Gene Expression Profiling in Pediatric Appendicitis Article Swipe
Bhavjinder K. Dhillon
,
Simone Kortbeek
,
Arjun Baghela
,
Mary Brindle
,
Dori-Ann Martin
,
Craig N. Jenne
,
Hans J. Vogel
,
Amy Huei‐Yi Lee
,
Graham C. Thompson
,
Robert E. W. Hancock
·
YOU?
·
· 2024
· Open Access
·
· DOI: https://doi.org/10.1001/jamapediatrics.2023.6721
YOU?
·
· 2024
· Open Access
·
· DOI: https://doi.org/10.1001/jamapediatrics.2023.6721
Importance Appendicitis is the most common indication for urgent surgery in the pediatric population, presenting across a range of severity and with variable complications. Differentiating simple appendicitis (SA) and perforated appendicitis (PA) on presentation may help direct further diagnostic workup and appropriate therapy selection, including antibiotic choice and timing of surgery. Objective To provide a mechanistic understanding of the differences in disease severity of appendicitis with the objective of developing improved diagnostics and treatments, specifically for the pediatric population. Design, Setting, and Participants The Gene Expression Profiling of Pediatric Appendicitis (GEPPA) study was a single-center prospective exploratory diagnostic study with transcriptomic profiling of peripheral blood collected from a cohort of children aged 5 to 17 years with abdominal pain and suspected appendicitis between November 2016 and April 2017 at the Alberta Children’s Hospital in Calgary, Alberta, Canada, with data analysis reported in August 2023. There was no patient follow-up in this study. Exposure SA, PA, or nonappendicitis abdominal pain. Main Outcomes and Measures Blood transcriptomics was used to develop a hypothesis of underlying mechanistic differences between SA and PA to build mechanistic hypotheses and blood-based diagnostics. Results Seventy-one children (mean [SD] age, 11.8 [3.0] years; 48 [67.6%] male) presenting to the emergency department with abdominal pain and suspected appendicitis were investigated using whole-blood transcriptomics. A central role for immune system pathways was revealed in PA, including a dampening of major innate interferon responses. Gene expression changes in patients with PA were consistent with downregulation of immune response and inflammation pathways and shared similarities with gene expression signatures derived from patients with sepsis, including the most severe sepsis endotypes. Despite the challenges in identifying early biomarkers of severe appendicitis, a 4-gene signature that was predictive of PA compared to SA, with an accuracy of 85.7% (95% CI, 72.8-94.1) was identified. Conclusions This study found that PA was complicated by a dysregulated immune response. This finding should inform improved diagnostics of severity, early management strategies, and prevention of further postsurgical complications.
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Concepts
Metadata
- Type
- letter
- Language
- en
- Landing Page
- https://doi.org/10.1001/jamapediatrics.2023.6721
- OA Status
- green
- Cited By
- 7
- References
- 66
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W4391933016
All OpenAlex metadata
Raw OpenAlex JSON
- OpenAlex ID
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https://openalex.org/W4391933016Canonical identifier for this work in OpenAlex
- DOI
-
https://doi.org/10.1001/jamapediatrics.2023.6721Digital Object Identifier
- Title
-
Gene Expression Profiling in Pediatric AppendicitisWork title
- Type
-
letterOpenAlex work type
- Language
-
enPrimary language
- Publication year
-
2024Year of publication
- Publication date
-
2024-02-19Full publication date if available
- Authors
-
Bhavjinder K. Dhillon, Simone Kortbeek, Arjun Baghela, Mary Brindle, Dori-Ann Martin, Craig N. Jenne, Hans J. Vogel, Amy Huei‐Yi Lee, Graham C. Thompson, Robert E. W. HancockList of authors in order
- Landing page
-
https://doi.org/10.1001/jamapediatrics.2023.6721Publisher landing page
- Open access
-
YesWhether a free full text is available
- OA status
-
greenOpen access status per OpenAlex
- OA URL
-
https://www.ncbi.nlm.nih.gov/pmc/articles/10877506Direct OA link when available
- Concepts
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Medicine, Appendicitis, Abdominal pain, Population, Emergency department, Internal medicine, Intensive care medicine, Surgery, Environmental health, PsychiatryTop concepts (fields/topics) attached by OpenAlex
- Cited by
