Genetic Basis of Extramedullary Plasmablastic Transformation of Multiple Myeloma Article Swipe
Ying Liu
,
Fatima Zahra Jelloul
,
Yanming Zhang
,
Tapan Bhavsar
,
Caleb Ho
,
Mamta Rao
,
Natasha Lewis
,
Robert Cimera
,
Jeeyeon Baik
,
Allison Sigler
,
Filiz Şen
,
Mariko Yabe
,
Mikhail Roshal
,
Ola Landgren
,
Ahmet Doğan
,
Wenbin Xiao
·
YOU?
·
· 2020
· Open Access
·
· DOI: https://doi.org/10.1097/pas.0000000000001459
YOU?
·
· 2020
· Open Access
·
· DOI: https://doi.org/10.1097/pas.0000000000001459
In patients with multiple myeloma, plasmablastic transformation in the bone marrow is rare and associated with poor outcomes. The significance of discordant extramedullary plasmablastic transformation in patients with small, mature clonal plasma cells in the bone marrow has not been well studied. Here, we report the clinicopathologic, cytogenetic, and molecular features of 10 such patients (male/female: 6/4, median age: 65 y, range: 48 to 76 y) with an established diagnosis of multiple myeloma in the bone marrow composed of small, mature plasma cells in parallel with a concurrent or subsequent extramedullary plasmablastic transformation. Eight patients with available survival data showed an overall aggressive clinical course with a median survival of 4.5 months after the diagnosis of extramedullary plasmablastic transformation, despite aggressive treatment and even in patients with low-level bone marrow involvement. Pathologically, the extramedullary plasmablastic myeloma were clonally related to the corresponding bone marrow plasma cells, showed high levels of CMYC and/or P53 expression with a high Ki-67 proliferation index by immunohistochemistry and harbored more complex genomic aberrations including frequent mutations in the RAS pathway and MYC rearrangements compared with their bone marrow counterparts. In summary, although genetic and immunohistochemical studies were not uniformly performed on all cases due to the retrospective nature of this study, our data suggest that discordant extramedullary plasmablastic transformation of multiple myeloma has an aggressive clinical course and is characterized by frequent mutations in the RAS pathway and more complex genomic abnormalities.
Related Topics
Concepts
Metadata
- Type
- article
- Language
- en
- Landing Page
- https://doi.org/10.1097/pas.0000000000001459
- OA Status
- green
- Cited By
- 43
- References
- 38
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W3009071170
All OpenAlex metadata
Raw OpenAlex JSON
- OpenAlex ID
-
https://openalex.org/W3009071170Canonical identifier for this work in OpenAlex
- DOI
-
https://doi.org/10.1097/pas.0000000000001459Digital Object Identifier
- Title
-
Genetic Basis of Extramedullary Plasmablastic Transformation of Multiple MyelomaWork title
- Type
-
articleOpenAlex work type
- Language
-
enPrimary language
- Publication year
-
2020Year of publication
- Publication date
-
2020-02-28Full publication date if available
- Authors
-
Ying Liu, Fatima Zahra Jelloul, Yanming Zhang, Tapan Bhavsar, Caleb Ho, Mamta Rao, Natasha Lewis, Robert Cimera, Jeeyeon Baik, Allison Sigler, Filiz Şen, Mariko Yabe, Mikhail Roshal, Ola Landgren, Ahmet Doğan, Wenbin XiaoList of authors in order
- Landing page
-
https://doi.org/10.1097/pas.0000000000001459Publisher landing page
- Open access
-
YesWhether a free full text is available
- OA status
-
greenOpen access status per OpenAlex
- OA URL
-
https://www.ncbi.nlm.nih.gov/pmc/articles/7225029Direct OA link when available
- Concepts
-
Multiple myeloma, Bone marrow, Pathology, Immunohistochemistry, Plasma cell, Medicine, Plasma Cell Myeloma, Proliferation index, Cancer research, Internal medicineTop concepts (fields/topics) attached by OpenAlex
- Cited by
-
43Total citation count in OpenAlex
- Citations by year (recent)
-
2025: 11, 2024: 10, 2023: 9, 2022: 8, 2021: 5Per-year citation counts (last 5 years)
- References (count)
-
38Number of works referenced by this work
- Related works (count)
-
10Other works algorithmically related by OpenAlex
Full payload
| id | https://openalex.org/W3009071170 |
|---|---|
| doi | https://doi.org/10.1097/pas.0000000000001459 |
| ids.doi | https://doi.org/10.1097/pas.0000000000001459 |
| ids.mag | 3009071170 |
| ids.pmid | https://pubmed.ncbi.nlm.nih.gov/32118627 |
| ids.openalex | https://openalex.org/W3009071170 |
| fwci | 3.45251318 |
| mesh[0].qualifier_ui | |
| mesh[0].descriptor_ui | D000368 |
| mesh[0].is_major_topic | False |
| mesh[0].qualifier_name | |
| mesh[0].descriptor_name | Aged |
| mesh[1].qualifier_ui | |
| mesh[1].descriptor_ui | D005260 |
| mesh[1].is_major_topic | False |
| mesh[1].qualifier_name | |
| mesh[1].descriptor_name | Female |
| mesh[2].qualifier_ui | |
| mesh[2].descriptor_ui | D006801 |
| mesh[2].is_major_topic | False |
| mesh[2].qualifier_name | |
| mesh[2].descriptor_name | Humans |
| mesh[3].qualifier_ui | |
| mesh[3].descriptor_ui | D008297 |
| mesh[3].is_major_topic | False |
| mesh[3].qualifier_name | |
| mesh[3].descriptor_name | Male |
| mesh[4].qualifier_ui | |
