Gene Expression Microarray Data Identify Hub Genes Involved in Osteoarthritis Article Swipe
Jian Zhou
,
Dazhi Zou
,
Rongjun Wan
,
Jie Liu
,
Qiong Zhou
,
Zhen Zhou
,
Wanchun Wang
,
Tao Cheng
,
Tang Liu
·
YOU?
·
· 2022
· Open Access
·
· DOI: https://doi.org/10.3389/fgene.2022.870590
YOU?
·
· 2022
· Open Access
·
· DOI: https://doi.org/10.3389/fgene.2022.870590
The present study was performed to explore the underlying molecular mechanisms and screen hub genes of osteoarthritis (OA) via bioinformatics analysis. In total, twenty-five OA synovial tissue samples and 25 normal synovial tissue samples were derived from three datasets, namely, GSE55457, GSE55235, and GSE1919, and were used to identify the differentially expressed genes (DEGs) of OA by R language. The Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) analysis of DEGs were conducted using the Database for Annotation, Visualization, and Integrated Discovery (DAVID). A Venn diagram was built to show the potential hub genes identified in all three datasets. The STRING database was used for constructing the protein–protein interaction (PPI) networks and submodules of DEGs. We identified 507 upregulated and 620 downregulated genes. Upregulated DEGs were significantly involved in immune response, MHC class II receptor activity, and presented in the extracellular region, while downregulated DEGs were mainly enriched in response to organic substances, extracellular region parts, and cadmium ion binding. Results of KEGG analysis indicated that the upregulated DEGs mainly existed in cell adhesion molecules (CAMs), while downregulated DEGs were significantly involved in the MAPK signaling pathway. A total of eighteen intersection genes were identified across the three datasets. These include Nell-1, ATF3, RhoB, STC1, and VEGFA. In addition, 10 hub genes including CXCL12, CXCL8, CCL20, and CCL4 were found in the PPI network and module construction. Identification of DEGs and hub genes associated with OA may be helpful for revealing the molecular mechanisms of OA and further promotes the development of relevant biomarkers and drug targets.
Related Topics
Concepts
KEGG
Biology
Gene
Computational biology
Microarray analysis techniques
Genetics
Gene expression
Transcriptome
Metadata
- Type
- article
- Language
- en
- Landing Page
- https://doi.org/10.3389/fgene.2022.870590
- https://www.frontiersin.org/articles/10.3389/fgene.2022.870590/pdf
- OA Status
- gold
- Cited By
- 7
- References
- 45
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W4281735915
All OpenAlex metadata
Raw OpenAlex JSON
- OpenAlex ID
-
https://openalex.org/W4281735915Canonical identifier for this work in OpenAlex
- DOI
-
https://doi.org/10.3389/fgene.2022.870590Digital Object Identifier
- Title
-
Gene Expression Microarray Data Identify Hub Genes Involved in OsteoarthritisWork title
- Type
-
articleOpenAlex work type
- Language
-
enPrimary language
- Publication year
-
2022Year of publication
- Publication date
-
2022-06-06Full publication date if available
- Authors
-
Jian Zhou, Dazhi Zou, Rongjun Wan, Jie Liu, Qiong Zhou, Zhen Zhou, Wanchun Wang, Tao Cheng, Tang LiuList of authors in order
- Landing page
-
https://doi.org/10.3389/fgene.2022.870590Publisher landing page
- PDF URL
-
https://www.frontiersin.org/articles/10.3389/fgene.2022.870590/pdfDirect link to full text PDF
- Open access
-
YesWhether a free full text is available
- OA status
-
goldOpen access status per OpenAlex
- OA URL
-
https://www.frontiersin.org/articles/10.3389/fgene.2022.870590/pdfDirect OA link when available
- Concepts
-
KEGG, Biology, Gene, Computational biology, Microarray analysis techniques, Genetics, Gene expression, TranscriptomeTop concepts (fields/topics) attached by OpenAlex
- Cited by
-
7Total citation count in OpenAlex
- Citations by year (recent)
-
2025: 1, 2024: 3, 2023: 2, 2022: 1Per-year citation counts (last 5 years)
- References (count)
-
45Number of works referenced by this work
- Related works (count)
-
10Other works algorithmically related by OpenAlex
Full payload
| id | https://openalex.org/W4281735915 |
|---|---|
| doi | https://doi.org/10.3389/fgene.2022.870590 |
| ids.doi | https://doi.org/10.3389/fgene.2022.870590 |
| ids.pmid | https://pubmed.ncbi.nlm.nih.gov/35734433 |
| ids.openalex | https://openalex.org/W4281735915 |
| fwci | 1.76177425 |
| type | article |
| title | Gene Expression Microarray Data Identify Hub Genes Involved in Osteoarthritis |
| awards[0].id | https://openalex.org/G7382953619 |
| awards[0].funder_id | https://openalex.org/F4320321001 |
| awards[0].display_name | |
| awards[0].funder_award_id | 82072441 81871783 81672176 |
| awards[0].funder_display_name | National Natural Science Foundation of China |
| biblio.issue | |
| biblio.volume | 13 |
| biblio.last_page | 870590 |
| biblio.first_page | 870590 |
| topics[0].id | https://openalex.org/T10105 |
| topics[0].field.id | https://openalex.org/fields/27 |
| topics[0].field.display_name | Medicine |
| topics[0].score | 0.9997000098228455 |
| topics[0].domain.id | https://openalex.org/domains/4 |
| topics[0].domain.display_name | Health Sciences |
