Genetic influence on urinary vitamin D binding protein excretion and serum levels: a focus on rs4588 C>A polymorphism in the GC gene Article Swipe
Durmuş Doğan
,
Eda Gül Özcan
,
Dilek Ülker Çakır
,
Fatma Sılan
·
YOU?
·
· 2023
· Open Access
·
· DOI: https://doi.org/10.3389/fendo.2023.1281112
YOU?
·
· 2023
· Open Access
·
· DOI: https://doi.org/10.3389/fendo.2023.1281112
Introduction Vitamin D binding protein (VDBP) plays a crucial role in vitamin D transport and metabolism. The rs4588-A polymorphism of the GC gene, encoding VDBP, has been associated with altered serum VDBP and 25-hydroxyvitamin D (25OHD) levels. However, the mechanisms underlying these effects remain unclear. We aimed to investigate the relationship between urinary VDBP excretion and serum VDBP and 25OHD levels in individuals with and without the rs4588-A allele. Methods A cross-sectional study was conducted on 109 children (mean age: 11.96 years) to explore the impact of rs4588-A on vitamin D metabolism and urinary VDBP excretion. Biochemical analyses determined serum 25OHD and VDBP levels, and urinary VDBP-to-creatinine ratio (u-VDBP/Cr). Genotyping for rs4588 SNP was performed using LightSNiP assay. Statistical analyses included correlation, linear regression, and comparison between allele groups. Results Participants carrying the rs4588-A allele exhibited lower serum 25OHD levels compared to non-carriers (median (IQR): 11.85 (3.5) vs. 12.86 (4.9), p = 0.023). However, no statistically significant differences were observed in serum VDBP levels (126.34 ± 59.3 in rs4588-A vs. 136.49 ± 51.3 in non-rs4588-A, p = 0.141) or in u-VDBP/Cr (median (IQR): 0.4 (0.35) in rs4588-A vs. 0.386 (0.43) in non-rs4588-A, p = 0.189) between the two allele groups. A significant inverse correlation between u-VDBP/Cr and serum VDBP levels was found only in rs4588-A carriers (r = -0.367, p = 0.024). No such correlation was observed in non-carriers or the entire cohort. A linear regression analysis confirmed the impact of u-VDBP/Cr on serum VDBP levels in rs4588-A carriers (B = -0.269, t = -2.185, p = 0.035). Conclusion Individuals with the rs4588-A allele in the GC gene had lower serum 25OHD levels. An inverse correlation between urinary VDBP excretion and serum VDBP levels was observed, suggesting a partial role of the renal pathway in altered serum VDBP and 25OHD levels linked to the rs4588-A allele.
Related Topics
Concepts
Vitamin D-binding protein
Vitamin D and neurology
Medicine
Excretion
Internal medicine
Single-nucleotide polymorphism
Genotype
Endocrinology
Biology
Gene
Genetics
Metadata
- Type
- article
- Language
- en
- Landing Page
- https://doi.org/10.3389/fendo.2023.1281112
- https://www.frontiersin.org/articles/10.3389/fendo.2023.1281112/pdf?isPublishedV2=False
- OA Status
- gold
- Cited By
- 4
- References
- 32
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W4389435790
All OpenAlex metadata
Raw OpenAlex JSON
- OpenAlex ID
-
https://openalex.org/W4389435790Canonical identifier for this work in OpenAlex
- DOI
-
https://doi.org/10.3389/fendo.2023.1281112Digital Object Identifier
- Title
-
Genetic influence on urinary vitamin D binding protein excretion and serum levels: a focus on rs4588 C>A polymorphism in the GC geneWork title
- Type
-
articleOpenAlex work type
- Language
-
enPrimary language
- Publication year
-
2023Year of publication
- Publication date
-
2023-12-07Full publication date if available
- Authors
-
Durmuş Doğan, Eda Gül Özcan, Dilek Ülker Çakır, Fatma SılanList of authors in order
- Landing page
-
https://doi.org/10.3389/fendo.2023.1281112Publisher landing page
- PDF URL
-
https://www.frontiersin.org/articles/10.3389/fendo.2023.1281112/pdf?isPublishedV2=FalseDirect link to full text PDF
- Open access
-
YesWhether a free full text is available
- OA status
-
goldOpen access status per OpenAlex
- OA URL
-
https://www.frontiersin.org/articles/10.3389/fendo.2023.1281112/pdf?isPublishedV2=FalseDirect OA link when available
- Concepts
-
Vitamin D-binding protein, Vitamin D and neurology, Medicine, Excretion, Internal medicine, Single-nucleotide polymorphism, Genotype, Endocrinology, Biology, Gene, GeneticsTop concepts (fields/topics) attached by OpenAlex
- Cited by
-
4Total citation count in OpenAlex
- Citations by year (recent)
-
2025: 3, 2024: 1Per-year citation counts (last 5 years)
- References (count)
-
32Number of works referenced by this work
- Related works (count)
-
10Other works algorithmically related by OpenAlex
Full payload
| id | https://openalex.org/W4389435790 |
|---|---|
| doi | https://doi.org/10.3389/fendo.2023.1281112 |
| ids.doi | https://doi.org/10.3389/fendo.2023.1281112 |
| ids.pmid | https://pubmed.ncbi.nlm.nih.gov/38144557 |
| ids.openalex | https://openalex.org/W4389435790 |
| fwci | 1.52857751 |
| mesh[0].qualifier_ui | Q000097 |
| mesh[0].descriptor_ui | D014809 |
| mesh[0].is_major_topic | True |
| mesh[0].qualifier_name | blood |
| mesh[0].descriptor_name | Vitamin D-Binding Protein |
| mesh[1].qualifier_ui | Q000235 |
| mesh[1].descriptor_ui | D014809 |
| mesh[1].is_major_topic | True |
| mesh[1].qualifier_name | genetics |
| mesh[1].descriptor_name | Vitamin D-Binding Protein |
| mesh[2].qualifier_ui | Q000652 |
| mesh[2].descriptor_ui | D014809 |
| mesh[2].is_major_topic | True |
