Genetic markers associated with host status and clonal expansion of Group B Streptococcus in the Netherlands Article Swipe
Uzma Basit Khan
,
Victoria Dyster
,
Chrispin Chaguza
,
Nina M. van Sorge
,
Diederik van de Beek
,
Wing Kit Man
,
Stephen D. Bentley
,
Merijn W. Bijlsma
,
Dorota Jamrozy
·
YOU?
·
· 2024
· Open Access
·
· DOI: https://doi.org/10.3389/fmicb.2024.1410651
YOU?
·
· 2024
· Open Access
·
· DOI: https://doi.org/10.3389/fmicb.2024.1410651
Objectives Certain Group B Streptococcus (GBS) genotypes are associated with invasive disease in neonates. We conducted a comparative genomic analysis of GBS isolates from neonatal disease and maternal carriage in the Netherlands to determine distribution of genetic markers between the two host groups. Methods Whole genome sequencing was used to characterise 685 neonatal invasive isolates (2006–2021) and 733 maternal carriage isolates (2017–2021) collected in the Netherlands. Results Clonal complex (CC) 17 and serotype III were significantly more common in disease while carriage isolates were associated with serotypes II, IV, V as well as CC1. Previously reported CC17-A1 sub-lineage was dominant among disease isolates and significantly less common in carriage. The phiStag1 phage, previously associated with expansion of invasive CC17 isolates in the Netherlands, was more common among disease isolates compared to carriage isolates overall, however it was equally distributed between CC17 isolates from carriage and disease. Prevalence of antimicrobial resistance genes was overall lower in disease compared to carriage isolates, but increased significantly over time, mediated by rise in prevalence of a multidrug resistance element ICESag37 among disease isolates. Conclusion There is a stable association between certain GBS genotypes and invasive disease, which suggests opportunities for developing more precise disease prevention strategies based on GBS targeted screening. In contrast, GBS mobile genetic elements appear less likely to be correlated with carriage or disease, and instead are associated with clonal expansion events across the GBS population.
Related Topics
Concepts
Biology
Carriage
Streptococcus
Group B
Streptococcus agalactiae
Genotype
Group A
Genetics
Host (biology)
Disease
Genetic marker
Microbiology
Gene
Medicine
Bacteria
Internal medicine
Pathology
Metadata
- Type
- article
- Language
- en
- Landing Page
- https://doi.org/10.3389/fmicb.2024.1410651
- https://www.frontiersin.org/journals/microbiology/articles/10.3389/fmicb.2024.1410651/pdf
- OA Status
- gold
- Cited By
- 3
- References
- 21
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W4400512923
All OpenAlex metadata
Raw OpenAlex JSON
- OpenAlex ID
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https://openalex.org/W4400512923Canonical identifier for this work in OpenAlex
- DOI
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https://doi.org/10.3389/fmicb.2024.1410651Digital Object Identifier
- Title
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Genetic markers associated with host status and clonal expansion of Group B Streptococcus in the NetherlandsWork title
- Type
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articleOpenAlex work type
- Language
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enPrimary language
- Publication year
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2024Year of publication
- Publication date
-
2024-07-10Full publication date if available
- Authors
-
Uzma Basit Khan, Victoria Dyster, Chrispin Chaguza, Nina M. van Sorge, Diederik van de Beek, Wing Kit Man, Stephen D. Bentley, Merijn W. Bijlsma, Dorota JamrozyList of authors in order
- Landing page
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https://doi.org/10.3389/fmicb.2024.1410651Publisher landing page
- PDF URL
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https://www.frontiersin.org/journals/microbiology/articles/10.3389/fmicb.2024.1410651/pdfDirect link to full text PDF
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YesWhether a free full text is available
- OA status
-
goldOpen access status per OpenAlex
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https://www.frontiersin.org/journals/microbiology/articles/10.3389/fmicb.2024.1410651/pdfDirect OA link when available
- Concepts
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Biology, Carriage, Streptococcus, Group B, Streptococcus agalactiae, Genotype, Group A, Genetics, Host (biology), Disease, Genetic marker, Microbiology, Gene, Medicine, Bacteria, Internal medicine, PathologyTop concepts (fields/topics) attached by OpenAlex
- Cited by
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3Total citation count in OpenAlex
- Citations by year (recent)
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2025: 3Per-year citation counts (last 5 years)
- References (count)
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21Number of works referenced by this work
- Related works (count)
-
10Other works algorithmically related by OpenAlex
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