Gene therapy: an emerging therapy for hair cells regeneration in the cochlea Article Swipe
Jipeng Wang
,
Jianwei Zheng
,
Haiyan Wang
,
Haoying He
,
Shuang Li
,
Ya Zhang
,
You Wang
,
Xiaoxiang Xu
,
Shuyi Wang
·
YOU?
·
· 2023
· Open Access
·
· DOI: https://doi.org/10.3389/fnins.2023.1177791
YOU?
·
· 2023
· Open Access
·
· DOI: https://doi.org/10.3389/fnins.2023.1177791
Sensorineural hearing loss is typically caused by damage to the cochlear hair cells (HCs) due to external stimuli or because of one’s genetic factors and the inability to convert sound mechanical energy into nerve impulses. Adult mammalian cochlear HCs cannot regenerate spontaneously; therefore, this type of deafness is usually considered irreversible. Studies on the developmental mechanisms of HC differentiation have revealed that nonsensory cells in the cochlea acquire the ability to differentiate into HCs after the overexpression of specific genes, such as Atoh1 , which makes HC regeneration possible. Gene therapy, through in vitro selection and editing of target genes, transforms exogenous gene fragments into target cells and alters the expression of genes in target cells to activate the corresponding differentiation developmental program in target cells. This review summarizes the genes that have been associated with the growth and development of cochlear HCs in recent years and provides an overview of gene therapy approaches in the field of HC regeneration. It concludes with a discussion of the limitations of the current therapeutic approaches to facilitate the early implementation of this therapy in a clinical setting.
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Metadata
- Type
- review
- Language
- en
- Landing Page
- https://doi.org/10.3389/fnins.2023.1177791
- https://www.frontiersin.org/articles/10.3389/fnins.2023.1177791/pdf
- OA Status
- gold
- Cited By
- 12
- References
- 104
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W4368405212
All OpenAlex metadata
Raw OpenAlex JSON
- OpenAlex ID
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https://openalex.org/W4368405212Canonical identifier for this work in OpenAlex
- DOI
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https://doi.org/10.3389/fnins.2023.1177791Digital Object Identifier
- Title
-
Gene therapy: an emerging therapy for hair cells regeneration in the cochleaWork title
- Type
-
reviewOpenAlex work type
- Language
-
enPrimary language
- Publication year
-
2023Year of publication
- Publication date
-
2023-05-03Full publication date if available
- Authors
-
Jipeng Wang, Jianwei Zheng, Haiyan Wang, Haoying He, Shuang Li, Ya Zhang, You Wang, Xiaoxiang Xu, Shuyi WangList of authors in order
- Landing page
-
https://doi.org/10.3389/fnins.2023.1177791Publisher landing page
- PDF URL
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https://www.frontiersin.org/articles/10.3389/fnins.2023.1177791/pdfDirect link to full text PDF
- Open access
-
YesWhether a free full text is available
- OA status
-
goldOpen access status per OpenAlex
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https://www.frontiersin.org/articles/10.3389/fnins.2023.1177791/pdfDirect OA link when available
- Concepts
-
Regeneration (biology), Cochlea, Genetic enhancement, Neuroscience, Inner ear, Sensorineural hearing loss, Gene, Hearing loss, Biology, Cell therapy, Hair cell, Cell biology, Stem cell, Medicine, Genetics, AudiologyTop concepts (fields/topics) attached by OpenAlex
- Cited by
-
12Total citation count in OpenAlex
- Citations by year (recent)
-
2025: 4, 2024: 5, 2023: 3Per-year citation counts (last 5 years)
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104Number of works referenced by this work
- Related works (count)
-
10Other works algorithmically related by OpenAlex
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