Gabapentin for Pain Management after Major Surgery: A Placebo-controlled, Double-blinded, Randomized Clinical Trial (the GAP Study) Article Swipe
Sarah Baos
,
M. Lui
,
Terrie Walker-Smith
,
Maria Pufulete
,
David Messenger
,
Reyad Abbadi
,
Tim Batchelor
,
Gianluca Casali
,
Mark Edwards
,
Nick Goddard
,
Mohammad Abu Hilal
,
Aiman Alzetani
,
Marius Vaida
,
Petr Martinovsky
,
P Saravanan
,
Tim Cook
,
Rajiv Malhotra
,
Anna Simpson
,
Ross A. Little
,
Sarah Wordsworth
,
Elizabeth A Stokes
,
Jingjing Jiang Eu-HEM
,
Barnaby C Reeves
,
Lucy Culliford
,
Laura Collett
,
Rachel Maishman
,
Nilesh Chauhan
,
Liz McCullagh
,
Holly E. McKeon
,
Samantha Abbs
,
Jenny Lamb
,
Anna Gilbert
,
Chloe Hughes
,
David Wynick
,
Gianni D. Angelini
,
Michael P. W. Grocott
,
Ben Gibbison
,
Chris Rogers
·
YOU?
·
· 2025
· Open Access
·
· DOI: https://doi.org/10.1097/aln.0000000000005655
YOU?
·
· 2025
· Open Access
·
· DOI: https://doi.org/10.1097/aln.0000000000005655
Background: Gabapentin is an anticonvulsant medication with approval for use in neuropathic pain and epileptic disorders. It is frequently added to multimodal analgesic regimens during and after surgery to reduce opioid use while controlling pain effectively. There is little evidence to show its effectiveness in major surgery. Methods: In this multicenter, double-blinded randomized controlled trial, adults undergoing major cardiac, thoracic, or abdominal surgery were randomized to receive either gabapentin (600 mg before surgery, 300 mg twice daily for 2 days after surgery) or placebo. The primary outcome was length of hospital stay. Secondary outcomes included acute and chronic pain, total opioid use, adverse health events, and health-related quality of life. Patients were followed up daily in-hospital until discharge and then at 4 weeks and 4 months after surgery. Results: A total of 1,196 participants were randomized (500 underwent cardiac, 346 thoracic, and 350 abdominal surgery); 596 were allocated to placebo, and 600 were allocated to gabapentin. Median length of hospital stay was similar in the two groups (gabapentin, 5.94 [interquartile range (IQR), 4.08 to 8.04] days; placebo, 6.15 [IQR, 4.22 to 8.97] days; hazard ratio, 1.07; 95% CI, 0.95 to 1.20; P = 0.26). Overall, 384 participants experienced one or more serious adverse events (gabapentin, 189 of 596 [31.7%]; placebo, 195 of 599 [32.6%]), with some variation across surgical specialties. Conclusions: Among patients undergoing major cardiac, thoracic, and abdominal surgery, adding gabapentin to multimodal analgesic regimes did not alter the length of hospital stay or the number of serious adverse events.
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Metadata
- Type
- article
- Language
- en
- Landing Page
- https://doi.org/10.1097/aln.0000000000005655
- OA Status
- hybrid
- Cited By
- 2
- References
- 19
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W4412436331
All OpenAlex metadata
Raw OpenAlex JSON
- OpenAlex ID
-
https://openalex.org/W4412436331Canonical identifier for this work in OpenAlex
- DOI
-
https://doi.org/10.1097/aln.0000000000005655Digital Object Identifier
- Title
-
Gabapentin for Pain Management after Major Surgery: A Placebo-controlled, Double-blinded, Randomized Clinical Trial (the GAP Study)Work title
- Type
-
articleOpenAlex work type
- Language
-
enPrimary language
- Publication year
-
2025Year of publication
- Publication date
-
2025-07-15Full publication date if available
- Authors
-
