Future treatments for hepatitis delta virus infection Article Swipe
Tarik Asselah
,
Dimitri Loureiro
,
Issam Tout
,
Corinne Castelnau
,
Nathalie Boyer
,
Patrick Marcellin
,
Abdellah Mansouri
·
YOU?
·
· 2020
· Open Access
·
· DOI: https://doi.org/10.1111/liv.14356
YOU?
·
· 2020
· Open Access
·
· DOI: https://doi.org/10.1111/liv.14356
Around 15‐20 million people develop chronic hepatitis delta virus worldwide. Hepatitis delta virus (HDV) is a defective RNA virus requiring the presence of the hepatitis B virus surface antigen (HBsAg) to complete its life cycle. HDV infects hepatocytes using the hepatitis B virus (HBV) receptor, the sodium taurocholate cotransporting polypeptide (NTCP). The HDV genome is a circular single‐stranded RNA which encodes for a single hepatitis delta antigen (HDAg) that exists in two forms (S‐HDAg and L‐HDAg), and its replication is mediated by the host RNA polymerases. The HBsAg‐coated HDV virions contain a ribonucleoprotein (RNP) formed by the RNA genome packaged with small and large HDAg. Farnesylation of the L‐HDAg is the limiting step for anchoring this RNP to HBsAg, and thus for assembling, secreting and propagating virion particles. There is an important risk of morbidity and mortality caused by end‐stage liver disease and hepatocellular carcinoma with HDV and current treatment is pegylated‐interferon (PEG‐IFN) for 48 weeks with no other options in patients who fail treatment. The ideal goal for HDV treatment is the clearance of HBsAg, but a reasonably achievable goal is a sustained HDV virological response (negative HDV RNA 6 months after stopping treatment). New drug development must take into account the interaction of HBV and HDV. In this review, we will present the new insights in the HDV life cycle that have led to the development of novel classes of drugs and discuss antiviral approaches in phase II and III of development: bulevirtide (entry inhibitor), lonafarnib, (prenylation inhibitor) and REP 2139 (HBsAg release inhibitor).
Related Topics
Concepts
Hepatitis D virus
Hepatitis D
Virology
HBsAg
Hepatitis B virus
Virus
RNA
Hepatitis B
Biology
Medicine
Gene
Genetics
Metadata
- Type
- review
- Language
- en
- Landing Page
- https://doi.org/10.1111/liv.14356
- https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/liv.14356
- OA Status
- bronze
- Cited By
- 43
- References
- 30
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W3007855789
All OpenAlex metadata
Raw OpenAlex JSON
- OpenAlex ID
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https://openalex.org/W3007855789Canonical identifier for this work in OpenAlex
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https://doi.org/10.1111/liv.14356Digital Object Identifier
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Future treatments for hepatitis delta virus infectionWork title
- Type
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reviewOpenAlex work type
- Language
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enPrimary language
- Publication year
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2020Year of publication
- Publication date
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2020-02-01Full publication date if available
- Authors
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Tarik Asselah, Dimitri Loureiro, Issam Tout, Corinne Castelnau, Nathalie Boyer, Patrick Marcellin, Abdellah MansouriList of authors in order
- Landing page
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https://doi.org/10.1111/liv.14356Publisher landing page
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https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/liv.14356Direct link to full text PDF
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YesWhether a free full text is available
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bronzeOpen access status per OpenAlex
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https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/liv.14356Direct OA link when available