| mesh[2].qualifier_name | urine |
| mesh[2].descriptor_name | Vitamin D-Binding Protein |
| mesh[3].qualifier_ui | |
| mesh[3].descriptor_ui | D011110 |
| mesh[3].is_major_topic | True |
| mesh[3].qualifier_name | |
| mesh[3].descriptor_name | Polymorphism, Genetic |
| mesh[4].qualifier_ui | |
| mesh[4].descriptor_ui | D003430 |
| mesh[4].is_major_topic | False |
| mesh[4].qualifier_name | |
| mesh[4].descriptor_name | Cross-Sectional Studies |
| mesh[5].qualifier_ui | |
| mesh[5].descriptor_ui | D006801 |
| mesh[5].is_major_topic | False |
| mesh[5].qualifier_name | |
| mesh[5].descriptor_name | Humans |
| mesh[6].qualifier_ui | |
| mesh[6].descriptor_ui | D008297 |
| mesh[6].is_major_topic | False |
| mesh[6].qualifier_name | |
| mesh[6].descriptor_name | Male |
| mesh[7].qualifier_ui | |
| mesh[7].descriptor_ui | D005260 |
| mesh[7].is_major_topic | False |
| mesh[7].qualifier_name | |
| mesh[7].descriptor_name | Female |
| mesh[8].qualifier_ui | |
| mesh[8].descriptor_ui | D002648 |
| mesh[8].is_major_topic | False |
| mesh[8].qualifier_name | |
| mesh[8].descriptor_name | Child |
| mesh[9].qualifier_ui | |
| mesh[9].descriptor_ui | D000293 |
| mesh[9].is_major_topic | False |
| mesh[9].qualifier_name | |
| mesh[9].descriptor_name | Adolescent |
| mesh[10].qualifier_ui | |
| mesh[10].descriptor_ui | D005787 |
| mesh[10].is_major_topic | False |
| mesh[10].qualifier_name | |
| mesh[10].descriptor_name | Gene Frequency |
| mesh[11].qualifier_ui | |
| mesh[11].descriptor_ui | D005838 |
| mesh[11].is_major_topic | False |
| mesh[11].qualifier_name | |
| mesh[11].descriptor_name | Genotype |
| mesh[12].qualifier_ui | Q000097 |
| mesh[12].descriptor_ui | D014809 |
| mesh[12].is_major_topic | True |
| mesh[12].qualifier_name | blood |
| mesh[12].descriptor_name | Vitamin D-Binding Protein |
| mesh[13].qualifier_ui | Q000235 |
| mesh[13].descriptor_ui | D014809 |
| mesh[13].is_major_topic | True |
| mesh[13].qualifier_name | genetics |
| mesh[13].descriptor_name | Vitamin D-Binding Protein |
| mesh[14].qualifier_ui | Q000652 |
| mesh[14].descriptor_ui | D014809 |
| mesh[14].is_major_topic | True |
| mesh[14].qualifier_name | urine |
| mesh[14].descriptor_name | Vitamin D-Binding Protein |
| mesh[15].qualifier_ui | |
| mesh[15].descriptor_ui | D011110 |
| mesh[15].is_major_topic | True |
| mesh[15].qualifier_name | |
| mesh[15].descriptor_name | Polymorphism, Genetic |
| mesh[16].qualifier_ui | |
| mesh[16].descriptor_ui | D003430 |
| mesh[16].is_major_topic | False |
| mesh[16].qualifier_name | |
| mesh[16].descriptor_name | Cross-Sectional Studies |
| mesh[17].qualifier_ui | |
| mesh[17].descriptor_ui | D006801 |
| mesh[17].is_major_topic | False |
| mesh[17].qualifier_name | |
| mesh[17].descriptor_name | Humans |
| mesh[18].qualifier_ui | |
| mesh[18].descriptor_ui | D008297 |
| mesh[18].is_major_topic | False |
| mesh[18].qualifier_name | |
| mesh[18].descriptor_name | Male |
| mesh[19].qualifier_ui | |
| mesh[19].descriptor_ui | D005260 |
| mesh[19].is_major_topic | False |
| mesh[19].qualifier_name | |
| mesh[19].descriptor_name | Female |
| mesh[20].qualifier_ui | |
| mesh[20].descriptor_ui | D002648 |
| mesh[20].is_major_topic | False |
| mesh[20].qualifier_name | |
| mesh[20].descriptor_name | Child |
| mesh[21].qualifier_ui | |
| mesh[21].descriptor_ui | D000293 |
| mesh[21].is_major_topic | False |
| mesh[21].qualifier_name | |
| mesh[21].descriptor_name | Adolescent |
| mesh[22].qualifier_ui | |
| mesh[22].descriptor_ui | D005787 |
| mesh[22].is_major_topic | False |
| mesh[22].qualifier_name | |
| mesh[22].descriptor_name | Gene Frequency |
| mesh[23].qualifier_ui | |
| mesh[23].descriptor_ui | D005838 |
| mesh[23].is_major_topic | False |
| mesh[23].qualifier_name | |
| mesh[23].descriptor_name | Genotype |
| mesh[24].qualifier_ui | Q000097 |
| mesh[24].descriptor_ui | D014809 |
| mesh[24].is_major_topic | True |
| mesh[24].qualifier_name | blood |
| mesh[24].descriptor_name | Vitamin D-Binding Protein |
| mesh[25].qualifier_ui | Q000235 |
| mesh[25].descriptor_ui | D014809 |
| mesh[25].is_major_topic | True |
| mesh[25].qualifier_name | genetics |
| mesh[25].descriptor_name | Vitamin D-Binding Protein |
| mesh[26].qualifier_ui | Q000652 |
| mesh[26].descriptor_ui | D014809 |
| mesh[26].is_major_topic | True |
| mesh[26].qualifier_name | urine |
| mesh[26].descriptor_name | Vitamin D-Binding Protein |
| mesh[27].qualifier_ui | |
| mesh[27].descriptor_ui | D011110 |
| mesh[27].is_major_topic | True |
| mesh[27].qualifier_name | |
| mesh[27].descriptor_name | Polymorphism, Genetic |
| mesh[28].qualifier_ui | |
| mesh[28].descriptor_ui | D003430 |
| mesh[28].is_major_topic | False |
| mesh[28].qualifier_name | |
| mesh[28].descriptor_name | Cross-Sectional Studies |
| mesh[29].qualifier_ui | |
| mesh[29].descriptor_ui | D006801 |
| mesh[29].is_major_topic | False |
| mesh[29].qualifier_name | |
| mesh[29].descriptor_name | Humans |
| mesh[30].qualifier_ui | |
| mesh[30].descriptor_ui | D008297 |
| mesh[30].is_major_topic | False |
| mesh[30].qualifier_name | |
| mesh[30].descriptor_name | Male |
| mesh[31].qualifier_ui | |
| mesh[31].descriptor_ui | D005260 |
| mesh[31].is_major_topic | False |
| mesh[31].qualifier_name | |
| mesh[31].descriptor_name | Female |