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7Total citation count in OpenAlex
- Citations by year (recent)
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2025: 4, 2024: 3Per-year citation counts (last 5 years)
- References (count)
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66Number of works referenced by this work
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10Other works algorithmically related by OpenAlex
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| abstract_inverted_index.Gene | 84, 233 |
| abstract_inverted_index.Main | 159 |
| abstract_inverted_index.This | 300, 312 |
| abstract_inverted_index.[SD] | 190 |
| abstract_inverted_index.age, | 191 |
| abstract_inverted_index.aged | 111 |
| abstract_inverted_index.data | 138 |
| abstract_inverted_index.from | 106, 258 |
| abstract_inverted_index.gene | 254 |
| abstract_inverted_index.help | 35 |
| abstract_inverted_index.most | 4, 264 |
| abstract_inverted_index.pain | 118, 205 |
| abstract_inverted_index.role | 216 |
| abstract_inverted_index.that | 281, 303 |
| abstract_inverted_index.this | 150 |
| abstract_inverted_index.used | 166 |
| abstract_inverted_index.were | 209, 240 |
| abstract_inverted_index.with | 21, 65, 99, 116, 137, 203, 238, 242, 253, 260, 289 |
| abstract_inverted_index.(mean | 189 |
| abstract_inverted_index.2023. | 143 |
| abstract_inverted_index.85.7% | 293 |
| abstract_inverted_index.April | 126 |
| abstract_inverted_index.Blood | 163 |
| abstract_inverted_index.There | 144 |
| abstract_inverted_index.[3.0] | 193 |
| abstract_inverted_index.blood | 104 |
| abstract_inverted_index.build | 180 |
| abstract_inverted_index.early | 273, 320 |
| abstract_inverted_index.found | 302 |
| abstract_inverted_index.major | 229 |
| abstract_inverted_index.male) | 197 |
| abstract_inverted_index.pain. | 158 |
| abstract_inverted_index.range | 17 |
| abstract_inverted_index.study | 91, 98, 301 |
| abstract_inverted_index.using | 211 |
| abstract_inverted_index.years | 115 |
| abstract_inverted_index.4-gene | 279 |
| abstract_inverted_index.August | 142 |
| abstract_inverted_index.across | 15 |
| abstract_inverted_index.choice | 46 |
| abstract_inverted_index.cohort | 108 |
| abstract_inverted_index.common | 5 |
| abstract_inverted_index.direct | 36 |
| abstract_inverted_index.immune | 218, 245, 310 |
| abstract_inverted_index.inform | 315 |
| abstract_inverted_index.innate | 230 |
| abstract_inverted_index.sepsis | 266 |
| abstract_inverted_index.severe | 265, 276 |
| abstract_inverted_index.shared | 251 |
| abstract_inverted_index.should | 314 |
| abstract_inverted_index.simple | 25 |
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| abstract_inverted_index.urgent | 8 |
| abstract_inverted_index.workup | 39 |
| abstract_inverted_index.years; | 194 |
| abstract_inverted_index.(GEPPA) | 90 |
| abstract_inverted_index.Alberta | 130 |
| abstract_inverted_index.Canada, | 136 |
| abstract_inverted_index.Design, | 79 |
| abstract_inverted_index.Despite | 268 |
| abstract_inverted_index.Results | 186 |
| abstract_inverted_index.[67.6%] | 196 |
| abstract_inverted_index.between | 122, 175 |
| abstract_inverted_index.central | 215 |
| abstract_inverted_index.changes | 235 |
| abstract_inverted_index.derived | 257 |
| abstract_inverted_index.develop | 168 |
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| abstract_inverted_index.finding | 313 |
| abstract_inverted_index.further | 37, 326 |
| abstract_inverted_index.patient | 147 |
| abstract_inverted_index.provide | 53 |
| abstract_inverted_index.sepsis, | 261 |
| abstract_inverted_index.surgery | 9 |
| abstract_inverted_index.therapy | 42 |
| abstract_inverted_index.Alberta, | 135 |
| abstract_inverted_index.Calgary, | 134 |
| abstract_inverted_index.Exposure | 152 |
| abstract_inverted_index.Hospital | 132 |
| abstract_inverted_index.Measures | 162 |
| abstract_inverted_index.November | 123 |
| abstract_inverted_index.Outcomes | 160 |
| abstract_inverted_index.Setting, | 80 |
| abstract_inverted_index.accuracy | 291 |
| abstract_inverted_index.analysis | 139 |
| abstract_inverted_index.children | 110, 188 |
| abstract_inverted_index.compared | 286 |
| abstract_inverted_index.improved | 70, 316 |
| abstract_inverted_index.pathways | 220, 249 |
| abstract_inverted_index.patients | 237, 259 |
| abstract_inverted_index.reported | 140 |
| abstract_inverted_index.response | 246 |
| abstract_inverted_index.revealed | 222 |