| mesh[4].descriptor_ui | D008875 |
| mesh[4].is_major_topic | False |
| mesh[4].qualifier_name | |
| mesh[4].descriptor_name | Middle Aged |
| mesh[5].qualifier_ui | Q000235 |
| mesh[5].descriptor_ui | D009101 |
| mesh[5].is_major_topic | False |
| mesh[5].qualifier_name | genetics |
| mesh[5].descriptor_name | Multiple Myeloma |
| mesh[6].qualifier_ui | Q000473 |
| mesh[6].descriptor_ui | D009101 |
| mesh[6].is_major_topic | False |
| mesh[6].qualifier_name | pathology |
| mesh[6].descriptor_name | Multiple Myeloma |
| mesh[7].qualifier_ui | Q000473 |
| mesh[7].descriptor_ui | D010950 |
| mesh[7].is_major_topic | False |
| mesh[7].qualifier_name | pathology |
| mesh[7].descriptor_name | Plasma Cells |
| mesh[8].qualifier_ui | |
| mesh[8].descriptor_ui | D000368 |
| mesh[8].is_major_topic | False |
| mesh[8].qualifier_name | |
| mesh[8].descriptor_name | Aged |
| mesh[9].qualifier_ui | |
| mesh[9].descriptor_ui | D005260 |
| mesh[9].is_major_topic | False |
| mesh[9].qualifier_name | |
| mesh[9].descriptor_name | Female |
| mesh[10].qualifier_ui | |
| mesh[10].descriptor_ui | D006801 |
| mesh[10].is_major_topic | False |
| mesh[10].qualifier_name | |
| mesh[10].descriptor_name | Humans |
| mesh[11].qualifier_ui | |
| mesh[11].descriptor_ui | D008297 |
| mesh[11].is_major_topic | False |
| mesh[11].qualifier_name | |
| mesh[11].descriptor_name | Male |
| mesh[12].qualifier_ui | |
| mesh[12].descriptor_ui | D008875 |
| mesh[12].is_major_topic | False |
| mesh[12].qualifier_name | |
| mesh[12].descriptor_name | Middle Aged |
| mesh[13].qualifier_ui | Q000235 |
| mesh[13].descriptor_ui | D009101 |
| mesh[13].is_major_topic | False |
| mesh[13].qualifier_name | genetics |
| mesh[13].descriptor_name | Multiple Myeloma |
| mesh[14].qualifier_ui | Q000473 |
| mesh[14].descriptor_ui | D009101 |
| mesh[14].is_major_topic | False |
| mesh[14].qualifier_name | pathology |
| mesh[14].descriptor_name | Multiple Myeloma |
| mesh[15].qualifier_ui | Q000473 |
| mesh[15].descriptor_ui | D010950 |
| mesh[15].is_major_topic | False |
| mesh[15].qualifier_name | pathology |
| mesh[15].descriptor_name | Plasma Cells |
| type | article |
| title | Genetic Basis of Extramedullary Plasmablastic Transformation of Multiple Myeloma |
| biblio.issue | 6 |
| biblio.volume | 44 |
| biblio.last_page | 848 |
| biblio.first_page | 838 |
| topics[0].id | https://openalex.org/T10649 |
| topics[0].field.id | https://openalex.org/fields/27 |
| topics[0].field.display_name | Medicine |
| topics[0].score | 1.0 |
| topics[0].domain.id | https://openalex.org/domains/4 |
| topics[0].domain.display_name | Health Sciences |
| topics[0].subfield.id | https://openalex.org/subfields/2720 |
| topics[0].subfield.display_name | Hematology |
| topics[0].display_name | Multiple Myeloma Research and Treatments |
| topics[1].id | https://openalex.org/T12534 |
| topics[1].field.id | https://openalex.org/fields/13 |
| topics[1].field.display_name | Biochemistry, Genetics and Molecular Biology |
| topics[1].score | 0.9937999844551086 |
| topics[1].domain.id | https://openalex.org/domains/1 |
| topics[1].domain.display_name | Life Sciences |
| topics[1].subfield.id | https://openalex.org/subfields/1312 |
| topics[1].subfield.display_name | Molecular Biology |
| topics[1].display_name | Protein Degradation and Inhibitors |
| topics[2].id | https://openalex.org/T11041 |
| topics[2].field.id | https://openalex.org/fields/13 |
| topics[2].field.display_name | Biochemistry, Genetics and Molecular Biology |
| topics[2].score | 0.991100013256073 |
| topics[2].domain.id | https://openalex.org/domains/1 |
| topics[2].domain.display_name | Life Sciences |
| topics[2].subfield.id | https://openalex.org/subfields/1312 |
| topics[2].subfield.display_name | Molecular Biology |
| topics[2].display_name | Ubiquitin and proteasome pathways |
| is_xpac | False |
| apc_list | |
| apc_paid | |
| concepts[0].id | https://openalex.org/C2776364478 |
| concepts[0].level | 2 |
| concepts[0].score | 0.7852910757064819 |
| concepts[0].wikidata | https://www.wikidata.org/wiki/Q467635 |
| concepts[0].display_name | Multiple myeloma |
| concepts[1].id | https://openalex.org/C2780007613 |
| concepts[1].level | 2 |
| concepts[1].score | 0.7317905426025391 |
| concepts[1].wikidata | https://www.wikidata.org/wiki/Q546523 |
| concepts[1].display_name | Bone marrow |
| concepts[2].id | https://openalex.org/C142724271 |
| concepts[2].level | 1 |
| concepts[2].score | 0.6214639544487 |
| concepts[2].wikidata | https://www.wikidata.org/wiki/Q7208 |
| concepts[2].display_name | Pathology |
| concepts[3].id | https://openalex.org/C204232928 |
| concepts[3].level | 2 |
| concepts[3].score | 0.5904114246368408 |
| concepts[3].wikidata | https://www.wikidata.org/wiki/Q899285 |
| concepts[3].display_name | Immunohistochemistry |
| concepts[4].id | https://openalex.org/C2776396001 |
| concepts[4].level | 3 |
| concepts[4].score | 0.5365583300590515 |
| concepts[4].wikidata | https://www.wikidata.org/wiki/Q250694 |
| concepts[4].display_name | Plasma cell |
