Genetic analysis of Mycobacterium abscessus reveals genomic diversity linked to global plasmid distribution Article Swipe
Kensuke Ohse
,
Atsushi Yoshida
,
Keisuke Kamada
,
Hironobu Kitazawa
,
Yusuke Ito
,
Takayo Shoji
,
Kenichiro Watanabe
,
Hiroshi Koganemaru
,
Ken Kikuchi
,
Masashi Toyoda
·
YOU?
·
· 2024
· Open Access
·
· DOI: https://doi.org/10.1101/2024.06.11.597493
YOU?
·
· 2024
· Open Access
·
· DOI: https://doi.org/10.1101/2024.06.11.597493
SUMMARY Genetic epidemiological analysis of mobile genetic elements, such as plasmids, has rarely been carried out in Mycobacterium abscessus, regardless of its usefulness in speculating the past contact between bacteria. In this study, through whole genome sequencing analysis of clinical isolates of M. abscessus sequentially collected from the same patient, we identified a single nucleotide variant that could cause antibiotic resistance, and three plasmids (pMAB625-1, pMAB625-2 and pMAB625-3) not found in the type strain. We investigated the distribution of plasmids previously identified in M. abscessus, including pMAB625 plasmids, in 462 clinical isolates worldwide in silico . pMAB625-3 was detected in the largest number of isolates. Furthermore, phylogenetic tree analysis revealed that these plasmids transferred beyond regions and subspecies and acquired unique mutations. These results indicate that transmission of plasmids increases the genomic diversity in M. abscessus, and plasmid epidemiology is useful for estimating the past contact between bacteria.
Related Topics
Concepts
Plasmid
Mycobacterium abscessus
Biology
Genetics
Phylogenetic tree
Genetic diversity
Mobile genetic elements
Mycobacterium
Bacteria
Gene
Medicine
Population
Environmental health
Metadata
- Type
- preprint
- Language
- en
- Landing Page
- https://doi.org/10.1101/2024.06.11.597493
- https://www.biorxiv.org/content/biorxiv/early/2024/06/12/2024.06.11.597493.full.pdf
- OA Status
- green
- References
- 75
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W4399617047
All OpenAlex metadata
Raw OpenAlex JSON
- OpenAlex ID
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- DOI
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https://doi.org/10.1101/2024.06.11.597493Digital Object Identifier
- Title
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Genetic analysis of Mycobacterium abscessus reveals genomic diversity linked to global plasmid distributionWork title
- Type
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preprintOpenAlex work type
- Language
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enPrimary language
- Publication year
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2024Year of publication
- Publication date
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2024-06-12Full publication date if available
- Authors
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Kensuke Ohse, Atsushi Yoshida, Keisuke Kamada, Hironobu Kitazawa, Yusuke Ito, Takayo Shoji, Kenichiro Watanabe, Hiroshi Koganemaru, Ken Kikuchi, Masashi ToyodaList of authors in order
- Landing page
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https://doi.org/10.1101/2024.06.11.597493Publisher landing page
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https://www.biorxiv.org/content/biorxiv/early/2024/06/12/2024.06.11.597493.full.pdfDirect link to full text PDF
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YesWhether a free full text is available
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greenOpen access status per OpenAlex
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https://www.biorxiv.org/content/biorxiv/early/2024/06/12/2024.06.11.597493.full.pdfDirect OA link when available
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0Total citation count in OpenAlex
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75Number of works referenced by this work
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10Other works algorithmically related by OpenAlex
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