| mesh[32].qualifier_ui | |
| mesh[32].descriptor_ui | D002648 |
| mesh[32].is_major_topic | False |
| mesh[32].qualifier_name | |
| mesh[32].descriptor_name | Child |
| mesh[33].qualifier_ui | |
| mesh[33].descriptor_ui | D000293 |
| mesh[33].is_major_topic | False |
| mesh[33].qualifier_name | |
| mesh[33].descriptor_name | Adolescent |
| mesh[34].qualifier_ui | |
| mesh[34].descriptor_ui | D005787 |
| mesh[34].is_major_topic | False |
| mesh[34].qualifier_name | |
| mesh[34].descriptor_name | Gene Frequency |
| mesh[35].qualifier_ui | |
| mesh[35].descriptor_ui | D005838 |
| mesh[35].is_major_topic | False |
| mesh[35].qualifier_name | |
| mesh[35].descriptor_name | Genotype |
| mesh[36].qualifier_ui | Q000097 |
| mesh[36].descriptor_ui | D014809 |
| mesh[36].is_major_topic | True |
| mesh[36].qualifier_name | blood |
| mesh[36].descriptor_name | Vitamin D-Binding Protein |
| mesh[37].qualifier_ui | Q000235 |
| mesh[37].descriptor_ui | D014809 |
| mesh[37].is_major_topic | True |
| mesh[37].qualifier_name | genetics |
| mesh[37].descriptor_name | Vitamin D-Binding Protein |
| mesh[38].qualifier_ui | Q000652 |
| mesh[38].descriptor_ui | D014809 |
| mesh[38].is_major_topic | True |
| mesh[38].qualifier_name | urine |
| mesh[38].descriptor_name | Vitamin D-Binding Protein |
| mesh[39].qualifier_ui | |
| mesh[39].descriptor_ui | D011110 |
| mesh[39].is_major_topic | True |
| mesh[39].qualifier_name | |
| mesh[39].descriptor_name | Polymorphism, Genetic |
| mesh[40].qualifier_ui | |
| mesh[40].descriptor_ui | D003430 |
| mesh[40].is_major_topic | False |
| mesh[40].qualifier_name | |
| mesh[40].descriptor_name | Cross-Sectional Studies |
| mesh[41].qualifier_ui | |
| mesh[41].descriptor_ui | D006801 |
| mesh[41].is_major_topic | False |
| mesh[41].qualifier_name | |
| mesh[41].descriptor_name | Humans |
| mesh[42].qualifier_ui | |
| mesh[42].descriptor_ui | D008297 |
| mesh[42].is_major_topic | False |
| mesh[42].qualifier_name | |
| mesh[42].descriptor_name | Male |
| mesh[43].qualifier_ui | |
| mesh[43].descriptor_ui | D005260 |
| mesh[43].is_major_topic | False |
| mesh[43].qualifier_name | |
| mesh[43].descriptor_name | Female |
| mesh[44].qualifier_ui | |
| mesh[44].descriptor_ui | D002648 |
| mesh[44].is_major_topic | False |
| mesh[44].qualifier_name | |
| mesh[44].descriptor_name | Child |
| mesh[45].qualifier_ui | |
| mesh[45].descriptor_ui | D000293 |
| mesh[45].is_major_topic | False |
| mesh[45].qualifier_name | |
| mesh[45].descriptor_name | Adolescent |
| mesh[46].qualifier_ui | |
| mesh[46].descriptor_ui | D005787 |
| mesh[46].is_major_topic | False |
| mesh[46].qualifier_name | |
| mesh[46].descriptor_name | Gene Frequency |
| mesh[47].qualifier_ui | |
| mesh[47].descriptor_ui | D005838 |
| mesh[47].is_major_topic | False |
| mesh[47].qualifier_name | |
| mesh[47].descriptor_name | Genotype |
| mesh[48].qualifier_ui | |
| mesh[48].descriptor_ui | D002648 |
| mesh[48].is_major_topic | False |
| mesh[48].qualifier_name | |
| mesh[48].descriptor_name | Child |
| mesh[49].qualifier_ui | |
| mesh[49].descriptor_ui | D006801 |
| mesh[49].is_major_topic | False |
| mesh[49].qualifier_name | |
| mesh[49].descriptor_name | Humans |
| type | article |
| title | Genetic influence on urinary vitamin D binding protein excretion and serum levels: a focus on rs4588 C>A polymorphism in the GC gene |
| biblio.issue | |
| biblio.volume | 14 |
| biblio.last_page | 1281112 |
| biblio.first_page | 1281112 |
| topics[0].id | https://openalex.org/T10277 |
| topics[0].field.id | https://openalex.org/fields/27 |
| topics[0].field.display_name | Medicine |
| topics[0].score | 0.9998000264167786 |
| topics[0].domain.id | https://openalex.org/domains/4 |
| topics[0].domain.display_name | Health Sciences |
| topics[0].subfield.id | https://openalex.org/subfields/2734 |
| topics[0].subfield.display_name | Pathology and Forensic Medicine |
| topics[0].display_name | Vitamin D Research Studies |
| topics[1].id | https://openalex.org/T10499 |
| topics[1].field.id | https://openalex.org/fields/27 |
| topics[1].field.display_name | Medicine |
| topics[1].score | 0.9980000257492065 |
| topics[1].domain.id | https://openalex.org/domains/4 |
| topics[1].domain.display_name | Health Sciences |
| topics[1].subfield.id | https://openalex.org/subfields/2745 |
| topics[1].subfield.display_name | Rheumatology |
| topics[1].display_name | Folate and B Vitamins Research |
| topics[2].id | https://openalex.org/T10452 |
| topics[2].field.id | https://openalex.org/fields/27 |
| topics[2].field.display_name | Medicine |
| topics[2].score | 0.9818000197410583 |
| topics[2].domain.id | https://openalex.org/domains/4 |
| topics[2].domain.display_name | Health Sciences |
| topics[2].subfield.id | https://openalex.org/subfields/2720 |
| topics[2].subfield.display_name | Hematology |
| topics[2].display_name | Iron Metabolism and Disorders |
| is_xpac | False |
| apc_list.value | 2950 |
| apc_list.currency | USD |
| apc_list.value_usd | 2950 |
| apc_paid.value | 2950 |
| apc_paid.currency | USD |
| apc_paid.value_usd | 2950 |
| concepts[0].id | https://openalex.org/C153639570 |
| concepts[0].level | 3 |
| concepts[0].score | 0.930540919303894 |
| concepts[0].wikidata | https://www.wikidata.org/wiki/Q906435 |