Sarah Baos, M. Lui, Terrie Walker-Smith, Maria Pufulete, David Messenger, Reyad Abbadi, Tim Batchelor, Gianluca Casali, Mark Edwards, Nick Goddard, Mohammad Abu Hilal, Aiman Alzetani, Marius Vaida, Petr Martinovsky, P Saravanan, Tim Cook, Rajiv Malhotra, Anna Simpson, Ross A. Little, Sarah Wordsworth, Elizabeth A Stokes, Jingjing Jiang Eu-HEM, Barnaby C Reeves, Lucy Culliford, Laura Collett, Rachel Maishman, Nilesh Chauhan, Liz McCullagh, Holly E. McKeon, Samantha Abbs, Jenny Lamb, Anna Gilbert, Chloe Hughes, David Wynick, Gianni D. Angelini, Michael P. W. Grocott, Ben Gibbison, Chris RogersList of authors in order
- Landing page
-
https://doi.org/10.1097/aln.0000000000005655Publisher landing page
- Open access
-
YesWhether a free full text is available
- OA status
-
hybridOpen access status per OpenAlex
- OA URL
-
https://doi.org/10.1097/aln.0000000000005655Direct OA link when available
- Concepts
-
Medicine, Gabapentin, Placebo, Anesthesia, Adverse effect, Analgesic, Randomized controlled trial, Neuropathic pain, Clinical trial, Surgery, Internal medicine, Alternative medicine, PathologyTop concepts (fields/topics) attached by OpenAlex
- Cited by
-
2Total citation count in OpenAlex
- Citations by year (recent)
-
2025: 2Per-year citation counts (last 5 years)
- References (count)
-
19Number of works referenced by this work
- Related works (count)
-
10Other works algorithmically related by OpenAlex
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| abstract_inverted_index.4.08 | 172 |
| abstract_inverted_index.4.22 | 179 |
| abstract_inverted_index.5.94 | 168 |
| abstract_inverted_index.6.15 | 177 |
| abstract_inverted_index.days | 79 |
| abstract_inverted_index.more | 200 |
| abstract_inverted_index.pain | 12, 34 |
| abstract_inverted_index.show | 41 |
| abstract_inverted_index.some | 215 |
| abstract_inverted_index.stay | 160, 243 |
| abstract_inverted_index.then | 119 |
| abstract_inverted_index.this | 49 |
| abstract_inverted_index.use, | 101 |
| abstract_inverted_index.were | 63, 111, 134, 146, 152 |
| abstract_inverted_index.with | 6, 214 |
| abstract_inverted_index.1,196 | 132 |
| abstract_inverted_index.1.07; | 185 |
| abstract_inverted_index.1.20; | 190 |
| abstract_inverted_index.8.04] | 174 |
| abstract_inverted_index.8.97] | 181 |
| abstract_inverted_index.Among | 221 |
| abstract_inverted_index.There | 36 |
| abstract_inverted_index.[IQR, | 178 |
| abstract_inverted_index.acute | 95 |
| abstract_inverted_index.added | 19 |
| abstract_inverted_index.after | 26, 80, 126 |
| abstract_inverted_index.alter | 238 |
| abstract_inverted_index.daily | 76, 114 |
| abstract_inverted_index.days; | 175, 182 |
| abstract_inverted_index.life. | 109 |
| abstract_inverted_index.major | 45, 57, 224 |
| abstract_inverted_index.pain, | 98 |
| abstract_inverted_index.range | 170 |
| abstract_inverted_index.stay. | 91 |
| abstract_inverted_index.total | 99, 130 |
| abstract_inverted_index.twice | 75 |
| abstract_inverted_index.until | 116 |
| abstract_inverted_index.weeks | 122 |
| abstract_inverted_index.while | 32 |
| abstract_inverted_index.(IQR), | 171 |
| abstract_inverted_index.0.26). | 193 |
| abstract_inverted_index.Median | 156 |
| abstract_inverted_index.across | 217 |
| abstract_inverted_index.adding | 230 |
| abstract_inverted_index.adults | 55 |
| abstract_inverted_index.before | 71 |
| abstract_inverted_index.during | 24 |
| abstract_inverted_index.either | 67 |
| abstract_inverted_index.events | 203 |
| abstract_inverted_index.groups | 166 |
| abstract_inverted_index.hazard | 183 |
| abstract_inverted_index.health | 103 |
| abstract_inverted_index.length | 88, 157, 240 |
| abstract_inverted_index.little | 38 |
| abstract_inverted_index.months | 125 |
| abstract_inverted_index.number | 246 |
| abstract_inverted_index.opioid | 30, 100 |
| abstract_inverted_index.ratio, | 184 |
| abstract_inverted_index.reduce | 29 |
| abstract_inverted_index.trial, | 54 |
| abstract_inverted_index.adverse | 102, 202, 249 |
| abstract_inverted_index.chronic | 97 |