| concepts[5].id | https://openalex.org/C71924100 |
| concepts[5].level | 0 |
| concepts[5].score | 0.49239933490753174 |
| concepts[5].wikidata | https://www.wikidata.org/wiki/Q11190 |
| concepts[5].display_name | Medicine |
| concepts[6].id | https://openalex.org/C2908937092 |
| concepts[6].level | 3 |
| concepts[6].score | 0.4737085700035095 |
| concepts[6].wikidata | https://www.wikidata.org/wiki/Q467635 |
| concepts[6].display_name | Plasma Cell Myeloma |
| concepts[7].id | https://openalex.org/C2910938049 |
| concepts[7].level | 3 |
| concepts[7].score | 0.416892409324646 |
| concepts[7].wikidata | https://www.wikidata.org/wiki/Q7249605 |
| concepts[7].display_name | Proliferation index |
| concepts[8].id | https://openalex.org/C502942594 |
| concepts[8].level | 1 |
| concepts[8].score | 0.36578604578971863 |
| concepts[8].wikidata | https://www.wikidata.org/wiki/Q3421914 |
| concepts[8].display_name | Cancer research |
| concepts[9].id | https://openalex.org/C126322002 |
| concepts[9].level | 1 |
| concepts[9].score | 0.23525971174240112 |
| concepts[9].wikidata | https://www.wikidata.org/wiki/Q11180 |
| concepts[9].display_name | Internal medicine |
| keywords[0].id | https://openalex.org/keywords/multiple-myeloma |
| keywords[0].score | 0.7852910757064819 |
| keywords[0].display_name | Multiple myeloma |
| keywords[1].id | https://openalex.org/keywords/bone-marrow |
| keywords[1].score | 0.7317905426025391 |
| keywords[1].display_name | Bone marrow |
| keywords[2].id | https://openalex.org/keywords/pathology |
| keywords[2].score | 0.6214639544487 |
| keywords[2].display_name | Pathology |
| keywords[3].id | https://openalex.org/keywords/immunohistochemistry |
| keywords[3].score | 0.5904114246368408 |
| keywords[3].display_name | Immunohistochemistry |
| keywords[4].id | https://openalex.org/keywords/plasma-cell |
| keywords[4].score | 0.5365583300590515 |
| keywords[4].display_name | Plasma cell |
| keywords[5].id | https://openalex.org/keywords/medicine |
| keywords[5].score | 0.49239933490753174 |
| keywords[5].display_name | Medicine |
| keywords[6].id | https://openalex.org/keywords/plasma-cell-myeloma |
| keywords[6].score | 0.4737085700035095 |
| keywords[6].display_name | Plasma Cell Myeloma |
| keywords[7].id | https://openalex.org/keywords/proliferation-index |
| keywords[7].score | 0.416892409324646 |
| keywords[7].display_name | Proliferation index |
| keywords[8].id | https://openalex.org/keywords/cancer-research |
| keywords[8].score | 0.36578604578971863 |
| keywords[8].display_name | Cancer research |
| keywords[9].id | https://openalex.org/keywords/internal-medicine |
| keywords[9].score | 0.23525971174240112 |
| keywords[9].display_name | Internal medicine |
| language | en |
| locations[0].id | doi:10.1097/pas.0000000000001459 |
| locations[0].is_oa | False |
| locations[0].source.id | https://openalex.org/S37879208 |
| locations[0].source.issn | 0147-5185, 1532-0979 |
| locations[0].source.type | journal |
| locations[0].source.is_oa | False |
| locations[0].source.issn_l | 0147-5185 |
| locations[0].source.is_core | True |
| locations[0].source.is_in_doaj | False |
| locations[0].source.display_name | The American Journal of Surgical Pathology |
| locations[0].source.host_organization | https://openalex.org/P4310315671 |
| locations[0].source.host_organization_name | Lippincott Williams & Wilkins |
| locations[0].source.host_organization_lineage | https://openalex.org/P4310315671, https://openalex.org/P4310318547 |
| locations[0].source.host_organization_lineage_names | Lippincott Williams & Wilkins, Wolters Kluwer |
| locations[0].license | |
| locations[0].pdf_url | |
| locations[0].version | publishedVersion |
| locations[0].raw_type | journal-article |
| locations[0].license_id | |
| locations[0].is_accepted | True |
| locations[0].is_published | True |
| locations[0].raw_source_name | American Journal of Surgical Pathology |
| locations[0].landing_page_url | https://doi.org/10.1097/pas.0000000000001459 |
| locations[1].id | pmid:32118627 |
| locations[1].is_oa | False |
| locations[1].source.id | https://openalex.org/S4306525036 |
| locations[1].source.issn | |
| locations[1].source.type | repository |
| locations[1].source.is_oa | False |
| locations[1].source.issn_l | |
| locations[1].source.is_core | False |
| locations[1].source.is_in_doaj | False |
| locations[1].source.display_name | PubMed |
| locations[1].source.host_organization | https://openalex.org/I1299303238 |
| locations[1].source.host_organization_name | National Institutes of Health |
| locations[1].source.host_organization_lineage | https://openalex.org/I1299303238 |
| locations[1].license | |
| locations[1].pdf_url | |
| locations[1].version | publishedVersion |
| locations[1].raw_type | |
| locations[1].license_id | |
| locations[1].is_accepted | True |
| locations[1].is_published | True |
| locations[1].raw_source_name | The American journal of surgical pathology |
| locations[1].landing_page_url | https://pubmed.ncbi.nlm.nih.gov/32118627 |