| concepts[0].display_name | Vitamin D-binding protein |
| concepts[1].id | https://openalex.org/C124490489 |
| concepts[1].level | 2 |
| concepts[1].score | 0.6073914170265198 |
| concepts[1].wikidata | https://www.wikidata.org/wiki/Q7936963 |
| concepts[1].display_name | Vitamin D and neurology |
| concepts[2].id | https://openalex.org/C71924100 |
| concepts[2].level | 0 |
| concepts[2].score | 0.42361754179000854 |
| concepts[2].wikidata | https://www.wikidata.org/wiki/Q11190 |
| concepts[2].display_name | Medicine |
| concepts[3].id | https://openalex.org/C10146269 |
| concepts[3].level | 2 |
| concepts[3].score | 0.4203200340270996 |
| concepts[3].wikidata | https://www.wikidata.org/wiki/Q185557 |
| concepts[3].display_name | Excretion |
| concepts[4].id | https://openalex.org/C126322002 |
| concepts[4].level | 1 |
| concepts[4].score | 0.41683536767959595 |
| concepts[4].wikidata | https://www.wikidata.org/wiki/Q11180 |
| concepts[4].display_name | Internal medicine |
| concepts[5].id | https://openalex.org/C153209595 |
| concepts[5].level | 4 |
| concepts[5].score | 0.4158981740474701 |
| concepts[5].wikidata | https://www.wikidata.org/wiki/Q501128 |
| concepts[5].display_name | Single-nucleotide polymorphism |
| concepts[6].id | https://openalex.org/C135763542 |
| concepts[6].level | 3 |
| concepts[6].score | 0.3958466947078705 |
| concepts[6].wikidata | https://www.wikidata.org/wiki/Q106016 |
| concepts[6].display_name | Genotype |
| concepts[7].id | https://openalex.org/C134018914 |
| concepts[7].level | 1 |
| concepts[7].score | 0.3337304890155792 |
| concepts[7].wikidata | https://www.wikidata.org/wiki/Q162606 |
| concepts[7].display_name | Endocrinology |
| concepts[8].id | https://openalex.org/C86803240 |
| concepts[8].level | 0 |
| concepts[8].score | 0.29204094409942627 |
| concepts[8].wikidata | https://www.wikidata.org/wiki/Q420 |
| concepts[8].display_name | Biology |
| concepts[9].id | https://openalex.org/C104317684 |
| concepts[9].level | 2 |
| concepts[9].score | 0.18884143233299255 |
| concepts[9].wikidata | https://www.wikidata.org/wiki/Q7187 |
| concepts[9].display_name | Gene |
| concepts[10].id | https://openalex.org/C54355233 |
| concepts[10].level | 1 |
| concepts[10].score | 0.14362114667892456 |
| concepts[10].wikidata | https://www.wikidata.org/wiki/Q7162 |
| concepts[10].display_name | Genetics |
| keywords[0].id | https://openalex.org/keywords/vitamin-d-binding-protein |
| keywords[0].score | 0.930540919303894 |
| keywords[0].display_name | Vitamin D-binding protein |
| keywords[1].id | https://openalex.org/keywords/vitamin-d-and-neurology |
| keywords[1].score | 0.6073914170265198 |
| keywords[1].display_name | Vitamin D and neurology |
| keywords[2].id | https://openalex.org/keywords/medicine |
| keywords[2].score | 0.42361754179000854 |
| keywords[2].display_name | Medicine |
| keywords[3].id | https://openalex.org/keywords/excretion |
| keywords[3].score | 0.4203200340270996 |
| keywords[3].display_name | Excretion |
| keywords[4].id | https://openalex.org/keywords/internal-medicine |
| keywords[4].score | 0.41683536767959595 |
| keywords[4].display_name | Internal medicine |
| keywords[5].id | https://openalex.org/keywords/single-nucleotide-polymorphism |
| keywords[5].score | 0.4158981740474701 |
| keywords[5].display_name | Single-nucleotide polymorphism |
| keywords[6].id | https://openalex.org/keywords/genotype |
| keywords[6].score | 0.3958466947078705 |
| keywords[6].display_name | Genotype |
| keywords[7].id | https://openalex.org/keywords/endocrinology |
| keywords[7].score | 0.3337304890155792 |
| keywords[7].display_name | Endocrinology |
| keywords[8].id | https://openalex.org/keywords/biology |
| keywords[8].score | 0.29204094409942627 |
| keywords[8].display_name | Biology |
| keywords[9].id | https://openalex.org/keywords/gene |
| keywords[9].score | 0.18884143233299255 |
| keywords[9].display_name | Gene |
| keywords[10].id | https://openalex.org/keywords/genetics |
| keywords[10].score | 0.14362114667892456 |
| keywords[10].display_name | Genetics |
| language | en |
| locations[0].id | doi:10.3389/fendo.2023.1281112 |
| locations[0].is_oa | True |
| locations[0].source.id | https://openalex.org/S2597401208 |
| locations[0].source.issn | 1664-2392 |
| locations[0].source.type | journal |
| locations[0].source.is_oa | True |
| locations[0].source.issn_l | 1664-2392 |
| locations[0].source.is_core | True |
| locations[0].source.is_in_doaj | True |
| locations[0].source.display_name | Frontiers in Endocrinology |
| locations[0].source.host_organization | https://openalex.org/P4310320527 |
| locations[0].source.host_organization_name | Frontiers Media |
| locations[0].source.host_organization_lineage | https://openalex.org/P4310320527 |
| locations[0].license | cc-by |
| locations[0].pdf_url | https://www.frontiersin.org/articles/10.3389/fendo.2023.1281112/pdf?isPublishedV2=False |
| locations[0].version | publishedVersion |
| locations[0].raw_type | journal-article |
| locations[0].license_id | https://openalex.org/licenses/cc-by |
| locations[0].is_accepted | True |
| locations[0].is_published | True |
| locations[0].raw_source_name | Frontiers in Endocrinology |
| locations[0].landing_page_url | https://doi.org/10.3389/fendo.2023.1281112 |