| topics[0].subfield.id | https://openalex.org/subfields/2745 |
| topics[0].subfield.display_name | Rheumatology |
| topics[0].display_name | Osteoarthritis Treatment and Mechanisms |
| topics[1].id | https://openalex.org/T10678 |
| topics[1].field.id | https://openalex.org/fields/27 |
| topics[1].field.display_name | Medicine |
| topics[1].score | 0.9975000023841858 |
| topics[1].domain.id | https://openalex.org/domains/4 |
| topics[1].domain.display_name | Health Sciences |
| topics[1].subfield.id | https://openalex.org/subfields/2736 |
| topics[1].subfield.display_name | Pharmacology |
| topics[1].display_name | Inflammatory mediators and NSAID effects |
| topics[2].id | https://openalex.org/T11219 |
| topics[2].field.id | https://openalex.org/fields/13 |
| topics[2].field.display_name | Biochemistry, Genetics and Molecular Biology |
| topics[2].score | 0.9908000230789185 |
| topics[2].domain.id | https://openalex.org/domains/1 |
| topics[2].domain.display_name | Life Sciences |
| topics[2].subfield.id | https://openalex.org/subfields/1312 |
| topics[2].subfield.display_name | Molecular Biology |
| topics[2].display_name | Bone Metabolism and Diseases |
| funders[0].id | https://openalex.org/F4320321001 |
| funders[0].ror | https://ror.org/01h0zpd94 |
| funders[0].display_name | National Natural Science Foundation of China |
| is_xpac | False |
| apc_list.value | 2950 |
| apc_list.currency | USD |
| apc_list.value_usd | 2950 |
| apc_paid.value | 2950 |
| apc_paid.currency | USD |
| apc_paid.value_usd | 2950 |
| concepts[0].id | https://openalex.org/C152724338 |
| concepts[0].level | 5 |
| concepts[0].score | 0.8816794157028198 |
| concepts[0].wikidata | https://www.wikidata.org/wiki/Q909442 |
| concepts[0].display_name | KEGG |
| concepts[1].id | https://openalex.org/C86803240 |
| concepts[1].level | 0 |
| concepts[1].score | 0.5992822647094727 |
| concepts[1].wikidata | https://www.wikidata.org/wiki/Q420 |
| concepts[1].display_name | Biology |
| concepts[2].id | https://openalex.org/C104317684 |
| concepts[2].level | 2 |
| concepts[2].score | 0.5913543105125427 |
| concepts[2].wikidata | https://www.wikidata.org/wiki/Q7187 |
| concepts[2].display_name | Gene |
| concepts[3].id | https://openalex.org/C70721500 |
| concepts[3].level | 1 |
| concepts[3].score | 0.4439624845981598 |
| concepts[3].wikidata | https://www.wikidata.org/wiki/Q177005 |
| concepts[3].display_name | Computational biology |
| concepts[4].id | https://openalex.org/C8415881 |
| concepts[4].level | 4 |
| concepts[4].score | 0.43905457854270935 |
| concepts[4].wikidata | https://www.wikidata.org/wiki/Q6839217 |
| concepts[4].display_name | Microarray analysis techniques |
| concepts[5].id | https://openalex.org/C54355233 |
| concepts[5].level | 1 |
| concepts[5].score | 0.41194021701812744 |
| concepts[5].wikidata | https://www.wikidata.org/wiki/Q7162 |
| concepts[5].display_name | Genetics |
| concepts[6].id | https://openalex.org/C150194340 |
| concepts[6].level | 3 |
| concepts[6].score | 0.3284270167350769 |
| concepts[6].wikidata | https://www.wikidata.org/wiki/Q26972 |
| concepts[6].display_name | Gene expression |
| concepts[7].id | https://openalex.org/C162317418 |
| concepts[7].level | 4 |
| concepts[7].score | 0.1936374306678772 |
| concepts[7].wikidata | https://www.wikidata.org/wiki/Q252857 |
| concepts[7].display_name | Transcriptome |
| keywords[0].id | https://openalex.org/keywords/kegg |
| keywords[0].score | 0.8816794157028198 |
| keywords[0].display_name | KEGG |
| keywords[1].id | https://openalex.org/keywords/biology |
| keywords[1].score | 0.5992822647094727 |
| keywords[1].display_name | Biology |
| keywords[2].id | https://openalex.org/keywords/gene |
| keywords[2].score | 0.5913543105125427 |
| keywords[2].display_name | Gene |
| keywords[3].id | https://openalex.org/keywords/computational-biology |
| keywords[3].score | 0.4439624845981598 |
| keywords[3].display_name | Computational biology |
| keywords[4].id | https://openalex.org/keywords/microarray-analysis-techniques |
| keywords[4].score | 0.43905457854270935 |
| keywords[4].display_name | Microarray analysis techniques |
| keywords[5].id | https://openalex.org/keywords/genetics |
| keywords[5].score | 0.41194021701812744 |
| keywords[5].display_name | Genetics |
| keywords[6].id | https://openalex.org/keywords/gene-expression |
| keywords[6].score | 0.3284270167350769 |
| keywords[6].display_name | Gene expression |
| keywords[7].id | https://openalex.org/keywords/transcriptome |
| keywords[7].score | 0.1936374306678772 |
| keywords[7].display_name | Transcriptome |
| language | en |
| locations[0].id | doi:10.3389/fgene.2022.870590 |
| locations[0].is_oa | True |
| locations[0].source.id | https://openalex.org/S2597340651 |
| locations[0].source.issn | 1664-8021 |
| locations[0].source.type | journal |
| locations[0].source.is_oa | True |
| locations[0].source.issn_l | 1664-8021 |
| locations[0].source.is_core | True |
| locations[0].source.is_in_doaj | True |
| locations[0].source.display_name | Frontiers in Genetics |
| locations[0].source.host_organization | https://openalex.org/P4310320527 |