| abstract_inverted_index.severity | 19, 62 |
| abstract_inverted_index.surgery. | 50 |
| abstract_inverted_index.variable | 22 |
| abstract_inverted_index.Objective | 51 |
| abstract_inverted_index.Pediatric | 88 |
| abstract_inverted_index.Profiling | 86 |
| abstract_inverted_index.abdominal | 117, 157, 204 |
| abstract_inverted_index.collected | 105 |
| abstract_inverted_index.dampening | 227 |
| abstract_inverted_index.emergency | 201 |
| abstract_inverted_index.follow-up | 148 |
| abstract_inverted_index.including | 44, 225, 262 |
| abstract_inverted_index.objective | 67 |
| abstract_inverted_index.pediatric | 12, 77 |
| abstract_inverted_index.profiling | 101 |
| abstract_inverted_index.response. | 311 |
| abstract_inverted_index.severity, | 319 |
| abstract_inverted_index.signature | 280 |
| abstract_inverted_index.suspected | 120, 207 |
| abstract_inverted_index.72.8-94.1) | 296 |
| abstract_inverted_index.Expression | 85 |
| abstract_inverted_index.Importance | 0 |
| abstract_inverted_index.antibiotic | 45 |
| abstract_inverted_index.biomarkers | 274 |
| abstract_inverted_index.challenges | 270 |
| abstract_inverted_index.consistent | 241 |
| abstract_inverted_index.department | 202 |
| abstract_inverted_index.developing | 69 |
| abstract_inverted_index.diagnostic | 38, 97 |
| abstract_inverted_index.endotypes. | 267 |
| abstract_inverted_index.expression | 234, 255 |
| abstract_inverted_index.hypotheses | 182 |
| abstract_inverted_index.hypothesis | 170 |
| abstract_inverted_index.indication | 6 |
| abstract_inverted_index.interferon | 231 |
| abstract_inverted_index.management | 321 |
| abstract_inverted_index.perforated | 29 |
| abstract_inverted_index.peripheral | 103 |
| abstract_inverted_index.predictive | 283 |
| abstract_inverted_index.presenting | 14, 198 |
| abstract_inverted_index.prevention | 324 |
| abstract_inverted_index.responses. | 232 |
| abstract_inverted_index.selection, | 43 |
| abstract_inverted_index.signatures | 256 |
| abstract_inverted_index.underlying | 172 |
| abstract_inverted_index.Conclusions | 299 |
| abstract_inverted_index.Seventy-one | 187 |
| abstract_inverted_index.appropriate | 41 |
| abstract_inverted_index.blood-based | 184 |
| abstract_inverted_index.complicated | 306 |
| abstract_inverted_index.diagnostics | 71, 317 |
| abstract_inverted_index.differences | 59, 174 |
| abstract_inverted_index.exploratory | 96 |
| abstract_inverted_index.identified. | 298 |
| abstract_inverted_index.identifying | 272 |
| abstract_inverted_index.mechanistic | 55, 173, 181 |
| abstract_inverted_index.population, | 13 |
| abstract_inverted_index.population. | 78 |
| abstract_inverted_index.prospective | 95 |
| abstract_inverted_index.strategies, | 322 |
| abstract_inverted_index.treatments, | 73 |
| abstract_inverted_index.whole-blood | 212 |
| abstract_inverted_index.Appendicitis | 1, 89 |
| abstract_inverted_index.Children’s | 131 |
| abstract_inverted_index.Participants | 82 |
| abstract_inverted_index.appendicitis | 26, 30, 64, 121, 208 |
| abstract_inverted_index.diagnostics. | 185 |
| abstract_inverted_index.dysregulated | 309 |
| abstract_inverted_index.inflammation | 248 |
| abstract_inverted_index.investigated | 210 |
| abstract_inverted_index.postsurgical | 327 |
| abstract_inverted_index.presentation | 33 |
| abstract_inverted_index.similarities | 252 |
| abstract_inverted_index.specifically | 74 |
| abstract_inverted_index.appendicitis, | 277 |
| abstract_inverted_index.single-center | 94 |
| abstract_inverted_index.understanding | 56 |
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| abstract_inverted_index.downregulation | 243 |
| abstract_inverted_index.transcriptomic | 100 |
| abstract_inverted_index.Differentiating | 24 |
| abstract_inverted_index.nonappendicitis | 156 |
| abstract_inverted_index.transcriptomics | 164 |
| abstract_inverted_index.transcriptomics. | 213 |
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| cited_by_percentile_year.min | 96 |
| countries_distinct_count | 1 |
| institutions_distinct_count | 10 |
| sustainable_development_goals[0].id | https://metadata.un.org/sdg/3 |
| sustainable_development_goals[0].score | 0.5299999713897705 |
| sustainable_development_goals[0].display_name | Good health and well-being |
| citation_normalized_percentile.value | 0.96202777 |
| citation_normalized_percentile.is_in_top_1_percent | False |
| citation_normalized_percentile.is_in_top_10_percent | True |