| locations[1].id | pmid:38144557 |
| locations[1].is_oa | False |
| locations[1].source.id | https://openalex.org/S4306525036 |
| locations[1].source.issn | |
| locations[1].source.type | repository |
| locations[1].source.is_oa | False |
| locations[1].source.issn_l | |
| locations[1].source.is_core | False |
| locations[1].source.is_in_doaj | False |
| locations[1].source.display_name | PubMed |
| locations[1].source.host_organization | https://openalex.org/I1299303238 |
| locations[1].source.host_organization_name | National Institutes of Health |
| locations[1].source.host_organization_lineage | https://openalex.org/I1299303238 |
| locations[1].license | |
| locations[1].pdf_url | |
| locations[1].version | publishedVersion |
| locations[1].raw_type | |
| locations[1].license_id | |
| locations[1].is_accepted | True |
| locations[1].is_published | True |
| locations[1].raw_source_name | Frontiers in endocrinology |
| locations[1].landing_page_url | https://pubmed.ncbi.nlm.nih.gov/38144557 |
| locations[2].id | pmh:oai:pubmedcentral.nih.gov:10740204 |
| locations[2].is_oa | True |
| locations[2].source.id | https://openalex.org/S2764455111 |
| locations[2].source.issn | |
| locations[2].source.type | repository |
| locations[2].source.is_oa | False |
| locations[2].source.issn_l | |
| locations[2].source.is_core | False |
| locations[2].source.is_in_doaj | False |
| locations[2].source.display_name | PubMed Central |
| locations[2].source.host_organization | https://openalex.org/I1299303238 |
| locations[2].source.host_organization_name | National Institutes of Health |
| locations[2].source.host_organization_lineage | https://openalex.org/I1299303238 |
| locations[2].license | cc-by |
| locations[2].pdf_url | https://pmc.ncbi.nlm.nih.gov/articles/PMC10740204/pdf/fendo-14-1281112.pdf |
| locations[2].version | submittedVersion |
| locations[2].raw_type | Text |
| locations[2].license_id | https://openalex.org/licenses/cc-by |
| locations[2].is_accepted | False |
| locations[2].is_published | False |
| locations[2].raw_source_name | Front Endocrinol (Lausanne) |
| locations[2].landing_page_url | https://www.ncbi.nlm.nih.gov/pmc/articles/10740204 |
| locations[3].id | pmh:oai:doaj.org/article:c1d3bd95258744f2bf63ed7a08cdf48f |
| locations[3].is_oa | False |
| locations[3].source.id | https://openalex.org/S4306401280 |
| locations[3].source.issn | |
| locations[3].source.type | repository |
| locations[3].source.is_oa | False |
| locations[3].source.issn_l | |
| locations[3].source.is_core | False |
| locations[3].source.is_in_doaj | False |
| locations[3].source.display_name | DOAJ (DOAJ: Directory of Open Access Journals) |
| locations[3].source.host_organization | |
| locations[3].source.host_organization_name | |
| locations[3].source.host_organization_lineage | |
| locations[3].license | |
| locations[3].pdf_url | |
| locations[3].version | submittedVersion |
| locations[3].raw_type | article |
| locations[3].license_id | |
| locations[3].is_accepted | False |
| locations[3].is_published | False |
| locations[3].raw_source_name | Frontiers in Endocrinology, Vol 14 (2023) |
| locations[3].landing_page_url | https://doaj.org/article/c1d3bd95258744f2bf63ed7a08cdf48f |
| indexed_in | crossref, doaj, pubmed |
| authorships[0].author.id | https://openalex.org/A5032635247 |
| authorships[0].author.orcid | https://orcid.org/0000-0001-5369-8797 |
| authorships[0].author.display_name | Durmuş Doğan |
| authorships[0].countries | TR |
| authorships[0].affiliations[0].institution_ids | https://openalex.org/I115953327 |
| authorships[0].affiliations[0].raw_affiliation_string | Department of Pediatric Medicine, Division of Pediatric Endocrinology, Çanakkale Onsekiz Mart University, Çanakkale, Türkiye |
| authorships[0].institutions[0].id | https://openalex.org/I115953327 |
| authorships[0].institutions[0].ror | https://ror.org/05rsv8p09 |
| authorships[0].institutions[0].type | education |
| authorships[0].institutions[0].lineage | https://openalex.org/I115953327 |
| authorships[0].institutions[0].country_code | TR |
| authorships[0].institutions[0].display_name | Çanakkale Onsekiz Mart Üniversitesi |
| authorships[0].author_position | first |
| authorships[0].raw_author_name | Durmus Doğan |
| authorships[0].is_corresponding | True |
| authorships[0].raw_affiliation_strings | Department of Pediatric Medicine, Division of Pediatric Endocrinology, Çanakkale Onsekiz Mart University, Çanakkale, Türkiye |
| authorships[1].author.id | https://openalex.org/A5108883890 |
| authorships[1].author.orcid | |
| authorships[1].author.display_name | Eda Gül Özcan |
| authorships[1].countries | TR |
| authorships[1].affiliations[0].institution_ids | https://openalex.org/I115953327 |
| authorships[1].affiliations[0].raw_affiliation_string | Department of Pediatric Medicine, Çanakkale Onsekiz Mart University, Çanakkale, Türkiye |
| authorships[1].institutions[0].id | https://openalex.org/I115953327 |
| authorships[1].institutions[0].ror | https://ror.org/05rsv8p09 |
| authorships[1].institutions[0].type | education |
| authorships[1].institutions[0].lineage | https://openalex.org/I115953327 |
| authorships[1].institutions[0].country_code | TR |
| authorships[1].institutions[0].display_name | Çanakkale Onsekiz Mart Üniversitesi |