| locations[0].source.host_organization_name | Frontiers Media |
| locations[0].source.host_organization_lineage | https://openalex.org/P4310320527 |
| locations[0].source.host_organization_lineage_names | Frontiers Media |
| locations[0].license | cc-by |
| locations[0].pdf_url | https://www.frontiersin.org/articles/10.3389/fgene.2022.870590/pdf |
| locations[0].version | publishedVersion |
| locations[0].raw_type | journal-article |
| locations[0].license_id | https://openalex.org/licenses/cc-by |
| locations[0].is_accepted | True |
| locations[0].is_published | True |
| locations[0].raw_source_name | Frontiers in Genetics |
| locations[0].landing_page_url | https://doi.org/10.3389/fgene.2022.870590 |
| locations[1].id | pmid:35734433 |
| locations[1].is_oa | False |
| locations[1].source.id | https://openalex.org/S4306525036 |
| locations[1].source.issn | |
| locations[1].source.type | repository |
| locations[1].source.is_oa | False |
| locations[1].source.issn_l | |
| locations[1].source.is_core | False |
| locations[1].source.is_in_doaj | False |
| locations[1].source.display_name | PubMed |
| locations[1].source.host_organization | https://openalex.org/I1299303238 |
| locations[1].source.host_organization_name | National Institutes of Health |
| locations[1].source.host_organization_lineage | https://openalex.org/I1299303238 |
| locations[1].license | |
| locations[1].pdf_url | |
| locations[1].version | publishedVersion |
| locations[1].raw_type | |
| locations[1].license_id | |
| locations[1].is_accepted | True |
| locations[1].is_published | True |
| locations[1].raw_source_name | Frontiers in genetics |
| locations[1].landing_page_url | https://pubmed.ncbi.nlm.nih.gov/35734433 |
| locations[2].id | pmh:oai:eprints.utas.edu.au:46683 |
| locations[2].is_oa | False |
| locations[2].source.id | https://openalex.org/S4306400075 |
| locations[2].source.issn | |
| locations[2].source.type | repository |
| locations[2].source.is_oa | False |
| locations[2].source.issn_l | |
| locations[2].source.is_core | False |
| locations[2].source.is_in_doaj | False |
| locations[2].source.display_name | Open Access Repository (University of Tasmania) |
| locations[2].source.host_organization | https://openalex.org/I129801699 |
| locations[2].source.host_organization_name | University of Tasmania |
| locations[2].source.host_organization_lineage | https://openalex.org/I129801699 |
| locations[2].license | |
| locations[2].pdf_url | |
| locations[2].version | acceptedVersion |
| locations[2].raw_type | Article |
| locations[2].license_id | |
| locations[2].is_accepted | True |
| locations[2].is_published | False |
| locations[2].raw_source_name | |
| locations[2].landing_page_url | |
| locations[3].id | pmh:oai:doaj.org/article:bc5c1f66de614def8fd2ad8dbdb20154 |
| locations[3].is_oa | True |
| locations[3].source.id | https://openalex.org/S4306401280 |
| locations[3].source.issn | |
| locations[3].source.type | repository |
| locations[3].source.is_oa | False |
| locations[3].source.issn_l | |
| locations[3].source.is_core | False |
| locations[3].source.is_in_doaj | False |
| locations[3].source.display_name | DOAJ (DOAJ: Directory of Open Access Journals) |
| locations[3].source.host_organization | |
| locations[3].source.host_organization_name | |
| locations[3].license | cc-by-sa |
| locations[3].pdf_url | |
| locations[3].version | submittedVersion |
| locations[3].raw_type | article |
| locations[3].license_id | https://openalex.org/licenses/cc-by-sa |
| locations[3].is_accepted | False |
| locations[3].is_published | False |
| locations[3].raw_source_name | Frontiers in Genetics, Vol 13 (2022) |
| locations[3].landing_page_url | https://doaj.org/article/bc5c1f66de614def8fd2ad8dbdb20154 |
| locations[4].id | pmh:oai:pubmedcentral.nih.gov:9207392 |
| locations[4].is_oa | True |
| locations[4].source.id | https://openalex.org/S2764455111 |
| locations[4].source.issn | |
| locations[4].source.type | repository |
| locations[4].source.is_oa | False |
| locations[4].source.issn_l | |
| locations[4].source.is_core | False |
| locations[4].source.is_in_doaj | False |
| locations[4].source.display_name | PubMed Central |
| locations[4].source.host_organization | https://openalex.org/I1299303238 |
| locations[4].source.host_organization_name | National Institutes of Health |
| locations[4].source.host_organization_lineage | https://openalex.org/I1299303238 |
| locations[4].license | other-oa |
| locations[4].pdf_url | |
| locations[4].version | submittedVersion |
| locations[4].raw_type | Text |
| locations[4].license_id | https://openalex.org/licenses/other-oa |
| locations[4].is_accepted | False |
| locations[4].is_published | False |
| locations[4].raw_source_name | Front Genet |
| locations[4].landing_page_url | https://www.ncbi.nlm.nih.gov/pmc/articles/9207392 |
| indexed_in | crossref, doaj, pubmed |
| authorships[0].author.id | https://openalex.org/A5052941070 |
| authorships[0].author.orcid | https://orcid.org/0000-0001-7800-881X |
| authorships[0].author.display_name | Jian Zhou |
| authorships[0].countries | CN |
| authorships[0].affiliations[0].institution_ids | https://openalex.org/I139660479, https://openalex.org/I4210153856 |
