Total citation count in OpenAlex
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2023: 1Per-year citation counts (last 5 years)
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- Related works (count)
-
10Other works algorithmically related by OpenAlex
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