| authorships[1].author_position | middle |
| authorships[1].raw_author_name | Eda Gül Özcan |
| authorships[1].is_corresponding | False |
| authorships[1].raw_affiliation_strings | Department of Pediatric Medicine, Çanakkale Onsekiz Mart University, Çanakkale, Türkiye |
| authorships[2].author.id | https://openalex.org/A5058348842 |
| authorships[2].author.orcid | https://orcid.org/0000-0002-8796-6363 |
| authorships[2].author.display_name | Dilek Ülker Çakır |
| authorships[2].countries | TR |
| authorships[2].affiliations[0].institution_ids | https://openalex.org/I115953327 |
| authorships[2].affiliations[0].raw_affiliation_string | Department of Biochemistry, Çanakkale Onsekiz Mart University, Çanakkale, Türkiye |
| authorships[2].institutions[0].id | https://openalex.org/I115953327 |
| authorships[2].institutions[0].ror | https://ror.org/05rsv8p09 |
| authorships[2].institutions[0].type | education |
| authorships[2].institutions[0].lineage | https://openalex.org/I115953327 |
| authorships[2].institutions[0].country_code | TR |
| authorships[2].institutions[0].display_name | Çanakkale Onsekiz Mart Üniversitesi |
| authorships[2].author_position | middle |
| authorships[2].raw_author_name | Dilek Ülker Çakır |
| authorships[2].is_corresponding | False |
| authorships[2].raw_affiliation_strings | Department of Biochemistry, Çanakkale Onsekiz Mart University, Çanakkale, Türkiye |
| authorships[3].author.id | https://openalex.org/A5090032580 |
| authorships[3].author.orcid | https://orcid.org/0000-0001-7191-2240 |
| authorships[3].author.display_name | Fatma Sılan |
| authorships[3].countries | TR |
| authorships[3].affiliations[0].institution_ids | https://openalex.org/I115953327 |
| authorships[3].affiliations[0].raw_affiliation_string | Department of Medical Genetics, Çanakkale Onsekiz Mart University, Çanakkale, Türkiye |
| authorships[3].institutions[0].id | https://openalex.org/I115953327 |
| authorships[3].institutions[0].ror | https://ror.org/05rsv8p09 |
| authorships[3].institutions[0].type | education |
| authorships[3].institutions[0].lineage | https://openalex.org/I115953327 |
| authorships[3].institutions[0].country_code | TR |
| authorships[3].institutions[0].display_name | Çanakkale Onsekiz Mart Üniversitesi |
| authorships[3].author_position | last |
| authorships[3].raw_author_name | Fatma Sılan |
| authorships[3].is_corresponding | False |
| authorships[3].raw_affiliation_strings | Department of Medical Genetics, Çanakkale Onsekiz Mart University, Çanakkale, Türkiye |
| has_content.pdf | True |
| has_content.grobid_xml | True |
| is_paratext | False |
| open_access.is_oa | True |
| open_access.oa_url | https://www.frontiersin.org/articles/10.3389/fendo.2023.1281112/pdf?isPublishedV2=False |
| open_access.oa_status | gold |
| open_access.any_repository_has_fulltext | False |
| created_date | 2023-12-08T00:00:00 |
| display_name | Genetic influence on urinary vitamin D binding protein excretion and serum levels: a focus on rs4588 C>A polymorphism in the GC gene |
| has_fulltext | True |
| is_retracted | False |
| updated_date | 2025-11-06T03:46:38.306776 |
| primary_topic.id | https://openalex.org/T10277 |
| primary_topic.field.id | https://openalex.org/fields/27 |
| primary_topic.field.display_name | Medicine |
| primary_topic.score | 0.9998000264167786 |
| primary_topic.domain.id | https://openalex.org/domains/4 |
| primary_topic.domain.display_name | Health Sciences |
| primary_topic.subfield.id | https://openalex.org/subfields/2734 |
| primary_topic.subfield.display_name | Pathology and Forensic Medicine |
| primary_topic.display_name | Vitamin D Research Studies |
| related_works | https://openalex.org/W2189500309, https://openalex.org/W4377691739, https://openalex.org/W2612860809, https://openalex.org/W4387821929, https://openalex.org/W2064667572, https://openalex.org/W4295735944, https://openalex.org/W3176871034, https://openalex.org/W2079918742, https://openalex.org/W2186308418, https://openalex.org/W4235539897 |
| cited_by_count | 4 |
| counts_by_year[0].year | 2025 |
| counts_by_year[0].cited_by_count | 3 |
| counts_by_year[1].year | 2024 |
| counts_by_year[1].cited_by_count | 1 |
| locations_count | 4 |
| best_oa_location.id | doi:10.3389/fendo.2023.1281112 |
| best_oa_location.is_oa | True |
| best_oa_location.source.id | https://openalex.org/S2597401208 |
| best_oa_location.source.issn | 1664-2392 |
| best_oa_location.source.type | journal |
| best_oa_location.source.is_oa | True |
| best_oa_location.source.issn_l | 1664-2392 |
| best_oa_location.source.is_core | True |
| best_oa_location.source.is_in_doaj | True |
| best_oa_location.source.display_name | Frontiers in Endocrinology |
| best_oa_location.source.host_organization | https://openalex.org/P4310320527 |
| best_oa_location.source.host_organization_name | Frontiers Media |
| best_oa_location.source.host_organization_lineage | https://openalex.org/P4310320527 |
| best_oa_location.license | cc-by |
| best_oa_location.pdf_url | https://www.frontiersin.org/articles/10.3389/fendo.2023.1281112/pdf?isPublishedV2=False |
| best_oa_location.version | publishedVersion |
| best_oa_location.raw_type | journal-article |
| best_oa_location.license_id | https://openalex.org/licenses/cc-by |
