Functional muscle hypertrophy by increased insulin‐like growth factor 1 does not require dysferlin Article Swipe
Elisabeth R. Barton
,
Jennifer Pham
,
Becky K. Brisson
,
Soo-Hyun Park
,
Lucas Smith
,
Min Liu
,
Zuozhen Tian
,
David W. Hammers
,
Georgios Vassilakos
,
H. Lee Sweeney
·
YOU?
·
· 2019
· Open Access
·
· DOI: https://doi.org/10.1002/mus.26641
YOU?
·
· 2019
· Open Access
·
· DOI: https://doi.org/10.1002/mus.26641
Introduction Dysferlin loss‐of‐function mutations cause muscular dystrophy, accompanied by impaired membrane repair and muscle weakness. Growth promoting strategies including insulin‐like growth factor 1 (IGF‐1) could provide benefit but may cause strength loss or be ineffective. The objective of this study was to determine whether locally increased IGF‐1 promotes functional muscle hypertrophy in dysferlin‐null ( Dysf −/− ) mice. Methods Muscle‐specific transgenic expression and postnatal viral delivery of Igf1 were used in Dysf −/− and control mice. Increased IGF‐1 levels were confirmed by enzyme‐linked immunosorbent assay. Testing for skeletal muscle mass and function was performed in male and female mice. Results Muscle hypertrophy occurred in response to increased IGF‐1 in mice with and without dysferlin. Male mice showed a more robust response compared with females. Increased IGF‐1 did not cause loss of force per cross‐sectional area in Dysf −/− muscles. Discussion We conclude that increased local IGF‐1 promotes functional hypertrophy when dysferlin is absent and reestablishes IGF‐1 as a potential therapeutic for dysferlinopathies.
Related Topics
Concepts
Dysferlin
Muscle hypertrophy
Internal medicine
Medicine
Endocrinology
Insulin-like growth factor
Insulin
Growth factor
Skeletal muscle
Receptor
Metadata
- Type
- article
- Language
- en
- Landing Page
- https://doi.org/10.1002/mus.26641
- OA Status
- hybrid
- Cited By
- 7
- References
- 44
- Related Works
- 10
- OpenAlex ID
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All OpenAlex metadata
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https://openalex.org/W2962726916Canonical identifier for this work in OpenAlex
- DOI
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https://doi.org/10.1002/mus.26641Digital Object Identifier
- Title
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Functional muscle hypertrophy by increased insulin‐like growth factor 1 does not require dysferlinWork title
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articleOpenAlex work type
- Language
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enPrimary language
- Publication year
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2019Year of publication
- Publication date
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2019-07-19Full publication date if available
- Authors
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Elisabeth R. Barton, Jennifer Pham, Becky K. Brisson, Soo-Hyun Park, Lucas Smith, Min Liu, Zuozhen Tian, David W. Hammers, Georgios Vassilakos, H. Lee SweeneyList of authors in order
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https://doi.org/10.1002/mus.26641Publisher landing page
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YesWhether a free full text is available
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hybridOpen access status per OpenAlex
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https://doi.org/10.1002/mus.26641Direct OA link when available
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Dysferlin, Muscle hypertrophy, Internal medicine, Medicine, Endocrinology, Insulin-like growth factor, Insulin, Growth factor, Skeletal muscle, ReceptorTop concepts (fields/topics) attached by OpenAlex
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7Total citation count in OpenAlex
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2023: 2, 2021: 2, 2020: 1, 2019: 1Per-year citation counts (last 5 years)
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10Other works algorithmically related by OpenAlex
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| citation_normalized_percentile.value | 0.6011146 |
| citation_normalized_percentile.is_in_top_1_percent | False |
| citation_normalized_percentile.is_in_top_10_percent | False |