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Hepatitis D virus, Hepatitis D, Virology, HBsAg, Hepatitis B virus, Virus, RNA, Hepatitis B, Biology, Medicine, Gene, GeneticsTop concepts (fields/topics) attached by OpenAlex
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43Total citation count in OpenAlex
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2025: 1, 2024: 5, 2023: 9, 2022: 7, 2021: 13Per-year citation counts (last 5 years)
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30Number of works referenced by this work
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10Other works algorithmically related by OpenAlex
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| abstract_inverted_index.HBV | 206 |
| abstract_inverted_index.HDV | 36, 53, 89, 147, 170, 185, 189, 220 |
| abstract_inverted_index.III | 242 |
| abstract_inverted_index.New | 196 |
| abstract_inverted_index.REP | 252 |
| abstract_inverted_index.RNA | 18, 59, 85, 98, 190 |
| abstract_inverted_index.RNP | 117 |
| abstract_inverted_index.The | 52, 87, 166 |
| abstract_inverted_index.and | 75, 77, 103, 120, 125, 136, 143, 148, 207, 234, 241, 251 |
| abstract_inverted_index.but | 177 |
| abstract_inverted_index.for | 62, 114, 122, 154, 169 |
| abstract_inverted_index.its | 33, 78 |
| abstract_inverted_index.led | 225 |
| abstract_inverted_index.new | 216 |
| abstract_inverted_index.the | 21, 24, 40, 46, 83, 97, 108, 111, 173, 203, 215, 219, 227 |
| abstract_inverted_index.two | 72 |
| abstract_inverted_index.who | 163 |
| abstract_inverted_index.2139 | 253 |
| abstract_inverted_index.HDV. | 208 |
| abstract_inverted_index.drug | 197 |
| abstract_inverted_index.fail | 164 |
| abstract_inverted_index.goal | 168, 181 |
| abstract_inverted_index.have | 224 |
| abstract_inverted_index.host | 84 |
| abstract_inverted_index.into | 201 |
| abstract_inverted_index.life | 34, 221 |
| abstract_inverted_index.must | 199 |
| abstract_inverted_index.risk | 133 |
| abstract_inverted_index.step | 113 |
| abstract_inverted_index.take | 200 |
| abstract_inverted_index.that | 69, 223 |
| abstract_inverted_index.this | 116, 210 |
| abstract_inverted_index.thus | 121 |
| abstract_inverted_index.will | 213 |
| abstract_inverted_index.with | 101, 146, 157 |
| abstract_inverted_index.(HBV) | 44 |
| abstract_inverted_index.(HDV) | 14 |
| abstract_inverted_index.(RNP) | 94 |
| abstract_inverted_index.HDAg. | 105 |
| abstract_inverted_index.There | 129 |
| abstract_inverted_index.after | 193 |
| abstract_inverted_index.cycle | 222 |
| abstract_inverted_index.delta | 8, 12, 66 |
| abstract_inverted_index.drugs | 233 |
| abstract_inverted_index.forms | 73 |
| abstract_inverted_index.ideal | 167 |
| abstract_inverted_index.large | 104 |
| abstract_inverted_index.liver | 141 |
| abstract_inverted_index.novel | 230 |
| abstract_inverted_index.other | 159 |
| abstract_inverted_index.phase | 239 |
| abstract_inverted_index.small | 102 |
| abstract_inverted_index.using | 39 |
| abstract_inverted_index.virus | 9, 13, 19, 27, 43 |
| abstract_inverted_index.weeks | 156 |
| abstract_inverted_index.which | 60 |
| abstract_inverted_index.(HBsAg | 254 |
| abstract_inverted_index.(HDAg) | 68 |
| abstract_inverted_index.(entry | 246 |
| abstract_inverted_index.Around | 1 |
| abstract_inverted_index.HBsAg, | 119, 176 |
| abstract_inverted_index.caused | 138 |
| abstract_inverted_index.cycle. | 35 |
| abstract_inverted_index.exists | 70 |
| abstract_inverted_index.formed | 95 |
| abstract_inverted_index.genome | 54, 99 |
| abstract_inverted_index.months | 192 |
| abstract_inverted_index.people | 4 |
| abstract_inverted_index.single | 64 |
| abstract_inverted_index.sodium | 47 |
| abstract_inverted_index.virion | 127 |
| abstract_inverted_index.(HBsAg) | 30 |
| abstract_inverted_index.(NTCP). | 51 |
| abstract_inverted_index.15‐20 | 2 |
| abstract_inverted_index.account | 202 |
| abstract_inverted_index.antigen | 29, 67 |
| abstract_inverted_index.chronic | 6 |
| abstract_inverted_index.classes | 231 |