| locations[2].id | pmh:oai:pubmedcentral.nih.gov:7225029 |
| locations[2].is_oa | True |
| locations[2].source.id | https://openalex.org/S2764455111 |
| locations[2].source.issn | |
| locations[2].source.type | repository |
| locations[2].source.is_oa | False |
| locations[2].source.issn_l | |
| locations[2].source.is_core | False |
| locations[2].source.is_in_doaj | False |
| locations[2].source.display_name | PubMed Central |
| locations[2].source.host_organization | https://openalex.org/I1299303238 |
| locations[2].source.host_organization_name | National Institutes of Health |
| locations[2].source.host_organization_lineage | https://openalex.org/I1299303238 |
| locations[2].license | |
| locations[2].pdf_url | |
| locations[2].version | submittedVersion |
| locations[2].raw_type | Text |
| locations[2].license_id | |
| locations[2].is_accepted | False |
| locations[2].is_published | False |
| locations[2].raw_source_name | Am J Surg Pathol |
| locations[2].landing_page_url | https://www.ncbi.nlm.nih.gov/pmc/articles/7225029 |
| indexed_in | crossref, pubmed |
| authorships[0].author.id | https://openalex.org/A5100414285 |
| authorships[0].author.orcid | https://orcid.org/0000-0002-6540-0473 |
| authorships[0].author.display_name | Ying Liu |
| authorships[0].affiliations[0].raw_affiliation_string | Department of Pathology, Hematopathology Service |
| authorships[0].author_position | first |
| authorships[0].raw_author_name | Ying Liu |
| authorships[0].is_corresponding | True |
| authorships[0].raw_affiliation_strings | Department of Pathology, Hematopathology Service |
| authorships[1].author.id | https://openalex.org/A5072687747 |
| authorships[1].author.orcid | https://orcid.org/0000-0002-3791-3204 |
| authorships[1].author.display_name | Fatima Zahra Jelloul |
| authorships[1].affiliations[0].raw_affiliation_string | Department of Pathology, Hematopathology Service |
| authorships[1].author_position | middle |
| authorships[1].raw_author_name | Fatima Jelloul |
| authorships[1].is_corresponding | True |
| authorships[1].raw_affiliation_strings | Department of Pathology, Hematopathology Service |
| authorships[2].author.id | https://openalex.org/A5115587797 |
| authorships[2].author.orcid | https://orcid.org/0009-0001-8154-3351 |
| authorships[2].author.display_name | Yanming Zhang |
| authorships[2].affiliations[0].raw_affiliation_string | Department of Pathology, Cytogenetic Laboratory |
| authorships[2].author_position | middle |
| authorships[2].raw_author_name | Yanming Zhang |
| authorships[2].is_corresponding | False |
| authorships[2].raw_affiliation_strings | Department of Pathology, Cytogenetic Laboratory |
| authorships[3].author.id | https://openalex.org/A5040855823 |
| authorships[3].author.orcid | |
| authorships[3].author.display_name | Tapan Bhavsar |
| authorships[3].countries | US |
| authorships[3].affiliations[0].institution_ids | https://openalex.org/I185443292, https://openalex.org/I2801816960 |
| authorships[3].affiliations[0].raw_affiliation_string | Department of Pathology, Wayne State University School of Medicine, Detroit Receiving Hospital, Detroit, MI |
| authorships[3].affiliations[1].institution_ids | https://openalex.org/I193531525, https://openalex.org/I4210135078 |
| authorships[3].affiliations[1].raw_affiliation_string | Present address: Tapan Bhavsar, Department of Pathology, George Washington University Medical Center, 900 23rd Street, Washington, DC 20037. |
| authorships[3].institutions[0].id | https://openalex.org/I2801816960 |
| authorships[3].institutions[0].ror | https://ror.org/00682eh61 |
| authorships[3].institutions[0].type | healthcare |
| authorships[3].institutions[0].lineage | https://openalex.org/I2800326109, https://openalex.org/I2801816960 |
| authorships[3].institutions[0].country_code | US |
| authorships[3].institutions[0].display_name | Detroit Receiving Hospital |
| authorships[3].institutions[1].id | https://openalex.org/I193531525 |
| authorships[3].institutions[1].ror | https://ror.org/00y4zzh67 |
| authorships[3].institutions[1].type | education |
| authorships[3].institutions[1].lineage | https://openalex.org/I193531525 |
| authorships[3].institutions[1].country_code | US |
| authorships[3].institutions[1].display_name | George Washington University |
| authorships[3].institutions[2].id | https://openalex.org/I4210135078 |
| authorships[3].institutions[2].ror | https://ror.org/036c27j91 |
| authorships[3].institutions[2].type | healthcare |
| authorships[3].institutions[2].lineage | https://openalex.org/I4210135078 |
| authorships[3].institutions[2].country_code | US |
| authorships[3].institutions[2].display_name | Washington University Medical Center |
| authorships[3].institutions[3].id | https://openalex.org/I185443292 |
| authorships[3].institutions[3].ror | https://ror.org/01070mq45 |
| authorships[3].institutions[3].type | education |
| authorships[3].institutions[3].lineage | https://openalex.org/I185443292 |
| authorships[3].institutions[3].country_code | US |