| best_oa_location.is_accepted | True |
| best_oa_location.is_published | True |
| best_oa_location.raw_source_name | Frontiers in Endocrinology |
| best_oa_location.landing_page_url | https://doi.org/10.3389/fendo.2023.1281112 |
| primary_location.id | doi:10.3389/fendo.2023.1281112 |
| primary_location.is_oa | True |
| primary_location.source.id | https://openalex.org/S2597401208 |
| primary_location.source.issn | 1664-2392 |
| primary_location.source.type | journal |
| primary_location.source.is_oa | True |
| primary_location.source.issn_l | 1664-2392 |
| primary_location.source.is_core | True |
| primary_location.source.is_in_doaj | True |
| primary_location.source.display_name | Frontiers in Endocrinology |
| primary_location.source.host_organization | https://openalex.org/P4310320527 |
| primary_location.source.host_organization_name | Frontiers Media |
| primary_location.source.host_organization_lineage | https://openalex.org/P4310320527 |
| primary_location.license | cc-by |
| primary_location.pdf_url | https://www.frontiersin.org/articles/10.3389/fendo.2023.1281112/pdf?isPublishedV2=False |
| primary_location.version | publishedVersion |
| primary_location.raw_type | journal-article |
| primary_location.license_id | https://openalex.org/licenses/cc-by |
| primary_location.is_accepted | True |
| primary_location.is_published | True |
| primary_location.raw_source_name | Frontiers in Endocrinology |
| primary_location.landing_page_url | https://doi.org/10.3389/fendo.2023.1281112 |
| publication_date | 2023-12-07 |
| publication_year | 2023 |
| referenced_works | https://openalex.org/W1916465006, https://openalex.org/W2114096305, https://openalex.org/W2086690571, https://openalex.org/W3000631773, https://openalex.org/W2756675063, https://openalex.org/W1589100385, https://openalex.org/W4210997264, https://openalex.org/W2293120381, https://openalex.org/W2028927099, https://openalex.org/W2237789533, https://openalex.org/W2169620528, https://openalex.org/W3049760005, https://openalex.org/W2062361583, https://openalex.org/W3207129955, https://openalex.org/W3162571239, https://openalex.org/W2252206298, https://openalex.org/W2139819306, https://openalex.org/W2039921880, https://openalex.org/W2161519087, https://openalex.org/W2807534993, https://openalex.org/W2091828309, https://openalex.org/W2110646769, https://openalex.org/W2014794183, https://openalex.org/W2103859910, https://openalex.org/W2013222365, https://openalex.org/W2783077594, https://openalex.org/W2804503043, https://openalex.org/W4285741328, https://openalex.org/W2795945775, https://openalex.org/W2578172301, https://openalex.org/W2127474337, https://openalex.org/W1499916502 |
| referenced_works_count | 32 |
| abstract_inverted_index.= | 151, 176, 193, 217, 220, 250, 253, 256 |
| abstract_inverted_index.A | 70, 200, 233 |
| abstract_inverted_index.D | 2, 12, 34, 90 |
| abstract_inverted_index.a | 7, 287 |
| abstract_inverted_index.p | 150, 175, 192, 219, 255 |
| abstract_inverted_index.t | 252 |
| abstract_inverted_index.(B | 249 |
| abstract_inverted_index.(r | 216 |
| abstract_inverted_index.An | 273 |
| abstract_inverted_index.GC | 21, 266 |
| abstract_inverted_index.No | 222 |
| abstract_inverted_index.We | 45 |
| abstract_inverted_index.in | 10, 61, 160, 167, 173, 179, 185, 190, 213, 227, 246, 264, 294 |
| abstract_inverted_index.no | 154 |
| abstract_inverted_index.of | 19, 86, 240, 290 |
| abstract_inverted_index.on | 75, 88, 242 |
| abstract_inverted_index.or | 178, 229 |
| abstract_inverted_index.to | 47, 82, 141, 302 |
| abstract_inverted_index.± | 165, 171 |
| abstract_inverted_index.0.4 | 183 |
| abstract_inverted_index.109 | 76 |
| abstract_inverted_index.SNP | 112 |
| abstract_inverted_index.The | 16 |
| abstract_inverted_index.and | 14, 32, 55, 58, 64, 92, 101, 104, 124, 206, 280, 298 |
| abstract_inverted_index.for | 110 |
| abstract_inverted_index.had | 268 |
| abstract_inverted_index.has | 25 |
| abstract_inverted_index.the | 20, 38, 49, 66, 84, 132, 196, 230, 238, 261, 265, 291, 303 |
| abstract_inverted_index.two | 197 |
| abstract_inverted_index.vs. | 147, 169, 187 |
| abstract_inverted_index.was | 73, 113, 210, 225, 284 |
| abstract_inverted_index.51.3 | 172 |
| abstract_inverted_index.59.3 | 166 |
| abstract_inverted_index.VDBP | 31, 53, 57, 94, 102, 162, 208, 244, 278, 282, 297 |
| abstract_inverted_index.age: | 79 |
| abstract_inverted_index.been | 26 |
| abstract_inverted_index.gene | 267 |
| abstract_inverted_index.only | 212 |
| abstract_inverted_index.role | 9, 289 |
| abstract_inverted_index.such | 223 |
| abstract_inverted_index.were | 158 |
| abstract_inverted_index.with | 28, 63, 260 |
| abstract_inverted_index.(3.5) | 146 |
| abstract_inverted_index.(mean | 78 |
| abstract_inverted_index.0.386 | 188 |
| abstract_inverted_index.11.85 | 145 |
| abstract_inverted_index.11.96 | 80 |
| abstract_inverted_index.12.86 | 148 |
| abstract_inverted_index.25OHD | 59, 100, 138, 271, 299 |
| abstract_inverted_index.VDBP, | 24 |
| abstract_inverted_index.aimed | 46 |
| abstract_inverted_index.found | 211 |
| abstract_inverted_index.gene, | 22 |
| abstract_inverted_index.lower | 136, 269 |
| abstract_inverted_index.plays | 6 |
| abstract_inverted_index.ratio | 107 |
| abstract_inverted_index.renal | 292 |
