GABAA Receptor-Mediated Epileptogenicity in Focal Cortical Dysplasia (FCD) Depends on Age at Epilepsy Onset Article Swipe
Jyotirmoy Banerjee
,
Soumil Dey
,
Aparna Banerjee Dixit
,
Ramesh Doddamani
,
Meher Chand Sharma
,
Ajay Garg
,
P. Sarat Chandra
,
Manjari Tripathi
·
YOU?
·
· 2020
· Open Access
·
· DOI: https://doi.org/10.3389/fncel.2020.562811
YOU?
·
· 2020
· Open Access
·
· DOI: https://doi.org/10.3389/fncel.2020.562811
Enhanced spontaneous GABAA receptor activity is associated with focal cortical dysplasia (FCD), a developmental malformation of the cerebral cortex. Clinical manifestations in FCD vary with age at epilepsy onset with a more favorable prognosis in patients with late-onset (LO) compared to that in cases with early-onset (EO). This study was designed to test the hypothesis in FCD that spontaneous GABAA receptor-mediated epileptogenicity depends on the age at epilepsy onset and varies between patients with early and late-onset age in FCD. To this end, brain specimens were obtained from the maximal spiking region (MAX) and minimal spiking region (MIN) of the epileptic foci of EO (n = 14, mean age = 10.6 ± 2.9 years) and LO (n = 10, mean age = 27 ± 5.6 years) patients undergoing electrocorticography (ECoG) guided surgery. The whole-cell patch-clamp technique was used to record spontaneous GABAergic currents from normal-looking pyramidal neurons in slice preparations of resected brain samples. We detected higher frequency and amplitude of GABAergic events in MAX samples compared to MIN samples of LO patients, while they were comparable in MIN and MAX samples of EO patients. Further GABAergic activity in the MIN and MAX samples of EO patients was higher than the MIN samples of LO patients. This suggests that in LO patients, GABAA receptor-mediated epileptogenicity is confined only to the high spiking areas, but in EO patients, it affects low spiking regions as well.
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- Type
- article
- Language
- en
- Landing Page
- https://doi.org/10.3389/fncel.2020.562811
- https://www.frontiersin.org/articles/10.3389/fncel.2020.562811/pdf
- OA Status
- gold
- Cited By
- 11
- References
- 30
- Related Works
- 10
- OpenAlex ID
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- OpenAlex ID
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https://openalex.org/W3090873082Canonical identifier for this work in OpenAlex
- DOI
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https://doi.org/10.3389/fncel.2020.562811Digital Object Identifier
- Title
-
GABAA Receptor-Mediated Epileptogenicity in Focal Cortical Dysplasia (FCD) Depends on Age at Epilepsy OnsetWork title
- Type
-
articleOpenAlex work type
- Language
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enPrimary language
- Publication year
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2020Year of publication
- Publication date
-
2020-09-30Full publication date if available
- Authors
-
Jyotirmoy Banerjee, Soumil Dey, Aparna Banerjee Dixit, Ramesh Doddamani, Meher Chand Sharma, Ajay Garg, P. Sarat Chandra, Manjari TripathiList of authors in order
- Landing page
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https://doi.org/10.3389/fncel.2020.562811Publisher landing page
- PDF URL
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https://www.frontiersin.org/articles/10.3389/fncel.2020.562811/pdfDirect link to full text PDF
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YesWhether a free full text is available
- OA status
-
goldOpen access status per OpenAlex
- OA URL
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https://www.frontiersin.org/articles/10.3389/fncel.2020.562811/pdfDirect OA link when available
- Concepts
-
Cortical dysplasia, Epilepsy, Neuroscience, GABAA receptor, Epileptogenesis, Medicine, Psychology, Receptor, Internal medicineTop concepts (fields/topics) attached by OpenAlex
- Cited by
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11Total citation count in OpenAlex
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2025: 3, 2024: 2, 2023: 1, 2022: 2, 2021: 3Per-year citation counts (last 5 years)
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30Number of works referenced by this work
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10Other works algorithmically related by OpenAlex
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