| authorships[3].institutions[3].display_name | Wayne State University |
| authorships[3].author_position | middle |
| authorships[3].raw_author_name | Tapan Bhavsar |
| authorships[3].is_corresponding | False |
| authorships[3].raw_affiliation_strings | Department of Pathology, Wayne State University School of Medicine, Detroit Receiving Hospital, Detroit, MI, Present address: Tapan Bhavsar, Department of Pathology, George Washington University Medical Center, 900 23rd Street, Washington, DC 20037. |
| authorships[4].author.id | https://openalex.org/A5081913602 |
| authorships[4].author.orcid | https://orcid.org/0000-0001-5448-4635 |
| authorships[4].author.display_name | Caleb Ho |
| authorships[4].affiliations[0].raw_affiliation_string | Department of Pathology, Diagnostic Molecular Pathology Service |
| authorships[4].affiliations[1].raw_affiliation_string | Department of Pathology, Hematopathology Service |
| authorships[4].author_position | middle |
| authorships[4].raw_author_name | Caleb Ho |
| authorships[4].is_corresponding | True |
| authorships[4].raw_affiliation_strings | Department of Pathology, Diagnostic Molecular Pathology Service, Department of Pathology, Hematopathology Service |
| authorships[5].author.id | https://openalex.org/A5112562606 |
| authorships[5].author.orcid | |
| authorships[5].author.display_name | Mamta Rao |
| authorships[5].affiliations[0].raw_affiliation_string | Department of Pathology, Cytogenetic Laboratory |
| authorships[5].author_position | middle |
| authorships[5].raw_author_name | Mamta Rao |
| authorships[5].is_corresponding | False |
| authorships[5].raw_affiliation_strings | Department of Pathology, Cytogenetic Laboratory |
| authorships[6].author.id | https://openalex.org/A5017431865 |
| authorships[6].author.orcid | https://orcid.org/0000-0002-0640-7114 |
| authorships[6].author.display_name | Natasha Lewis |
| authorships[6].affiliations[0].raw_affiliation_string | Department of Pathology, Hematopathology Service |
| authorships[6].author_position | middle |
| authorships[6].raw_author_name | Natasha E. Lewis |
| authorships[6].is_corresponding | True |
| authorships[6].raw_affiliation_strings | Department of Pathology, Hematopathology Service |
| authorships[7].author.id | https://openalex.org/A5035845182 |
| authorships[7].author.orcid | |
| authorships[7].author.display_name | Robert Cimera |
| authorships[7].affiliations[0].raw_affiliation_string | Department of Pathology, Cytogenetic Laboratory |
| authorships[7].author_position | middle |
| authorships[7].raw_author_name | Robert Cimera |
| authorships[7].is_corresponding | False |
| authorships[7].raw_affiliation_strings | Department of Pathology, Cytogenetic Laboratory |
| authorships[8].author.id | https://openalex.org/A5044561007 |
| authorships[8].author.orcid | |
| authorships[8].author.display_name | Jeeyeon Baik |
| authorships[8].affiliations[0].raw_affiliation_string | Department of Pathology, Hematopathology Service |
| authorships[8].author_position | middle |
| authorships[8].raw_author_name | Jeeyeon Baik |
| authorships[8].is_corresponding | True |
| authorships[8].raw_affiliation_strings | Department of Pathology, Hematopathology Service |
| authorships[9].author.id | https://openalex.org/A5070830465 |
| authorships[9].author.orcid | https://orcid.org/0000-0002-1519-2119 |
| authorships[9].author.display_name | Allison Sigler |
| authorships[9].affiliations[0].raw_affiliation_string | Department of Pathology, Hematopathology Service |
| authorships[9].author_position | middle |
| authorships[9].raw_author_name | Allison Sigler |
| authorships[9].is_corresponding | True |
| authorships[9].raw_affiliation_strings | Department of Pathology, Hematopathology Service |
| authorships[10].author.id | https://openalex.org/A5030239977 |
| authorships[10].author.orcid | https://orcid.org/0009-0000-9852-5398 |
| authorships[10].author.display_name | Filiz Şen |
| authorships[10].affiliations[0].raw_affiliation_string | Department of Pathology, Hematopathology Service |
| authorships[10].author_position | middle |
| authorships[10].raw_author_name | Filiz Sen |
| authorships[10].is_corresponding | True |
| authorships[10].raw_affiliation_strings | Department of Pathology, Hematopathology Service |
| authorships[11].author.id | https://openalex.org/A5087788162 |
| authorships[11].author.orcid | https://orcid.org/0000-0002-3864-7921 |
| authorships[11].author.display_name | Mariko Yabe |
| authorships[11].affiliations[0].raw_affiliation_string | Department of Pathology, Hematopathology Service |
| authorships[11].author_position | middle |
| authorships[11].raw_author_name | Mariko Yabe |
| authorships[11].is_corresponding | True |
| authorships[11].raw_affiliation_strings | Department of Pathology, Hematopathology Service |
| authorships[12].author.id | https://openalex.org/A5079953387 |
| authorships[12].author.orcid | https://orcid.org/0000-0002-9585-0790 |
| authorships[12].author.display_name | Mikhail Roshal |
