Genetic load in incomplete lupus erythematosus Article Swipe
Matt Slief
,
Joseph Kheir
,
Miles Smith
,
C. Mowery
,
Susan Macwana
,
Wade DeJager
,
Catriona A. Wagner
,
Teresa Aberle
,
Judith A. James
,
Joel M. Guthridge
·
YOU?
·
· 2022
· Open Access
·
· DOI: https://doi.org/10.1101/2022.02.14.480411
YOU?
·
· 2022
· Open Access
·
· DOI: https://doi.org/10.1101/2022.02.14.480411
Incomplete lupus erythematosus (ILE) patients have lupus features but insufficient criteria for systemic lupus erythematosus (SLE) classification. Some ILE patients transition to SLE, but most avoid major organ involvement. This study tested whether the milder disease course in ILE is influenced by reduced SLE-risk allele genetic load. We calculated the genetic load based on 99 SLE-associated risk alleles in European American SLE patients ( > 4 ACR-1997 criteria, n=171), ILE patients (3 ACR-1997 criteria; n=174), a subset of ILE patients not meeting SLICC classification (ILE SLICC , n=119), and healthy controls (n=133). ILE and SLE patients had significantly greater SLE-risk allele genetic load compared to healthy controls, while ILE SLICC patients had a trend toward an increased genetic load, although not statistically significant. However, the genetic load did not differ between ILE and SLE. In conclusion, ILE and SLE patients have comparable genetic loads of SLE risk loci, suggesting similar genetic predisposition between these conditions. Phenotypic differences between SLE and ILE may instead be influenced by ILE-specific variants and gene-environment interactions.
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Metadata
- Type
- preprint
- Language
- en
- Landing Page
- https://doi.org/10.1101/2022.02.14.480411
- https://www.biorxiv.org/content/biorxiv/early/2022/02/14/2022.02.14.480411.full.pdf
- OA Status
- green
- References
- 15
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W4213236306
All OpenAlex metadata
Raw OpenAlex JSON
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Genetic load in incomplete lupus erythematosusWork title
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preprintOpenAlex work type
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enPrimary language
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2022Year of publication
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2022-02-14Full publication date if available
- Authors
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Matt Slief, Joseph Kheir, Miles Smith, C. Mowery, Susan Macwana, Wade DeJager, Catriona A. Wagner, Teresa Aberle, Judith A. James, Joel M. GuthridgeList of authors in order
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https://doi.org/10.1101/2022.02.14.480411Publisher landing page
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https://www.biorxiv.org/content/biorxiv/early/2022/02/14/2022.02.14.480411.full.pdfDirect link to full text PDF
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YesWhether a free full text is available
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greenOpen access status per OpenAlex
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https://www.biorxiv.org/content/biorxiv/early/2022/02/14/2022.02.14.480411.full.pdfDirect OA link when available
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Allele, Medicine, Genetic predisposition, Systemic lupus erythematosus, Lupus erythematosus, Immunology, Disease, Autoimmune disease, Internal medicine, Gene, Genetics, Biology, AntibodyTop concepts (fields/topics) attached by OpenAlex
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0Total citation count in OpenAlex
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10Other works algorithmically related by OpenAlex
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