| authorships[0].affiliations[0].raw_affiliation_string | Department of Orthopedics, The Second Xiangya Hospital of Central South University, Changsha, China |
| authorships[0].institutions[0].id | https://openalex.org/I139660479 |
| authorships[0].institutions[0].ror | https://ror.org/00f1zfq44 |
| authorships[0].institutions[0].type | education |
| authorships[0].institutions[0].lineage | https://openalex.org/I139660479 |
| authorships[0].institutions[0].country_code | CN |
| authorships[0].institutions[0].display_name | Central South University |
| authorships[0].institutions[1].id | https://openalex.org/I4210153856 |
| authorships[0].institutions[1].ror | https://ror.org/053v2gh09 |
| authorships[0].institutions[1].type | healthcare |
| authorships[0].institutions[1].lineage | https://openalex.org/I4210153856 |
| authorships[0].institutions[1].country_code | CN |
| authorships[0].institutions[1].display_name | Second Xiangya Hospital of Central South University |
| authorships[0].author_position | first |
| authorships[0].raw_author_name | Jian Zhou |
| authorships[0].is_corresponding | False |
| authorships[0].raw_affiliation_strings | Department of Orthopedics, The Second Xiangya Hospital of Central South University, Changsha, China |
| authorships[1].author.id | https://openalex.org/A5113895253 |
| authorships[1].author.orcid | |
| authorships[1].author.display_name | Dazhi Zou |
| authorships[1].affiliations[0].raw_affiliation_string | Department of Spine Surgery, Longhui People's Hospital, Shaoyang, China |
| authorships[1].author_position | middle |
| authorships[1].raw_author_name | Dazhi Zou |
| authorships[1].is_corresponding | False |
| authorships[1].raw_affiliation_strings | Department of Spine Surgery, Longhui People's Hospital, Shaoyang, China |
| authorships[2].author.id | https://openalex.org/A5003036189 |
| authorships[2].author.orcid | https://orcid.org/0000-0003-2643-3173 |
| authorships[2].author.display_name | Rongjun Wan |
| authorships[2].countries | CN |
| authorships[2].affiliations[0].institution_ids | https://openalex.org/I139660479, https://openalex.org/I4210159865 |
| authorships[2].affiliations[0].raw_affiliation_string | Branch of National Clinical Research Center for Respiratory Disease, Department of Respiratory Medicine, National Key Clinical Specialty, Xiangya Hospital, Central South University, Changsha, China |
| authorships[2].affiliations[1].raw_affiliation_string | National Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Changsha, China |
| authorships[2].institutions[0].id | https://openalex.org/I139660479 |
| authorships[2].institutions[0].ror | https://ror.org/00f1zfq44 |
| authorships[2].institutions[0].type | education |
| authorships[2].institutions[0].lineage | https://openalex.org/I139660479 |
| authorships[2].institutions[0].country_code | CN |
| authorships[2].institutions[0].display_name | Central South University |
| authorships[2].institutions[1].id | https://openalex.org/I4210159865 |
| authorships[2].institutions[1].ror | https://ror.org/05c1yfj14 |
| authorships[2].institutions[1].type | healthcare |
| authorships[2].institutions[1].lineage | https://openalex.org/I4210159865 |
| authorships[2].institutions[1].country_code | CN |
| authorships[2].institutions[1].display_name | Xiangya Hospital Central South University |
| authorships[2].author_position | middle |
| authorships[2].raw_author_name | Rongjun Wan |
| authorships[2].is_corresponding | False |
| authorships[2].raw_affiliation_strings | Branch of National Clinical Research Center for Respiratory Disease, Department of Respiratory Medicine, National Key Clinical Specialty, Xiangya Hospital, Central South University, Changsha, China, National Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Changsha, China |
| authorships[3].author.id | https://openalex.org/A5100454057 |
| authorships[3].author.orcid | https://orcid.org/0000-0002-1069-2384 |
| authorships[3].author.display_name | Jie Liu |
| authorships[3].countries | CN |
| authorships[3].affiliations[0].institution_ids | https://openalex.org/I4210112143 |
| authorships[3].affiliations[0].raw_affiliation_string | Department of Cardiology, The Fourth Hospital of Changsha, Changsha, China |
| authorships[3].institutions[0].id | https://openalex.org/I4210112143 |
| authorships[3].institutions[0].ror | https://ror.org/01wkath48 |
| authorships[3].institutions[0].type | healthcare |
| authorships[3].institutions[0].lineage | https://openalex.org/I4210112143 |
| authorships[3].institutions[0].country_code | CN |
| authorships[3].institutions[0].display_name | Fourth Hospital of Changsha |
| authorships[3].author_position | middle |
| authorships[3].raw_author_name | Jie Liu |
| authorships[3].is_corresponding | False |
| authorships[3].raw_affiliation_strings | Department of Cardiology, The Fourth Hospital of Changsha, Changsha, China |
| authorships[4].author.id | https://openalex.org/A5100314425 |
| authorships[4].author.orcid | https://orcid.org/0009-0005-9161-3009 |
| authorships[4].author.display_name | Qiong Zhou |
| authorships[4].countries | CN |