| authorships[12].affiliations[0].raw_affiliation_string | Department of Pathology, Hematopathology Service |
| authorships[12].author_position | middle |
| authorships[12].raw_author_name | Mikhail Roshal |
| authorships[12].is_corresponding | True |
| authorships[12].raw_affiliation_strings | Department of Pathology, Hematopathology Service |
| authorships[13].author.id | https://openalex.org/A5082004555 |
| authorships[13].author.orcid | https://orcid.org/0000-0001-6485-4839 |
| authorships[13].author.display_name | Ola Landgren |
| authorships[13].countries | US |
| authorships[13].affiliations[0].institution_ids | https://openalex.org/I1334819555 |
| authorships[13].affiliations[0].raw_affiliation_string | Department of Medicine, Myeloma Service, Memorial Sloan Kettering Cancer Center, New York, NY |
| authorships[13].institutions[0].id | https://openalex.org/I1334819555 |
| authorships[13].institutions[0].ror | https://ror.org/02yrq0923 |
| authorships[13].institutions[0].type | healthcare |
| authorships[13].institutions[0].lineage | https://openalex.org/I1334819555 |
| authorships[13].institutions[0].country_code | US |
| authorships[13].institutions[0].display_name | Memorial Sloan Kettering Cancer Center |
| authorships[13].author_position | middle |
| authorships[13].raw_author_name | Ola Landgren |
| authorships[13].is_corresponding | False |
| authorships[13].raw_affiliation_strings | Department of Medicine, Myeloma Service, Memorial Sloan Kettering Cancer Center, New York, NY |
| authorships[14].author.id | https://openalex.org/A5024505450 |
| authorships[14].author.orcid | https://orcid.org/0000-0001-6576-5256 |
| authorships[14].author.display_name | Ahmet Doğan |
| authorships[14].affiliations[0].raw_affiliation_string | Department of Pathology, Hematopathology Service |
| authorships[14].author_position | middle |
| authorships[14].raw_author_name | Ahmet Dogan |
| authorships[14].is_corresponding | True |
| authorships[14].raw_affiliation_strings | Department of Pathology, Hematopathology Service |
| authorships[15].author.id | https://openalex.org/A5055506298 |
| authorships[15].author.orcid | https://orcid.org/0000-0001-8586-8500 |
| authorships[15].author.display_name | Wenbin Xiao |
| authorships[15].affiliations[0].raw_affiliation_string | Department of Pathology, Hematopathology Service |
| authorships[15].author_position | last |
| authorships[15].raw_author_name | Wenbin Xiao |
| authorships[15].is_corresponding | True |
| authorships[15].raw_affiliation_strings | Department of Pathology, Hematopathology Service |
| has_content.pdf | False |
| has_content.grobid_xml | False |
| is_paratext | False |
| open_access.is_oa | True |
| open_access.oa_url | https://www.ncbi.nlm.nih.gov/pmc/articles/7225029 |
| open_access.oa_status | green |
| open_access.any_repository_has_fulltext | False |
| created_date | 2025-10-10T00:00:00 |
| display_name | Genetic Basis of Extramedullary Plasmablastic Transformation of Multiple Myeloma |
| has_fulltext | False |
| is_retracted | False |
| updated_date | 2025-11-06T03:46:38.306776 |
| primary_topic.id | https://openalex.org/T10649 |
| primary_topic.field.id | https://openalex.org/fields/27 |
| primary_topic.field.display_name | Medicine |
| primary_topic.score | 1.0 |
| primary_topic.domain.id | https://openalex.org/domains/4 |
| primary_topic.domain.display_name | Health Sciences |
| primary_topic.subfield.id | https://openalex.org/subfields/2720 |
| primary_topic.subfield.display_name | Hematology |
| primary_topic.display_name | Multiple Myeloma Research and Treatments |
| related_works | https://openalex.org/W3168598779, https://openalex.org/W2005843898, https://openalex.org/W2218447560, https://openalex.org/W1996955576, https://openalex.org/W2406089054, https://openalex.org/W2949617280, https://openalex.org/W3119937120, https://openalex.org/W4283034076, https://openalex.org/W4231880000, https://openalex.org/W2893011256 |
| cited_by_count | 43 |
| counts_by_year[0].year | 2025 |
| counts_by_year[0].cited_by_count | 11 |
| counts_by_year[1].year | 2024 |
| counts_by_year[1].cited_by_count | 10 |
| counts_by_year[2].year | 2023 |
| counts_by_year[2].cited_by_count | 9 |
| counts_by_year[3].year | 2022 |
| counts_by_year[3].cited_by_count | 8 |
| counts_by_year[4].year | 2021 |
| counts_by_year[4].cited_by_count | 5 |
| locations_count | 3 |
| best_oa_location.id | pmh:oai:pubmedcentral.nih.gov:7225029 |
| best_oa_location.is_oa | True |
| best_oa_location.source.id | https://openalex.org/S2764455111 |
| best_oa_location.source.issn | |
| best_oa_location.source.type | repository |
| best_oa_location.source.is_oa | False |
| best_oa_location.source.issn_l | |
| best_oa_location.source.is_core | False |
| best_oa_location.source.is_in_doaj | False |
| best_oa_location.source.display_name | PubMed Central |
| best_oa_location.source.host_organization | https://openalex.org/I1299303238 |
| best_oa_location.source.host_organization_name | National Institutes of Health |
| best_oa_location.source.host_organization_lineage | https://openalex.org/I1299303238 |