| abstract_inverted_index.serum | 30, 56, 99, 137, 161, 207, 243, 270, 281, 296 |
| abstract_inverted_index.study | 72 |
| abstract_inverted_index.these | 41 |
| abstract_inverted_index.using | 115 |
| abstract_inverted_index.(0.35) | 184 |
| abstract_inverted_index.(0.43) | 189 |
| abstract_inverted_index.(4.9), | 149 |
| abstract_inverted_index.(IQR): | 144, 182 |
| abstract_inverted_index.(VDBP) | 5 |
| abstract_inverted_index.0.141) | 177 |
| abstract_inverted_index.0.189) | 194 |
| abstract_inverted_index.136.49 | 170 |
| abstract_inverted_index.allele | 127, 134, 198, 263 |
| abstract_inverted_index.assay. | 117 |
| abstract_inverted_index.entire | 231 |
| abstract_inverted_index.impact | 85, 239 |
| abstract_inverted_index.levels | 60, 139, 163, 209, 245, 283, 300 |
| abstract_inverted_index.linear | 122, 234 |
| abstract_inverted_index.linked | 301 |
| abstract_inverted_index.remain | 43 |
| abstract_inverted_index.rs4588 | 111 |
| abstract_inverted_index.years) | 81 |
| abstract_inverted_index.(126.34 | 164 |
| abstract_inverted_index.(25OHD) | 35 |
| abstract_inverted_index.(median | 143, 181 |
| abstract_inverted_index.-0.269, | 251 |
| abstract_inverted_index.-0.367, | 218 |
| abstract_inverted_index.-2.185, | 254 |
| abstract_inverted_index.0.023). | 152 |
| abstract_inverted_index.0.024). | 221 |
| abstract_inverted_index.0.035). | 257 |
| abstract_inverted_index.Methods | 69 |
| abstract_inverted_index.Results | 129 |
| abstract_inverted_index.Vitamin | 1 |
| abstract_inverted_index.allele. | 68, 305 |
| abstract_inverted_index.altered | 29, 295 |
| abstract_inverted_index.between | 51, 126, 195, 204, 276 |
| abstract_inverted_index.binding | 3 |
| abstract_inverted_index.cohort. | 232 |
| abstract_inverted_index.crucial | 8 |
| abstract_inverted_index.effects | 42 |
| abstract_inverted_index.explore | 83 |
| abstract_inverted_index.groups. | 128, 199 |
| abstract_inverted_index.inverse | 202, 274 |
| abstract_inverted_index.levels, | 103 |
| abstract_inverted_index.levels. | 36, 272 |
| abstract_inverted_index.partial | 288 |
| abstract_inverted_index.pathway | 293 |
| abstract_inverted_index.protein | 4 |
| abstract_inverted_index.urinary | 52, 93, 105, 277 |
| abstract_inverted_index.vitamin | 11, 89 |
| abstract_inverted_index.without | 65 |
| abstract_inverted_index.However, | 37, 153 |
| abstract_inverted_index.analyses | 97, 119 |
| abstract_inverted_index.analysis | 236 |
| abstract_inverted_index.carriers | 215, 248 |
| abstract_inverted_index.carrying | 131 |
| abstract_inverted_index.children | 77 |
| abstract_inverted_index.compared | 140 |
| abstract_inverted_index.encoding | 23 |
| abstract_inverted_index.included | 120 |
| abstract_inverted_index.observed | 159, 226 |
| abstract_inverted_index.rs4588-A | 17, 67, 87, 133, 168, 186, 214, 247, 262, 304 |
| abstract_inverted_index.unclear. | 44 |
| abstract_inverted_index.LightSNiP | 116 |
| abstract_inverted_index.conducted | 74 |
| abstract_inverted_index.confirmed | 237 |
| abstract_inverted_index.excretion | 54, 279 |
| abstract_inverted_index.exhibited | 135 |
| abstract_inverted_index.observed, | 285 |
| abstract_inverted_index.performed | 114 |
| abstract_inverted_index.transport | 13 |
| abstract_inverted_index.u-VDBP/Cr | 180, 205, 241 |
| abstract_inverted_index.Conclusion | 258 |
| abstract_inverted_index.Genotyping | 109 |
| abstract_inverted_index.associated | 27 |
| abstract_inverted_index.comparison | 125 |
| abstract_inverted_index.determined | 98 |
| abstract_inverted_index.excretion. | 95 |
| abstract_inverted_index.mechanisms | 39 |
| abstract_inverted_index.metabolism | 91 |
| abstract_inverted_index.regression | 235 |
| abstract_inverted_index.suggesting | 286 |
| abstract_inverted_index.underlying | 40 |
| abstract_inverted_index.Biochemical | 96 |
| abstract_inverted_index.Individuals | 259 |
| abstract_inverted_index.Statistical | 118 |
| abstract_inverted_index.correlation | 203, 224, 275 |
| abstract_inverted_index.differences | 157 |
| abstract_inverted_index.individuals | 62 |
| abstract_inverted_index.investigate | 48 |
| abstract_inverted_index.metabolism. | 15 |
| abstract_inverted_index.regression, | 123 |
| abstract_inverted_index.significant | 156, 201 |
| abstract_inverted_index.(u-VDBP/Cr). | 108 |
| abstract_inverted_index.Introduction | 0 |
| abstract_inverted_index.Participants | 130 |
| abstract_inverted_index.correlation, | 121 |
| abstract_inverted_index.non-carriers | 142, 228 |
| abstract_inverted_index.polymorphism | 18 |
| abstract_inverted_index.relationship | 50 |
| abstract_inverted_index.non-rs4588-A, | 174, 191 |
| abstract_inverted_index.statistically | 155 |
| abstract_inverted_index.cross-sectional | 71 |
| abstract_inverted_index.25-hydroxyvitamin | 33 |
| abstract_inverted_index.VDBP-to-creatinine | 106 |
| cited_by_percentile_year.max | 98 |
| cited_by_percentile_year.min | 90 |
| corresponding_author_ids | https://openalex.org/A5032635247 |
| countries_distinct_count | 1 |
| institutions_distinct_count | 4 |
| corresponding_institution_ids | https://openalex.org/I115953327 |
| citation_normalized_percentile.value | 0.80773745 |
| citation_normalized_percentile.is_in_top_1_percent | False |
| citation_normalized_percentile.is_in_top_10_percent | False |