| authorships[4].affiliations[0].institution_ids | https://openalex.org/I4210112143 |
| authorships[4].affiliations[0].raw_affiliation_string | Department of Cardiology, The Fourth Hospital of Changsha, Changsha, China |
| authorships[4].institutions[0].id | https://openalex.org/I4210112143 |
| authorships[4].institutions[0].ror | https://ror.org/01wkath48 |
| authorships[4].institutions[0].type | healthcare |
| authorships[4].institutions[0].lineage | https://openalex.org/I4210112143 |
| authorships[4].institutions[0].country_code | CN |
| authorships[4].institutions[0].display_name | Fourth Hospital of Changsha |
| authorships[4].author_position | middle |
| authorships[4].raw_author_name | Qiong Zhou |
| authorships[4].is_corresponding | False |
| authorships[4].raw_affiliation_strings | Department of Cardiology, The Fourth Hospital of Changsha, Changsha, China |
| authorships[5].author.id | https://openalex.org/A5017929396 |
| authorships[5].author.orcid | https://orcid.org/0000-0002-7880-5998 |
| authorships[5].author.display_name | Zhen Zhou |
| authorships[5].countries | AU |
| authorships[5].affiliations[0].institution_ids | https://openalex.org/I129801699 |
| authorships[5].affiliations[0].raw_affiliation_string | Menzies Institute for Medical Research, University of Tasmania, Hobart, TAS, Australia |
| authorships[5].institutions[0].id | https://openalex.org/I129801699 |
| authorships[5].institutions[0].ror | https://ror.org/01nfmeh72 |
| authorships[5].institutions[0].type | education |
| authorships[5].institutions[0].lineage | https://openalex.org/I129801699 |
| authorships[5].institutions[0].country_code | AU |
| authorships[5].institutions[0].display_name | University of Tasmania |
| authorships[5].author_position | middle |
| authorships[5].raw_author_name | Zhen Zhou |
| authorships[5].is_corresponding | False |
| authorships[5].raw_affiliation_strings | Menzies Institute for Medical Research, University of Tasmania, Hobart, TAS, Australia |
| authorships[6].author.id | https://openalex.org/A5075524725 |
| authorships[6].author.orcid | https://orcid.org/0000-0002-0610-4180 |
| authorships[6].author.display_name | Wanchun Wang |
| authorships[6].countries | CN |
| authorships[6].affiliations[0].institution_ids | https://openalex.org/I139660479, https://openalex.org/I4210153856 |
| authorships[6].affiliations[0].raw_affiliation_string | Department of Orthopedics, The Second Xiangya Hospital of Central South University, Changsha, China |
| authorships[6].institutions[0].id | https://openalex.org/I139660479 |
| authorships[6].institutions[0].ror | https://ror.org/00f1zfq44 |
| authorships[6].institutions[0].type | education |
| authorships[6].institutions[0].lineage | https://openalex.org/I139660479 |
| authorships[6].institutions[0].country_code | CN |
| authorships[6].institutions[0].display_name | Central South University |
| authorships[6].institutions[1].id | https://openalex.org/I4210153856 |
| authorships[6].institutions[1].ror | https://ror.org/053v2gh09 |
| authorships[6].institutions[1].type | healthcare |
| authorships[6].institutions[1].lineage | https://openalex.org/I4210153856 |
| authorships[6].institutions[1].country_code | CN |
| authorships[6].institutions[1].display_name | Second Xiangya Hospital of Central South University |
| authorships[6].author_position | middle |
| authorships[6].raw_author_name | Wanchun Wang |
| authorships[6].is_corresponding | False |
| authorships[6].raw_affiliation_strings | Department of Orthopedics, The Second Xiangya Hospital of Central South University, Changsha, China |
| authorships[7].author.id | https://openalex.org/A5060867127 |
| authorships[7].author.orcid | https://orcid.org/0000-0002-5925-2769 |
| authorships[7].author.display_name | Tao Cheng |
| authorships[7].countries | CN |
| authorships[7].affiliations[0].institution_ids | https://openalex.org/I139660479, https://openalex.org/I4210153856 |
| authorships[7].affiliations[0].raw_affiliation_string | Department of Orthopedics, The Second Xiangya Hospital of Central South University, Changsha, China |
| authorships[7].institutions[0].id | https://openalex.org/I139660479 |
| authorships[7].institutions[0].ror | https://ror.org/00f1zfq44 |
| authorships[7].institutions[0].type | education |
| authorships[7].institutions[0].lineage | https://openalex.org/I139660479 |
| authorships[7].institutions[0].country_code | CN |
| authorships[7].institutions[0].display_name | Central South University |
| authorships[7].institutions[1].id | https://openalex.org/I4210153856 |
| authorships[7].institutions[1].ror | https://ror.org/053v2gh09 |
| authorships[7].institutions[1].type | healthcare |
| authorships[7].institutions[1].lineage | https://openalex.org/I4210153856 |
| authorships[7].institutions[1].country_code | CN |
| authorships[7].institutions[1].display_name | Second Xiangya Hospital of Central South University |
| authorships[7].author_position | middle |
| authorships[7].raw_author_name | Cheng Tao |
| authorships[7].is_corresponding | True |
| authorships[7].raw_affiliation_strings | Department of Orthopedics, The Second Xiangya Hospital of Central South University, Changsha, China |