| best_oa_location.license | |
| best_oa_location.pdf_url | |
| best_oa_location.version | submittedVersion |
| best_oa_location.raw_type | Text |
| best_oa_location.license_id | |
| best_oa_location.is_accepted | False |
| best_oa_location.is_published | False |
| best_oa_location.raw_source_name | Am J Surg Pathol |
| best_oa_location.landing_page_url | https://www.ncbi.nlm.nih.gov/pmc/articles/7225029 |
| primary_location.id | doi:10.1097/pas.0000000000001459 |
| primary_location.is_oa | False |
| primary_location.source.id | https://openalex.org/S37879208 |
| primary_location.source.issn | 0147-5185, 1532-0979 |
| primary_location.source.type | journal |
| primary_location.source.is_oa | False |
| primary_location.source.issn_l | 0147-5185 |
| primary_location.source.is_core | True |
| primary_location.source.is_in_doaj | False |
| primary_location.source.display_name | The American Journal of Surgical Pathology |
| primary_location.source.host_organization | https://openalex.org/P4310315671 |
| primary_location.source.host_organization_name | Lippincott Williams & Wilkins |
| primary_location.source.host_organization_lineage | https://openalex.org/P4310315671, https://openalex.org/P4310318547 |
| primary_location.source.host_organization_lineage_names | Lippincott Williams & Wilkins, Wolters Kluwer |
| primary_location.license | |
| primary_location.pdf_url | |
| primary_location.version | publishedVersion |
| primary_location.raw_type | journal-article |
| primary_location.license_id | |
| primary_location.is_accepted | True |
| primary_location.is_published | True |
| primary_location.raw_source_name | American Journal of Surgical Pathology |
| primary_location.landing_page_url | https://doi.org/10.1097/pas.0000000000001459 |
| publication_date | 2020-02-28 |
| publication_year | 2020 |
| referenced_works | https://openalex.org/W2122628319, https://openalex.org/W1985949282, https://openalex.org/W2318206769, https://openalex.org/W1746468402, https://openalex.org/W2095642828, https://openalex.org/W2104149194, https://openalex.org/W2768222175, https://openalex.org/W2217721749, https://openalex.org/W2085851235, https://openalex.org/W1986189948, https://openalex.org/W223909586, https://openalex.org/W2294723338, https://openalex.org/W1777794242, https://openalex.org/W66769261, https://openalex.org/W1794666720, https://openalex.org/W2321940176, https://openalex.org/W2790464636, https://openalex.org/W2045149893, https://openalex.org/W2100572488, https://openalex.org/W2101035019, https://openalex.org/W2059581635, https://openalex.org/W2055927459, https://openalex.org/W2123429489, https://openalex.org/W2402102307, https://openalex.org/W2805293188, https://openalex.org/W6602676303, https://openalex.org/W2127096655, https://openalex.org/W1992208750, https://openalex.org/W2050552243, https://openalex.org/W2765850868, https://openalex.org/W2224927009, https://openalex.org/W2127842142, https://openalex.org/W2060413939, https://openalex.org/W2772192917, https://openalex.org/W2524618670, https://openalex.org/W2019812127, https://openalex.org/W2074724450, https://openalex.org/W4239969573 |
| referenced_works_count | 38 |
| abstract_inverted_index.a | 86, 106, 155 |
| abstract_inverted_index.10 | 52 |
| abstract_inverted_index.48 | 62 |
| abstract_inverted_index.65 | 59 |
| abstract_inverted_index.76 | 64 |
| abstract_inverted_index.In | 0, 184 |
| abstract_inverted_index.an | 67, 100, 218 |
| abstract_inverted_index.by | 160, 225 |
| abstract_inverted_index.in | 7, 25, 33, 73, 83, 124, 171, 228 |
| abstract_inverted_index.is | 11, 223 |
| abstract_inverted_index.of | 20, 51, 70, 78, 109, 115, 149, 203, 214 |
| abstract_inverted_index.on | 195 |
| abstract_inverted_index.or | 88 |
| abstract_inverted_index.to | 63, 139, 199 |
| abstract_inverted_index.we | 43 |
| abstract_inverted_index.y) | 65 |
| abstract_inverted_index.y, | 60 |
| abstract_inverted_index.4.5 | 110 |
| abstract_inverted_index.MYC | 176 |
| abstract_inverted_index.P53 | 152 |
| abstract_inverted_index.RAS | 173, 230 |
| abstract_inverted_index.The | 18 |
| abstract_inverted_index.all | 196 |
| abstract_inverted_index.and | 13, 48, 122, 162, 175, 188, 222, 232 |
| abstract_inverted_index.due | 198 |
| abstract_inverted_index.has | 37, 217 |
| abstract_inverted_index.not | 38, 192 |
| abstract_inverted_index.our | 206 |
| abstract_inverted_index.the | 8, 34, 45, 74, 113, 132, 140, 172, 200, 229 |
| abstract_inverted_index.6/4, | 56 |
| abstract_inverted_index.CMYC | 150 |
| abstract_inverted_index.age: | 58 |
| abstract_inverted_index.been | 39 |
| abstract_inverted_index.bone | 9, 35, 75, 128, 142, 181 |
| abstract_inverted_index.data | 98, 207 |
| abstract_inverted_index.even | 123 |
| abstract_inverted_index.high | 147, 156 |
| abstract_inverted_index.more | 164, 233 |
| abstract_inverted_index.poor | 16 |
| abstract_inverted_index.rare | 12 |
| abstract_inverted_index.such | 53 |
| abstract_inverted_index.that | 209 |
| abstract_inverted_index.this | 204 |
| abstract_inverted_index.well | 40 |
