Generation of a Double Reporter mES Cell Line to Simultaneously Trace the Generation of Retinal Progenitors and Photoreceptors Article Swipe
Oleksandr Zabiegalov
,
Adeline Berger
,
Dhryata Kamdar
,
Kabirou Adamou
,
Chuanxi Tian
,
Martial Mbefo
,
Mathieu Quinodoz
,
Florian Udry
,
Carlo Rivolta
,
Corinne Kostic
,
Yvan Arsenijévic
·
YOU?
·
· 2025
· Open Access
·
· DOI: https://doi.org/10.3390/cells14040252
YOU?
·
· 2025
· Open Access
·
· DOI: https://doi.org/10.3390/cells14040252
Three-dimensional retinal culture systems help to understand eye development and the pathology of disorders. There is a need for reporter stem cell lines to allow in vitro studies on retinal progenitors and photoreceptors and their developmental dynamics or properties and to test therapeutic approaches. The isolation of pure progenitor populations or photoreceptor precursors may serve for drug, gene, and cell therapy development. Here, we generated a dual-reporter mouse embryonic stem cell line Crx-GFP;Rax-mCherry enabling the visualization or isolation of photoreceptors and retinal progenitors from retinal organoid settings. From day 4 organoids, we isolated mCherry-positive cells to assess their early retinal progenitor identity with proliferation tests as well as transcriptomic and proteomic profiling. The timing of eye field transcription factor expression at the transcriptomic and protein levels is in accordance with mouse retinogenesis. This new line will be helpful for rapidly investigating biological questions or testing therapeutics before using human induced pluripotent stem cells (iPSCs), which require a much longer time for retinal organoid formation.
Related Topics
Concepts
Biology
Cell biology
Retinal
Progenitor cell
Induced pluripotent stem cell
mCherry
Embryonic stem cell
Stem cell
Organoid
Cell fate determination
Transcriptome
Cellular differentiation
Cell culture
Green fluorescent protein
Transcription factor
Genetics
Gene expression
Gene
Botany
Metadata
- Type
- article
- Language
- en
- Landing Page
- https://doi.org/10.3390/cells14040252
- OA Status
- gold
- Cited By
- 1
- References
- 78
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W4407352480
All OpenAlex metadata
Raw OpenAlex JSON
- OpenAlex ID
-
https://openalex.org/W4407352480Canonical identifier for this work in OpenAlex
- DOI
-
https://doi.org/10.3390/cells14040252Digital Object Identifier
- Title
-
Generation of a Double Reporter mES Cell Line to Simultaneously Trace the Generation of Retinal Progenitors and PhotoreceptorsWork title
- Type
-
articleOpenAlex work type
- Language
-
enPrimary language
- Publication year
-
2025Year of publication
- Publication date
-
2025-02-10Full publication date if available
- Authors
-
Oleksandr Zabiegalov, Adeline Berger, Dhryata Kamdar, Kabirou Adamou, Chuanxi Tian, Martial Mbefo, Mathieu Quinodoz, Florian Udry, Carlo Rivolta, Corinne Kostic, Yvan ArsenijévicList of authors in order
- Landing page
-
https://doi.org/10.3390/cells14040252Publisher landing page
- Open access
-
YesWhether a free full text is available
- OA status
-
goldOpen access status per OpenAlex
- OA URL
-
https://doi.org/10.3390/cells14040252Direct OA link when available
- Concepts
-
Biology, Cell biology, Retinal, Progenitor cell, Induced pluripotent stem cell, mCherry, Embryonic stem cell, Stem cell, Organoid, Cell fate determination, Transcriptome, Cellular differentiation, Cell culture, Green fluorescent protein, Transcription factor, Genetics, Gene expression, Gene, BotanyTop concepts (fields/topics) attached by OpenAlex
- Cited by
-
1Total citation count in OpenAlex
- Citations by year (recent)
-
2025: 1Per-year citation counts (last 5 years)
- References (count)
-
78Number of works referenced by this work
- Related works (count)
-
10Other works algorithmically related by OpenAlex
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