| authorships[8].author.id | https://openalex.org/A5100764957 |
| authorships[8].author.orcid | https://orcid.org/0000-0002-0040-4270 |
| authorships[8].author.display_name | Tang Liu |
| authorships[8].countries | CN |
| authorships[8].affiliations[0].institution_ids | https://openalex.org/I139660479, https://openalex.org/I4210153856 |
| authorships[8].affiliations[0].raw_affiliation_string | Department of Orthopedics, The Second Xiangya Hospital of Central South University, Changsha, China |
| authorships[8].institutions[0].id | https://openalex.org/I139660479 |
| authorships[8].institutions[0].ror | https://ror.org/00f1zfq44 |
| authorships[8].institutions[0].type | education |
| authorships[8].institutions[0].lineage | https://openalex.org/I139660479 |
| authorships[8].institutions[0].country_code | CN |
| authorships[8].institutions[0].display_name | Central South University |
| authorships[8].institutions[1].id | https://openalex.org/I4210153856 |
| authorships[8].institutions[1].ror | https://ror.org/053v2gh09 |
| authorships[8].institutions[1].type | healthcare |
| authorships[8].institutions[1].lineage | https://openalex.org/I4210153856 |
| authorships[8].institutions[1].country_code | CN |
| authorships[8].institutions[1].display_name | Second Xiangya Hospital of Central South University |
| authorships[8].author_position | last |
| authorships[8].raw_author_name | Tang Liu |
| authorships[8].is_corresponding | True |
| authorships[8].raw_affiliation_strings | Department of Orthopedics, The Second Xiangya Hospital of Central South University, Changsha, China |
| has_content.pdf | True |
| has_content.grobid_xml | True |
| is_paratext | False |
| open_access.is_oa | True |
| open_access.oa_url | https://www.frontiersin.org/articles/10.3389/fgene.2022.870590/pdf |
| open_access.oa_status | gold |
| open_access.any_repository_has_fulltext | False |
| created_date | 2025-10-10T00:00:00 |
| display_name | Gene Expression Microarray Data Identify Hub Genes Involved in Osteoarthritis |
| has_fulltext | True |
| is_retracted | False |
| updated_date | 2025-11-06T03:46:38.306776 |
| primary_topic.id | https://openalex.org/T10105 |
| primary_topic.field.id | https://openalex.org/fields/27 |
| primary_topic.field.display_name | Medicine |
| primary_topic.score | 0.9997000098228455 |
| primary_topic.domain.id | https://openalex.org/domains/4 |
| primary_topic.domain.display_name | Health Sciences |
| primary_topic.subfield.id | https://openalex.org/subfields/2745 |
| primary_topic.subfield.display_name | Rheumatology |
| primary_topic.display_name | Osteoarthritis Treatment and Mechanisms |
| related_works | https://openalex.org/W2588180461, https://openalex.org/W1974573031, https://openalex.org/W1986669422, https://openalex.org/W3032874291, https://openalex.org/W2005057264, https://openalex.org/W2363156284, https://openalex.org/W2415025170, https://openalex.org/W2114540137, https://openalex.org/W2053053668, https://openalex.org/W2388669904 |
| cited_by_count | 7 |
| counts_by_year[0].year | 2025 |
| counts_by_year[0].cited_by_count | 1 |
| counts_by_year[1].year | 2024 |
| counts_by_year[1].cited_by_count | 3 |
| counts_by_year[2].year | 2023 |
| counts_by_year[2].cited_by_count | 2 |
| counts_by_year[3].year | 2022 |
| counts_by_year[3].cited_by_count | 1 |
| locations_count | 5 |
| best_oa_location.id | doi:10.3389/fgene.2022.870590 |
| best_oa_location.is_oa | True |
| best_oa_location.source.id | https://openalex.org/S2597340651 |
| best_oa_location.source.issn | 1664-8021 |
| best_oa_location.source.type | journal |
| best_oa_location.source.is_oa | True |
| best_oa_location.source.issn_l | 1664-8021 |
| best_oa_location.source.is_core | True |
| best_oa_location.source.is_in_doaj | True |
| best_oa_location.source.display_name | Frontiers in Genetics |
| best_oa_location.source.host_organization | https://openalex.org/P4310320527 |
| best_oa_location.source.host_organization_name | Frontiers Media |
| best_oa_location.source.host_organization_lineage | https://openalex.org/P4310320527 |
| best_oa_location.source.host_organization_lineage_names | Frontiers Media |
| best_oa_location.license | cc-by |
| best_oa_location.pdf_url | https://www.frontiersin.org/articles/10.3389/fgene.2022.870590/pdf |
| best_oa_location.version | publishedVersion |
| best_oa_location.raw_type | journal-article |
| best_oa_location.license_id | https://openalex.org/licenses/cc-by |
| best_oa_location.is_accepted | True |
| best_oa_location.is_published | True |
| best_oa_location.raw_source_name | Frontiers in Genetics |
| best_oa_location.landing_page_url | https://doi.org/10.3389/fgene.2022.870590 |
| primary_location.id | doi:10.3389/fgene.2022.870590 |
| primary_location.is_oa | True |
| primary_location.source.id | https://openalex.org/S2597340651 |
| primary_location.source.issn | 1664-8021 |
| primary_location.source.type | journal |
| primary_location.source.is_oa | True |
| primary_location.source.issn_l | 1664-8021 |
| primary_location.source.is_core | True |
| primary_location.source.is_in_doaj | True |