| abstract_inverted_index.were | 136, 191 |
| abstract_inverted_index.with | 2, 15, 27, 66, 85, 95, 105, 126, 154, 179 |
| abstract_inverted_index.Eight | 93 |
| abstract_inverted_index.Here, | 42 |
| abstract_inverted_index.Ki-67 | 157 |
| abstract_inverted_index.after | 112 |
| abstract_inverted_index.cases | 197 |
| abstract_inverted_index.cells | 32, 82 |
| abstract_inverted_index.index | 159 |
| abstract_inverted_index.their | 180 |
| abstract_inverted_index.and/or | 151 |
| abstract_inverted_index.cells, | 145 |
| abstract_inverted_index.clonal | 30 |
| abstract_inverted_index.course | 104, 221 |
| abstract_inverted_index.levels | 148 |
| abstract_inverted_index.marrow | 10, 36, 76, 129, 143, 182 |
| abstract_inverted_index.mature | 29, 80 |
| abstract_inverted_index.median | 57, 107 |
| abstract_inverted_index.months | 111 |
| abstract_inverted_index.nature | 202 |
| abstract_inverted_index.plasma | 31, 81, 144 |
| abstract_inverted_index.range: | 61 |
| abstract_inverted_index.report | 44 |
| abstract_inverted_index.showed | 99, 146 |
| abstract_inverted_index.small, | 28, 79 |
| abstract_inverted_index.study, | 205 |
| abstract_inverted_index.complex | 165, 234 |
| abstract_inverted_index.despite | 119 |
| abstract_inverted_index.genetic | 187 |
| abstract_inverted_index.genomic | 166, 235 |
| abstract_inverted_index.myeloma | 72, 135, 216 |
| abstract_inverted_index.overall | 101 |
| abstract_inverted_index.pathway | 174, 231 |
| abstract_inverted_index.related | 138 |
| abstract_inverted_index.studies | 190 |
| abstract_inverted_index.suggest | 208 |
| abstract_inverted_index.although | 186 |
| abstract_inverted_index.clinical | 103, 220 |
| abstract_inverted_index.clonally | 137 |
| abstract_inverted_index.compared | 178 |
| abstract_inverted_index.composed | 77 |
| abstract_inverted_index.features | 50 |
| abstract_inverted_index.frequent | 169, 226 |
| abstract_inverted_index.harbored | 163 |
| abstract_inverted_index.multiple | 3, 71, 215 |
| abstract_inverted_index.myeloma, | 4 |
| abstract_inverted_index.parallel | 84 |
| abstract_inverted_index.patients | 1, 26, 54, 94, 125 |
| abstract_inverted_index.studied. | 41 |
| abstract_inverted_index.summary, | 185 |
| abstract_inverted_index.survival | 97, 108 |
| abstract_inverted_index.available | 96 |
| abstract_inverted_index.diagnosis | 69, 114 |
| abstract_inverted_index.including | 168 |
| abstract_inverted_index.low-level | 127 |
| abstract_inverted_index.molecular | 49 |
| abstract_inverted_index.mutations | 170, 227 |
| abstract_inverted_index.outcomes. | 17 |
| abstract_inverted_index.performed | 194 |
| abstract_inverted_index.treatment | 121 |
| abstract_inverted_index.uniformly | 193 |
| abstract_inverted_index.aggressive | 102, 120, 219 |
| abstract_inverted_index.associated | 14 |
| abstract_inverted_index.concurrent | 87 |
| abstract_inverted_index.discordant | 21, 210 |
| abstract_inverted_index.expression | 153 |
| abstract_inverted_index.subsequent | 89 |
| abstract_inverted_index.aberrations | 167 |
| abstract_inverted_index.established | 68 |
| abstract_inverted_index.cytogenetic, | 47 |
| abstract_inverted_index.involvement. | 130 |
| abstract_inverted_index.significance | 19 |
| abstract_inverted_index.(male/female: | 55 |
| abstract_inverted_index.characterized | 224 |
| abstract_inverted_index.corresponding | 141 |
| abstract_inverted_index.counterparts. | 183 |
| abstract_inverted_index.plasmablastic | 5, 23, 91, 117, 134, 212 |
| abstract_inverted_index.proliferation | 158 |
| abstract_inverted_index.retrospective | 201 |
| abstract_inverted_index.abnormalities. | 236 |
| abstract_inverted_index.extramedullary | 22, 90, 116, 133, 211 |
| abstract_inverted_index.rearrangements | 177 |
| abstract_inverted_index.transformation | 6, 24, 213 |
| abstract_inverted_index.Pathologically, | 131 |
| abstract_inverted_index.transformation, | 118 |
| abstract_inverted_index.transformation. | 92 |
| abstract_inverted_index.clinicopathologic, | 46 |
| abstract_inverted_index.immunohistochemical | 189 |
| abstract_inverted_index.immunohistochemistry | 161 |
| cited_by_percentile_year.max | 99 |
| cited_by_percentile_year.min | 97 |
| corresponding_author_ids | https://openalex.org/A5079953387, https://openalex.org/A5081913602, https://openalex.org/A5087788162, https://openalex.org/A5024505450, https://openalex.org/A5100414285, https://openalex.org/A5017431865, https://openalex.org/A5055506298, https://openalex.org/A5070830465, https://openalex.org/A5030239977, https://openalex.org/A5072687747, https://openalex.org/A5044561007 |
| countries_distinct_count | 1 |
| institutions_distinct_count | 16 |
| sustainable_development_goals[0].id | https://metadata.un.org/sdg/1 |
| sustainable_development_goals[0].score | 0.49000000953674316 |
| sustainable_development_goals[0].display_name | No poverty |
| citation_normalized_percentile.value | 0.92202082 |
| citation_normalized_percentile.is_in_top_1_percent | False |
| citation_normalized_percentile.is_in_top_10_percent | True |