| abstract_inverted_index.contain | 91 |
| abstract_inverted_index.current | 149 |
| abstract_inverted_index.develop | 5 |
| abstract_inverted_index.discuss | 235 |
| abstract_inverted_index.disease | 142 |
| abstract_inverted_index.encodes | 61 |
| abstract_inverted_index.infects | 37 |
| abstract_inverted_index.million | 3 |
| abstract_inverted_index.options | 160 |
| abstract_inverted_index.present | 214 |
| abstract_inverted_index.release | 255 |
| abstract_inverted_index.review, | 211 |
| abstract_inverted_index.surface | 28 |
| abstract_inverted_index.virions | 90 |
| abstract_inverted_index.Abstract | 0 |
| abstract_inverted_index.L‐HDAg | 109 |
| abstract_inverted_index.circular | 57 |
| abstract_inverted_index.complete | 32 |
| abstract_inverted_index.insights | 217 |
| abstract_inverted_index.limiting | 112 |
| abstract_inverted_index.mediated | 81 |
| abstract_inverted_index.packaged | 100 |
| abstract_inverted_index.patients | 162 |
| abstract_inverted_index.presence | 22 |
| abstract_inverted_index.response | 187 |
| abstract_inverted_index.stopping | 194 |
| abstract_inverted_index.(S‐HDAg | 74 |
| abstract_inverted_index.(negative | 188 |
| abstract_inverted_index.Hepatitis | 11 |
| abstract_inverted_index.anchoring | 115 |
| abstract_inverted_index.antiviral | 236 |
| abstract_inverted_index.carcinoma | 145 |
| abstract_inverted_index.clearance | 174 |
| abstract_inverted_index.defective | 17 |
| abstract_inverted_index.hepatitis | 7, 25, 41, 65 |
| abstract_inverted_index.important | 132 |
| abstract_inverted_index.morbidity | 135 |
| abstract_inverted_index.mortality | 137 |
| abstract_inverted_index.receptor, | 45 |
| abstract_inverted_index.requiring | 20 |
| abstract_inverted_index.secreting | 124 |
| abstract_inverted_index.sustained | 184 |
| abstract_inverted_index.treatment | 150, 171 |
| abstract_inverted_index.L‐HDAg), | 76 |
| abstract_inverted_index.achievable | 180 |
| abstract_inverted_index.approaches | 237 |
| abstract_inverted_index.inhibitor) | 250 |
| abstract_inverted_index.particles. | 128 |
| abstract_inverted_index.reasonably | 179 |
| abstract_inverted_index.treatment. | 165 |
| abstract_inverted_index.worldwide. | 10 |
| abstract_inverted_index.(PEG‐IFN) | 153 |
| abstract_inverted_index.assembling, | 123 |
| abstract_inverted_index.bulevirtide | 245 |
| abstract_inverted_index.development | 198, 228 |
| abstract_inverted_index.end‐stage | 140 |
| abstract_inverted_index.hepatocytes | 38 |
| abstract_inverted_index.inhibitor), | 247 |
| abstract_inverted_index.inhibitor). | 256 |
| abstract_inverted_index.interaction | 204 |
| abstract_inverted_index.lonafarnib, | 248 |
| abstract_inverted_index.polypeptide | 50 |
| abstract_inverted_index.propagating | 126 |
| abstract_inverted_index.replication | 79 |
| abstract_inverted_index.treatment). | 195 |
| abstract_inverted_index.virological | 186 |
| abstract_inverted_index.(prenylation | 249 |
| abstract_inverted_index.development: | 244 |
| abstract_inverted_index.polymerases. | 86 |
| abstract_inverted_index.taurocholate | 48 |
| abstract_inverted_index.Farnesylation | 106 |
| abstract_inverted_index.HBsAg‐coated | 88 |
| abstract_inverted_index.cotransporting | 49 |
| abstract_inverted_index.hepatocellular | 144 |
| abstract_inverted_index.ribonucleoprotein | 93 |
| abstract_inverted_index.single‐stranded | 58 |
| abstract_inverted_index.pegylated‐interferon | 152 |
| cited_by_percentile_year.max | 99 |
| cited_by_percentile_year.min | 91 |
| corresponding_author_ids | https://openalex.org/A5009032052 |
| countries_distinct_count | 1 |
| institutions_distinct_count | 7 |
| corresponding_institution_ids | https://openalex.org/I154526488, https://openalex.org/I169173203, https://openalex.org/I204730241, https://openalex.org/I2799502834, https://openalex.org/I4210091437 |
| citation_normalized_percentile.value | 0.96825451 |
| citation_normalized_percentile.is_in_top_1_percent | False |
| citation_normalized_percentile.is_in_top_10_percent | True |