Generation of a quenched phosphonate activity-based probe for labelling the active KLK7 protease Article Swipe

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Evangelos Bisyris , Eleni Zingkou , Golfo G. Kordopati , Minos–Timotheos Matsoukas , Plato Α. Magriotis , Georgios Pampalakis , Georgia Sotiropoulou ·

YOU? · · 2021 · Open Access · · DOI: https://doi.org/10.1039/d1ob01273h

A mixed alkyl aryl phosphonate qABP for KLK7 was developed where the internally-quenching system is realeased upon binding of the qABP to the active enzyme.

Related Topics

Chemistry

Protease

Biochemistry

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Chemistry Phosphonate Protease Serine protease Proteases Active site Enzyme Biochemistry

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Type: article
Language: en
Landing Page: https://doi.org/10.1039/d1ob01273h
PDF: https://pubs.rsc.org/en/content/articlepdf/2021/ob/d1ob01273h
OA Status: hybrid
Cited By: 13
References: 36
Related Works: 10
OpenAlex ID: https://openalex.org/W3185487840

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OpenAlex ID: https://openalex.org/W3185487840

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DOI: https://doi.org/10.1039/d1ob01273h

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Title: Generation of a quenched phosphonate activity-based probe for labelling the active KLK7 protease

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Type: article

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Language: en

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Publication year: 2021

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Publication date: 2021-01-01

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Authors: Evangelos Bisyris, Eleni Zingkou, Golfo G. Kordopati, Minos–Timotheos Matsoukas, Plato Α. Magriotis, Georgios Pampalakis, Georgia Sotiropoulou

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Landing page: https://doi.org/10.1039/d1ob01273h

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Concepts: Chemistry, Phosphonate, Protease, Serine protease, Proteases, Active site, Enzyme, Biochemistry

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Cited by: 13

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