Functional regionalization of the differentiating cerebellar Purkinje cell population occurs in an activity-dependent manner Article Swipe
Alessandro Dorigo
,
Komali Valishetti
,
Florian Hetsch
,
Hideaki Matsui
,
Jochen C. Meier
,
Kazuhiko Namikawa
,
Reinhard W. Köster
·
YOU?
·
· 2023
· Open Access
·
· DOI: https://doi.org/10.3389/fnmol.2023.1166900
YOU?
·
· 2023
· Open Access
·
· DOI: https://doi.org/10.3389/fnmol.2023.1166900
Introduction The cerebellum is organized into functional regions each dedicated to process different motor or sensory inputs for controlling different locomotor behaviors. This functional regionalization is prominent in the evolutionary conserved single-cell layered Purkinje cell (PC) population. Fragmented gene expression domains suggest a genetic organization of PC layer regionalization during cerebellum development. However, the establishment of such functionally specific domains during PC differentiation remained elusive. Methods and results We show the progressive emergence of functional regionalization of PCs from broad responses to spatially restricted regions in zebrafish by means of in vivo Ca2+-imaging during stereotypic locomotive behavior. Moreover, we reveal that formation of new dendritic spines during cerebellar development using in vivo imaging parallels the time course of functional domain development. Pharmacological as well as cell-type specific optogenetic inhibition of PC neuronal activity results in reduced PC dendritic spine density and an altered stagnant pattern of functional domain formation in the PC layer. Discussion Hence, our study suggests that functional regionalization of the PC layer is driven by physiological activity of maturing PCs themselves.
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- Type
- article
- Language
- en
- Landing Page
- https://doi.org/10.3389/fnmol.2023.1166900
- https://www.frontiersin.org/articles/10.3389/fnmol.2023.1166900/pdf?isPublishedV2=False
- OA Status
- gold
- Cited By
- 7
- References
- 38
- Related Works
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- OpenAlex ID
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Raw OpenAlex JSON
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https://openalex.org/W4367184010Canonical identifier for this work in OpenAlex
- DOI
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https://doi.org/10.3389/fnmol.2023.1166900Digital Object Identifier
- Title
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Functional regionalization of the differentiating cerebellar Purkinje cell population occurs in an activity-dependent mannerWork title
- Type
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articleOpenAlex work type
- Language
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enPrimary language
- Publication year
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2023Year of publication
- Publication date
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2023-04-27Full publication date if available
- Authors
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Alessandro Dorigo, Komali Valishetti, Florian Hetsch, Hideaki Matsui, Jochen C. Meier, Kazuhiko Namikawa, Reinhard W. KösterList of authors in order
- Landing page
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https://doi.org/10.3389/fnmol.2023.1166900Publisher landing page
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https://www.frontiersin.org/articles/10.3389/fnmol.2023.1166900/pdf?isPublishedV2=FalseDirect link to full text PDF
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YesWhether a free full text is available
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goldOpen access status per OpenAlex
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https://www.frontiersin.org/articles/10.3389/fnmol.2023.1166900/pdf?isPublishedV2=FalseDirect OA link when available
- Concepts
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Neuroscience, Purkinje cell, Cerebellum, Population, Biology, Medicine, Environmental healthTop concepts (fields/topics) attached by OpenAlex
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7Total citation count in OpenAlex
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2025: 3, 2024: 2, 2023: 2Per-year citation counts (last 5 years)
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10Other works algorithmically related by OpenAlex
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