| abstract_inverted_index.events, | 104 |
| abstract_inverted_index.events. | 250 |
| abstract_inverted_index.outcome | 86 |
| abstract_inverted_index.primary | 85 |
| abstract_inverted_index.quality | 107 |
| abstract_inverted_index.receive | 66 |
| abstract_inverted_index.regimes | 235 |
| abstract_inverted_index.serious | 201, 248 |
| abstract_inverted_index.similar | 162 |
| abstract_inverted_index.surgery | 27, 62 |
| abstract_inverted_index.Methods: | 47 |
| abstract_inverted_index.Overall, | 194 |
| abstract_inverted_index.Patients | 110 |
| abstract_inverted_index.Results: | 128 |
| abstract_inverted_index.[31.7%]; | 208 |
| abstract_inverted_index.approval | 7 |
| abstract_inverted_index.cardiac, | 58, 138, 225 |
| abstract_inverted_index.evidence | 39 |
| abstract_inverted_index.followed | 112 |
| abstract_inverted_index.hospital | 90, 159, 242 |
| abstract_inverted_index.included | 94 |
| abstract_inverted_index.outcomes | 93 |
| abstract_inverted_index.patients | 222 |
| abstract_inverted_index.placebo, | 149, 176, 209 |
| abstract_inverted_index.placebo. | 83 |
| abstract_inverted_index.regimens | 23 |
| abstract_inverted_index.surgery) | 81 |
| abstract_inverted_index.surgery, | 72, 229 |
| abstract_inverted_index.surgery. | 46, 127 |
| abstract_inverted_index.surgical | 218 |
| abstract_inverted_index.Secondary | 92 |
| abstract_inverted_index.[32.6%]), | 213 |
| abstract_inverted_index.abdominal | 61, 143, 228 |
| abstract_inverted_index.allocated | 147, 153 |
| abstract_inverted_index.analgesic | 22, 234 |
| abstract_inverted_index.discharge | 117 |
| abstract_inverted_index.epileptic | 14 |
| abstract_inverted_index.surgery); | 144 |
| abstract_inverted_index.thoracic, | 59, 140, 226 |
| abstract_inverted_index.underwent | 137 |
| abstract_inverted_index.variation | 216 |
| abstract_inverted_index.Gabapentin | 1 |
| abstract_inverted_index.controlled | 53 |
| abstract_inverted_index.disorders. | 15 |
| abstract_inverted_index.frequently | 18 |
| abstract_inverted_index.gabapentin | 68, 231 |
| abstract_inverted_index.medication | 5 |
| abstract_inverted_index.multimodal | 21, 233 |
| abstract_inverted_index.randomized | 52, 64, 135 |
| abstract_inverted_index.undergoing | 56, 223 |
| abstract_inverted_index.Background: | 0 |
| abstract_inverted_index.controlling | 33 |
| abstract_inverted_index.experienced | 197 |
| abstract_inverted_index.gabapentin. | 155 |
| abstract_inverted_index.in-hospital | 115 |
| abstract_inverted_index.neuropathic | 11 |
| abstract_inverted_index.(gabapentin, | 167, 204 |
| abstract_inverted_index.Conclusions: | 220 |
| abstract_inverted_index.effectively. | 35 |
| abstract_inverted_index.multicenter, | 50 |
| abstract_inverted_index.participants | 133, 196 |
| abstract_inverted_index.specialties. | 219 |
| abstract_inverted_index.effectiveness | 43 |
| abstract_inverted_index.[interquartile | 169 |
| abstract_inverted_index.anticonvulsant | 4 |
| abstract_inverted_index.double-blinded | 51 |
| abstract_inverted_index.health-related | 106 |
| cited_by_percentile_year.max | 97 |
| cited_by_percentile_year.min | 95 |
| corresponding_author_ids | https://openalex.org/A5017078933 |
| countries_distinct_count | 3 |
| institutions_distinct_count | 38 |
| corresponding_institution_ids | https://openalex.org/I2800789647, https://openalex.org/I36234482, https://openalex.org/I4392738148 |
| sustainable_development_goals[0].id | https://metadata.un.org/sdg/3 |
| sustainable_development_goals[0].score | 0.7599999904632568 |
| sustainable_development_goals[0].display_name | Good health and well-being |
| citation_normalized_percentile.value | 0.972463 |
| citation_normalized_percentile.is_in_top_1_percent | False |
| citation_normalized_percentile.is_in_top_10_percent | True |