| primary_location.source.display_name | Frontiers in Genetics |
| primary_location.source.host_organization | https://openalex.org/P4310320527 |
| primary_location.source.host_organization_name | Frontiers Media |
| primary_location.source.host_organization_lineage | https://openalex.org/P4310320527 |
| primary_location.source.host_organization_lineage_names | Frontiers Media |
| primary_location.license | cc-by |
| primary_location.pdf_url | https://www.frontiersin.org/articles/10.3389/fgene.2022.870590/pdf |
| primary_location.version | publishedVersion |
| primary_location.raw_type | journal-article |
| primary_location.license_id | https://openalex.org/licenses/cc-by |
| primary_location.is_accepted | True |
| primary_location.is_published | True |
| primary_location.raw_source_name | Frontiers in Genetics |
| primary_location.landing_page_url | https://doi.org/10.3389/fgene.2022.870590 |
| publication_date | 2022-06-06 |
| publication_year | 2022 |
| referenced_works | https://openalex.org/W2027831505, https://openalex.org/W2145752025, https://openalex.org/W6611231361, https://openalex.org/W168577092, https://openalex.org/W2527824850, https://openalex.org/W2995378701, https://openalex.org/W6771681399, https://openalex.org/W2462580620, https://openalex.org/W1824455782, https://openalex.org/W2810155239, https://openalex.org/W4211067786, https://openalex.org/W1977010138, https://openalex.org/W2378868465, https://openalex.org/W1988791506, https://openalex.org/W2017712522, https://openalex.org/W3198799004, https://openalex.org/W1965637156, https://openalex.org/W331153270, https://openalex.org/W2895809993, https://openalex.org/W1978040821, https://openalex.org/W2905764440, https://openalex.org/W2406165887, https://openalex.org/W2783989997, https://openalex.org/W2076104046, https://openalex.org/W2106686893, https://openalex.org/W1974248935, https://openalex.org/W2091170678, https://openalex.org/W2101310299, https://openalex.org/W2082954333, https://openalex.org/W2019223535, https://openalex.org/W2049220563, https://openalex.org/W2123888073, https://openalex.org/W2026757955, https://openalex.org/W2906066866, https://openalex.org/W2323735766, https://openalex.org/W2516583270, https://openalex.org/W2086964102, https://openalex.org/W2901622397, https://openalex.org/W1984466107, https://openalex.org/W1988483010, https://openalex.org/W2809646888, https://openalex.org/W2804127346, https://openalex.org/W2950194809, https://openalex.org/W2959145605, https://openalex.org/W3047478742 |
| referenced_works_count | 45 |
| abstract_inverted_index.A | 86, 190 |
| abstract_inverted_index.R | 57 |
| abstract_inverted_index.10 | 212 |
| abstract_inverted_index.25 | 29 |
| abstract_inverted_index.II | 136 |
| abstract_inverted_index.In | 21, 210 |
| abstract_inverted_index.OA | 24, 55, 238, 248 |
| abstract_inverted_index.We | 118 |
| abstract_inverted_index.be | 240 |
| abstract_inverted_index.by | 56 |
| abstract_inverted_index.in | 98, 131, 141, 151, 174, 185, 223 |
| abstract_inverted_index.of | 15, 54, 66, 72, 116, 164, 192, 231, 247, 254 |
| abstract_inverted_index.to | 5, 47, 91, 153 |
| abstract_inverted_index.507 | 120 |
| abstract_inverted_index.620 | 123 |
| abstract_inverted_index.MHC | 134 |
| abstract_inverted_index.PPI | 225 |
| abstract_inverted_index.The | 0, 59, 102 |
| abstract_inverted_index.all | 99 |
| abstract_inverted_index.and | 11, 28, 42, 44, 63, 68, 82, 114, 122, 139, 159, 208, 219, 227, 233, 249, 257 |
| abstract_inverted_index.for | 79, 107, 242 |
| abstract_inverted_index.hub | 13, 95, 213, 234 |
| abstract_inverted_index.ion | 161 |
| abstract_inverted_index.may | 239 |
| abstract_inverted_index.the | 7, 49, 77, 93, 109, 142, 169, 186, 199, 224, 244, 252 |
| abstract_inverted_index.via | 18 |
| abstract_inverted_index.was | 3, 89, 105 |
| abstract_inverted_index.(GO) | 62 |
| abstract_inverted_index.(OA) | 17 |
| abstract_inverted_index.CCL4 | 220 |
| abstract_inverted_index.DEGs | 73, 127, 147, 171, 181, 232 |
| abstract_inverted_index.Gene | 60 |
| abstract_inverted_index.KEGG | 165 |
| abstract_inverted_index.MAPK | 187 |
| abstract_inverted_index.Venn | 87 |
| abstract_inverted_index.cell | 175 |
| abstract_inverted_index.drug | 258 |
| abstract_inverted_index.from | 36 |
| abstract_inverted_index.show | 92 |
| abstract_inverted_index.that | 168 |
| abstract_inverted_index.used | 46, 106 |
| abstract_inverted_index.were | 34, 45, 74, 128, 148, 182, 196, 221 |
| abstract_inverted_index.with | 237 |
| abstract_inverted_index.(PPI) | 112 |
| abstract_inverted_index.ATF3, | 205 |
| abstract_inverted_index.DEGs. | 117 |
| abstract_inverted_index.Genes | 67 |
| abstract_inverted_index.Kyoto | 64 |
| abstract_inverted_index.RhoB, | 206 |
| abstract_inverted_index.STC1, | 207 |
| abstract_inverted_index.These | 202 |
| abstract_inverted_index.built | 90 |
| abstract_inverted_index.class | 135 |
| abstract_inverted_index.found | 222 |
| abstract_inverted_index.genes | 14, 52, 96, 195, 214, 235 |
| abstract_inverted_index.study | 2 |
| abstract_inverted_index.three | 37, 100, 200 |
| abstract_inverted_index.total | 191 |
| abstract_inverted_index.using | 76 |
