Functional Mapping of Phenotypic Plasticity of Staphylococcus aureus Under Vancomycin Pressure Article Swipe
Dengcheng Yang
,
Xuyang Zheng
,
Libo Jiang
,
Meixia Ye
,
Xiaoqing He
,
Yi Jin
,
Rongling Wu
·
YOU?
·
· 2021
· Open Access
·
· DOI: https://doi.org/10.3389/fmicb.2021.696730
YOU?
·
· 2021
· Open Access
·
· DOI: https://doi.org/10.3389/fmicb.2021.696730
Phenotypic plasticity is the exhibition of various phenotypic traits produced by a single genotype in response to environmental changes, enabling organisms to adapt to environmental changes by maintaining growth and reproduction. Despite its significance in evolutionary studies, we still know little about the genetic control of phenotypic plasticity. In this study, we designed and conducted a genome-wide association study (GWAS) to reveal genetic architecture of how Staphylococcus aureus strains respond to increasing concentrations of vancomycin (0, 2, 4, and 6 μg/mL) in a time course. We implemented functional mapping, a dynamic model for genetic mapping using longitudinal data, to map specific loci that mediate the growth trajectories of abundance of vancomycin-exposed S. aureus strains. 78 significant single nucleotide polymorphisms were identified following analysis of the whole growth and development process, and seven genes might play a pivotal role in governing phenotypic plasticity to the pressure of vancomycin. These seven genes, SAOUHSC_00020 ( walR ), SAOUHSC_00176, SAOUHSC_00544 ( sdrC ), SAOUHSC_02998, SAOUHSC_00025, SAOUHSC_00169, and SAOUHSC_02023, were found to help S. aureus regulate antibiotic pressure. Our dynamic gene mapping technique provides a tool for dissecting the phenotypic plasticity mechanisms of S. aureus under vancomycin pressure, emphasizing the feasibility and potential of functional mapping in the study of bacterial phenotypic plasticity.
Related Topics
Concepts
Biology
Phenotype
Phenotypic plasticity
Staphylococcus aureus
Genetic architecture
Genetics
Vancomycin
Genome-wide association study
Gene
Single-nucleotide polymorphism
Genotype
Bacteria
Metadata
- Type
- article
- Language
- en
- Landing Page
- https://doi.org/10.3389/fmicb.2021.696730
- https://www.frontiersin.org/articles/10.3389/fmicb.2021.696730/pdf
- OA Status
- gold
- Cited By
- 5
- References
- 55
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W3197280922
All OpenAlex metadata
Raw OpenAlex JSON
- OpenAlex ID
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https://openalex.org/W3197280922Canonical identifier for this work in OpenAlex
- DOI
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https://doi.org/10.3389/fmicb.2021.696730Digital Object Identifier
- Title
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Functional Mapping of Phenotypic Plasticity of Staphylococcus aureus Under Vancomycin PressureWork title
- Type
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articleOpenAlex work type
- Language
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enPrimary language
- Publication year
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2021Year of publication
- Publication date
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2021-09-09Full publication date if available
- Authors
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Dengcheng Yang, Xuyang Zheng, Libo Jiang, Meixia Ye, Xiaoqing He, Yi Jin, Rongling WuList of authors in order
- Landing page
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https://doi.org/10.3389/fmicb.2021.696730Publisher landing page
- PDF URL
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https://www.frontiersin.org/articles/10.3389/fmicb.2021.696730/pdfDirect link to full text PDF
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YesWhether a free full text is available
- OA status
-
goldOpen access status per OpenAlex
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https://www.frontiersin.org/articles/10.3389/fmicb.2021.696730/pdfDirect OA link when available
- Concepts
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Biology, Phenotype, Phenotypic plasticity, Staphylococcus aureus, Genetic architecture, Genetics, Vancomycin, Genome-wide association study, Gene, Single-nucleotide polymorphism, Genotype, BacteriaTop concepts (fields/topics) attached by OpenAlex
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5Total citation count in OpenAlex
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2025: 2, 2024: 2, 2022: 1Per-year citation counts (last 5 years)
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-
10Other works algorithmically related by OpenAlex
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