| abstract_inverted_index.while | 145, 179 |
| abstract_inverted_index.(DEGs) | 53 |
| abstract_inverted_index.(KEGG) | 70 |
| abstract_inverted_index.CCL20, | 218 |
| abstract_inverted_index.CXCL8, | 217 |
| abstract_inverted_index.STRING | 103 |
| abstract_inverted_index.VEGFA. | 209 |
| abstract_inverted_index.across | 198 |
| abstract_inverted_index.genes. | 125 |
| abstract_inverted_index.immune | 132 |
| abstract_inverted_index.mainly | 149, 172 |
| abstract_inverted_index.module | 228 |
| abstract_inverted_index.normal | 30 |
| abstract_inverted_index.parts, | 158 |
| abstract_inverted_index.region | 157 |
| abstract_inverted_index.screen | 12 |
| abstract_inverted_index.tissue | 26, 32 |
| abstract_inverted_index.total, | 22 |
| abstract_inverted_index.(CAMs), | 178 |
| abstract_inverted_index.CXCL12, | 216 |
| abstract_inverted_index.Genomes | 69 |
| abstract_inverted_index.Nell-1, | 204 |
| abstract_inverted_index.Results | 163 |
| abstract_inverted_index.cadmium | 160 |
| abstract_inverted_index.derived | 35 |
| abstract_inverted_index.diagram | 88 |
| abstract_inverted_index.existed | 173 |
| abstract_inverted_index.explore | 6 |
| abstract_inverted_index.further | 250 |
| abstract_inverted_index.helpful | 241 |
| abstract_inverted_index.include | 203 |
| abstract_inverted_index.namely, | 39 |
| abstract_inverted_index.network | 226 |
| abstract_inverted_index.organic | 154 |
| abstract_inverted_index.present | 1 |
| abstract_inverted_index.region, | 144 |
| abstract_inverted_index.samples | 27, 33 |
| abstract_inverted_index.(DAVID). | 85 |
| abstract_inverted_index.Database | 78 |
| abstract_inverted_index.GSE1919, | 43 |
| abstract_inverted_index.Ontology | 61 |
| abstract_inverted_index.adhesion | 176 |
| abstract_inverted_index.analysis | 71, 166 |
| abstract_inverted_index.binding. | 162 |
| abstract_inverted_index.database | 104 |
| abstract_inverted_index.eighteen | 193 |
| abstract_inverted_index.enriched | 150 |
| abstract_inverted_index.identify | 48 |
| abstract_inverted_index.involved | 130, 184 |
| abstract_inverted_index.networks | 113 |
| abstract_inverted_index.pathway. | 189 |
| abstract_inverted_index.promotes | 251 |
| abstract_inverted_index.receptor | 137 |
| abstract_inverted_index.relevant | 255 |
| abstract_inverted_index.response | 152 |
| abstract_inverted_index.synovial | 25, 31 |
| abstract_inverted_index.targets. | 259 |
| abstract_inverted_index.Discovery | 84 |
| abstract_inverted_index.GSE55235, | 41 |
| abstract_inverted_index.GSE55457, | 40 |
| abstract_inverted_index.activity, | 138 |
| abstract_inverted_index.addition, | 211 |
| abstract_inverted_index.analysis. | 20 |
| abstract_inverted_index.conducted | 75 |
| abstract_inverted_index.datasets, | 38 |
| abstract_inverted_index.datasets. | 101, 201 |
| abstract_inverted_index.expressed | 51 |
| abstract_inverted_index.including | 215 |
| abstract_inverted_index.indicated | 167 |
| abstract_inverted_index.language. | 58 |
| abstract_inverted_index.molecular | 9, 245 |
| abstract_inverted_index.molecules | 177 |
| abstract_inverted_index.performed | 4 |
| abstract_inverted_index.potential | 94 |
| abstract_inverted_index.presented | 140 |
| abstract_inverted_index.response, | 133 |
| abstract_inverted_index.revealing | 243 |
| abstract_inverted_index.signaling | 188 |
| abstract_inverted_index.Integrated | 83 |
| abstract_inverted_index.associated | 236 |
| abstract_inverted_index.biomarkers | 256 |
| abstract_inverted_index.identified | 97, 119, 197 |
| abstract_inverted_index.mechanisms | 10, 246 |
| abstract_inverted_index.submodules | 115 |
| abstract_inverted_index.underlying | 8 |
| abstract_inverted_index.Annotation, | 80 |
| abstract_inverted_index.Upregulated | 126 |
| abstract_inverted_index.development | 253 |
| abstract_inverted_index.interaction | 111 |
| abstract_inverted_index.substances, | 155 |
| abstract_inverted_index.twenty-five | 23 |
| abstract_inverted_index.upregulated | 121, 170 |
| abstract_inverted_index.Encyclopedia | 65 |
| abstract_inverted_index.constructing | 108 |
| abstract_inverted_index.intersection | 194 |
| abstract_inverted_index.construction. | 229 |
| abstract_inverted_index.downregulated | 124, 146, 180 |
| abstract_inverted_index.extracellular | 143, 156 |
| abstract_inverted_index.significantly | 129, 183 |
| abstract_inverted_index.Identification | 230 |
| abstract_inverted_index.Visualization, | 81 |
| abstract_inverted_index.bioinformatics | 19 |
| abstract_inverted_index.differentially | 50 |
| abstract_inverted_index.osteoarthritis | 16 |
| abstract_inverted_index.protein–protein | 110 |
| cited_by_percentile_year.max | 97 |
| cited_by_percentile_year.min | 89 |
| corresponding_author_ids | https://openalex.org/A5060867127, https://openalex.org/A5100764957 |
| countries_distinct_count | 2 |
| institutions_distinct_count | 9 |
| corresponding_institution_ids | https://openalex.org/I139660479, https://openalex.org/I4210153856 |
| citation_normalized_percentile.value | 0.79337831 |
| citation_normalized_percentile.is_in_top_1_percent | False |
| citation_normalized_percentile.is_in_top_10_percent | False |